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Protein

T cell receptor beta constant 1

Gene

TRBC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Constant region of T cell receptor (TR) alpha chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).4 Publications

GO - Molecular functioni

  • antigen binding Source: GO_Central
  • immunoglobulin receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-389948 PD-1 signaling
SIGNORiP01850

Names & Taxonomyi

Protein namesi
Recommended name:
T cell receptor beta constant 11 Publication
Gene namesi
Name:TRBC11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000211751.8
HGNCiHGNC:12156 TRBC1
MIMi186930 gene
neXtProtiNX_P01850

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi28639

Chemistry databases

DrugBankiDB02740 3-Indolebutyric Acid

Polymorphism and mutation databases

DMDMi294862488

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000184526‹1 – 176T cell receptor beta constant 1Add BLAST›176

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 95PROSITE-ProRule annotation1 Publication
Glycosylationi69N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP01850
PRIDEiP01850
ProteomicsDBi51492

PTM databases

iPTMnetiP01850
PhosphoSitePlusiP01850

Expressioni

Gene expression databases

BgeeiENSG00000211751 Expressed in 187 organ(s), highest expression level in thymus

Interactioni

Subunit structurei

Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octomeric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiP01850, 3 interactors

Structurei

Secondary structure

1176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP01850
SMRiP01850
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01850

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 117Ig-likePROSITE-ProRule annotationAdd BLAST110

Keywords - Domaini

Immunoglobulin domain, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017899
InParanoidiP01850
OMAiRVTASKW
PhylomeDBiP01850

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

P01850-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
DLNKVFPPEV AVFEPSEAEI SHTQKATLVC LATGFFPDHV ELSWWVNGKE
60 70 80 90 100
VHSGVSTDPQ PLKEQPALND SRYCLSSRLR VSATFWQNPR NHFRCQVQFY
110 120 130 140 150
GLSENDEWTQ DRAKPVTQIV SAEAWGRADC GFTSVSYQQG VLSATILYEI
160 170
LLGKATLYAV LVSALVLMAM VKRKDF
Length:176
Mass (Da):19,769
Last modified:July 18, 2018 - v4
Checksum:iF029F045A6FC73C5
GO

Sequence cautioni

The sequence CAA25134 differs from that shown. Chimeric mRNA corresponding to regions V, J and C of T cell receptor (TR) alpha chain.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Polymorphismi

There are several alleles. The sequence shown is that of IMGT allele TRBC1*01.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00437 mRNA Translation: CAA25134.1 Sequence problems.
M12887 Genomic DNA Translation: AAA60661.1
L36092 Genomic DNA Translation: AAC80213.1
AC245427 Genomic DNA No translation available.
CH471198 Genomic DNA Translation: EAW51914.1
PIRiB25777 RWHUCY
UniGeneiHs.382212

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00437 mRNA Translation: CAA25134.1 Sequence problems.
M12887 Genomic DNA Translation: AAA60661.1
L36092 Genomic DNA Translation: AAC80213.1
AC245427 Genomic DNA No translation available.
CH471198 Genomic DNA Translation: EAW51914.1
PIRiB25777 RWHUCY
UniGeneiHs.382212

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AO7X-ray2.60E1-129[»]
1FYTX-ray2.60E1-133[»]
1J8HX-ray2.40E1-133[»]
1KGCX-ray1.50E1-129[»]
1KTKX-ray3.00E/F4-129[»]
1MI5X-ray2.50E1-129[»]
1OGAX-ray1.40E1-129[»]
1YMMX-ray3.50E1-130[»]
1ZGLX-ray2.80P/R/T/V1-130[»]
2AK4X-ray2.50E/J/P/U1-129[»]
2AXHX-ray2.70A/B1-129[»]
2BNQX-ray1.70E1-129[»]
2BNRX-ray1.90E1-129[»]
2BNUX-ray1.40B1-129[»]
2CDEX-ray3.50B/D/F1-129[»]
2CDFX-ray2.25B1-129[»]
2CDGX-ray2.60B1-129[»]
2ESVX-ray2.60E1-129[»]
2F53X-ray2.10E1-129[»]
2F54X-ray2.70E/L5-129[»]
2GJ6X-ray2.56E1-129[»]
2IALX-ray1.92B/D1-129[»]
2IAMX-ray2.80D1-129[»]
2IANX-ray2.80E/J/O/T1-129[»]
2NTSX-ray2.40P5-127[»]
2NW2X-ray1.40B1-129[»]
2NX5X-ray2.70E/J/P/U1-129[»]
2P5EX-ray1.89E1-129[»]
2P5WX-ray2.20E1-129[»]
2PO6X-ray3.20D/H1-129[»]
2PYEX-ray2.30E1-129[»]
2PYFX-ray2.20B1-129[»]
2VLJX-ray2.40E1-129[»]
2VLKX-ray2.50E1-129[»]
2VLMX-ray1.98E1-129[»]
2VLRX-ray2.30E/J1-129[»]
2XN9X-ray2.30B1-129[»]
2XNAX-ray2.10B1-129[»]
3ARBX-ray2.70D1-129[»]
3ARDX-ray3.01D1-129[»]
3AREX-ray2.80D1-129[»]
3ARFX-ray2.90D1-129[»]
3ARGX-ray3.00D1-129[»]
3D39X-ray2.81E1-129[»]
3D3VX-ray2.80E1-129[»]
3DX9X-ray2.75B/D1-129[»]
3DXAX-ray3.50E/J/O1-129[»]
3FFCX-ray2.80E/J1-129[»]
3HE6X-ray2.90D1-129[»]
3HG1X-ray3.00E1-129[»]
3KPRX-ray2.60E/J1-129[»]
3KPSX-ray2.70E1-129[»]
3O4LX-ray2.54E1-129[»]
3TN0X-ray3.20D1-129[»]
4G8EX-ray2.20B1-129[»]
4G8FX-ray2.10B1-129[»]
4GG6X-ray3.20F/H1-129[»]
4GG8X-ray3.20B/F1-129[»]
4IIQX-ray2.86B1-129[»]
4JFDX-ray2.46E1-129[»]
4JFEX-ray2.70E1-129[»]
4JFFX-ray2.43E1-129[»]
4JFHX-ray2.40E1-129[»]
4JRXX-ray2.30E1-129[»]
4JRYX-ray2.80E1-129[»]
4L4TX-ray2.00E/H1-129[»]
4L4VX-ray1.90E/H1-129[»]
4L9LX-ray3.40B1-129[»]
4LCCX-ray3.26B1-129[»]
4LCWX-ray2.40E/H1-129[»]
4MJIX-ray2.99E/J1-129[»]
4MNQX-ray2.74E1-129[»]
4NQCX-ray2.50E/H1-129[»]
4NQDX-ray2.20E/H1-129[»]
4NQEX-ray2.10E/H1-129[»]
4OZFX-ray2.70H1-129[»]
4OZGX-ray3.00F/H1-129[»]
4OZHX-ray2.80F/H1-129[»]
4OZIX-ray3.20F/H1-129[»]
4P46X-ray2.85B1-127[»]
4PRHX-ray2.50E1-129[»]
4PRIX-ray2.40E1-129[»]
4PRPX-ray2.50E1-129[»]
4X6BX-ray2.10B/D1-129[»]
4X6CX-ray2.80F/H1-129[»]
4X6DX-ray2.98F/H1-129[»]
4ZDHX-ray2.10B1-129[»]
ProteinModelPortaliP01850
SMRiP01850
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01850, 3 interactors

Chemistry databases

DrugBankiDB02740 3-Indolebutyric Acid

PTM databases

iPTMnetiP01850
PhosphoSitePlusiP01850

Polymorphism and mutation databases

DMDMi294862488

Proteomic databases

PeptideAtlasiP01850
PRIDEiP01850
ProteomicsDBi51492

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi28639
EuPathDBiHostDB:ENSG00000211751.8
GeneCardsiTRBC1
HGNCiHGNC:12156 TRBC1
MIMi186930 gene
neXtProtiNX_P01850
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG017899
InParanoidiP01850
OMAiRVTASKW
PhylomeDBiP01850

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-389948 PD-1 signaling
SIGNORiP01850

Miscellaneous databases

ChiTaRSiTRBC1 human
EvolutionaryTraceiP01850
PROiPR:P01850
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000211751 Expressed in 187 organ(s), highest expression level in thymus

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
PfamiView protein in Pfam
PF07654 C1-set, 1 hit
SMARTiView protein in SMART
SM00407 IGc1, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRBC1_HUMAN
AccessioniPrimary (citable) accession number: P01850
Secondary accession number(s): A0A0J9YYE9, A0A5B8, A6NH51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 18, 2018
Last modified: November 7, 2018
This is version 151 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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