Igh-3

Functionⁱ

GO - Molecular functionⁱ

antigen binding
Source: MGI
Inferred from direct assayⁱ
- "A dual role for Src homology 2 domain-containing inositol-5-phosphatase (SHIP) in immunity: aberrant development and enhanced function of b lymphocytes in ship -/- mice."
  Helgason C.D., Kalberer C.P., Damen J.E., Chappel S.M., Pineault N., Krystal G., Humphries R.K.
  J Exp Med 191:781-794(2000) [PubMed] [Europe PMC] [Abstract]
- "Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody."
  Azeredo da Silveira S., Kikuchi S., Fossati-Jimack L., Moll T., Saito T., Verbeek J.S., Botto M., Walport M.J., Carroll M., Izui S.
  J Exp Med 195:665-672(2002) [PubMed] [Europe PMC] [Abstract]
- "FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection."
  Ioan-Facsinay A., de Kimpe S.J., Hellwig S.M.M., van Lent P.L., Hofhuis F.M.A., van Ojik H.H., Sedlik C., da Silveira S.A., Gerber J., de Jong Y.F., Roozendaal R., Aarden L.A., van den Berg W.B., Saito T., Mosser D., Amigorena S., Izui S., van Ommen G.-J.B.
  , van Vugt M., van de Winkel J.G.J., Verbeek J.S.
  Immunity 16:391-402(2002) [PubMed] [Europe PMC] [Abstract]
- "T-bet regulates T-independent IgG2a class switching."
  Gerth A.J., Lin L., Peng S.L.
  Int Immunol 15:937-944(2003) [PubMed] [Europe PMC] [Abstract]
- "Impaired IgA class switching in APRIL-deficient mice."
  Castigli E., Scott S., Dedeoglu F., Bryce P., Jabara H., Bhan A.K., Mizoguchi E., Geha R.S.
  Proc Natl Acad Sci U S A 101:3903-3908(2004) [PubMed] [Europe PMC] [Abstract]
- "Involvement of a tissue-specific autoantibody in skin disorders of murine systemic lupus erythematosus and autoinflammatory diseases."
  Nishimura H., Strominger J.L.
  Proc Natl Acad Sci U S A 103:3292-3297(2006) [PubMed] [Europe PMC] [Abstract]
- "Biological activities of antitrinitrophenyl and antidinitrophenyl mouse monoclonal antibodies."
  Hirayama N., Hirano T., Kohler G., Kurata A., Okumura K., Ovary Z.
  Proc Natl Acad Sci U S A 79:613-615(1982) [PubMed] [Europe PMC] [Abstract]
- "The absence of IgE antibody-mediated augmentation of immune responses in CD23-deficient mice."
  Fujiwara H., Kikutani H., Suematsu S., Naka T., Yoshida K., Yoshida K., Tanaka T., Suemura M., Matsumoto N., Kojima S.
  Proc Natl Acad Sci U S A 91:6835-6839(1994) [PubMed] [Europe PMC] [Abstract]
- "Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice."
  Takai T., Ono M., Hikida M., Ohmori H., Ravetch J.V.
  Nature 379:346-349(1996) [PubMed] [Europe PMC] [Abstract]
- "Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice."
  Hazenbos W.L., Gessner J.E., Hofhuis F.M., Kuipers H., Meyer D., Heijnen I.A., Schmidt R.E., Sandor M., Capel P.J., Daeron M., van de Winkel J.G., Verbeek J.S.
  Immunity 5:181-188(1996) [PubMed] [Europe PMC] [Abstract]
- "Murine IgG1 complexes trigger immune effector functions predominantly via Fc gamma RIII (CD16)."
  Hazenbos W.L., Heijnen I.A., Meyer D., Hofhuis F.M., Renardel de Lavalette C.R., Schmidt R.E., Capel P.J., van de Winkel J.G., Gessner J.E., van den Berg T.K., Verbeek J.S.
  J Immunol 161:3026-3032(1998) [PubMed] [Europe PMC] [Abstract]
immunoglobulin receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

Enzyme and pathway databases

Reactomeⁱ	R-MMU-166663, Initial triggering of complement R-MMU-173623, Classical antibody-mediated complement activation R-MMU-2029481, FCGR activation R-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation R-MMU-2029485, Role of phospholipids in phagocytosis R-MMU-977606, Regulation of Complement cascade

Reactomeⁱ

R-MMU-166663, Initial triggering of complement
R-MMU-173623, Classical antibody-mediated complement activation
R-MMU-2029481, FCGR activation
R-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation
R-MMU-2029485, Role of phospholipids in phagocytosis
R-MMU-977606, Regulation of Complement cascade

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ig gamma-2B chain C region
Gene namesⁱ	Name:Igh-3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:96445, Igh-3

Topology

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transmembraneⁱ	351 – 368	HelicalSequence analysisAdd BLAST		18
Topological domainⁱ	369 – 404	CytoplasmicSequence analysisAdd BLAST		36

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000153588	‹1 – 404	Ig gamma-2B chain C regionAdd BLAST		›404

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	14	Interchain (with a light chain)PROSITE-ProRule annotation
Disulfide bondⁱ	26 ↔ 81	PROSITE-ProRule annotation
Glycosylationⁱ	104	O-linked (GalNAc...) threonine1 Publication	1
Disulfide bondⁱ	108	Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondⁱ	111	Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondⁱ	114	Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondⁱ	117	Interchain (with a heavy chain)PROSITE-ProRule annotation
Disulfide bondⁱ	149 ↔ 209	PROSITE-ProRule annotation
Glycosylationⁱ	185	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	255 ↔ 313	PROSITE-ProRule annotation

Post-translational modificationⁱ

O-linked glycan consists of Gal-GalNAc disaccharide which is modified with 2 sialic acid residues.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal More...CPTACⁱ	non-CPTAC-3524 non-CPTAC-3525
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P01867
PeptideAtlas More...PeptideAtlasⁱ	P01867
PRIDEⁱ	P01867
ProteomicsDBⁱ	269537 [P01867-1] 269538 [P01867-2]

PTM databases

GlyConnectⁱ	684, 3 N-Linked glycans (1 site)
GlyGenⁱ	P01867, 2 sites, 1 N-linked glycan (1 site)
iPTMnetⁱ	P01867

Interactionⁱ

GO - Molecular functionⁱ

immunoglobulin receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
  Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
  Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	P01867, 2 interactors
Molecular INTeraction database More...MINTⁱ	P01867

Miscellaneous databases

RNActⁱ	P01867, protein

RNActⁱ

P01867, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	6 – 10	Combined sources	5
Beta strandⁱ	14 – 16	Combined sources	3
Beta strandⁱ	20 – 31	Combined sources	12
Beta strandⁱ	32 – 34	Combined sources	3
Beta strandⁱ	37 – 41	Combined sources	5
Turnⁱ	44 – 46	Combined sources	3
Beta strandⁱ	48 – 57	Combined sources	10
Beta strandⁱ	60 – 70	Combined sources	11
Helixⁱ	71 – 73	Combined sources	3
Turnⁱ	74 – 76	Combined sources	3
Beta strandⁱ	80 – 85	Combined sources	6
Helixⁱ	86 – 88	Combined sources	3
Beta strandⁱ	90 – 95	Combined sources	6
Beta strandⁱ	127 – 131	Combined sources	5
Helixⁱ	135 – 139	Combined sources	5
Beta strandⁱ	141 – 143	Combined sources	3
Beta strandⁱ	146 – 154	Combined sources	9
Beta strandⁱ	161 – 167	Combined sources	7
Beta strandⁱ	170 – 172	Combined sources	3
Beta strandⁱ	176 – 182	Combined sources	7
Turnⁱ	183 – 186	Combined sources	4
Beta strandⁱ	187 – 195	Combined sources	9
Helixⁱ	198 – 202	Combined sources	5
Beta strandⁱ	207 – 213	Combined sources	7
Beta strandⁱ	220 – 224	Combined sources	5
Beta strandⁱ	235 – 239	Combined sources	5
Helixⁱ	243 – 245	Combined sources	3
Beta strandⁱ	248 – 263	Combined sources	16
Beta strandⁱ	266 – 271	Combined sources	6
Beta strandⁱ	274 – 276	Combined sources	3
Beta strandⁱ	279 – 281	Combined sources	3
Beta strandⁱ	288 – 290	Combined sources	3
Beta strandⁱ	292 – 301	Combined sources	10
Helixⁱ	302 – 307	Combined sources	6
Beta strandⁱ	311 – 316	Combined sources	6
Helixⁱ	321 – 323	Combined sources	3
Beta strandⁱ	325 – 329	Combined sources	5

Show more details

3D structure databases

SMRⁱ	P01867
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P01867

EvolutionaryTraceⁱ

P01867

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	5 – 97	Ig-like 1Add BLAST	93
Domainⁱ	126 – 225	Ig-like 2Add BLAST	100
Domainⁱ	234 – 330	Ig-like 3Add BLAST	97

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidⁱ	P01867

InParanoidⁱ

P01867

Family and domain databases

Gene3Dⁱ	2.60.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654, C1-set, 3 hits
SMARTⁱ	View protein in SMART SM00407, IGc1, 3 hits
SUPFAMⁱ	SSF48726, SSF48726, 3 hits
PROSITEⁱ	View protein in PROSITE PS50835, IG_LIKE, 3 hits PS00290, IG_MHC, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P01867-1) [UniParc]FASTA Add to basket

Also known as: Membrane-bound

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
KTTPPSVYPL APGCGDTTGS SVTLGCLVKG YFPESVTVTW NSGSLSSSVH 
        60         70         80         90        100
TFPALLQSGL YTMSSSVTVP SSTWPSQTVT CSVAHPASST TVDKKLEPSG 
       110        120        130        140        150
PISTINPCPP CKECHKCPAP NLEGGPSVFI FPPNIKDVLM ISLTPKVTCV 
       160        170        180        190        200
VVDVSEDDPD VQISWFVNNV EVHTAQTQTH REDYNSTIRV VSTLPIQHQD 
       210        220        230        240        250
WMSGKEFKCK VNNKDLPSPI ERTISKIKGL VRAPQVYILP PPAEQLSRKD 
       260        270        280        290        300
VSLTCLVVGF NPGDISVEWT SNGHTEENYK DTAPVLDSDG SYFIYSKLNM 
       310        320        330        340        350
KTSKWEKTDS FSCNVRHEGL KNYYLKKTIS RSPGLDLDDI CAEAKDGELD 
       360        370        380        390        400
GLWTTITIFI SLFLLSVCYS ASVTLFKVKW IFSSVVELKQ KISPDYRNMI 

GQGA

Length:404

Mass (Da):44,259

Last modified:February 1, 2005 - v3

Checksum:ⁱAE17A03221F6EC0C

GO

Isoform 2 (identifier: P01867-2) [UniParc]FASTA Add to basket

Also known as: Secreted

The sequence of this isoform differs from the canonical sequence as follows:
335-335: L → K
336-404: Missing.

« Hide

        10         20         30         40         50
KTTPPSVYPL APGCGDTTGS SVTLGCLVKG YFPESVTVTW NSGSLSSSVH 
        60         70         80         90        100
TFPALLQSGL YTMSSSVTVP SSTWPSQTVT CSVAHPASST TVDKKLEPSG 
       110        120        130        140        150
PISTINPCPP CKECHKCPAP NLEGGPSVFI FPPNIKDVLM ISLTPKVTCV 
       160        170        180        190        200
VVDVSEDDPD VQISWFVNNV EVHTAQTQTH REDYNSTIRV VSTLPIQHQD 
       210        220        230        240        250
WMSGKEFKCK VNNKDLPSPI ERTISKIKGL VRAPQVYILP PPAEQLSRKD 
       260        270        280        290        300
VSLTCLVVGF NPGDISVEWT SNGHTEENYK DTAPVLDSDG SYFIYSKLNM 
       310        320        330 
KTSKWEKTDS FSCNVRHEGL KNYYLKKTIS RSPGK

Note: May be the major isoform.Curated

Show »

Length:335

Mass (Da):36,588

Checksum:ⁱ557C4C96ED38965A

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0A6YVP0	A0A0A6YVP0_MOUSE	Immunoglobulin heavy constant gamma... Immunoglobulin heavy constant gamma 2B	Ighg2b	405	Annotation score:
A0A075B5P3	A0A075B5P3_MOUSE	Immunoglobulin heavy constant gamma... Immunoglobulin heavy constant gamma 2B	Ighg2b	336	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Non-terminal residueⁱ	1		1
Sequence conflictⁱ	24	L → S (PubMed:117548).Curated	1
Sequence conflictⁱ	24	L → S (PubMed:117549).Curated	1
Sequence conflictⁱ	35	S → P (PubMed:117548).Curated	1
Sequence conflictⁱ	35	S → P (PubMed:117549).Curated	1
Sequence conflictⁱ	238	I → T (PubMed:117548).Curated	1
Sequence conflictⁱ	238	I → T (PubMed:117549).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱ	162	Q → R in allele B.	1
Natural variantⁱ	193	T → A in allele B.	1
Natural variantⁱ	299	N → D in allele B.	1
Natural variantⁱ	300	M → I in allele B.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_034614	335	L → K in isoform 2. Curated		1
Alternative sequenceⁱVSP_034615	336 – 404	Missing in isoform 2. CuratedAdd BLAST		69

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J00461, J00462 Genomic DNA Translation: AAB59659.1
PIRⁱ	C02154, G2MSBM S25057, G2MS11

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01867-2	CH2-domain (Fragment)		MOUSE		110	UniRef100_P01867-2
CH3-domain (Fragment)		MOUSE		107
+2

Protein	Similar proteins		Species	Score	Length	Source
P01867	Immunoglobulin heavy constant gamma 2B (Fragment)		MOUSE		405	UniRef90_P01867
Immunoglobulin heavy constant gamma 2B (Fragment)		MOUSE		336
P01867-2	CH2-domain (Fragment)		MOUSE		110	UniRef90_P01867-2
CH3-domain (Fragment)		MOUSE		107
+2

Protein	Similar proteins		Species	Score	Length	Source
P01867	Immunoglobulin heavy constant gamma 1	)	HUMAN		330	UniRef50_P01857
Ig gamma-1 chain C region	)	RAT		326
Ig gamma-2A chain C region secreted form	)	MOUSE		335
Ig gamma-3 chain C region		FUKDA		385
Uncharacterized protein		PIG		403
+123

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J00461, J00462 Genomic DNA Translation: AAB59659.1
PIRⁱ	C02154, G2MSBM S25057, G2MS11

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1CBV	X-ray	2.66	H	1-97	[»]
	1CF8	X-ray	2.70	H	1-98	[»]
	1CIC	X-ray	2.50	B	2-99	[»]
	1ETZ	X-ray	2.60	B/H	1-101	[»]
	1FJ1	X-ray	2.68	B/D	1-99	[»]
	1FL3	X-ray	2.45	A/H	1-97	[»]
	1HQ4	X-ray	2.70	B/D	1-98	[»]
	1MAM	X-ray	2.45	H	1-97	[»]
	1NBV	X-ray	2.00	H	1-97	[»]
	1OSP	X-ray	1.95	H	1-97	[»]
	1UB5	X-ray	2.00	A/H	1-97	[»]
	1UB6	X-ray	2.12	A/H	1-97	[»]
	1YNK	X-ray	2.10	H	1-102	[»]
	1YNL	X-ray	1.70	H	1-102	[»]
	1ZTX	X-ray	2.50	H	1-99	[»]
	2GJZ	X-ray	2.65	B/H	1-98	[»]
	2GK0	X-ray	2.45	B/H	1-98	[»]
	2Q8A	X-ray	2.40	H	1-97	[»]
	2Q8B	X-ray	2.30	H	1-97	[»]
	2RGS	X-ray	2.13	A/B	117-334	[»]
	3CFD	X-ray	2.50	B/H	1-99	[»]
	3CFE	X-ray	2.99	B/H	1-99	[»]
	5UBX	X-ray	2.70	A/B	108-334	[»]
	6KRU	X-ray	2.30	A/B/C/D/E/F	117-334	[»]
	6KRV	X-ray	3.30	A/B/C	117-334	[»]
SMRⁱ	P01867
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P01867, 2 interactors
MINTⁱ	P01867

PTM databases

GlyConnectⁱ	684, 3 N-Linked glycans (1 site)
GlyGenⁱ	P01867, 2 sites, 1 N-linked glycan (1 site)
iPTMnetⁱ	P01867

Proteomic databases

CPTACⁱ	non-CPTAC-3524 non-CPTAC-3525
MaxQBⁱ	P01867
PeptideAtlasⁱ	P01867
PRIDEⁱ	P01867
ProteomicsDBⁱ	269537 [P01867-1] 269538 [P01867-2]

Protocols and materials databases

ABCDⁱ	P01867, 4 sequenced antibodies

ABCDⁱ

P01867, 4 sequenced antibodies

Organism-specific databases

MGIⁱ	MGI:96445, Igh-3

Phylogenomic databases

InParanoidⁱ	P01867

InParanoidⁱ

P01867

Enzyme and pathway databases

Reactomeⁱ	R-MMU-166663, Initial triggering of complement R-MMU-173623, Classical antibody-mediated complement activation R-MMU-2029481, FCGR activation R-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation R-MMU-2029485, Role of phospholipids in phagocytosis R-MMU-977606, Regulation of Complement cascade

Reactomeⁱ

R-MMU-166663, Initial triggering of complement
R-MMU-173623, Classical antibody-mediated complement activation
R-MMU-2029481, FCGR activation
R-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation
R-MMU-2029485, Role of phospholipids in phagocytosis
R-MMU-977606, Regulation of Complement cascade

Miscellaneous databases

ChiTaRSⁱ	Ighg2b, mouse
EvolutionaryTraceⁱ	P01867
Protein Ontology More...PROⁱ	PR:P01867
RNActⁱ	P01867, protein
SOURCEⁱ	Search...

Family and domain databases

Gene3Dⁱ	2.60.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set
Pfamⁱ	View protein in Pfam PF07654, C1-set, 3 hits
SMARTⁱ	View protein in SMART SM00407, IGc1, 3 hits
SUPFAMⁱ	SSF48726, SSF48726, 3 hits
PROSITEⁱ	View protein in PROSITE PS50835, IG_LIKE, 3 hits PS00290, IG_MHC, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IGG2B_MOUSE
Accessionⁱ	P01867Primary (citable) accession number: P01867 Secondary accession number(s): P01866
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	February 1, 2005
	Last modified:	June 2, 2021
	This is version 150 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P01867 (IGG2B_MOUSE)

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Ig gamma-2B chain C region

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

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<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ