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UniProtKB - P01834 (IGKC_HUMAN)

Entry version 197 (07 Apr 2021)
Sequence version 2 (15 Mar 2017)
Previous versions | rss
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Protein

Immunoglobulin kappa constant

Gene

IGKC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).3 Publications

Caution

For an example of a full-length immunoglobulin kappa light chain see AC P0DOX7.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P01834

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-166663, Initial triggering of complement
R-HSA-173623, Classical antibody-mediated complement activation
R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733, Cell surface interactions at the vascular wall
R-HSA-2029481, FCGR activation
R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485, Role of phospholipids in phagocytosis
R-HSA-2168880, Scavenging of heme from plasma
R-HSA-2454202, Fc epsilon receptor (FCERI) signaling
R-HSA-2730905, Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796, FCERI mediated MAPK activation
R-HSA-2871809, FCERI mediated Ca+2 mobilization
R-HSA-2871837, FCERI mediated NF-kB activation
R-HSA-5690714, CD22 mediated BCR regulation
R-HSA-9664323, FCGR3A-mediated IL10 synthesis
R-HSA-9664422, FCGR3A-mediated phagocytosis
R-HSA-977606, Regulation of Complement cascade
R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Protein family/group databases

IMGT/GENE-DBIGKC

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Immunoglobulin kappa constant2 Publications
Alternative name(s):
Ig kappa chain C regionCurated
Ig kappa chain C region AG1 Publication
Ig kappa chain C region CUM1 Publication
Ig kappa chain C region EU1 Publication
Ig kappa chain C region OU1 Publication
Ig kappa chain C region ROY1 Publication
Ig kappa chain C region TI1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IGKC2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5716, IGKC

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		147200, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P01834

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000211592.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Immunoglobulin, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunoglobulin kappa light chain deficiency (IGKCD)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disease characterized by the complete absence of immunoglobulin kappa chains.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06640341W → R in IGKCD. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

MalaCards human disease database

More...MalaCardsi		IGKC
MIMi614102, phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		183675, Recurrent infections associated with rare immunoglobulin isotypes deficiency

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P01834, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB07909, (1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL
DB07416, (2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE
DB07716, (4Z)-2,8:7,12:11,15:14,18:17,22-PENTAANHYDRO-4,5,6,9,10,13,19,20,21-NONADEOXY-D-ARABINO-D-ALLO-D-ALLO-DOCOSA-4,9,20-TRIENITOL
DB07441, 3-{[(9-CYANO-9,10-DIHYDRO-10-METHYLACRIDIN-9-YL)CARBONYL]AMINO}PROPANOIC ACID
DB08562, 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID
DB07882, 4-{4-[2-(1A,7A-DIMETHYL-4-OXY-OCTAHYDRO-1-OXA-4-AZA-CYCLOPROPA[A]NAPHTHALEN-4-YL) -ACETYLAMINO]-PHENYLCARBAMOYL}-BUTYRIC ACID
DB07784, [4-(4-ACETYLAMINO-PHENYL)-3,5-DIOXO-4-AZA-TRICYCLO[5.2.2.0 2,6]UNDEC-1-YLCARBAMOYLOXY]-ACETIC ACID
DB07375, Etiocholanedione
DB08413, METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER
DB04688, Methylecgonine
DB08289, N-(PARA-GLUTARAMIDOPHENYL-ETHYL)-PIPERIDINIUM-N-OXIDE
DB07893, PHENYL[1-(N-SUCCINYLAMINO)PENTYL]PHOSPHONATE
DB01851, Tetrabutylammonium Ion
DB08647, TRAZEOLIDE

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IGKC

Domain mapping of disease mutations (DMDM)

More...DMDMi		125145

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000153596‹1 – 107Immunoglobulin kappa constantAdd BLAST›107

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi27 ↔ 87PROSITE-ProRule annotation1 Publication
Disulfide bondi107Interchain (with a heavy chain)1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P01834

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P01834

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P01834

PeptideAtlas

More...PeptideAtlasi		P01834

PRoteomics IDEntifications database

More...PRIDEi		P01834

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		51490

2D gel databases

University College Dublin 2-DE Proteome Database

More...UCD-2DPAGEi		P01834

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		P01834

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P01834

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P01834

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P01834

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000211592, Expressed in lymph node and 114 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

1 Publication

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		P01834, 67 interactors

Molecular INTeraction database

More...MINTi		P01834

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P01834, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1107
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P01834

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P01834

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini6 – 103Ig-likePROSITE-ProRule annotationAdd BLAST98

Keywords - Domaini

Immunoglobulin domain

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P01834

Database for complete collections of gene phylogenies

More...PhylomeDBi		P01834

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003597, Ig_C1-set

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07654, C1-set, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00407, IGc1, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS00290, IG_MHC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P01834-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
RTVAAPSVFI FPPSDEQLKS GTASVVCLLN NFYPREAKVQ WKVDNALQSG 
        60         70         80         90        100
NSQESVTEQD SKDSTYSLSS TLTLSKADYE KHKVYACEVT HQGLSSPVTK 

SFNRGEC
Length:107
Mass (Da):11,765
Last modified:March 15, 2017 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB97BEEBBA4D0B291
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5H1ZRQ3A0A5H1ZRQ3_HUMAN
Immunoglobulin kappa constant
IGKC
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA58989 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti15D → N AA sequence (PubMed:4893682).Curated1
Sequence conflicti15D → N AA sequence (PubMed:5447531).Curated1
Sequence conflicti58E → Q AA sequence (Ref. 3) Curated1
Sequence conflicti58E → Q AA sequence (PubMed:5586923).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

There are several alleles. The sequence shown is that of IMGT allele IGKC*01.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06640341W → R in IGKCD. 1 Publication1
Natural variantiVAR_00389784V → L1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
J00241 Genomic DNA Translation: AAA58989.1 Different initiation.
AC244205 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

More...PIRi		B90562, K3HU

Genome annotation databases

UCSC genome browser

More...UCSCi		uc061lpw.1, human
uc061lpy.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00241 Genomic DNA Translation: AAA58989.1 Different initiation.
AC244205 Genomic DNA No translation available.
PIRiB90562, K3HU

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A4JX-ray2.10A/L2-105[»]
1A4KX-ray2.40A/L2-105[»]
1CLYX-ray2.50L2-107[»]
1D5BX-ray2.80A/L2-104[»]
1D5IX-ray2.00L2-104[»]
1D6VX-ray2.00L2-104[»]
1DFBX-ray2.70L2-107[»]
1GAFX-ray1.95L2-107[»]
1HEZX-ray2.70A/C2-107[»]
1HKLX-ray2.68L2-107[»]
1HZHX-ray2.70L/M2-107[»]
1I7ZX-ray2.30A/C2-107[»]
1MIMX-ray2.60L2-106[»]
1N0XX-ray1.80L/M2-107[»]
1UCBX-ray2.50L2-107[»]
2NY7X-ray2.30L2-107[»]
2O5XX-ray2.05L2-107[»]
2O5YX-ray2.85L2-107[»]
2O5ZX-ray2.40L2-107[»]
2QQKX-ray2.75L2-107[»]
2QQLX-ray3.10L2-107[»]
2QQNX-ray2.20L2-107[»]
2QSCX-ray2.80L2-107[»]
2R56X-ray2.80L/M2-104[»]
2RFXX-ray2.50C94-102[»]
2VXQX-ray1.90L2-107[»]
3B2UX-ray2.58D/G/K/L/O/R/U/X2-105[»]
3B2VX-ray3.30L2-105[»]
3BDYX-ray2.60L2-107[»]
3BE1X-ray2.90L2-107[»]
3BKYX-ray2.61L2-107[»]
3BN9X-ray2.17C/E2-107[»]
3BQUX-ray3.00A2-107[»]
3C08X-ray2.15L2-106[»]
3C09X-ray3.20B/L2-106[»]
3CFJX-ray2.60A/C/E/L2-107[»]
3CFKX-ray2.60A/C/E/G/J/L/M/O2-107[»]
3CSYX-ray3.40B/D/F/H2-104[»]
3D0LX-ray2.35A2-106[»]
3D85X-ray1.90A2-107[»]
3DVGX-ray2.60A2-107[»]
3DVNX-ray2.70A/L2-107[»]
3EYFX-ray2.30A/C2-107[»]
3EYOX-ray2.50A/C2-107[»]
3EYQX-ray2.40C2-107[»]
3IU3X-ray2.90B/D/L2-106[»]
3O11X-ray2.80A/L2-107[»]
3QCTX-ray2.15L3-106[»]
3QCUX-ray1.98L/M3-106[»]
3QCVX-ray2.51L/M3-106[»]
3RU8X-ray2.07L2-107[»]
3U0WX-ray2.00L2-107[»]
3U7WX-ray2.60L2-107[»]
3U7YX-ray2.45L2-107[»]
3VH8X-ray1.80C/F94-102[»]
3WUWX-ray2.00C94-102[»]
3X11X-ray2.15C94-102[»]
3X12X-ray1.80C94-102[»]
4D3CX-ray2.62L2-107[»]
4D9RX-ray2.42D/L3-107[»]
4HIXX-ray2.20L2-107[»]
4NM4X-ray2.65L/M2-107[»]
4NM8X-ray4.00L/M/N2-107[»]
4XMPX-ray1.78L2-107[»]
4XNYX-ray2.30L2-107[»]
4XNZX-ray3.39C/F/L2-107[»]
4XXDX-ray2.41A/D2-107[»]
4YDVX-ray2.70A/L2-107[»]
5B38X-ray2.30C94-102[»]
5B39X-ray2.50C94-102[»]
5ESVX-ray3.10B/D/L2-107[»]
5ESZX-ray4.19B/L2-107[»]
5VEBX-ray2.34B/L1-107[»]
5VIYelectron microscopy6.20G/I1-107[»]
6AU5X-ray2.48A/C1-106[»]
6AXPX-ray2.48A/C1-106[»]
6AYNX-ray2.48A/C1-106[»]
6AZKX-ray2.48A/C1-106[»]
6AZLX-ray2.48A/C1-106[»]
6B9YX-ray2.14A1-107[»]
6B9ZX-ray1.82A1-107[»]
6BAEX-ray2.14A1-107[»]
6BAHX-ray1.90A1-107[»]
6DCVX-ray1.90A/L1-107[»]
6DCWX-ray2.00L1-107[»]
6N2XX-ray3.00K/L2-106[»]
6N32X-ray2.20L/M2-106[»]
6N35X-ray1.75K/L2-106[»]
6OGEelectron microscopy4.36B/D1-107[»]
6OKPelectron microscopy3.28N/P/R1-107[»]
SMRiP01834
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiP01834, 67 interactors
MINTiP01834

Chemistry databases

DrugBankiDB07909, (1S,2S,5S)2-(4-GLUTARIDYLBENZYL)-5-PHENYL-1-CYCLOHEXANOL
DB07416, (2S)-2-(BUTYRYLOXY)-3-HYDROXYPROPYL NONANOATE
DB07716, (4Z)-2,8:7,12:11,15:14,18:17,22-PENTAANHYDRO-4,5,6,9,10,13,19,20,21-NONADEOXY-D-ARABINO-D-ALLO-D-ALLO-DOCOSA-4,9,20-TRIENITOL
DB07441, 3-{[(9-CYANO-9,10-DIHYDRO-10-METHYLACRIDIN-9-YL)CARBONYL]AMINO}PROPANOIC ACID
DB08562, 4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID
DB07882, 4-{4-[2-(1A,7A-DIMETHYL-4-OXY-OCTAHYDRO-1-OXA-4-AZA-CYCLOPROPA[A]NAPHTHALEN-4-YL) -ACETYLAMINO]-PHENYLCARBAMOYL}-BUTYRIC ACID
DB07784, [4-(4-ACETYLAMINO-PHENYL)-3,5-DIOXO-4-AZA-TRICYCLO[5.2.2.0 2,6]UNDEC-1-YLCARBAMOYLOXY]-ACETIC ACID
DB07375, Etiocholanedione
DB08413, METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER
DB04688, Methylecgonine
DB08289, N-(PARA-GLUTARAMIDOPHENYL-ETHYL)-PIPERIDINIUM-N-OXIDE
DB07893, PHENYL[1-(N-SUCCINYLAMINO)PENTYL]PHOSPHONATE
DB01851, Tetrabutylammonium Ion
DB08647, TRAZEOLIDE

Protein family/group databases

IMGT/GENE-DBIGKC

PTM databases

CarbonylDBiP01834
iPTMnetiP01834
PhosphoSitePlusiP01834
SwissPalmiP01834

Genetic variation databases

BioMutaiIGKC
DMDMi125145

2D gel databases

UCD-2DPAGEiP01834

Proteomic databases

EPDiP01834
jPOSTiP01834
MassIVEiP01834
PeptideAtlasiP01834
PRIDEiP01834
ProteomicsDBi51490

Genome annotation databases

UCSCiuc061lpw.1, human
uc061lpy.1, human

Organism-specific databases

GeneCards: human genes, protein and diseases

More...GeneCardsi		IGKC
HGNCiHGNC:5716, IGKC
MalaCardsiIGKC
MIMi147200, gene
614102, phenotype
neXtProtiNX_P01834
Orphaneti183675, Recurrent infections associated with rare immunoglobulin isotypes deficiency
VEuPathDBiHostDB:ENSG00000211592.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

InParanoidiP01834
PhylomeDBiP01834

Enzyme and pathway databases

PathwayCommonsiP01834
ReactomeiR-HSA-166663, Initial triggering of complement
R-HSA-173623, Classical antibody-mediated complement activation
R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733, Cell surface interactions at the vascular wall
R-HSA-2029481, FCGR activation
R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485, Role of phospholipids in phagocytosis
R-HSA-2168880, Scavenging of heme from plasma
R-HSA-2454202, Fc epsilon receptor (FCERI) signaling
R-HSA-2730905, Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796, FCERI mediated MAPK activation
R-HSA-2871809, FCERI mediated Ca+2 mobilization
R-HSA-2871837, FCERI mediated NF-kB activation
R-HSA-5690714, CD22 mediated BCR regulation
R-HSA-9664323, FCGR3A-mediated IL10 synthesis
R-HSA-9664422, FCGR3A-mediated phagocytosis
R-HSA-977606, Regulation of Complement cascade
R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IGKC, human
EvolutionaryTraceiP01834
PharosiP01834, Tbio

Protein Ontology

More...PROi		PR:P01834
RNActiP01834, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000211592, Expressed in lymph node and 114 other tissues

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003006, Ig/MHC_CS
IPR003597, Ig_C1-set
PfamiView protein in Pfam
PF07654, C1-set, 1 hit
SMARTiView protein in SMART
SM00407, IGc1, 1 hit
SUPFAMiSSF48726, SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS00290, IG_MHC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIGKC_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01834
Secondary accession number(s): A0A075B6H6, A0A087X130
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: March 15, 2017
Last modified: April 7, 2021
This is version 197 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
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