Ighg

Functionⁱ

GO - Molecular functionⁱ

antigen binding Source: GO_Central
immunoglobulin receptor binding
Source: AgBase
Inferred from physical interactionⁱ
- 20031218

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

B cell receptor signaling pathway Source: GO_Central
complement activation, classical pathway Source: GO_Central
defense response to bacterium Source: GO_Central
innate immune response Source: GO_Central
phagocytosis, engulfment Source: GO_Central
phagocytosis, recognition Source: GO_Central
positive regulation of B cell activation Source: GO_Central

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ig gamma-2A chain C region, A allele Alternative name(s): Immunoglobulin heavy chain gamma polypeptide
Gene namesⁱ	Name:Ighg
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:2144967 Ighg

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000153584	‹1 – 330	Ig gamma-2A chain C region, A alleleAdd BLAST		›330

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	15	Interchain (with a light chain)PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	27 ↔ 82	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	107	Interchain (with a heavy chain)PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	110	Interchain (with a heavy chain)PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	112	Interchain (with a heavy chain)PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	144 ↔ 204	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	180	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	250 ↔ 308	PROSITE-ProRule annotation1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P01863
PeptideAtlas More...PeptideAtlasⁱ	P01863
PRIDEⁱ	P01863

PTM databases

iPTMnetⁱ	P01863

iPTMnetⁱ

P01863

Interactionⁱ

GO - Molecular functionⁱ

immunoglobulin receptor binding
Source: AgBase
Inferred from physical interactionⁱ
- 20031218

View the complete GO annotation on QuickGO ...

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	7 – 11	Combined sources	5
Helixⁱ	15 – 17	Combined sources	3
Turnⁱ	19 – 21	Combined sources	3
Beta strandⁱ	22 – 35	Combined sources	14
Beta strandⁱ	38 – 41	Combined sources	4
Helixⁱ	42 – 44	Combined sources	3
Beta strandⁱ	50 – 58	Combined sources	9
Beta strandⁱ	61 – 71	Combined sources	11
Turnⁱ	72 – 77	Combined sources	6
Beta strandⁱ	81 – 86	Combined sources	6
Helixⁱ	87 – 89	Combined sources	3
Beta strandⁱ	91 – 96	Combined sources	6
Beta strandⁱ	122 – 126	Combined sources	5
Helixⁱ	130 – 134	Combined sources	5
Beta strandⁱ	141 – 149	Combined sources	9
Beta strandⁱ	157 – 162	Combined sources	6
Beta strandⁱ	165 – 167	Combined sources	3
Beta strandⁱ	171 – 177	Combined sources	7
Turnⁱ	178 – 181	Combined sources	4
Beta strandⁱ	182 – 190	Combined sources	9
Helixⁱ	193 – 197	Combined sources	5
Beta strandⁱ	202 – 207	Combined sources	6
Beta strandⁱ	215 – 219	Combined sources	5
Beta strandⁱ	230 – 234	Combined sources	5
Helixⁱ	238 – 242	Combined sources	5
Beta strandⁱ	243 – 258	Combined sources	16
Beta strandⁱ	261 – 266	Combined sources	6
Beta strandⁱ	272 – 276	Combined sources	5
Beta strandⁱ	287 – 296	Combined sources	10
Helixⁱ	297 – 301	Combined sources	5
Beta strandⁱ	307 – 311	Combined sources	5
Helixⁱ	316 – 318	Combined sources	3
Beta strandⁱ	319 – 324	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	P01863
SMRⁱ	P01863
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P01863

EvolutionaryTraceⁱ

P01863

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	6 – 98	Ig-like 1Add BLAST	93
Domainⁱ	121 – 220	Ig-like 2Add BLAST	100
Domainⁱ	229 – 325	Ig-like 3Add BLAST	97

Keywords - Domainⁱ

Immunoglobulin C region, Immunoglobulin domain, Repeat

Phylogenomic databases

HOVERGENⁱ	HBG005814
InParanoidⁱ	P01863

Family and domain databases

Gene3Dⁱ	2.60.40.10, 3 hits
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003006 Ig/MHC_CS IPR003597 Ig_C1-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07654 C1-set, 3 hits
SMARTⁱ	View protein in SMART SM00407 IGc1, 3 hits
SUPFAMⁱ	SSF48726 SSF48726, 3 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 3 hits PS00290 IG_MHC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P01863-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
AKTTAPSVYP LAPVCGDTTG SSVTLGCLVK GYFPEPVTLT WNSGSLSSGV 
        60         70         80         90        100
HTFPAVLQSD LYTLSSSVTV TSSTWPSQSI TCNVAHPASS TKVDKKIEPR 
       110        120        130        140        150
GPTIKPCPPC KCPAPNLLGG PSVFIFPPKI KDVLMISLSP IVTCVVVDVS 
       160        170        180        190        200
EDDPDVQISW FVNNVEVHTA QTQTHREDYN STLRVVSALP IQHQDWMSGK 
       210        220        230        240        250
EFKCKVNNKD LPAPIERTIS KPKGSVRAPQ VYVLPPPEEE MTKKQVTLTC 
       260        270        280        290        300
MVTDFMPEDI YVEWTNNGKT ELNYKNTEPV LDSDGSYFMY SKLRVEKKNW 
       310        320        330
VERNSYSCSV VHEGLHNHHT TKSFSRTPGK

Length:330

Mass (Da):36,389

Last modified:July 21, 1986 - v1

Checksum:ⁱB84361C5445A6864

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Non-terminal residueⁱ	1			1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	V00798 mRNA Translation: CAA24178.1
PIRⁱ	A02152 G2MSA
UniGeneⁱ	Mm.342177 Mm.436014

Protein	Similar proteins		Species	Score	Length	Source
P01863	CH2 domain (Fragment)		MOUSE		110	UniRef100_P01863
UPI0003F4797D		MOUSE		467

Protein	Similar proteins		Species	Score	Length	Source
P01863	CH2 domain (Fragment)		MOUSE		110	UniRef90_P01863
Igh protein	)	MOUSE		468
UPI0003F4797D		MOUSE		467

Protein	Similar proteins		Species	Score	Length	Source
P01863	Ig gamma-2A chain C region, membrane-bound form	)	MOUSE		398	UniRef50_P01865
Ig gamma-1 chain C region	)	RAT		326
Uncharacterized protein (Fragment)		LOXAF		390
Ig gamma-2 chain C region		MYOBR		454
IgG heavy chain		PIG		475
+113

Entry informationⁱ

Entry nameⁱ	GCAA_MOUSE
Accessionⁱ	P01863Primary (citable) accession number: P01863
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	July 21, 1986
	Last modified:	December 20, 2017
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

UniProtKB - P01863 (GCAA_MOUSE)

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Ig gamma-2A chain C region, A allele

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

Extracellular region or secreted

Plasma Membrane

PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Experimental Info

Sequence databases

Similar proteinsⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProt is an ELIXIR core data resource

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P01863 (GCAA_MOUSE)

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Ig gamma-2A chain C region, A allele

Ighg

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Plasma Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ