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UniProtKB - P01863 (GCAA_MOUSE)
Protein
Ig gamma-2A chain C region, A allele
Gene
Ighg
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- antigen binding Source: GO_Central
- immunoglobulin receptor binding Source: AgBase
GO - Biological processi
- B cell receptor signaling pathway Source: GO_Central
- complement activation, classical pathway Source: GO_Central
- defense response to bacterium Source: GO_Central
- innate immune response Source: GO_Central
- phagocytosis, engulfment Source: GO_Central
- phagocytosis, recognition Source: GO_Central
- positive regulation of B cell activation Source: GO_Central
- response to bacterium Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: Ig gamma-2A chain C region, A alleleAlternative name(s): Immunoglobulin heavy chain gamma polypeptide |
Gene namesi | Name:Ighg |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2144967, Ighg |
Subcellular locationi
Extracellular region or secreted
- immunoglobulin complex, circulating Source: GO_Central
Plasma Membrane
- external side of plasma membrane Source: GO_Central
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000153584 | ‹1 – 330 | Ig gamma-2A chain C region, A alleleAdd BLAST | ›330 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 15 | Interchain (with a light chain)PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 27 ↔ 82 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 107 | Interchain (with a heavy chain)PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 110 | Interchain (with a heavy chain)PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 112 | Interchain (with a heavy chain)PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 144 ↔ 204 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 180 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 250 ↔ 308 | PROSITE-ProRule annotation1 Publication |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MaxQBi | P01863 |
PeptideAtlasi | P01863 |
PRIDEi | P01863 |
PTM databases
GlyGeni | P01863, 1 site |
iPTMneti | P01863 |
Interactioni
GO - Molecular functioni
- immunoglobulin receptor binding Source: AgBase
Miscellaneous databases
RNActi | P01863, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P01863 |
SMRi | P01863 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P01863 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 98 | Ig-like 1Add BLAST | 93 | |
Domaini | 121 – 220 | Ig-like 2Add BLAST | 100 | |
Domaini | 229 – 325 | Ig-like 3Add BLAST | 97 |
Keywords - Domaini
Immunoglobulin domain, RepeatPhylogenomic databases
InParanoidi | P01863 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set |
Pfami | View protein in Pfam PF07654, C1-set, 3 hits |
SMARTi | View protein in SMART SM00407, IGc1, 3 hits |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS00290, IG_MHC, 1 hit |
i Sequence
Sequence statusi: Complete.
P01863-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
AKTTAPSVYP LAPVCGDTTG SSVTLGCLVK GYFPEPVTLT WNSGSLSSGV
60 70 80 90 100
HTFPAVLQSD LYTLSSSVTV TSSTWPSQSI TCNVAHPASS TKVDKKIEPR
110 120 130 140 150
GPTIKPCPPC KCPAPNLLGG PSVFIFPPKI KDVLMISLSP IVTCVVVDVS
160 170 180 190 200
EDDPDVQISW FVNNVEVHTA QTQTHREDYN STLRVVSALP IQHQDWMSGK
210 220 230 240 250
EFKCKVNNKD LPAPIERTIS KPKGSVRAPQ VYVLPPPEEE MTKKQVTLTC
260 270 280 290 300
MVTDFMPEDI YVEWTNNGKT ELNYKNTEPV LDSDGSYFMY SKLRVEKKNW
310 320 330
VERNSYSCSV VHEGLHNHHT TKSFSRTPGK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00798 mRNA Translation: CAA24178.1 |
PIRi | A02152, G2MSA |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00798 mRNA Translation: CAA24178.1 |
PIRi | A02152, G2MSA |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1DQM | X-ray | 2.10 | H | 1-97 | [»] | |
1DQQ | X-ray | 1.80 | B/D | 1-97 | [»] | |
1EHL | X-ray | 2.40 | H | 1-99 | [»] | |
1FE8 | X-ray | 2.03 | H/I/J | 1-101 | [»] | |
1GGI | X-ray | 2.80 | H/J | 1-107 | [»] | |
1IGT | X-ray | 2.80 | B/D | 2-326 | [»] | |
1KEG | X-ray | 2.40 | H | 1-100 | [»] | |
1KN2 | X-ray | 1.90 | H | 1-99 | [»] | |
1KN4 | X-ray | 1.90 | H | 1-99 | [»] | |
1KNO | X-ray | 3.20 | B/D/F | 1-101 | [»] | |
1MH5 | X-ray | 2.10 | B/H | 1-111 | [»] | |
1MNU | X-ray | 2.50 | H | 1-104 | [»] | |
1MPA | X-ray | 2.60 | H | 1-104 | [»] | |
1OB1 | X-ray | 2.90 | B/E | 1-99 | [»] | |
1PG7 | X-ray | 2.50 | X/Z | 1-100 | [»] | |
1UYW | X-ray | 2.00 | H/M | 1-100 | [»] | |
1YEC | X-ray | 1.90 | H | 1-99 | [»] | |
1YEF | X-ray | 2.00 | H | 1-99 | [»] | |
1YEG | X-ray | 2.00 | H | 1-99 | [»] | |
1YEH | X-ray | 2.55 | H | 1-99 | [»] | |
1YEI | X-ray | 1.90 | H | 1-99 | [»] | |
1YEJ | X-ray | 1.85 | H | 1-99 | [»] | |
1YEK | X-ray | 2.10 | H | 1-99 | [»] | |
2IPU | X-ray | 1.65 | G/H | 1-103 | [»] | |
2MPA | X-ray | 2.60 | H | 1-104 | [»] | |
2R0W | X-ray | 2.50 | H | 1-100 | [»] | |
2R0Z | X-ray | 2.10 | H | 1-100 | [»] | |
2R29 | X-ray | 3.00 | H | 1-100 | [»] | |
2R69 | X-ray | 3.80 | H | 1-100 | [»] | |
2R6P | electron microscopy | 24.00 | D/F | 1-100 | [»] | |
2VL5 | X-ray | 2.10 | A/C | 1-99 | [»] | |
2ZCH | X-ray | 2.83 | H | 1-107 | [»] | |
2ZCK | X-ray | 3.10 | H | 1-107 | [»] | |
2ZCL | X-ray | 3.25 | H | 1-107 | [»] | |
3BGF | X-ray | 3.00 | B/H | 1-99 | [»] | |
3OZ9 | X-ray | 1.60 | H | 1-100 | [»] | |
3ZO0 | X-ray | 1.99 | A | 120-326 | [»] | |
4F37 | X-ray | 2.57 | F/H | 1-100 | [»] | |
4KVC | X-ray | 2.31 | H | 1-100 | [»] | |
5VAA | X-ray | 1.55 | A/B | 107-330 | [»] | |
AlphaFoldDBi | P01863 | |||||
SMRi | P01863 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
PTM databases
GlyGeni | P01863, 1 site |
iPTMneti | P01863 |
Proteomic databases
MaxQBi | P01863 |
PeptideAtlasi | P01863 |
PRIDEi | P01863 |
Protocols and materials databases
ABCDi | P01863, 12 sequenced antibodies |
Organism-specific databases
MGIi | MGI:2144967, Ighg |
Phylogenomic databases
InParanoidi | P01863 |
Miscellaneous databases
EvolutionaryTracei | P01863 |
PROi | PR:P01863 |
RNActi | P01863, protein |
SOURCEi | Search... |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set |
Pfami | View protein in Pfam PF07654, C1-set, 3 hits |
SMARTi | View protein in SMART SM00407, IGc1, 3 hits |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS00290, IG_MHC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GCAA_MOUSE | |
Accessioni | P01863Primary (citable) accession number: P01863 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | May 25, 2022 | |
This is version 138 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references