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Protein

Ig gamma-1 chain C region secreted form

Gene

Ighg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • antibacterial humoral response Source: MGI
  • antibody-dependent cellular cytotoxicity Source: MGI
  • complement activation, classical pathway Source: MGI
  • defense response to bacterium Source: MGI
  • humoral immune response mediated by circulating immunoglobulin Source: MGI
  • immunoglobulin mediated immune response Source: MGI
  • phagocytosis, engulfment Source: MGI
  • phagocytosis, recognition Source: MGI
  • positive regulation of immune response Source: MGI
  • positive regulation of phagocytosis Source: MGI
  • positive regulation of type I hypersensitivity Source: MGI
  • positive regulation of type IIa hypersensitivity Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-1 chain C region secreted form
Gene namesi
Name:Ighg1
Synonyms:Igh-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96446 Ighg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153582‹1 – 324Ig gamma-1 chain C region secreted formAdd BLAST›324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 82PROSITE-ProRule annotation1 Publication
Disulfide bondi102Interchain (with a light chain)PROSITE-ProRule annotation1 Publication
Disulfide bondi104Interchain (with a heavy chain)PROSITE-ProRule annotation1 Publication
Disulfide bondi107Interchain (with a heavy chain)PROSITE-ProRule annotation1 Publication
Disulfide bondi109Interchain (with a heavy chain)PROSITE-ProRule annotation1 Publication
Disulfide bondi138 ↔ 198PROSITE-ProRule annotation1 Publication
GlycosylationiCAR_000055174N-linked (GlcNAc...) asparagine1
Disulfide bondi244 ↔ 302PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP01868
PRIDEiP01868

PTM databases

GlyConnecti248
251
252
SwissPalmiP01868
UniCarbKBiP01868

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
P018432EBI-7139648,EBI-7139621

Protein-protein interaction databases

IntActiP01868, 6 interactors
MINTiP01868

Structurei

Secondary structure

1324
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 11Combined sources5
Beta strandi14 – 17Combined sources4
Beta strandi19 – 21Combined sources3
Beta strandi22 – 35Combined sources14
Beta strandi38 – 41Combined sources4
Helixi42 – 44Combined sources3
Beta strandi50 – 52Combined sources3
Beta strandi56 – 58Combined sources3
Beta strandi61 – 71Combined sources11
Turni72 – 77Combined sources6
Beta strandi81 – 86Combined sources6
Helixi87 – 89Combined sources3
Beta strandi91 – 96Combined sources6

3D structure databases

ProteinModelPortaliP01868
SMRiP01868
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01868

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 97CH1Add BLAST97
Regioni98 – 110HingeAdd BLAST13
Regioni111 – 217CH2Add BLAST107
Regioni218 – 324CH3Add BLAST107

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

HOVERGENiHBG005814

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
PfamiView protein in Pfam
PF07654 C1-set, 3 hits
SMARTiView protein in SMART
SM00407 IGc1, 2 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Secreted (identifier: P01868-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
AKTTPPSVYP LAPGSAAQTN SMVTLGCLVK GYFPEPVTVT WNSGSLSSGV
60 70 80 90 100
HTFPAVLQSD LYTLSSSVTV PSSPRPSETV TCNVAHPASS TKVDKKIVPR
110 120 130 140 150
DCGCKPCICT VPEVSSVFIF PPKPKDVLTI TLTPKVTCVV VDISKDDPEV
160 170 180 190 200
QFSWFVDDVE VHTAQTQPRE EQFNSTFRSV SELPIMHQDW LNGKEFKCRV
210 220 230 240 250
NSAAFPAPIE KTISKTKGRP KAPQVYTIPP PKEQMAKDKV SLTCMITDFF
260 270 280 290 300
PEDITVEWQW NGQPAENYKN TQPIMNTNGS YFVYSKLNVQ KSNWEAGNTF
310 320
TCSVLHEGLH NHHTEKSLSH SPGK
Note: May be the major isoform.
Length:324
Mass (Da):35,705
Last modified:July 21, 1986 - v1
Checksum:iA338812F3D1F2C93
GO
Isoform Membrane-bound (identifier: P01869-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P01869.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:393
Mass (Da):43,387
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti276N → D AA sequence (PubMed:98524).Curated1
Sequence conflicti278N → D AA sequence (PubMed:98524).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00453 Genomic DNA Translation: AAB59656.1
V00795 mRNA Translation: CAA24176.1
PIRiA02159 G1MS
UniGeneiMm.342177

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiIGHG1_MOUSE
AccessioniPrimary (citable) accession number: P01868
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 18, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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