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UniProtKB - P01867 (IGG2B_MOUSE)
Protein
Immunoglobulin heavy constant gamma 2B
Gene
Ighg2b
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- antigen binding Source: MGI
- Fc-gamma receptor I complex binding Source: MGI
- immunoglobulin receptor binding Source: GO_Central
GO - Biological processi
- adaptive immune response Source: MGI
- antibody-dependent cellular cytotoxicity Source: MGI
- B cell receptor signaling pathway Source: GO_Central
- complement activation, classical pathway Source: MGI
- complement-dependent cytotoxicity Source: MGI
- defense response to bacterium Source: GO_Central
- humoral immune response mediated by circulating immunoglobulin Source: MGI
- immunoglobulin mediated immune response Source: MGI
- innate immune response Source: GO_Central
- phagocytosis, engulfment Source: MGI
- phagocytosis, recognition Source: MGI
- positive regulation of B cell activation Source: GO_Central
- positive regulation of immune response Source: MGI
- positive regulation of phagocytosis Source: MGI
- positive regulation of type I hypersensitivity Source: MGI
- positive regulation of type IIa hypersensitivity Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-166663, Initial triggering of complement R-MMU-173623, Classical antibody-mediated complement activation R-MMU-2029481, FCGR activation R-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation R-MMU-2029485, Role of phospholipids in phagocytosis R-MMU-977606, Regulation of Complement cascade |
Names & Taxonomyi
Protein namesi | Recommended name: Immunoglobulin heavy constant gamma 2BImportedAlternative name(s): Ig gamma-2B chain C regionCurated |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96445, Ighg2b |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Single-pass membrane protein Curated
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: MGI
- immunoglobulin complex, circulating Source: MGI
Plasma Membrane
- external side of plasma membrane Source: GO_Central
Other locations
- IgG immunoglobulin complex Source: MGI
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 351 – 368 | HelicalSequence analysisAdd BLAST | 18 | |
Topological domaini | 369 – 404 | CytoplasmicSequence analysisAdd BLAST | 36 |
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000153588 | ‹1 – 404 | Immunoglobulin heavy constant gamma 2BAdd BLAST | ›404 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 14 | Interchain (with a light chain)PROSITE-ProRule annotation | ||
Disulfide bondi | 26 ↔ 81 | PROSITE-ProRule annotation | ||
Glycosylationi | 104 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Disulfide bondi | 108 | Interchain (with a heavy chain)PROSITE-ProRule annotation | ||
Disulfide bondi | 111 | Interchain (with a heavy chain)PROSITE-ProRule annotation | ||
Disulfide bondi | 114 | Interchain (with a heavy chain)PROSITE-ProRule annotation | ||
Disulfide bondi | 117 | Interchain (with a heavy chain)PROSITE-ProRule annotation | ||
Disulfide bondi | 149 ↔ 209 | PROSITE-ProRule annotation | ||
Glycosylationi | 185 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 255 ↔ 313 | PROSITE-ProRule annotation |
Post-translational modificationi
O-linked glycan consists of Gal-GalNAc disaccharide which is modified with 2 sialic acid residues.1 Publication
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
CPTACi | non-CPTAC-3524 non-CPTAC-3525 |
MaxQBi | P01867 |
PeptideAtlasi | P01867 |
PRIDEi | P01867 |
ProteomicsDBi | 269537 [P01867-1] 269538 [P01867-2] |
PTM databases
GlyConnecti | 684, 3 N-Linked glycans (1 site) |
GlyGeni | P01867, 2 sites, 4 N-linked glycans (1 site) |
iPTMneti | P01867 |
PhosphoSitePlusi | P01867 |
Interactioni
GO - Molecular functioni
- Fc-gamma receptor I complex binding Source: MGI
- immunoglobulin receptor binding Source: GO_Central
Protein-protein interaction databases
MINTi | P01867 |
Miscellaneous databases
RNActi | P01867, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P01867 |
SMRi | P01867 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P01867 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 97 | Ig-like 1Add BLAST | 93 | |
Domaini | 126 – 225 | Ig-like 2Add BLAST | 100 | |
Domaini | 234 – 330 | Ig-like 3Add BLAST | 97 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
InParanoidi | P01867 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set |
Pfami | View protein in Pfam PF07654, C1-set, 3 hits |
SMARTi | View protein in SMART SM00407, IGc1, 3 hits |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS00290, IG_MHC, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P01867-1) [UniParc]FASTAAdd to basket
Also known as: Membrane-bound
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
KTTPPSVYPL APGCGDTTGS SVTLGCLVKG YFPESVTVTW NSGSLSSSVH
60 70 80 90 100
TFPALLQSGL YTMSSSVTVP SSTWPSQTVT CSVAHPASST TVDKKLEPSG
110 120 130 140 150
PISTINPCPP CKECHKCPAP NLEGGPSVFI FPPNIKDVLM ISLTPKVTCV
160 170 180 190 200
VVDVSEDDPD VQISWFVNNV EVHTAQTQTH REDYNSTIRV VSTLPIQHQD
210 220 230 240 250
WMSGKEFKCK VNNKDLPSPI ERTISKIKGL VRAPQVYILP PPAEQLSRKD
260 270 280 290 300
VSLTCLVVGF NPGDISVEWT SNGHTEENYK DTAPVLDSDG SYFIYSKLNM
310 320 330 340 350
KTSKWEKTDS FSCNVRHEGL KNYYLKKTIS RSPGLDLDDI CAEAKDGELD
360 370 380 390 400
GLWTTITIFI SLFLLSVCYS ASVTLFKVKW IFSSVVELKQ KISPDYRNMI
GQGA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A6YVP0 | A0A0A6YVP0_MOUSE | Immunoglobulin heavy constant gamma... | Ighg2b | 405 | Annotation score: | ||
A0A075B5P3 | A0A075B5P3_MOUSE | Immunoglobulin heavy constant gamma... | Ighg2b | 336 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 | ||
Sequence conflicti | 24 | L → S (PubMed:117548).Curated | 1 | |
Sequence conflicti | 24 | L → S (PubMed:117549).Curated | 1 | |
Sequence conflicti | 35 | S → P (PubMed:117548).Curated | 1 | |
Sequence conflicti | 35 | S → P (PubMed:117549).Curated | 1 | |
Sequence conflicti | 238 | I → T (PubMed:117548).Curated | 1 | |
Sequence conflicti | 238 | I → T (PubMed:117549).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 162 | Q → R in allele B. | 1 | |
Natural varianti | 193 | T → A in allele B. | 1 | |
Natural varianti | 299 | N → D in allele B. | 1 | |
Natural varianti | 300 | M → I in allele B. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_034614 | 335 | L → K in isoform 2. Curated | 1 | |
Alternative sequenceiVSP_034615 | 336 – 404 | Missing in isoform 2. CuratedAdd BLAST | 69 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J00461, J00462 Genomic DNA Translation: AAB59659.1 |
PIRi | C02154, G2MSBM S25057, G2MS11 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J00461, J00462 Genomic DNA Translation: AAB59659.1 |
PIRi | C02154, G2MSBM S25057, G2MS11 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1CBV | X-ray | 2.66 | H | 1-97 | [»] | |
1CF8 | X-ray | 2.70 | H | 1-98 | [»] | |
1CIC | X-ray | 2.50 | B | 2-99 | [»] | |
1ETZ | X-ray | 2.60 | B/H | 1-101 | [»] | |
1FJ1 | X-ray | 2.68 | B/D | 1-99 | [»] | |
1FL3 | X-ray | 2.45 | A/H | 1-97 | [»] | |
1HQ4 | X-ray | 2.70 | B/D | 1-98 | [»] | |
1MAM | X-ray | 2.45 | H | 1-97 | [»] | |
1NBV | X-ray | 2.00 | H | 1-97 | [»] | |
1OSP | X-ray | 1.95 | H | 1-97 | [»] | |
1UB5 | X-ray | 2.00 | A/H | 1-97 | [»] | |
1UB6 | X-ray | 2.12 | A/H | 1-97 | [»] | |
1YNK | X-ray | 2.10 | H | 1-102 | [»] | |
1YNL | X-ray | 1.70 | H | 1-102 | [»] | |
1ZTX | X-ray | 2.50 | H | 1-99 | [»] | |
2GJZ | X-ray | 2.65 | B/H | 1-98 | [»] | |
2GK0 | X-ray | 2.45 | B/H | 1-98 | [»] | |
2Q8A | X-ray | 2.40 | H | 1-97 | [»] | |
2Q8B | X-ray | 2.30 | H | 1-97 | [»] | |
2RGS | X-ray | 2.13 | A/B | 117-334 | [»] | |
3CFD | X-ray | 2.50 | B/H | 1-99 | [»] | |
3CFE | X-ray | 2.99 | B/H | 1-99 | [»] | |
5UBX | X-ray | 2.70 | A/B | 108-334 | [»] | |
6KRU | X-ray | 2.30 | A/B/C/D/E/F | 117-334 | [»] | |
6KRV | X-ray | 3.30 | A/B/C | 117-334 | [»] | |
AlphaFoldDBi | P01867 | |||||
SMRi | P01867 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
MINTi | P01867 |
PTM databases
GlyConnecti | 684, 3 N-Linked glycans (1 site) |
GlyGeni | P01867, 2 sites, 4 N-linked glycans (1 site) |
iPTMneti | P01867 |
PhosphoSitePlusi | P01867 |
Proteomic databases
CPTACi | non-CPTAC-3524 non-CPTAC-3525 |
MaxQBi | P01867 |
PeptideAtlasi | P01867 |
PRIDEi | P01867 |
ProteomicsDBi | 269537 [P01867-1] 269538 [P01867-2] |
Protocols and materials databases
ABCDi | P01867, 4 sequenced antibodies |
Organism-specific databases
MGIi | MGI:96445, Ighg2b |
Phylogenomic databases
InParanoidi | P01867 |
Enzyme and pathway databases
Reactomei | R-MMU-166663, Initial triggering of complement R-MMU-173623, Classical antibody-mediated complement activation R-MMU-2029481, FCGR activation R-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation R-MMU-2029485, Role of phospholipids in phagocytosis R-MMU-977606, Regulation of Complement cascade |
Miscellaneous databases
ChiTaRSi | Ighg2b, mouse |
EvolutionaryTracei | P01867 |
PROi | PR:P01867 |
RNActi | P01867, protein |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set |
Pfami | View protein in Pfam PF07654, C1-set, 3 hits |
SMARTi | View protein in SMART SM00407, IGc1, 3 hits |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS00290, IG_MHC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IGG2B_MOUSE | |
Accessioni | P01867Primary (citable) accession number: P01867 Secondary accession number(s): P01866 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | February 1, 2005 | |
Last modified: | May 25, 2022 | |
This is version 153 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references