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UniProtKB - P01860 (IGHG3_HUMAN)

Entry version 187 (25 May 2022)
Sequence version 2 (01 Jul 2008)
Previous versions | rss
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Protein

Immunoglobulin heavy constant gamma 3

Gene

IGHG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).

The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).

3 Publications

Caution

For an example of a full-length immunoglobulin gamma heavy chain see AC P0DOX5.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P01860

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-166663, Initial triggering of complement
R-HSA-173623, Classical antibody-mediated complement activation
R-HSA-2029481, FCGR activation
R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485, Role of phospholipids in phagocytosis
R-HSA-9664323, FCGR3A-mediated IL10 synthesis
R-HSA-9664422, FCGR3A-mediated phagocytosis
R-HSA-977606, Regulation of Complement cascade

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P01860

Protein family/group databases

IMGT/GENE-DBIGHG3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Immunoglobulin heavy constant gamma 32 Publications
Alternative name(s):
HDC
Heavy chain disease protein
Ig gamma-3 chain C regionCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IGHG32 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5527, IGHG3

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		147120, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P01860

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Immunoglobulin, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P01860, Tclin

Chemistry databases

Drug and drug target database

More...DrugBanki		DB15258, Imlifidase

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IGHG3

Domain mapping of disease mutations (DMDM)

More...DMDMi		193806361

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001535801 – 377Immunoglobulin heavy constant gamma 3Add BLAST377

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi27 ↔ 83PROSITE-ProRule annotation
Disulfide bondi111Interchain (with heavy chain dimer)
Disulfide bondi114Interchain (with heavy chain dimer)
Disulfide bondi120Interchain (with heavy chain dimer)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi122O-linked (GalNAc...) threonine2 Publications1
Disulfide bondi126Interchain (with heavy chain dimer)
Disulfide bondi129Interchain (with heavy chain dimer)
Disulfide bondi135Interchain (with heavy chain dimer)
Glycosylationi137O-linked (GalNAc...) threonine2 Publications1
Disulfide bondi141Interchain (with heavy chain dimer)
Disulfide bondi144Interchain (with heavy chain dimer)
Disulfide bondi150Interchain (with heavy chain dimer)
Glycosylationi152O-linked (GalNAc...) threonine2 Publications1
Disulfide bondi156Interchain (with heavy chain dimer)
Disulfide bondi159Interchain (with heavy chain dimer)
Disulfide bondi191 ↔ 251PROSITE-ProRule annotation
Glycosylationi227N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi297 ↔ 355PROSITE-ProRule annotation
Glycosylationi322N-linked (GlcNAc...) asparagine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-linked glycans at Asn-322 are noncore fucosylated and the vast majority are diantennary species with a bisecting GlcNAc. Among them the most dominant glycans are HexNAc5Hex4, HexNAc5Hex5, and HexNAc5Hex5Sia1.1 Publication
N-linked glycans at Asn-227 are diantennary core fucosylated structures without bisecting GlcNAc (HexNAc4Hex4Fuc1, HexNAc4Hex5Fuc1, and HexNAc4Hex5Fuc1Sia1).1 Publication
O-linked glycans are non-, mono- and disialylated core 1-type O-glycans.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P01860

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P01860

MaxQB - The MaxQuant DataBase

More...MaxQBi		P01860

PeptideAtlas

More...PeptideAtlasi		P01860

PRoteomics IDEntifications database

More...PRIDEi		P01860

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51496

2D gel databases

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P01860

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1385, 44 N-Linked glycans (2 sites), 3 O-Linked glycans (3 sites)
233, 111 N-Linked glycans
271, 14 N-Linked glycans
2959, 4 O-Linked glycans (3 sites)
2960, 4 O-Linked glycans (3 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P01860, 6 sites, 106 N-linked glycans (3 sites), 7 O-linked glycans (4 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P01860

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P01860

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000211897, Expressed in lymph node and 106 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-6943, IgG3 - Ig kappa immunoglobulin complex, constant regions
CPX-6944, IgG3 - Ig lambda 1 immunoglobulin complex, constant regions
CPX-6945, IgG3 - Ig lambda 2 immunoglobulin complex, constant regions
CPX-6946, IgG3 - Ig lambda 3 immunoglobulin complex, constant regions
CPX-6947, IgG3 - Ig lambda 6 immunoglobulin complex, constant regions
CPX-6948, IgG3 - Ig lambda 7 immunoglobulin complex, constant regions

Protein interaction database and analysis system

More...IntActi		P01860, 13 interactors

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P01860, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1377
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P01860

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P01860

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 99Ig-like 1PROSITE-ProRule annotationAdd BLAST94
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati116 – 130Add BLAST15
Repeati131 – 145Add BLAST15
Repeati146 – 160Add BLAST15
Domaini168 – 267Ig-like 2PROSITE-ProRule annotationAdd BLAST100
Domaini276 – 372Ig-like 3PROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 98CH1Add BLAST98
Regioni99 – 160HingeAdd BLAST62
Regioni161 – 270CH2Add BLAST110
Regioni271 – 376CH3Add BLAST106

Keywords - Domaini

Immunoglobulin domain, Repeat

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P01860

Database for complete collections of gene phylogenies

More...PhylomeDBi		P01860

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003597, Ig_C1-set

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07654, C1-set, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00407, IGc1, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 3 hits
PS00290, IG_MHC, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P01860-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ASTKGPSVFP LAPCSRSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV 
        60         70         80         90        100
HTFPAVLQSS GLYSLSSVVT VPSSSLGTQT YTCNVNHKPS NTKVDKRVEL 
       110        120        130        140        150
KTPLGDTTHT CPRCPEPKSC DTPPPCPRCP EPKSCDTPPP CPRCPEPKSC 
       160        170        180        190        200
DTPPPCPRCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED 
       210        220        230        240        250
PEVQFKWYVD GVEVHNAKTK PREEQYNSTF RVVSVLTVLH QDWLNGKEYK 
       260        270        280        290        300
CKVSNKALPA PIEKTISKTK GQPREPQVYT LPPSREEMTK NQVSLTCLVK 
       310        320        330        340        350
GFYPSDIAVE WESSGQPENN YNTTPPMLDS DGSFFLYSKL TVDKSRWQQG 
       360        370 
NIFSCSVMHE ALHNRFTQKS LSLSPGK
Length:377
Mass (Da):41,287
Last modified:July 1, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFEB7F537953F807F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YES1A0A286YES1_HUMAN
Immunoglobulin heavy constant gamma...
IGHG3
446Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A4W9A917A0A4W9A917_HUMAN
Immunoglobulin heavy constant gamma...
IGHG3
377Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA52805 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

There are several alleles. The sequence shown is that of IMGT allele IGHG3*10.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0686951 – 76Missing in variant WIS. Add BLAST76
Natural variantiVAR_06869677 – 98GTQTY…VDKRV → QMQGVNCTVSS in variant WIS. Add BLAST22
Natural variantiVAR_068697213E → Q in variant WIS. 1
Natural variantiVAR_003891221P → L in variant OMM. 1
Natural variantiVAR_068698224E → Q in variant WIS. 1
Natural variantiVAR_003892226Y → F in variant ZUC and WIS. 1
Natural variantiVAR_068699242D → N in variant WIS. 1
Natural variantiVAR_068700245N → D in variant WIS. 1
Natural variantiVAR_003893269T → A in variant OMM. 1
Natural variantiVAR_003894314S → N in variant OMM. 1
Natural variantiVAR_003895314Missing in variant ZUC. 1
Natural variantiVAR_003896366F → Y in variant OMM. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X03604 Genomic DNA Translation: CAA27268.1
AC244226 Genomic DNA No translation available.
AC246787 Genomic DNA No translation available.
AL122127 Genomic DNA No translation available.
J00231 mRNA Translation: AAA52805.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...PIRi		A23511
A90442, G3HUWI

Genome annotation databases

UCSC genome browser

More...UCSCi		uc059gdk.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03604 Genomic DNA Translation: CAA27268.1
AC244226 Genomic DNA No translation available.
AC246787 Genomic DNA No translation available.
AL122127 Genomic DNA No translation available.
J00231 mRNA Translation: AAA52805.1 Different initiation.
PIRiA23511
A90442, G3HUWI

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4WWIX-ray2.31D/E/F168-377[»]
4ZNCX-ray2.28D/E/F168-377[»]
5M3VX-ray1.97A286-377[»]
5W38X-ray1.80A/B155-377[»]
6D58X-ray2.39A/B164-377[»]
6G1EX-ray1.88A204-377[»]
AlphaFoldDBiP01860
SMRiP01860
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-6943, IgG3 - Ig kappa immunoglobulin complex, constant regions
CPX-6944, IgG3 - Ig lambda 1 immunoglobulin complex, constant regions
CPX-6945, IgG3 - Ig lambda 2 immunoglobulin complex, constant regions
CPX-6946, IgG3 - Ig lambda 3 immunoglobulin complex, constant regions
CPX-6947, IgG3 - Ig lambda 6 immunoglobulin complex, constant regions
CPX-6948, IgG3 - Ig lambda 7 immunoglobulin complex, constant regions
IntActiP01860, 13 interactors

Chemistry databases

DrugBankiDB15258, Imlifidase

Protein family/group databases

IMGT/GENE-DBIGHG3

PTM databases

GlyConnecti1385, 44 N-Linked glycans (2 sites), 3 O-Linked glycans (3 sites)
233, 111 N-Linked glycans
271, 14 N-Linked glycans
2959, 4 O-Linked glycans (3 sites)
2960, 4 O-Linked glycans (3 sites)
GlyGeniP01860, 6 sites, 106 N-linked glycans (3 sites), 7 O-linked glycans (4 sites)
iPTMnetiP01860
PhosphoSitePlusiP01860

Genetic variation databases

BioMutaiIGHG3
DMDMi193806361

2D gel databases

UCD-2DPAGEiP01860

Proteomic databases

jPOSTiP01860
MassIVEiP01860
MaxQBiP01860
PeptideAtlasiP01860
PRIDEiP01860
ProteomicsDBi51496

Genome annotation databases

UCSCiuc059gdk.1, human

Organism-specific databases

GeneCards: human genes, protein and diseases

More...GeneCardsi		IGHG3
HGNCiHGNC:5527, IGHG3
MIMi147120, gene
neXtProtiNX_P01860

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

InParanoidiP01860
PhylomeDBiP01860

Enzyme and pathway databases

PathwayCommonsiP01860
ReactomeiR-HSA-166663, Initial triggering of complement
R-HSA-173623, Classical antibody-mediated complement activation
R-HSA-2029481, FCGR activation
R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485, Role of phospholipids in phagocytosis
R-HSA-9664323, FCGR3A-mediated IL10 synthesis
R-HSA-9664422, FCGR3A-mediated phagocytosis
R-HSA-977606, Regulation of Complement cascade
SignaLinkiP01860

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IGHG3, human
PharosiP01860, Tclin

Protein Ontology

More...PROi		PR:P01860
RNActiP01860, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000211897, Expressed in lymph node and 106 other tissues

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003597, Ig_C1-set
PfamiView protein in Pfam
PF07654, C1-set, 3 hits
SMARTiView protein in SMART
SM00407, IGc1, 3 hits
SUPFAMiSSF48726, SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 3 hits
PS00290, IG_MHC, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIGHG3_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01860
Secondary accession number(s): A0A075B6N8, A2NU35
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 2008
Last modified: May 25, 2022
This is version 187 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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