IGHM

Functionⁱ

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane-bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as a homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts (PubMed:3137579, PubMed:16895553).4 Publications1 Publication

Caution

For an example of a full-length immunoglobulin mu heavy chain see AC P0DOX6.Curated

GO - Molecular functionⁱ

antigen binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
immunoglobulin receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response
Source: UniProtKB
Inferred from direct assayⁱ
- 21786026
antibacterial humoral response
Source: UniProtKB
Inferred from direct assayⁱ
- 21786026
B cell receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
complement activation, classical pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
defense response to bacterium
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
defense response to Gram-negative bacterium
Source: UniProtKB
Inferred from direct assayⁱ
- 22427638
innate immune response
Source: UniProtKB
Inferred from direct assayⁱ
- 21786026
leukocyte migration Source: Reactome
phagocytosis, engulfment
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phagocytosis, recognition
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of B cell activation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Adaptive immunity, Immunity

Biological process

Adaptive immunity, Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-5690714 CD22 mediated BCR regulation R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Reactomeⁱ

R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Protein family/group databases

IMGT/GENE-DB	IGHM

IMGT/GENE-DB

IGHM

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Immunoglobulin heavy constant mu2 Publications Alternative name(s): Ig mu chain C regionCurated Ig mu chain C region BOT1 Publication Ig mu chain C region GAL1 Publication Ig mu chain C region OU1 Publication
Gene namesⁱ	Name:IGHM2 Publications
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000211899.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5541 IGHM
MIMⁱ	147020 gene
neXtProtⁱ	NX_P01871

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Agammaglobulinemia 1, autosomal recessive (AGM1)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3507
MalaCards human disease database More...MalaCardsⁱ	IGHM
MIMⁱ	601495 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000211899
Orphanetⁱ	33110 Autosomal agammaglobulinemia

Polymorphism and mutation databases

DMDMⁱ	127506

DMDMⁱ

127506

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000153619	‹1 – 453	Immunoglobulin heavy constant muAdd BLAST		›453

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	14	Interchain (with light chain)1 Publication
Disulfide bondⁱ	28 ↔ 88	PROSITE-ProRule annotation
Glycosylationⁱ	46	N-linked (GlcNAc...) (complex) asparagine3 Publications	1
Disulfide bondⁱ	134 ↔ 197	PROSITE-ProRule annotation
Glycosylationⁱ	209	N-linked (GlcNAc...) (complex) asparagine1 Publication	1
Disulfide bondⁱ	214	Interchain (with heavy chain)1 Publication
Disulfide bondⁱ	244 ↔ 303	PROSITE-ProRule annotation
Glycosylationⁱ	272	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	279	N-linked (GlcNAc...) asparagine2 Publications	1
Disulfide bondⁱ	291	Interchain (with heavy chain of another subunit)1 Publication
Disulfide bondⁱ	351 ↔ 413	PROSITE-ProRule annotation
GlycosylationⁱCAR_000219	440	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	452	Interchain (with heavy chain)1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	P01871
PRIDEⁱ	P01871
ProteomicsDBⁱ	51498 51499 [P01871-2] 51686

2D gel databases

UCD-2DPAGEⁱ	P01871

UCD-2DPAGEⁱ

P01871

PTM databases

CarbonylDBⁱ	P01871
GlyConnectⁱ	1389 1390 280 691 [P01871-2]
iPTMnetⁱ	P01871
PhosphoSitePlusⁱ	P01871
UniCarbKBⁱ	P01871

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000211899 Expressed in 178 organ(s), highest expression level in lymph node
ExpressionAtlasⁱ	P01871 baseline and differential

Interactionⁱ

Subunit structureⁱ

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CD19	P15391	2	EBI-953797,EBI-79902

With

Entry

#Exp.

IntAct

Notes

CD19

P15391

2

EBI-953797,EBI-79902

GO - Molecular functionⁱ

immunoglobulin receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

CORUMⁱ	P01871
IntActⁱ	P01871, 62 interactors
Molecular INTeraction database More...MINTⁱ	P01871

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	10 – 12	Combined sources	3
Beta strandⁱ	22 – 28	Combined sources	7
Beta strandⁱ	31 – 36	Combined sources	6
Beta strandⁱ	40 – 43	Combined sources	4
Beta strandⁱ	45 – 49	Combined sources	5
Beta strandⁱ	53 – 55	Combined sources	3
Beta strandⁱ	59 – 61	Combined sources	3
Beta strandⁱ	64 – 66	Combined sources	3
Beta strandⁱ	69 – 74	Combined sources	6
Helixⁱ	75 – 78	Combined sources	4
Beta strandⁱ	79 – 82	Combined sources	4
Beta strandⁱ	85 – 90	Combined sources	6
Beta strandⁱ	100 – 102	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	P01871
SMRⁱ	P01871
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P01871

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	6 – 102	Ig-like 1PROSITE-ProRule annotationAdd BLAST	97
Domainⁱ	111 – 211	Ig-like 2PROSITE-ProRule annotationAdd BLAST	101
Domainⁱ	229 – 319	Ig-like 3PROSITE-ProRule annotationAdd BLAST	91
Domainⁱ	329 – 430	Ig-like 4PROSITE-ProRule annotationAdd BLAST	102

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 105	CH1Add BLAST	105
Regionⁱ	106 – 217	CH2Add BLAST	112
Regionⁱ	218 – 323	CH3Add BLAST	106
Regionⁱ	324 – 452	CH4Add BLAST	129

Keywords - Domainⁱ

Immunoglobulin C region, Immunoglobulin domain, Transmembrane

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063726
HOGENOMⁱ	HOG000202819
HOVERGENⁱ	HBG005814
InParanoidⁱ	P01871
OMAⁱ	FTCVVGH
PhylomeDBⁱ	P01871

Family and domain databases

Gene3Dⁱ	2.60.40.10, 4 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654 C1-set, 4 hits
SMARTⁱ	View protein in SMART SM00407 IGc1, 4 hits
SUPFAMⁱ	SSF48726 SSF48726, 4 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 4 hits PS00290 IG_MHC, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P01871-1) [UniParc]FASTA Add to basket

Also known as: Secreted

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
GSASAPTLFP LVSCENSPSD TSSVAVGCLA QDFLPDSITF SWKYKNNSDI 
        60         70         80         90        100
SSTRGFPSVL RGGKYAATSQ VLLPSKDVMQ GTDEHVVCKV QHPNGNKEKN 
       110        120        130        140        150
VPLPVIAELP PKVSVFVPPR DGFFGNPRKS KLICQATGFS PRQIQVSWLR 
       160        170        180        190        200
EGKQVGSGVT TDQVQAEAKE SGPTTYKVTS TLTIKESDWL GQSMFTCRVD 
       210        220        230        240        250
HRGLTFQQNA SSMCVPDQDT AIRVFAIPPS FASIFLTKST KLTCLVTDLT 
       260        270        280        290        300
TYDSVTISWT RQNGEAVKTH TNISESHPNA TFSAVGEASI CEDDWNSGER 
       310        320        330        340        350
FTCTVTHTDL PSPLKQTISR PKGVALHRPD VYLLPPAREQ LNLRESATIT 
       360        370        380        390        400
CLVTGFSPAD VFVQWMQRGQ PLSPEKYVTS APMPEPQAPG RYFAHSILTV 
       410        420        430        440        450
SEEEWNTGET YTCVVAHEAL PNRVTERTVD KSTGKPTLYN VSLVMSDTAG 

TCY

Length:453

Mass (Da):49,440

Last modified:March 15, 2017 - v4

Checksum:ⁱ607CA2FA7BFA0D39

GO

Isoform 2 (identifier: P01871-2) [UniParc]FASTA Add to basket

Also known as: Membrane-bound

The sequence of this isoform differs from the canonical sequence as follows:
434-453: GKPTLYNVSLVMSDTAGTCY → EGEVSADEEGFENLWATASTFIVLFLLSLFYSTTVTLFKVK

« Hide

        10         20         30         40         50
GSASAPTLFP LVSCENSPSD TSSVAVGCLA QDFLPDSITF SWKYKNNSDI 
        60         70         80         90        100
SSTRGFPSVL RGGKYAATSQ VLLPSKDVMQ GTDEHVVCKV QHPNGNKEKN 
       110        120        130        140        150
VPLPVIAELP PKVSVFVPPR DGFFGNPRKS KLICQATGFS PRQIQVSWLR 
       160        170        180        190        200
EGKQVGSGVT TDQVQAEAKE SGPTTYKVTS TLTIKESDWL GQSMFTCRVD 
       210        220        230        240        250
HRGLTFQQNA SSMCVPDQDT AIRVFAIPPS FASIFLTKST KLTCLVTDLT 
       260        270        280        290        300
TYDSVTISWT RQNGEAVKTH TNISESHPNA TFSAVGEASI CEDDWNSGER 
       310        320        330        340        350
FTCTVTHTDL PSPLKQTISR PKGVALHRPD VYLLPPAREQ LNLRESATIT 
       360        370        380        390        400
CLVTGFSPAD VFVQWMQRGQ PLSPEKYVTS APMPEPQAPG RYFAHSILTV 
       410        420        430        440        450
SEEEWNTGET YTCVVAHEAL PNRVTERTVD KSTEGEVSAD EEGFENLWAT 
       460        470 
ASTFIVLFLL SLFYSTTVTL FKVK

Show »

Length:474

Mass (Da):51,924

Checksum:ⁱ7A66A47C8810BDF1

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A1B0GUU9	A0A1B0GUU9_HUMAN		Immunoglobulin heavy constant mu Immunoglobulin heavy constant mu	IGHM	474	Annotation score:

Sequence cautionⁱ

The sequence CAA33065 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence CAA33069 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence CAA33071 differs from that shown. Reason: Erroneous gene model prediction.Curated

The sequence CAA34971 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

The sequence CAE82013 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence CAE82014 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Non-terminal residueⁱ	1		1
Sequence conflictⁱ	128	R → RS in CAA34971 (PubMed:2115996).Curated	1
Sequence conflictⁱ	145	Q → E AA sequence (PubMed:6425189).Curated	1
Sequence conflictⁱ	163 – 165	QVQ → EVE AA sequence (PubMed:6425189).Curated	3
Sequence conflictⁱ	220	T → I in CAB37838 (Ref. 6) Curated	1
Sequence conflictⁱ	263	N → D AA sequence (PubMed:6425189).Curated	1
Sequence conflictⁱ	296	N → D AA sequence (PubMed:6425189).Curated	1
Isoform 2 (identifier: P01871-2)
Sequence conflictⁱ	438	S → N in AAB59422 (PubMed:6795593).Curated	1
Sequence conflictⁱ	440	D → E in AAB59422 (PubMed:6795593).Curated	1
Sequence conflictⁱ	449	A → T in AAB59422 (PubMed:6795593).Curated	1
Sequence conflictⁱ	472 – 474	KVK → K in AAB59422 (PubMed:6795593).Curated	3
Sequence conflictⁱ	472 – 474	KVK → K in CAA33065 (PubMed:2505237).Curated	3

Polymorphismⁱ

There are several alleles. The sequence shown is that of IMGT allele IGHM*04.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_077893	40	F → L in IMGT allele IGHM*01. 1 Publication	1
Natural variantⁱVAR_003903	191	G → S in IMGT allele IGHM*03. 1 Publication	1
Natural variantⁱVAR_003904	215	V → G1 PublicationCorresponds to variant dbSNP:rs12365Ensembl.	1
Natural variantⁱVAR_077894	414	Missing in IMGT allele IGHM01 IMGT allele IGHM02. 2 Publications	1
Natural variantⁱVAR_077895	418	E → D in IMGT allele IGHM*02. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_034488	434 – 453	GKPTL…AGTCY → EGEVSADEEGFENLWATAST FIVLFLLSLFYSTTVTLFKV K in isoform 2. 2 PublicationsAdd BLAST		20

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14940 Genomic DNA Translation: CAE82013.1 Different initiation. X14940 Genomic DNA Translation: CAE82014.1 Different initiation. X14940 Genomic DNA Translation: CAA33069.1 Different initiation. X14940 Genomic DNA Translation: CAA33070.1 X14940 Genomic DNA Translation: CAA33071.1 Sequence problems. X14939 Genomic DNA Translation: CAA33065.1 Different initiation. X17115 mRNA Translation: CAA34971.1 Different initiation. X57086 mRNA Translation: CAB37838.1 AC244226 Genomic DNA No translation available. AC245166 Genomic DNA No translation available. AC246787 Genomic DNA No translation available. AC247036 Genomic DNA No translation available. K01310 Genomic DNA Translation: AAB59422.1
PIRⁱ	A02163 MHHUBT S14683 S16510 MHHUM
UniGeneⁱ	Hs.510635

Genome annotation databases

Ensemblⁱ	ENST00000390559; ENSP00000375001; ENSG00000211899 [P01871-1] ENST00000626472; ENSP00000485962; ENSG00000282657 [P01871-1] ENST00000637539; ENSP00000490253; ENSG00000211899 [P01871-2]
UCSC genome browser More...UCSCⁱ	uc059gdp.1 human

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01871	Immunoglobulin heavy constant mu		MACMU		559	UniRef90_P01871
IGHM isoform 2 (Fragment)		PONAB		453
Uncharacterized protein		PANTR		130
Uncharacterized protein		PANPA		130
Uncharacterized protein (Fragment)		PANTR		452
P01871-2	Immunoglobulin heavy constant mu (Fragment)		HUMAN		474	UniRef90_P01871-2
Uncharacterized protein		PONAB		396
Immunoglobulin heavy constant mu		CHLSB		396
IGHM isoform 1 (Fragment)		PONAB		474

Protein	Similar proteins		Species	Score	Length	Source
P01871	Immunoglobulin heavy constant mu		MACMU		559	UniRef50_P01871
IGHM isoform 2 (Fragment)		PONAB		453
Uncharacterized protein		PANTR		130
Uncharacterized protein		PANPA		130
Ig mu chain C region secreted form		FUKDA		568
+2
P01871-2	Immunoglobulin heavy constant mu	)	MOUSE		454	UniRef50_P01872
Ig mu chain C region membrane-bound form		RABIT		479
Ig mu chain C region		CANLF		450
Ig mu chain C region		SUNMU		457
Ig mu chain C region		MESAU		454
+29

Cross-referencesⁱ

Web resourcesⁱ

IGHMbase

IGHM mutation db

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X14940 Genomic DNA Translation: CAE82013.1 Different initiation. X14940 Genomic DNA Translation: CAE82014.1 Different initiation. X14940 Genomic DNA Translation: CAA33069.1 Different initiation. X14940 Genomic DNA Translation: CAA33070.1 X14940 Genomic DNA Translation: CAA33071.1 Sequence problems. X14939 Genomic DNA Translation: CAA33065.1 Different initiation. X17115 mRNA Translation: CAA34971.1 Different initiation. X57086 mRNA Translation: CAB37838.1 AC244226 Genomic DNA No translation available. AC245166 Genomic DNA No translation available. AC246787 Genomic DNA No translation available. AC247036 Genomic DNA No translation available. K01310 Genomic DNA Translation: AAB59422.1
PIRⁱ	A02163 MHHUBT S14683 S16510 MHHUM
UniGeneⁱ	Hs.510635

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1HEZ	X-ray	2.70	B/D	1-104	[»]
	2AGJ	X-ray	2.60	H	169-428	[»]
ProteinModelPortalⁱ	P01871
SMRⁱ	P01871
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

CORUMⁱ	P01871
IntActⁱ	P01871, 62 interactors
MINTⁱ	P01871

Protein family/group databases

IMGT/GENE-DB	IGHM

IMGT/GENE-DB

IGHM

PTM databases

CarbonylDBⁱ	P01871
GlyConnectⁱ	1389 1390 280 691 [P01871-2]
iPTMnetⁱ	P01871
PhosphoSitePlusⁱ	P01871
UniCarbKBⁱ	P01871

Polymorphism and mutation databases

DMDMⁱ	127506

DMDMⁱ

127506

2D gel databases

UCD-2DPAGEⁱ	P01871

UCD-2DPAGEⁱ

P01871

Proteomic databases

PeptideAtlasⁱ	P01871
PRIDEⁱ	P01871
ProteomicsDBⁱ	51498 51499 [P01871-2] 51686

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000390559; ENSP00000375001; ENSG00000211899 [P01871-1] ENST00000626472; ENSP00000485962; ENSG00000282657 [P01871-1] ENST00000637539; ENSP00000490253; ENSG00000211899 [P01871-2]
UCSCⁱ	uc059gdp.1 human

Organism-specific databases

DisGeNETⁱ	3507
EuPathDBⁱ	HostDB:ENSG00000211899.8
GeneCardsⁱ	IGHM
HGNCⁱ	HGNC:5541 IGHM
MalaCardsⁱ	IGHM
MIMⁱ	147020 gene 601495 phenotype
neXtProtⁱ	NX_P01871
OpenTargetsⁱ	ENSG00000211899
Orphanetⁱ	33110 Autosomal agammaglobulinemia
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00530000063726
HOGENOMⁱ	HOG000202819
HOVERGENⁱ	HBG005814
InParanoidⁱ	P01871
OMAⁱ	FTCVVGH
PhylomeDBⁱ	P01871

Enzyme and pathway databases

Reactomeⁱ	R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-5690714 CD22 mediated BCR regulation R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Reactomeⁱ

R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

EvolutionaryTraceⁱ	P01871
Protein Ontology More...PROⁱ	PR:P01871
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000211899 Expressed in 178 organ(s), highest expression level in lymph node
ExpressionAtlasⁱ	P01871 baseline and differential

Family and domain databases

Gene3Dⁱ	2.60.40.10, 4 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set
Pfamⁱ	View protein in Pfam PF07654 C1-set, 4 hits
SMARTⁱ	View protein in SMART SM00407 IGc1, 4 hits
SUPFAMⁱ	SSF48726 SSF48726, 4 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 4 hits PS00290 IG_MHC, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IGHM_HUMAN
Accessionⁱ	P01871Primary (citable) accession number: P01871 Secondary accession number(s): A0A075B6N9 , A0A0G2JQL4, P04220, P20769
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	March 15, 2017
	Last modified:	November 7, 2018
	This is version 185 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

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Annotation systems

Supporting data

UniProtKB - P01871 (IGHM_HUMAN)

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Immunoglobulin heavy constant mu

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Plasma membrane

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ