UniProtKB - P01860 (IGHG3_HUMAN)
Immunoglobulin heavy constant gamma 3
IGHG3
Functioni
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268).
The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
3 PublicationsCaution
GO - Molecular functioni
- antigen binding Source: GO_Central
- immunoglobulin receptor binding Source: GO_Central
GO - Biological processi
- adaptive immune response Source: ComplexPortal
- B cell receptor signaling pathway Source: GO_Central
- complement activation, classical pathway Source: GO_Central
- defense response to bacterium Source: GO_Central
- innate immune response Source: GO_Central
- phagocytosis, engulfment Source: GO_Central
- phagocytosis, recognition Source: GO_Central
- positive regulation of B cell activation Source: GO_Central
- retina homeostasis Source: UniProtKB
Keywordsi
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
PathwayCommonsi | P01860 |
Reactomei | R-HSA-166663, Initial triggering of complement R-HSA-173623, Classical antibody-mediated complement activation R-HSA-2029481, FCGR activation R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485, Role of phospholipids in phagocytosis R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-9664422, FCGR3A-mediated phagocytosis R-HSA-977606, Regulation of Complement cascade |
SignaLinki | P01860 |
Protein family/group databases
IMGT/GENE-DB | IGHG3 |
Names & Taxonomyi
Protein namesi | Recommended name: Immunoglobulin heavy constant gamma 32 PublicationsAlternative name(s): HDC Heavy chain disease protein Ig gamma-3 chain C regionCurated |
Gene namesi | Name:IGHG32 Publications |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5527, IGHG3 |
MIMi | 147120, gene |
neXtProti | NX_P01860 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications
Extracellular region or secreted
- Secreted 2 Publications
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
- immunoglobulin complex, circulating Source: GO_Central
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- plasma membrane Source: ComplexPortal
Other locations
- IgG immunoglobulin complex Source: ComplexPortal
Keywords - Cellular componenti
Cell membrane, Immunoglobulin, Membrane, SecretedPathology & Biotechi
Miscellaneous databases
Pharosi | P01860, Tclin |
Chemistry databases
DrugBanki | DB15258, Imlifidase |
Genetic variation databases
BioMutai | IGHG3 |
DMDMi | 193806361 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000153580 | 1 – 377 | Immunoglobulin heavy constant gamma 3Add BLAST | 377 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 27 ↔ 83 | PROSITE-ProRule annotation | ||
Disulfide bondi | 111 | Interchain (with heavy chain dimer) | ||
Disulfide bondi | 114 | Interchain (with heavy chain dimer) | ||
Disulfide bondi | 120 | Interchain (with heavy chain dimer) | ||
Glycosylationi | 122 | O-linked (GalNAc...) threonine2 Publications | 1 | |
Disulfide bondi | 126 | Interchain (with heavy chain dimer) | ||
Disulfide bondi | 129 | Interchain (with heavy chain dimer) | ||
Disulfide bondi | 135 | Interchain (with heavy chain dimer) | ||
Glycosylationi | 137 | O-linked (GalNAc...) threonine2 Publications | 1 | |
Disulfide bondi | 141 | Interchain (with heavy chain dimer) | ||
Disulfide bondi | 144 | Interchain (with heavy chain dimer) | ||
Disulfide bondi | 150 | Interchain (with heavy chain dimer) | ||
Glycosylationi | 152 | O-linked (GalNAc...) threonine2 Publications | 1 | |
Disulfide bondi | 156 | Interchain (with heavy chain dimer) | ||
Disulfide bondi | 159 | Interchain (with heavy chain dimer) | ||
Disulfide bondi | 191 ↔ 251 | PROSITE-ProRule annotation | ||
Glycosylationi | 227 | N-linked (GlcNAc...) asparagine3 Publications | 1 | |
Disulfide bondi | 297 ↔ 355 | PROSITE-ProRule annotation | ||
Glycosylationi | 322 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | P01860 |
MassIVEi | P01860 |
MaxQBi | P01860 |
PeptideAtlasi | P01860 |
PRIDEi | P01860 |
ProteomicsDBi | 51496 |
2D gel databases
UCD-2DPAGEi | P01860 |
PTM databases
GlyConnecti | 1385, 44 N-Linked glycans (2 sites), 3 O-Linked glycans (3 sites) 233, 111 N-Linked glycans 271, 14 N-Linked glycans 2959, 4 O-Linked glycans (3 sites) 2960, 4 O-Linked glycans (3 sites) |
GlyGeni | P01860, 6 sites, 106 N-linked glycans (3 sites), 7 O-linked glycans (4 sites) |
iPTMneti | P01860 |
PhosphoSitePlusi | P01860 |
Expressioni
Gene expression databases
Bgeei | ENSG00000211897, Expressed in lymph node and 106 other tissues |
Interactioni
Subunit structurei
Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
1 PublicationGO - Molecular functioni
- immunoglobulin receptor binding Source: GO_Central
Protein-protein interaction databases
ComplexPortali | CPX-6943, IgG3 - Ig kappa immunoglobulin complex, constant regions CPX-6944, IgG3 - Ig lambda 1 immunoglobulin complex, constant regions CPX-6945, IgG3 - Ig lambda 2 immunoglobulin complex, constant regions CPX-6946, IgG3 - Ig lambda 3 immunoglobulin complex, constant regions CPX-6947, IgG3 - Ig lambda 6 immunoglobulin complex, constant regions CPX-6948, IgG3 - Ig lambda 7 immunoglobulin complex, constant regions |
IntActi | P01860, 13 interactors |
Miscellaneous databases
RNActi | P01860, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P01860 |
SMRi | P01860 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 99 | Ig-like 1PROSITE-ProRule annotationAdd BLAST | 94 | |
Repeati | 116 – 130 | Add BLAST | 15 | |
Repeati | 131 – 145 | Add BLAST | 15 | |
Repeati | 146 – 160 | Add BLAST | 15 | |
Domaini | 168 – 267 | Ig-like 2PROSITE-ProRule annotationAdd BLAST | 100 | |
Domaini | 276 – 372 | Ig-like 3PROSITE-ProRule annotationAdd BLAST | 97 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 98 | CH1Add BLAST | 98 | |
Regioni | 99 – 160 | HingeAdd BLAST | 62 | |
Regioni | 161 – 270 | CH2Add BLAST | 110 | |
Regioni | 271 – 376 | CH3Add BLAST | 106 |
Keywords - Domaini
Immunoglobulin domain, RepeatPhylogenomic databases
InParanoidi | P01860 |
PhylomeDBi | P01860 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set |
Pfami | View protein in Pfam PF07654, C1-set, 3 hits |
SMARTi | View protein in SMART SM00407, IGc1, 3 hits |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS00290, IG_MHC, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
ASTKGPSVFP LAPCSRSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV
60 70 80 90 100
HTFPAVLQSS GLYSLSSVVT VPSSSLGTQT YTCNVNHKPS NTKVDKRVEL
110 120 130 140 150
KTPLGDTTHT CPRCPEPKSC DTPPPCPRCP EPKSCDTPPP CPRCPEPKSC
160 170 180 190 200
DTPPPCPRCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED
210 220 230 240 250
PEVQFKWYVD GVEVHNAKTK PREEQYNSTF RVVSVLTVLH QDWLNGKEYK
260 270 280 290 300
CKVSNKALPA PIEKTISKTK GQPREPQVYT LPPSREEMTK NQVSLTCLVK
310 320 330 340 350
GFYPSDIAVE WESSGQPENN YNTTPPMLDS DGSFFLYSKL TVDKSRWQQG
360 370
NIFSCSVMHE ALHNRFTQKS LSLSPGK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A286YES1 | A0A286YES1_HUMAN | Immunoglobulin heavy constant gamma... | IGHG3 | 446 | Annotation score: | ||
A0A4W9A917 | A0A4W9A917_HUMAN | Immunoglobulin heavy constant gamma... | IGHG3 | 377 | Annotation score: |
Sequence cautioni
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_068695 | 1 – 76 | Missing in variant WIS. Add BLAST | 76 | |
Natural variantiVAR_068696 | 77 – 98 | GTQTY…VDKRV → QMQGVNCTVSS in variant WIS. Add BLAST | 22 | |
Natural variantiVAR_068697 | 213 | E → Q in variant WIS. | 1 | |
Natural variantiVAR_003891 | 221 | P → L in variant OMM. | 1 | |
Natural variantiVAR_068698 | 224 | E → Q in variant WIS. | 1 | |
Natural variantiVAR_003892 | 226 | Y → F in variant ZUC and WIS. | 1 | |
Natural variantiVAR_068699 | 242 | D → N in variant WIS. | 1 | |
Natural variantiVAR_068700 | 245 | N → D in variant WIS. | 1 | |
Natural variantiVAR_003893 | 269 | T → A in variant OMM. | 1 | |
Natural variantiVAR_003894 | 314 | S → N in variant OMM. | 1 | |
Natural variantiVAR_003895 | 314 | Missing in variant ZUC. | 1 | |
Natural variantiVAR_003896 | 366 | F → Y in variant OMM. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03604 Genomic DNA Translation: CAA27268.1 AC244226 Genomic DNA No translation available. AC246787 Genomic DNA No translation available. AL122127 Genomic DNA No translation available. J00231 mRNA Translation: AAA52805.1 Different initiation. |
PIRi | A23511 A90442, G3HUWI |
Genome annotation databases
UCSCi | uc059gdk.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03604 Genomic DNA Translation: CAA27268.1 AC244226 Genomic DNA No translation available. AC246787 Genomic DNA No translation available. AL122127 Genomic DNA No translation available. J00231 mRNA Translation: AAA52805.1 Different initiation. |
PIRi | A23511 A90442, G3HUWI |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4WWI | X-ray | 2.31 | D/E/F | 168-377 | [»] | |
4ZNC | X-ray | 2.28 | D/E/F | 168-377 | [»] | |
5M3V | X-ray | 1.97 | A | 286-377 | [»] | |
5W38 | X-ray | 1.80 | A/B | 155-377 | [»] | |
6D58 | X-ray | 2.39 | A/B | 164-377 | [»] | |
6G1E | X-ray | 1.88 | A | 204-377 | [»] | |
AlphaFoldDBi | P01860 | |||||
SMRi | P01860 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
ComplexPortali | CPX-6943, IgG3 - Ig kappa immunoglobulin complex, constant regions CPX-6944, IgG3 - Ig lambda 1 immunoglobulin complex, constant regions CPX-6945, IgG3 - Ig lambda 2 immunoglobulin complex, constant regions CPX-6946, IgG3 - Ig lambda 3 immunoglobulin complex, constant regions CPX-6947, IgG3 - Ig lambda 6 immunoglobulin complex, constant regions CPX-6948, IgG3 - Ig lambda 7 immunoglobulin complex, constant regions |
IntActi | P01860, 13 interactors |
Chemistry databases
DrugBanki | DB15258, Imlifidase |
Protein family/group databases
IMGT/GENE-DB | IGHG3 |
PTM databases
GlyConnecti | 1385, 44 N-Linked glycans (2 sites), 3 O-Linked glycans (3 sites) 233, 111 N-Linked glycans 271, 14 N-Linked glycans 2959, 4 O-Linked glycans (3 sites) 2960, 4 O-Linked glycans (3 sites) |
GlyGeni | P01860, 6 sites, 106 N-linked glycans (3 sites), 7 O-linked glycans (4 sites) |
iPTMneti | P01860 |
PhosphoSitePlusi | P01860 |
Genetic variation databases
BioMutai | IGHG3 |
DMDMi | 193806361 |
2D gel databases
UCD-2DPAGEi | P01860 |
Proteomic databases
jPOSTi | P01860 |
MassIVEi | P01860 |
MaxQBi | P01860 |
PeptideAtlasi | P01860 |
PRIDEi | P01860 |
ProteomicsDBi | 51496 |
Genome annotation databases
UCSCi | uc059gdk.1, human |
Organism-specific databases
GeneCardsi | IGHG3 |
HGNCi | HGNC:5527, IGHG3 |
MIMi | 147120, gene |
neXtProti | NX_P01860 |
GenAtlasi | Search... |
Phylogenomic databases
InParanoidi | P01860 |
PhylomeDBi | P01860 |
Enzyme and pathway databases
PathwayCommonsi | P01860 |
Reactomei | R-HSA-166663, Initial triggering of complement R-HSA-173623, Classical antibody-mediated complement activation R-HSA-2029481, FCGR activation R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485, Role of phospholipids in phagocytosis R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-9664422, FCGR3A-mediated phagocytosis R-HSA-977606, Regulation of Complement cascade |
SignaLinki | P01860 |
Miscellaneous databases
ChiTaRSi | IGHG3, human |
Pharosi | P01860, Tclin |
PROi | PR:P01860 |
RNActi | P01860, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000211897, Expressed in lymph node and 106 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set |
Pfami | View protein in Pfam PF07654, C1-set, 3 hits |
SMARTi | View protein in SMART SM00407, IGc1, 3 hits |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits PS00290, IG_MHC, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | IGHG3_HUMAN | |
Accessioni | P01860Primary (citable) accession number: P01860 Secondary accession number(s): A0A075B6N8, A2NU35 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 1, 2008 | |
Last modified: | May 25, 2022 | |
This is version 187 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references