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Protein

T cell receptor alpha constant

Gene

TRAC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Constant region of T cell receptor (TR) alpha chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).4 Publications

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202424 Downstream TCR signaling
R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains
R-HSA-202430 Translocation of ZAP-70 to Immunological synapse
R-HSA-202433 Generation of second messenger molecules
R-HSA-389948 PD-1 signaling
SIGNORiP01848

Names & Taxonomyi

Protein namesi
Recommended name:
T cell receptor alpha constant1 Publication
Gene namesi
Name:TRAC1 Publication
Synonyms:TCRA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000277734.5
HGNCiHGNC:12029 TRAC
MIMi186880 gene
neXtProtiNX_P01848

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei116 – 138HelicalSequence analysisAdd BLAST23
Topological domaini139 – 140CytoplasmicSequence analysis2

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency 7 (IMD7)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA primary immunodeficiency disorder manifesting with recurrent respiratory infections, candidiasis, diarrhea, and failure to thrive. Patients show a clear predisposition to herpes viral infections, and features of immune dysregulation, including hypereosinophilia, vitiligo, and alopecia areata. Other features include lymphadenopathy and hepatosplenomegaly. CD3+ T-cells express TCR-gamma/delta, but little or no TCR-alpha/beta.
See also OMIM:615387

Organism-specific databases

DisGeNETi28755
MalaCardsiTRAC
MIMi615387 phenotype
OpenTargetsiENSG00000277734
Orphaneti397959 TCR-alpha-beta-positive T-cell deficiency

Chemistry databases

ChEMBLiCHEMBL3580506
DrugBankiDB02740 3-Indolebutyric Acid

Polymorphism and mutation databases

DMDMi135511

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000184524‹1 – 140T cell receptor alpha constantAdd BLAST›140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 721 Publication
Glycosylationi32N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication1
Glycosylationi59N-linked (GlcNAc...) asparagine; atypical1 Publication1
Glycosylationi66N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1 Publication1
Glycosylationi77N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi113N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PeptideAtlasiP01848
PRIDEiP01848
ProteomicsDBi51491

PTM databases

iPTMnetiP01848

Expressioni

Gene expression databases

BgeeiENSG00000277734

Interactioni

Subunit structurei

Alpha-beta TR is a heterodimer composed of an alpha and beta chain; disulfide-linked. The alpha-beta TR is associated with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TcR or TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octomeric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains, respectively. The association of the CD247 homodimer is the last step of TcR assembly in the endoplasmic reticulum and is required for transport to the cell surface.1 Publication

Protein-protein interaction databases

IntActiP01848, 3 interactors

Structurei

Secondary structure

1140
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi7 – 15Combined sources9
Beta strandi20 – 26Combined sources7
Beta strandi29 – 31Combined sources3
Beta strandi37 – 40Combined sources4
Beta strandi41 – 43Combined sources3
Beta strandi47 – 51Combined sources5
Helixi52 – 54Combined sources3
Beta strandi56 – 66Combined sources11
Beta strandi67 – 69Combined sources3
Helixi72 – 75Combined sources4
Turni76 – 78Combined sources3

3D structure databases

ProteinModelPortaliP01848
SMRiP01848
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01848

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00530000064609
HOVERGENiHBG017898
InParanoidiP01848
PhylomeDBiP01848

Family and domain databases

CDDicd07688 IgC_TCR_alpha, 1 hit
Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR015370 TCR_alpha_C
PfamiView protein in Pfam
PF09291 DUF1968, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit

Sequencei

Sequence statusi: Complete.

P01848-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IQNPDPAVYQ LRDSKSSDKS VCLFTDFDSQ TNVSQSKDSD VYITDKTVLD
60 70 80 90 100
MRSMDFKSNS AVAWSNKSDF ACANAFNNSI IPEDTFFPSP ESSCDVKLVE
110 120 130 140
KSFETDTNLN FQNLSVIGFR ILLLKVAGFN LLMTLRLWSS
Length:140
Mass (Da):15,717
Last modified:July 18, 2018 - v2
Checksum:iCF6B38A0F653035D
GO

Sequence cautioni

The sequence CAA26435 differs from that shown. Chimeric mRNA corresponding to regions V, J and C of T cell receptor (TR) alpha chain.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Polymorphismi

There are several alleles. The sequence shown is that of IMGT allele TRAC*01.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02592 mRNA Translation: CAA26435.1 Sequence problems.
AC243965 Genomic DNA No translation available.
PIRiS18893 RWHUAC
UniGeneiHs.74647

Genome annotation databases

UCSCiuc058zhj.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTRAC_HUMAN
AccessioniPrimary (citable) accession number: P01848
Secondary accession number(s): A0A087WWC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 18, 2018
Last modified: July 18, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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