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Protein

Ig gamma-2A chain C region secreted form

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

The sequence differs from that of the a allele, from BALB/c mice, at 15% of the positions.

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Ig gamma-2A chain C region secreted form
Alternative name(s):
B allele
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153585‹1 – 335Ig gamma-2A chain C region secreted formAdd BLAST›335

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi185N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP01864
PeptideAtlasiP01864
PRIDEiP01864

PTM databases

iPTMnetiP01864

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
IgkcP018372EBI-8630371,EBI-1035302

Protein-protein interaction databases

IntActiP01864, 1 interactor
MINTiP01864
STRINGi10090.ENSMUSP00000100212

Structurei

Secondary structure

1335
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 6Combined sources4
Beta strandi10 – 12Combined sources3
Beta strandi18 – 27Combined sources10
Helixi29 – 31Combined sources3
Beta strandi34 – 40Combined sources7
Turni41 – 43Combined sources3
Beta strandi44 – 51Combined sources8
Turni53 – 55Combined sources3
Beta strandi58 – 60Combined sources3
Helixi62 – 64Combined sources3
Turni65 – 67Combined sources3
Beta strandi68 – 73Combined sources6
Turni74 – 77Combined sources4
Beta strandi78 – 83Combined sources6
Helixi88 – 90Combined sources3
Beta strandi92 – 97Combined sources6
Beta strandi99 – 102Combined sources4
Beta strandi106 – 110Combined sources5
Beta strandi119 – 123Combined sources5
Beta strandi133 – 147Combined sources15
Beta strandi150 – 153Combined sources4
Turni154 – 157Combined sources4
Beta strandi162 – 164Combined sources3
Beta strandi168 – 170Combined sources3
Beta strandi173 – 183Combined sources11
Turni184 – 189Combined sources6
Beta strandi193 – 198Combined sources6
Helixi199 – 201Combined sources3
Beta strandi203 – 208Combined sources6

3D structure databases

ProteinModelPortaliP01864
SMRiP01864
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01864

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 98Ig-like 1Add BLAST93
Domaini126 – 225Ig-like 2Add BLAST100
Domaini234 – 330Ig-like 3Add BLAST97

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat

Phylogenomic databases

eggNOGiENOG410IJ6J Eukaryota
ENOG410YNB1 LUCA
HOVERGENiHBG005814
PhylomeDBiP01864

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
PfamiView protein in Pfam
PF07654 C1-set, 3 hits
SMARTiView protein in SMART
SM00407 IGc1, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00290 IG_MHC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Secreted (identifier: P01864-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
AKTTAPSVYP LVPVCGGTTG SSVTLGCLVK GYFPEPVTLT WNSGSLSSGV
60 70 80 90 100
HTFPALLQSG LYTLSSSVTV TSNTWPSQTI TCNVAHPASS TKVDKKIEPR
110 120 130 140 150
VPITQNPCPP HQRVPPCAAP DLLGGPSVFI FPPKIKDVLM ISLSPMVTCV
160 170 180 190 200
VVDVSEDDPD VQISWFVNNV EVHTAQTQTH REDYNSTLRV VSALPIQHQD
210 220 230 240 250
WMSGKEFKCK VNNRALPSPI EKTISKPRGP VRAPQVYVLP PPAEEMTKKE
260 270 280 290 300
FSLTCMITGF LPAEIAVDWT SNGRTEQNYK NTATVLDSDG SYFMYSKLRV
310 320 330
QKSTWERGSL FACSVVHEVL HNHLTTKTIS RSLGK
Note: Probably the major isoform.
Length:335
Mass (Da):36,596
Last modified:July 21, 1986 - v1
Checksum:iFA3382792CBB13C6
GO
Isoform Membrane-bound (identifier: P01865-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P01865.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:398
Mass (Da):43,949
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00479 Genomic DNA No translation available.
PIRiA02153 G2MSAB

Genome annotation databases

UCSCiuc007pgl.2 mouse [P01864-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGCAB_MOUSE
AccessioniPrimary (citable) accession number: P01864
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 18, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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