Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Immunoglobulin heavy constant gamma 1

Gene

IGHG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).3 Publications

Caution

For an example of a full-length immunoglobulin gamma heavy chain see AC P0DOX5.Curated

GO - Molecular functioni

  • antigen binding Source: GO_Central
  • immunoglobulin receptor binding Source: GO_Central
  • serine-type endopeptidase activity Source: Reactome

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-977606 Regulation of Complement cascade

Protein family/group databases

IMGT/GENE-DBIGHG1

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin heavy constant gamma 12 Publications
Alternative name(s):
Ig gamma-1 chain C regionCurated
Ig gamma-1 chain C region EU2 Publications
Ig gamma-1 chain C region KOL1 Publication
Ig gamma-1 chain C region NIE1 Publication
Gene namesi
Name:IGHG12 Publications
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000211896.7
HGNCiHGNC:5525 IGHG1
MIMi147100 gene
neXtProtiNX_P01857

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Involvement in diseasei

Multiple myeloma (MM)2 Publications
The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
Disease descriptionA malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia.
See also OMIM:254500

Organism-specific databases

DisGeNETi3500
MalaCardsiIGHG1
MIMi254500 phenotype
OpenTargetsiENSG00000211896
Orphaneti67038 B-cell chronic lymphocytic leukemia

Chemistry databases

DrugBankiDB07883 (2-AMINO-3-PHENYL-BICYCLO[2.2.1]HEPT-2-YL)-PHENYL-METHANONE
DB08294 2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID
DB07371 3-(10-METHYL-ANTHRACEN-9-YL)-PROPIONIC ACID
DB08562 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID
DB08409 4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE
DB08296 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID
DB08412 6-{4-[HYDROXY-(4-NITRO-PHENOXY)-PHOSPHORYL]-BUTYRYLAMINO}-HEXANOIC ACID
DB08332 [2'-CARBOXYLETHYL]-10-METHYL-ANTHRACENE ENDOPEROXIDE
DB04473 Alpha-L-Fucose
DB04639 Biphenylalanine
DB07764 FLUORESCIN
DB01631 Methyl Nonanoate (Ester)
DB07816 N-(P-CYANOPHENYL)-N'-DIPHENYLMETHYL-GUANIDINE-ACETIC ACID
DB03740 N-acetyl-alpha-D-glucosamine
DB07881 N-{[2-({[1-(4-CARBOXYBUTANOYL)AMINO]-2-PHENYLETHYL}-HYDROXYPHOSPHINYL)OXY]ACETYL}-2-PHENYLETHYLAMINE
DB08410 PARA-NITROBENZYL GLUTARYL GLYCINIC ACID
DB08377 PARA-NITROPHENYL PHOSPHONOBUTANOYL D-ALANINE
DB08411 PARA-NITROPHENYL PHOSPHONOBUTANOYL L-ALANINE
DB08394 PARA-NITROPHENYLPHOSPHONOBUTANOYL-GLYCINE
DB07672 TRANS-2-(DIMETHYLPHENYLSILYL)-PIPERIDINE-N-OXIDE

Polymorphism and mutation databases

DMDMi121039

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153578‹1 – 330Immunoglobulin heavy constant gamma 1Add BLAST›330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 83PROSITE-ProRule annotation
Disulfide bondi103Interchain (with light chain)
Disulfide bondi109Interchain (with heavy chain)
Disulfide bondi112Interchain (with heavy chain)
Disulfide bondi144 ↔ 204PROSITE-ProRule annotation
Glycosylationi180N-linked (GlcNAc...) (complex) asparagine3 Publications1
Disulfide bondi250 ↔ 308PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP01857
MaxQBiP01857
PeptideAtlasiP01857
PRIDEiP01857
ProteomicsDBi51494

2D gel databases

DOSAC-COBS-2DPAGEiP01857
REPRODUCTION-2DPAGEiP01857
UCD-2DPAGEiP01857

PTM databases

CarbonylDBiP01857
GlyConnecti671
iPTMnetiP01857
PhosphoSitePlusiP01857
SwissPalmiP01857
UniCarbKBiP01857

Expressioni

Gene expression databases

BgeeiENSG00000211896 Expressed in 113 organ(s), highest expression level in lymph node
CleanExiHS_IGHG1
ExpressionAtlasiP01857 baseline and differential
GenevisibleiP01857 HS

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-29187N
IntActiP01857, 86 interactors
MINTiP01857

Structurei

Secondary structure

1330
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP01857
SMRiP01857
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01857

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 99Ig-like 1PROSITE-ProRule annotationAdd BLAST94
Domaini121 – 220Ig-like 2PROSITE-ProRule annotationAdd BLAST100
Domaini229 – 325Ig-like 3PROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 98CH1Add BLAST98
Regioni99 – 110HingeAdd BLAST12
Regioni111 – 223CH2Add BLAST113
Regioni224 – 330CH3Add BLAST107

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

GeneTreeiENSGT00530000063726
HOVERGENiHBG005814
InParanoidiP01857
PhylomeDBiP01857

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
PfamiView protein in Pfam
PF07654 C1-set, 3 hits
SMARTiView protein in SMART
SM00407 IGc1, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00290 IG_MHC, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P01857-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV
60 70 80 90 100
HTFPAVLQSS GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKKVEP
110 120 130 140 150
KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS
160 170 180 190 200
HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK
210 220 230 240 250
EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC
260 270 280 290 300
LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW
310 320 330
QQGNVFSCSV MHEALHNHYT QKSLSLSPGK
Length:330
Mass (Da):36,106
Last modified:July 21, 1986 - v1
Checksum:i3770EE106C2FA33D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MS08A0A0A0MS08_HUMAN
Immunoglobulin heavy constant gamma...
IGHG1
399Annotation score:
A0A0A0MS07A0A0A0MS07_HUMAN
Immunoglobulin heavy constant gamma...
IGHG1
295Annotation score:

Sequence cautioni

The sequence AAC82527 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Polymorphismi

There are several alleles. The sequence shown is that of IMGT allele IGHG1*05.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00388697K → R in IMGT allele IGHG1*03. 1
Natural variantiVAR_003887239D → E in IMGT allele IGHG1*03. 1
Natural variantiVAR_003888241L → M in IMGT allele IGHG1*03. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00228 Genomic DNA Translation: AAC82527.1 Different initiation.
AL122127 Genomic DNA No translation available.
PIRiA93433 GHHU
UniGeneiHs.510635

Genome annotation databases

EnsembliENST00000390549; ENSP00000374991; ENSG00000211896
ENST00000631466; ENSP00000488387; ENSG00000277633
UCSCiuc059gdc.1 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00228 Genomic DNA Translation: AAC82527.1 Different initiation.
AL122127 Genomic DNA No translation available.
PIRiA93433 GHHU
UniGeneiHs.510635

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AJ7X-ray2.10H1-103[»]
1AQKX-ray1.84H21-245[»]
1AXSX-ray2.60B/H1-101[»]
1BEYX-ray3.25H1-98[»]
1D5BX-ray2.80B/H1-101[»]
1D5IX-ray2.00H1-101[»]
1D6VX-ray2.00H1-101[»]
1DFBX-ray2.70H1-103[»]
1DN2X-ray2.70A/B120-326[»]
1E4KX-ray3.20A/B106-330[»]
1FC1X-ray2.90A/B106-329[»]
1FC2X-ray2.80D106-329[»]
1FCCX-ray3.20A/B121-326[»]
1GAFX-ray1.95H1-103[»]
1H3TX-ray2.40A/B108-330[»]
1H3UX-ray2.40A/B108-330[»]
1H3VX-ray3.10A/B108-330[»]
1H3WX-ray2.85M108-330[»]
1H3XX-ray2.44A/B108-330[»]
1H3YX-ray4.10A/B108-330[»]
1HKLX-ray2.68H1-103[»]
1HZHX-ray2.70H/K1-330[»]
1I7ZX-ray2.30B/D1-103[»]
1L6XX-ray1.65A120-326[»]
1N7MX-ray1.80L2-102[»]
1OP3X-ray1.75H/M1-102[»]
1OQOX-ray2.30A/B119-330[»]
1OQXX-ray2.60A/B119-330[»]
1PG7X-ray2.50H/I1-100[»]
1T83X-ray3.00A/B107-330[»]
1T89X-ray3.50A/B107-330[»]
1VGEX-ray2.00H1-103[»]
2DTSX-ray2.20A/B108-330[»]
2GJ7X-ray5.00A/B106-330[»]
2I5YX-ray2.20H1-101[»]
2IWGX-ray2.35A/D120-326[»]
2J6EX-ray3.00A/B99-330[»]
2JB5X-ray2.80H1-102[»]
2JB6X-ray2.85B/H1-102[»]
2O5XX-ray2.05H1-108[»]
2O5YX-ray2.85H1-108[»]
2O5ZX-ray2.40H1-108[»]
2OSLX-ray2.60A/H1-103[»]
2QADX-ray3.30D/H1-101[»]
2QL1X-ray2.53A106-330[»]
2QQKX-ray2.75H1-107[»]
2QQLX-ray3.10H1-107[»]
2QQNX-ray2.20H1-107[»]
2QR0X-ray3.50B/F/H/L/N/R/T/X1-103[»]
2R56X-ray2.80H/I1-100[»]
2RCJX-ray-C/D/G/H/K/L/O/P/S/T1-326[»]
2RCSX-ray2.10H1-103[»]
2VXQX-ray1.90H1-100[»]
2WAHX-ray2.51A/B120-328[»]
3AGVX-ray2.15A/B120-330[»]
3AVEX-ray2.00A/B108-330[»]
3AY4X-ray2.20A/B108-330[»]
3B2UX-ray2.58C/F/H/J/N/Q/T/W1-102[»]
3B2VX-ray3.30H1-102[»]
3BDYX-ray2.60H1-107[»]
3BE1X-ray2.90H1-107[»]
3BKYX-ray2.61H1-104[»]
3BN9X-ray2.17D/F1-107[»]
3BQUX-ray3.00B2-103[»]
3C08X-ray2.15H1-102[»]
3C09X-ray3.20C/H1-102[»]
3C2SX-ray2.30A106-330[»]
3CFJX-ray2.60B/D/F/H1-104[»]
3CFKX-ray2.60B/D/F/H/I/K/N/P1-104[»]
3CSYX-ray3.40A/C/E/G1-101[»]
3D0LX-ray2.35B2-105[»]
3D0VX-ray2.05B2-105[»]
3D6GX-ray2.30A/B119-328[»]
3D85X-ray1.90B1-108[»]
3DJ9X-ray1.75A119-225[»]
3DNKX-ray2.84A/B119-330[»]
3DO3X-ray2.50A/B119-330[»]
3DROX-ray3.90B2-103[»]
3DRQX-ray2.00B2-103[»]
3DVGX-ray2.60B1-107[»]
3DVNX-ray2.70B/H1-107[»]
3EYFX-ray2.30B/D1-108[»]
3EYOX-ray2.50B/D1-108[»]
3EYQX-ray2.40D1-108[»]
3FJTX-ray2.50A/B119-327[»]
3MCLX-ray1.70H1-107[»]
3O11X-ray2.80B/H1-103[»]
3RY6X-ray3.80A/B114-327[»]
3S7GX-ray3.13A/B/C/D104-330[»]
3SGJX-ray2.20A/B106-330[»]
3SGKX-ray2.40A/B106-330[»]
3TV3X-ray1.29H1-104[»]
3TWCX-ray1.65H1-104[»]
3TYGX-ray3.25H1-104[»]
3U0WX-ray2.00H1-103[»]
3U7WX-ray2.60H1-104[»]
3U7YX-ray2.45H1-104[»]
3V7MX-ray2.02A119-327[»]
3V8CX-ray2.77A/B119-330[»]
3V95X-ray2.70A/B119-330[»]
3WJJX-ray2.60A/B99-328[»]
3WJLX-ray2.86A/B99-328[»]
3WKNX-ray2.90A/B/C/D/I/J/M/N119-330[»]
3WN5X-ray2.78A/B/D/E99-328[»]
4ACPX-ray2.49A/B101-329[»]
4B7IX-ray2.36A/B120-329[»]
4BM7X-ray1.95A/B106-329[»]
4BSVX-ray1.75A/B106-330[»]
4BSWX-ray2.15A/B106-330[»]
4BYHX-ray2.30A/B106-329[»]
4CDHX-ray2.30A/B101-330[»]
4D9QX-ray2.28E/H2-102[»]
4D9RX-ray2.42E/H2-103[»]
4DAGX-ray3.39H2-98[»]
4DZ8X-ray1.91A/B108-330[»]
4EOWX-ray1.97H1-101[»]
4HIXX-ray2.20H1-107[»]
4J12X-ray1.90A119-327[»]
4KU1X-ray1.90A/B120-327[»]
4LLDX-ray1.19A1-103[»]
4LLMX-ray1.75A1-103[»]
4LLQX-ray1.42A1-103[»]
4N0UX-ray3.80E119-327[»]
4NQSX-ray2.64A/B/G/H118-330[»]
4NQTX-ray2.10A118-330[»]
4NQUX-ray2.50A118-330[»]
4NWTX-ray1.75H6-95[»]
4NWUX-ray1.60H6-105[»]
4O4YX-ray1.85A106-119[»]
4O51X-ray2.20M/N/O/P106-119[»]
4Q6YX-ray3.00A/B/C/D109-329[»]
4Q74X-ray2.19A/B108-329[»]
4Q7DX-ray2.35A/B109-329[»]
4W4NX-ray1.80A/B107-329[»]
4W4OX-ray1.80A/B107-330[»]
4WI2X-ray1.90A/B120-327[»]
4WI3X-ray2.70A/B120-327[»]
4WI4X-ray2.80A/B121-327[»]
4WI5X-ray2.80A/B120-327[»]
4WI6X-ray2.20A/B120-327[»]
4WI7X-ray1.90A/B120-327[»]
4WI8X-ray2.80A/B120-327[»]
4WI9X-ray2.65A/B120-327[»]
4X4MX-ray3.48A/B/C/D112-330[»]
4X98X-ray2.50A108-327[»]
B121-327[»]
4X99X-ray2.50A/B108-330[»]
4XMPX-ray1.78H1-103[»]
4XNYX-ray2.30H1-103[»]
4XNZX-ray3.39B/E/H1-103[»]
4XXDX-ray2.41B/E1-107[»]
4ZNEX-ray2.42E/J104-330[»]
5BW7X-ray3.00A/B108-330[»]
5D4QX-ray2.39A/B109-329[»]
5D6DX-ray3.13A/B108-329[»]
5DI8X-ray1.90A/B104-330[»]
5DJ0X-ray2.28A/B104-330[»]
5DJ2X-ray2.56A/B104-330[»]
5DJ6X-ray2.00A/B104-330[»]
5DJ8X-ray2.40A/B104-330[»]
5DJAX-ray2.90A/B104-330[»]
5DJCX-ray2.10A/B/D/E104-330[»]
5DJDX-ray2.30A/B104-330[»]
5DJXX-ray2.25A/B/D/E104-330[»]
5DJYX-ray2.15A/B104-330[»]
5DJZX-ray1.90A/B104-330[»]
5DK0X-ray2.30A/B104-330[»]
5DK2X-ray2.60A/B/D/E104-330[»]
5DVKX-ray2.60A104-330[»]
5DVLX-ray1.90A104-330[»]
5DVMX-ray2.95A104-330[»]
5DVNX-ray2.50A104-330[»]
5DVOX-ray2.50A/B104-330[»]
5GSQX-ray1.85A/B/C/D106-330[»]
5HSFX-ray1.52A/B221-330[»]
5HY9X-ray2.70A/B104-330[»]
5HYEX-ray1.89A/C104-330[»]
5HYFX-ray1.80A104-330[»]
5HYIX-ray2.90A/B/C/D104-330[»]
5IQ7X-ray3.29H1-102[»]
5IQ9X-ray2.40A/H1-101[»]
5IW3X-ray2.05A119-326[»]
5IW6X-ray2.34A119-327[»]
B122-326[»]
5JIHX-ray1.66A/B108-329[»]
5JIIX-ray1.79A/B108-329[»]
5JIKX-ray1.82A/B108-329[»]
5K33X-ray3.30A108-329[»]
5K64X-ray2.44A/B108-330[»]
5K65X-ray2.50A/B108-330[»]
5K8DX-ray4.19B104-329[»]
5KWGX-ray4.30A108-330[»]
5M3VX-ray1.97A/B104-330[»]
5TPSX-ray2.70A/B104-330[»]
5U4YX-ray2.50A/B118-329[»]
5U52X-ray1.94A/B119-326[»]
5U66X-ray1.70A120-326[»]
5V43X-ray2.32A/B104-329[»]
5V4EX-ray3.22A/B/C/D/E/F/G/H104-329[»]
6DCVX-ray1.90B/H1-107[»]
6DCWX-ray2.00H1-107[»]
6DE7X-ray4.12D1-105[»]
H1-103[»]
ProteinModelPortaliP01857
SMRiP01857
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29187N
IntActiP01857, 86 interactors
MINTiP01857

Chemistry databases

DrugBankiDB07883 (2-AMINO-3-PHENYL-BICYCLO[2.2.1]HEPT-2-YL)-PHENYL-METHANONE
DB08294 2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID
DB07371 3-(10-METHYL-ANTHRACEN-9-YL)-PROPIONIC ACID
DB08562 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID
DB08409 4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE
DB08296 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID
DB08412 6-{4-[HYDROXY-(4-NITRO-PHENOXY)-PHOSPHORYL]-BUTYRYLAMINO}-HEXANOIC ACID
DB08332 [2'-CARBOXYLETHYL]-10-METHYL-ANTHRACENE ENDOPEROXIDE
DB04473 Alpha-L-Fucose
DB04639 Biphenylalanine
DB07764 FLUORESCIN
DB01631 Methyl Nonanoate (Ester)
DB07816 N-(P-CYANOPHENYL)-N'-DIPHENYLMETHYL-GUANIDINE-ACETIC ACID
DB03740 N-acetyl-alpha-D-glucosamine
DB07881 N-{[2-({[1-(4-CARBOXYBUTANOYL)AMINO]-2-PHENYLETHYL}-HYDROXYPHOSPHINYL)OXY]ACETYL}-2-PHENYLETHYLAMINE
DB08410 PARA-NITROBENZYL GLUTARYL GLYCINIC ACID
DB08377 PARA-NITROPHENYL PHOSPHONOBUTANOYL D-ALANINE
DB08411 PARA-NITROPHENYL PHOSPHONOBUTANOYL L-ALANINE
DB08394 PARA-NITROPHENYLPHOSPHONOBUTANOYL-GLYCINE
DB07672 TRANS-2-(DIMETHYLPHENYLSILYL)-PIPERIDINE-N-OXIDE

Protein family/group databases

IMGT/GENE-DBIGHG1

PTM databases

CarbonylDBiP01857
GlyConnecti671
iPTMnetiP01857
PhosphoSitePlusiP01857
SwissPalmiP01857
UniCarbKBiP01857

Polymorphism and mutation databases

DMDMi121039

2D gel databases

DOSAC-COBS-2DPAGEiP01857
REPRODUCTION-2DPAGEiP01857
UCD-2DPAGEiP01857

Proteomic databases

EPDiP01857
MaxQBiP01857
PeptideAtlasiP01857
PRIDEiP01857
ProteomicsDBi51494

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000390549; ENSP00000374991; ENSG00000211896
ENST00000631466; ENSP00000488387; ENSG00000277633
UCSCiuc059gdc.1 human

Organism-specific databases

DisGeNETi3500
EuPathDBiHostDB:ENSG00000211896.7
GeneCardsiIGHG1
HGNCiHGNC:5525 IGHG1
MalaCardsiIGHG1
MIMi147100 gene
254500 phenotype
neXtProtiNX_P01857
OpenTargetsiENSG00000211896
Orphaneti67038 B-cell chronic lymphocytic leukemia
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063726
HOVERGENiHBG005814
InParanoidiP01857
PhylomeDBiP01857

Enzyme and pathway databases

ReactomeiR-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-977606 Regulation of Complement cascade

Miscellaneous databases

ChiTaRSiIGHG1 human
EvolutionaryTraceiP01857
PROiPR:P01857
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000211896 Expressed in 113 organ(s), highest expression level in lymph node
CleanExiHS_IGHG1
ExpressionAtlasiP01857 baseline and differential
GenevisibleiP01857 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
PfamiView protein in Pfam
PF07654 C1-set, 3 hits
SMARTiView protein in SMART
SM00407 IGc1, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00290 IG_MHC, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIGHG1_HUMAN
AccessioniPrimary (citable) accession number: P01857
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 7, 2018
This is version 203 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again