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Entry version 212 (16 Oct 2019)
Sequence version 1 (21 Jul 1986)
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Protein

Immunoglobulin heavy constant gamma 1

Gene

IGHG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).3 Publications

Caution

For an example of a full-length immunoglobulin gamma heavy chain see AC P0DOX5.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-977606 Regulation of Complement cascade

Protein family/group databases

IMGT/GENE-DBIGHG1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Immunoglobulin heavy constant gamma 12 Publications
Alternative name(s):
Ig gamma-1 chain C regionCurated
Ig gamma-1 chain C region EU2 Publications
Ig gamma-1 chain C region KOL1 Publication
Ig gamma-1 chain C region NIE1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IGHG12 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5525 IGHG1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
147100 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01857

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Immunoglobulin, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Multiple myeloma (MM)2 Publications
The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
Disease descriptionA malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia.
Related information in OMIM

Organism-specific databases

DisGeNET

More...
DisGeNETi
3500

MalaCards human disease database

More...
MalaCardsi
IGHG1
MIMi254500 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000211896

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
67038 B-cell chronic lymphocytic leukemia

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P01857

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB07909 (1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL
DB07883 (2-AMINO-3-PHENYL-BICYCLO[2.2.1]HEPT-2-YL)-PHENYL-METHANONE
DB08294 2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID
DB07371 3-(10-methyl-9-anthryl)propanoic acid
DB07441 3-{[(9-CYANO-9,10-DIHYDRO-10-METHYLACRIDIN-9-YL)CARBONYL]AMINO}PROPANOIC ACID
DB08562 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID
DB08409 4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE
DB08296 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID
DB07375 5-BETA-ANDROSTANE-3,17-DIONE
DB08412 6-{4-[HYDROXY-(4-NITRO-PHENOXY)-PHOSPHORYL]-BUTYRYLAMINO}-HEXANOIC ACID
DB08332 9-(2-carboxyethyl)-10-methylanthracene endoperoxide
DB04473 Alpha-L-Fucose
DB04639 Biphenylalanine
DB09130 Copper
DB07764 FLUORESCIN
DB01631 Methyl Nonanoate (Ester)
DB07816 N-(P-CYANOPHENYL)-N'-DIPHENYLMETHYL-GUANIDINE-ACETIC ACID
DB08377 N-[4-(4-nitrophenylphospho)butanoyl]-D-alanine
DB08411 N-[4-(4-nitrophenylphospho)butanoyl]-L-alanine
DB03740 N-acetyl-alpha-D-glucosamine
DB07881 N-{[2-({[1-(4-CARBOXYBUTANOYL)AMINO]-2-PHENYLETHYL}-HYDROXYPHOSPHINYL)OXY]ACETYL}-2-PHENYLETHYLAMINE
DB08410 PARA-NITROBENZYL GLUTARYL GLYCINIC ACID
DB08394 PARA-NITROPHENYLPHOSPHONOBUTANOYL-GLYCINE
DB07672 TRANS-2-(DIMETHYLPHENYLSILYL)-PIPERIDINE-N-OXIDE

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IGHG1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
121039

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000153578‹1 – 330Immunoglobulin heavy constant gamma 1Add BLAST›330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi27 ↔ 83PROSITE-ProRule annotation
Disulfide bondi103Interchain (with light chain)
Disulfide bondi109Interchain (with heavy chain)
Disulfide bondi112Interchain (with heavy chain)
Disulfide bondi144 ↔ 204PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi180N-linked (GlcNAc...) (complex) asparagine3 Publications1
Disulfide bondi250 ↔ 308PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
CPTAC-669

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P01857

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P01857

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P01857

PeptideAtlas

More...
PeptideAtlasi
P01857

PRoteomics IDEntifications database

More...
PRIDEi
P01857

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
51494

2D gel databases

DOSAC-COBS 2D-PAGE database

More...
DOSAC-COBS-2DPAGEi
P01857

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
P01857

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
P01857

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
P01857

GlyConnect protein glycosylation platform

More...
GlyConnecti
671

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01857

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01857

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P01857

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P01857

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000211896 Expressed in 113 organ(s), highest expression level in lymph node

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P01857 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01857 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-29187N

Protein interaction database and analysis system

More...
IntActi
P01857, 116 interactors

Molecular INTeraction database

More...
MINTi
P01857

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1330
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01857

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01857

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 99Ig-like 1PROSITE-ProRule annotationAdd BLAST94
Domaini121 – 220Ig-like 2PROSITE-ProRule annotationAdd BLAST100
Domaini229 – 325Ig-like 3PROSITE-ProRule annotationAdd BLAST97

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 98CH1Add BLAST98
Regioni99 – 110HingeAdd BLAST12
Regioni111 – 223CH2Add BLAST113
Regioni224 – 330CH3Add BLAST107

Keywords - Domaini

Immunoglobulin domain

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162793

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01857

Database of Orthologous Groups

More...
OrthoDBi
1242894at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01857

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07654 C1-set, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00407 IGc1, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00290 IG_MHC, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P01857-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV
60 70 80 90 100
HTFPAVLQSS GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKKVEP
110 120 130 140 150
KSCDKTHTCP PCPAPELLGG PSVFLFPPKP KDTLMISRTP EVTCVVVDVS
160 170 180 190 200
HEDPEVKFNW YVDGVEVHNA KTKPREEQYN STYRVVSVLT VLHQDWLNGK
210 220 230 240 250
EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE LTKNQVSLTC
260 270 280 290 300
LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW
310 320 330
QQGNVFSCSV MHEALHNHYT QKSLSLSPGK
Length:330
Mass (Da):36,106
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3770EE106C2FA33D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MS08A0A0A0MS08_HUMAN
Immunoglobulin heavy constant gamma...
IGHG1
399Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MS07A0A0A0MS07_HUMAN
Immunoglobulin heavy constant gamma...
IGHG1
295Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC82527 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

There are several alleles. The sequence shown is that of IMGT allele IGHG1*05.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00388697K → R in IMGT allele IGHG1*03. 1
Natural variantiVAR_003887239D → E in IMGT allele IGHG1*03. 1
Natural variantiVAR_003888241L → M in IMGT allele IGHG1*03. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
J00228 Genomic DNA Translation: AAC82527.1 Different initiation.
AL122127 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

More...
PIRi
A93433 GHHU

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000390549; ENSP00000374991; ENSG00000211896
ENST00000631466; ENSP00000488387; ENSG00000277633

UCSC genome browser

More...
UCSCi
uc059gdc.1 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00228 Genomic DNA Translation: AAC82527.1 Different initiation.
AL122127 Genomic DNA No translation available.
PIRiA93433 GHHU

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AJ7X-ray2.10H1-103[»]
1AQKX-ray1.84H1-103[»]
1AXSX-ray2.60B/H1-101[»]
1BEYX-ray3.25H1-98[»]
1D5BX-ray2.80B/H1-101[»]
1D5IX-ray2.00H1-101[»]
1D6VX-ray2.00H1-101[»]
1DFBX-ray2.70H1-103[»]
1DN2X-ray2.70A/B120-326[»]
1E4KX-ray3.20A/B106-330[»]
1FC1X-ray2.90A/B106-329[»]
1FC2X-ray2.80D106-329[»]
1FCCX-ray3.20A/B121-326[»]
1GAFX-ray1.95H1-103[»]
1H3TX-ray2.40A/B108-330[»]
1H3UX-ray2.40A/B108-330[»]
1H3VX-ray3.10A/B108-330[»]
1H3WX-ray2.85M108-330[»]
1H3XX-ray2.44A/B108-330[»]
1H3YX-ray4.10A/B108-330[»]
1HKLX-ray2.68H1-103[»]
1HZHX-ray2.70H/K1-330[»]
1I7ZX-ray2.30B/D1-103[»]
1L6XX-ray1.65A120-326[»]
1N7MX-ray1.80L2-102[»]
1OQOX-ray2.30A/B119-330[»]
1OQXX-ray2.60A/B119-330[»]
1PG7X-ray2.50H/I1-100[»]
1T83X-ray3.00A/B107-330[»]
1T89X-ray3.50A/B107-330[»]
1VGEX-ray2.00H1-103[»]
2DTSX-ray2.20A/B108-330[»]
2GJ7X-ray5.00A/B106-330[»]
2I5YX-ray2.20H1-101[»]
2IWGX-ray2.35A/D120-326[»]
2J6EX-ray3.00A/B99-330[»]
2JB5X-ray2.80H1-102[»]
2JB6X-ray2.85B/H1-102[»]
2O5XX-ray2.05H1-108[»]
2O5YX-ray2.85H1-108[»]
2O5ZX-ray2.40H1-108[»]
2OSLX-ray2.60A/H1-103[»]
2QADX-ray3.30D/H1-101[»]
2QL1X-ray2.53A106-330[»]
2QQKX-ray2.75H1-107[»]
2QQLX-ray3.10H1-107[»]
2QQNX-ray2.20H1-107[»]
2QR0X-ray3.50B/F/H/L/N/R/T/X1-103[»]
2R56X-ray2.80H/I1-100[»]
2RCSX-ray2.10H1-103[»]
2VXQX-ray1.90H1-100[»]
2WAHX-ray2.51A/B120-328[»]
3AGVX-ray2.15A/B120-330[»]
3AVEX-ray2.00A/B108-330[»]
3AY4X-ray2.20A/B108-330[»]
3B2UX-ray2.58C/F/H/J/N/Q/T/W1-102[»]
3B2VX-ray3.30H1-102[»]
3BDYX-ray2.60H1-107[»]
3BE1X-ray2.90H1-107[»]
3BKYX-ray2.61H1-104[»]
3BN9X-ray2.17D/F1-107[»]
3BQUX-ray3.00B2-103[»]
3C08X-ray2.15H1-102[»]
3C09X-ray3.20C/H1-102[»]
3C2SX-ray2.30A106-330[»]
3CFJX-ray2.60B/D/F/H1-104[»]
3CFKX-ray2.60B/D/F/H/I/K/N/P1-104[»]
3CSYX-ray3.40A/C/E/G1-101[»]
3D0LX-ray2.35B2-105[»]
3D0VX-ray2.05B2-105[»]
3D6GX-ray2.30A/B119-328[»]
3D85X-ray1.90B1-108[»]
3DJ9X-ray1.75A119-225[»]
3DNKX-ray2.84A/B119-330[»]
3DO3X-ray2.50A/B119-330[»]
3DROX-ray3.90B2-103[»]
3DRQX-ray2.00B2-103[»]
3DVGX-ray2.60B1-107[»]
3DVNX-ray2.70B/H1-107[»]
3EYFX-ray2.30B/D1-108[»]
3EYOX-ray2.50B/D1-108[»]
3EYQX-ray2.40D1-108[»]
3FJTX-ray2.50A/B119-327[»]
3MCLX-ray1.70H1-107[»]
3O11X-ray2.80B/H1-103[»]
3RY6X-ray3.80A/B114-327[»]
3S7GX-ray3.13A/B/C/D104-330[»]
3SGJX-ray2.20A/B106-330[»]
3SGKX-ray2.40A/B106-330[»]
3TV3X-ray1.29H1-104[»]
3TWCX-ray1.65H1-104[»]
3TYGX-ray3.25H1-104[»]
3U0WX-ray2.00H1-103[»]
3U7WX-ray2.60H1-104[»]
3U7YX-ray2.45H1-104[»]
3V7MX-ray2.02A119-327[»]
3V8CX-ray2.77A/B119-330[»]
3V95X-ray2.70A/B119-330[»]
3WJJX-ray2.60A/B99-328[»]
3WJLX-ray2.86A/B99-328[»]
3WKNX-ray2.90A/B/C/D/I/J/M/N119-330[»]
3WN5X-ray2.78A/B/D/E99-328[»]
4ACPX-ray2.49A/B101-329[»]
4B7IX-ray2.36A/B120-329[»]
4BM7X-ray1.95A/B106-329[»]
4BSVX-ray1.75A/B106-330[»]
4BSWX-ray2.15A/B106-330[»]
4BYHX-ray2.30A/B106-329[»]
4CDHX-ray2.30A/B101-330[»]
4D9QX-ray2.28E/H2-102[»]
4D9RX-ray2.42E/H2-103[»]
4DAGX-ray3.39H2-98[»]
4DZ8X-ray1.91A/B108-330[»]
4EOWX-ray1.97H1-101[»]
4HIXX-ray2.20H1-107[»]
4J12X-ray1.90A119-327[»]
4KU1X-ray1.90A/B120-327[»]
4LLDX-ray1.19A1-103[»]
4LLMX-ray1.75A1-103[»]
4LLQX-ray1.42A1-103[»]
4N0UX-ray3.80E119-327[»]
4NQSX-ray2.64A/B/G/H118-330[»]
4NQTX-ray2.10A118-330[»]
4NQUX-ray2.50A118-330[»]
4NWTX-ray1.75H6-95[»]
4NWUX-ray1.60H6-105[»]
4O4YX-ray1.85A106-119[»]
4O51X-ray2.20M/N/O/P106-119[»]
4Q6YX-ray3.00A/B/C/D109-329[»]
4Q74X-ray2.19A/B108-329[»]
4Q7DX-ray2.35A/B109-329[»]
4W4NX-ray1.80A/B107-329[»]
4W4OX-ray1.80A/B107-330[»]
4WI2X-ray1.90A/B120-327[»]
4WI3X-ray2.70A/B120-327[»]
4WI4X-ray2.80A/B121-327[»]
4WI5X-ray2.80A/B120-327[»]
4WI6X-ray2.20A/B120-327[»]
4WI7X-ray1.90A/B120-327[»]
4WI8X-ray2.80A/B120-327[»]
4WI9X-ray2.65A/B120-327[»]
4X4MX-ray3.48A/B/C/D112-330[»]
4X98X-ray2.50A108-327[»]
B121-327[»]
4X99X-ray2.50A/B108-330[»]
4XMPX-ray1.78H1-103[»]
4XNYX-ray2.30H1-103[»]
4XNZX-ray3.39B/E/H1-103[»]
4XXDX-ray2.41B/E1-107[»]
4ZNEX-ray2.42E/J104-330[»]
5BW7X-ray3.00A/B108-330[»]
5D4QX-ray2.39A/B109-329[»]
5D6DX-ray3.13A/B108-329[»]
5DI8X-ray1.90A/B104-330[»]
5DJ0X-ray2.28A/B104-330[»]
5DJ2X-ray2.56A/B104-330[»]
5DJ6X-ray2.00A/B104-330[»]
5DJ8X-ray2.40A/B104-330[»]
5DJAX-ray2.90A/B104-330[»]
5DJCX-ray2.10A/B/D/E104-330[»]
5DJDX-ray2.30A/B104-330[»]
5DJXX-ray2.25A/B/D/E104-330[»]
5DJYX-ray2.15A/B104-330[»]
5DJZX-ray1.90A/B104-330[»]
5DK0X-ray2.30A/B104-330[»]
5DK2X-ray2.60A/B/D/E104-330[»]
5DVKX-ray2.60A104-330[»]
5DVLX-ray1.90A104-330[»]
5DVMX-ray2.95A104-330[»]
5DVNX-ray2.50A104-330[»]
5DVOX-ray2.50A/B104-330[»]
5GSQX-ray1.85A/B/C/D106-330[»]
5HSFX-ray1.52A/B221-330[»]
5HY9X-ray2.70A/B104-330[»]
5HYEX-ray1.89A/C104-330[»]
5HYFX-ray1.80A104-330[»]
5HYIX-ray2.90A/B/C/D104-330[»]
5IQ7X-ray3.29H1-102[»]
5IQ9X-ray2.40A/H1-101[»]
5IW3X-ray2.05A119-326[»]
5IW6X-ray2.34A119-327[»]
B122-326[»]
5JIHX-ray1.66A/B108-329[»]
5JIIX-ray1.79A/B108-329[»]
5JIKX-ray1.82A/B108-329[»]
5K33X-ray3.30A108-329[»]
5K64X-ray2.44A/B108-330[»]
5K65X-ray2.50A/B108-330[»]
5K8DX-ray4.19B104-329[»]
5KWGX-ray4.30A108-330[»]
5M3VX-ray1.97A/B104-330[»]
5TPSX-ray2.70A/B104-330[»]
5U4YX-ray2.50A/B118-329[»]
5U52X-ray1.94A/B119-326[»]
5U66X-ray1.70A120-326[»]
5V43X-ray2.32A/B104-329[»]
5V4EX-ray3.22A/B/C/D/E/F/G/H104-329[»]
6DCVX-ray1.90B/H1-107[»]
6DCWX-ray2.00H1-107[»]
6DE7X-ray4.12D1-105[»]
H1-103[»]
6F2ZX-ray2.30A/B104-330[»]
6G1EX-ray1.88A104-156[»]
6N35X-ray1.75H/M1-102[»]
SMRiP01857
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-29187N
IntActiP01857, 116 interactors
MINTiP01857

Chemistry databases

DrugBankiDB07909 (1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL
DB07883 (2-AMINO-3-PHENYL-BICYCLO[2.2.1]HEPT-2-YL)-PHENYL-METHANONE
DB08294 2-(4-HYDROXY-3-NITROPHENYL)ACETIC ACID
DB07371 3-(10-methyl-9-anthryl)propanoic acid
DB07441 3-{[(9-CYANO-9,10-DIHYDRO-10-METHYLACRIDIN-9-YL)CARBONYL]AMINO}PROPANOIC ACID
DB08562 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID
DB08409 4-NITRO-BENZYLPHOSPHONOBUTANOYL-GLYCINE
DB08296 5-(PARA-NITROPHENYL PHOSPHONATE)-PENTANOIC ACID
DB07375 5-BETA-ANDROSTANE-3,17-DIONE
DB08412 6-{4-[HYDROXY-(4-NITRO-PHENOXY)-PHOSPHORYL]-BUTYRYLAMINO}-HEXANOIC ACID
DB08332 9-(2-carboxyethyl)-10-methylanthracene endoperoxide
DB04473 Alpha-L-Fucose
DB04639 Biphenylalanine
DB09130 Copper
DB07764 FLUORESCIN
DB01631 Methyl Nonanoate (Ester)
DB07816 N-(P-CYANOPHENYL)-N'-DIPHENYLMETHYL-GUANIDINE-ACETIC ACID
DB08377 N-[4-(4-nitrophenylphospho)butanoyl]-D-alanine
DB08411 N-[4-(4-nitrophenylphospho)butanoyl]-L-alanine
DB03740 N-acetyl-alpha-D-glucosamine
DB07881 N-{[2-({[1-(4-CARBOXYBUTANOYL)AMINO]-2-PHENYLETHYL}-HYDROXYPHOSPHINYL)OXY]ACETYL}-2-PHENYLETHYLAMINE
DB08410 PARA-NITROBENZYL GLUTARYL GLYCINIC ACID
DB08394 PARA-NITROPHENYLPHOSPHONOBUTANOYL-GLYCINE
DB07672 TRANS-2-(DIMETHYLPHENYLSILYL)-PIPERIDINE-N-OXIDE

Protein family/group databases

IMGT/GENE-DBIGHG1

PTM databases

CarbonylDBiP01857
GlyConnecti671
iPTMnetiP01857
PhosphoSitePlusiP01857
SwissPalmiP01857
UniCarbKBiP01857

Polymorphism and mutation databases

BioMutaiIGHG1
DMDMi121039

2D gel databases

DOSAC-COBS-2DPAGEiP01857
REPRODUCTION-2DPAGEiP01857
UCD-2DPAGEiP01857

Proteomic databases

CPTACiCPTAC-669
jPOSTiP01857
MassIVEiP01857
MaxQBiP01857
PeptideAtlasiP01857
PRIDEiP01857
ProteomicsDBi51494

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P01857

Genome annotation databases

EnsembliENST00000390549; ENSP00000374991; ENSG00000211896
ENST00000631466; ENSP00000488387; ENSG00000277633
UCSCiuc059gdc.1 human

Organism-specific databases

DisGeNETi3500

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IGHG1
HGNCiHGNC:5525 IGHG1
MalaCardsiIGHG1
MIMi147100 gene
254500 phenotype
neXtProtiNX_P01857
OpenTargetsiENSG00000211896
Orphaneti67038 B-cell chronic lymphocytic leukemia

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000162793
InParanoidiP01857
OrthoDBi1242894at2759
PhylomeDBiP01857

Enzyme and pathway databases

ReactomeiR-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-977606 Regulation of Complement cascade

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IGHG1 human
EvolutionaryTraceiP01857
PharosiP01857

Protein Ontology

More...
PROi
PR:P01857

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000211896 Expressed in 113 organ(s), highest expression level in lymph node
ExpressionAtlasiP01857 baseline and differential
GenevisibleiP01857 HS

Family and domain databases

Gene3Di2.60.40.10, 3 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
PfamiView protein in Pfam
PF07654 C1-set, 3 hits
SMARTiView protein in SMART
SM00407 IGc1, 3 hits
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS00290 IG_MHC, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIGHG1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01857
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 16, 2019
This is version 212 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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