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Protein

Immunoglobulin heavy constant epsilon

Gene

IGHE

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).3 Publications

Caution

For an example of a full-length immunoglobulin epsilon heavy chain see AC P0DOX4.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • antigen binding Source: GO_Central
  • immunoglobulin receptor binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling

Protein family/group databases

IMGT/GENE-DBIGHE

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Immunoglobulin heavy constant epsilon2 Publications
Alternative name(s):
Ig epsilon chain C regionCurated
Ig epsilon chain C region ND1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IGHE2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000211891.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5522 IGHE

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
147180 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01854

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3497

Open Targets

More...
OpenTargetsi
ENSG00000211891

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1834

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2741

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IGHE

Domain mapping of disease mutations (DMDM)

More...
DMDMi
119512

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000153574‹1 – 428Immunoglobulin heavy constant epsilonAdd BLAST›428

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi14Interchain (with a light chain)
Disulfide bondi15 ↔ 105
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi21N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi29 ↔ 85PROSITE-ProRule annotation
Glycosylationi49N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi99N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi121Interchain (with a heavy chain)
Disulfide bondi135 ↔ 193PROSITE-ProRule annotation
Glycosylationi146N-linked (GlcNAc...) asparagine1
Disulfide bondi209Interchain (with a heavy chain)
Disulfide bondi239 ↔ 299PROSITE-ProRule annotation
Glycosylationi252N-linked (GlcNAc...) asparagine1
Glycosylationi275N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi345 ↔ 405PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P01854

PeptideAtlas

More...
PeptideAtlasi
P01854

PRoteomics IDEntifications database

More...
PRIDEi
P01854

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51493

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
765

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01854

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01854

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P01854

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000211891 Expressed in 42 organ(s), highest expression level in mucosa of transverse colon

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P01854 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01854 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-6167N

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1428
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F6AX-ray3.50B/D211-428[»]
1FP5X-ray2.30A211-428[»]
1G84NMR-A106-208[»]
1IGEmodel-A/B107-428[»]
1O0VX-ray2.60A/B104-427[»]
2WQRX-ray1.90A/B105-427[»]
2Y7QX-ray3.40B/D104-428[»]
3H9YX-ray2.23A/B/E209-428[»]
3H9ZX-ray2.45A/B/C/D209-428[»]
3HA0X-ray2.80A/B/C/D/E/F209-428[»]
4EZMX-ray3.10A/B/C/D/E/F209-428[»]
4GKOX-ray3.30A/B/C/D/E/F209-428[»]
4GRGX-ray4.24C/D210-428[»]
4GT7X-ray2.61A/B/C/D210-426[»]
4J4PX-ray2.91A/B105-427[»]
4KI1X-ray3.20A/B/C/D209-428[»]
5ANMX-ray2.85E/F/G211-428[»]
5HYSX-ray2.50G/I/J/K209-428[»]
5LGJX-ray2.60A108-426[»]
B108-427[»]
5LGKX-ray3.50A/B/C/D114-421[»]
5MOIX-ray2.20A/B/C/D/E/F209-428[»]
5MOJX-ray2.26A/B209-428[»]
5MOKX-ray2.00A/B/C/D209-428[»]
5MOLX-ray1.75A/B104-428[»]
5NQWX-ray3.40A/B215-426[»]
6EYOX-ray3.70A/B104-428[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P01854

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P01854

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01854

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 103Ig-like 1PROSITE-ProRule annotationAdd BLAST98
Domaini112 – 210Ig-like 2PROSITE-ProRule annotationAdd BLAST99
Domaini214 – 318Ig-like 3PROSITE-ProRule annotationAdd BLAST105
Domaini324 – 423Ig-like 4PROSITE-ProRule annotationAdd BLAST100

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain, Repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000163076

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG096066

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01854

Identification of Orthologs from Complete Genome Data

More...
OMAi
PKITCLV

Database of Orthologous Groups

More...
OrthoDBi
614790at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01854

TreeFam database of animal gene trees

More...
TreeFami
TF334176

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07654 C1-set, 4 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00407 IGc1, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 4 hits
PS00290 IG_MHC, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P01854-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ASTQSPSVFP LTRCCKNIPS NATSVTLGCL ATGYFPEPVM VTWDTGSLNG
60 70 80 90 100
TTMTLPATTL TLSGHYATIS LLTVSGAWAK QMFTCRVAHT PSSTDWVDNK
110 120 130 140 150
TFSVCSRDFT PPTVKILQSS CDGGGHFPPT IQLLCLVSGY TPGTINITWL
160 170 180 190 200
EDGQVMDVDL STASTTQEGE LASTQSELTL SQKHWLSDRT YTCQVTYQGH
210 220 230 240 250
TFEDSTKKCA DSNPRGVSAY LSRPSPFDLF IRKSPTITCL VVDLAPSKGT
260 270 280 290 300
VNLTWSRASG KPVNHSTRKE EKQRNGTLTV TSTLPVGTRD WIEGETYQCR
310 320 330 340 350
VTHPHLPRAL MRSTTKTSGP RAAPEVYAFA TPEWPGSRDK RTLACLIQNF
360 370 380 390 400
MPEDISVQWL HNEVQLPDAR HSTTQPRKTK GSGFFVFSRL EVTRAEWEQK
410 420
DEFICRAVHE AASPSQTVQR AVSVNPGK
Length:428
Mass (Da):47,019
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i25C4CA072AA558A0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A286YES5A0A286YES5_HUMAN
Immunoglobulin heavy constant epsil...
IGHE
494Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB59395 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAB59424 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1 – 5ASTQS → GAWTL AA sequence (Ref. 1) Curated5
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11
Sequence conflicti53 – 54Missing AA sequence (Ref. 1) Curated2
Sequence conflicti93 – 94Missing AA sequence (Ref. 1) Curated2
Sequence conflicti124G → L AA sequence (Ref. 1) Curated1
Sequence conflicti166 – 168TQE → ESQ AA sequence (Ref. 1) Curated3
Sequence conflicti175Q → E AA sequence (Ref. 1) Curated1
Sequence conflicti177E → Q AA sequence (Ref. 1) Curated1
Sequence conflicti203E → Q AA sequence (Ref. 1) Curated1
Sequence conflicti398 – 399EQ → QE AA sequence (Ref. 1) Curated2

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

There are several alleles. The sequence shown is that of IMGT allele IGHE*04.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04422943W → C in IMGT allele IGHE*01. 1 Publication1
Natural variantiVAR_003885359W → L Possible polymorphism. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L00022 Genomic DNA Translation: AAB59424.1 Different initiation.
J00222 Genomic DNA Translation: AAB59395.1 Different initiation.
AL928742 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

More...
PIRi
A22771 EHHU

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000390541; ENSP00000374983; ENSG00000211891
ENST00000610670; ENSP00000481089; ENSG00000276192

UCSC genome browser

More...
UCSCi
uc059gcp.1 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00022 Genomic DNA Translation: AAB59424.1 Different initiation.
J00222 Genomic DNA Translation: AAB59395.1 Different initiation.
AL928742 Genomic DNA No translation available.
PIRiA22771 EHHU

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F6AX-ray3.50B/D211-428[»]
1FP5X-ray2.30A211-428[»]
1G84NMR-A106-208[»]
1IGEmodel-A/B107-428[»]
1O0VX-ray2.60A/B104-427[»]
2WQRX-ray1.90A/B105-427[»]
2Y7QX-ray3.40B/D104-428[»]
3H9YX-ray2.23A/B/E209-428[»]
3H9ZX-ray2.45A/B/C/D209-428[»]
3HA0X-ray2.80A/B/C/D/E/F209-428[»]
4EZMX-ray3.10A/B/C/D/E/F209-428[»]
4GKOX-ray3.30A/B/C/D/E/F209-428[»]
4GRGX-ray4.24C/D210-428[»]
4GT7X-ray2.61A/B/C/D210-426[»]
4J4PX-ray2.91A/B105-427[»]
4KI1X-ray3.20A/B/C/D209-428[»]
5ANMX-ray2.85E/F/G211-428[»]
5HYSX-ray2.50G/I/J/K209-428[»]
5LGJX-ray2.60A108-426[»]
B108-427[»]
5LGKX-ray3.50A/B/C/D114-421[»]
5MOIX-ray2.20A/B/C/D/E/F209-428[»]
5MOJX-ray2.26A/B209-428[»]
5MOKX-ray2.00A/B/C/D209-428[»]
5MOLX-ray1.75A/B104-428[»]
5NQWX-ray3.40A/B215-426[»]
6EYOX-ray3.70A/B104-428[»]
ProteinModelPortaliP01854
SMRiP01854
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6167N

Chemistry databases

ChEMBLiCHEMBL1834
GuidetoPHARMACOLOGYi2741

Protein family/group databases

IMGT/GENE-DBIGHE

PTM databases

GlyConnecti765
iPTMnetiP01854
PhosphoSitePlusiP01854
UniCarbKBiP01854

Polymorphism and mutation databases

BioMutaiIGHE
DMDMi119512

Proteomic databases

jPOSTiP01854
PeptideAtlasiP01854
PRIDEiP01854
ProteomicsDBi51493

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000390541; ENSP00000374983; ENSG00000211891
ENST00000610670; ENSP00000481089; ENSG00000276192
UCSCiuc059gcp.1 human

Organism-specific databases

DisGeNETi3497
EuPathDBiHostDB:ENSG00000211891.5

GeneCards: human genes, protein and diseases

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GeneCardsi
IGHE
HGNCiHGNC:5522 IGHE
MIMi147180 gene
neXtProtiNX_P01854
OpenTargetsiENSG00000211891

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000163076
HOVERGENiHBG096066
InParanoidiP01854
OMAiPKITCLV
OrthoDBi614790at2759
PhylomeDBiP01854
TreeFamiTF334176

Enzyme and pathway databases

ReactomeiR-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling

Miscellaneous databases

EvolutionaryTraceiP01854

Protein Ontology

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PROi
PR:P01854

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000211891 Expressed in 42 organ(s), highest expression level in mucosa of transverse colon
ExpressionAtlasiP01854 baseline and differential
GenevisibleiP01854 HS

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003006 Ig/MHC_CS
IPR003597 Ig_C1-set
PfamiView protein in Pfam
PF07654 C1-set, 4 hits
SMARTiView protein in SMART
SM00407 IGc1, 4 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 4 hits
PS00290 IG_MHC, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIGHE_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01854
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: January 16, 2019
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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