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Entry version 190 (13 Feb 2019)
Sequence version 4 (26 Jun 2007)
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Protein

Polymeric immunoglobulin receptor

Gene

PIGR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • polymeric immunoglobulin receptor activity Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Polymeric immunoglobulin receptor
Short name:
PIgR
Short name:
Poly-Ig receptor
Alternative name(s):
Hepatocellular carcinoma-associated protein TB6
Cleaved into the following chain:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIGR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000162896.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8968 PIGR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
173880 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01833

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 638ExtracellularSequence analysisAdd BLAST620
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei639 – 661HelicalSequence analysisAdd BLAST23
Topological domaini662 – 764CytoplasmicSequence analysisAdd BLAST103

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5284

Open Targets

More...
OpenTargetsi
ENSG00000162896

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33300

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PIGR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
150421625

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 182 PublicationsAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001490019 – 764Polymeric immunoglobulin receptorAdd BLAST746
ChainiPRO_000001490119 – 603Secretory componentAdd BLAST585

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi40 ↔ 110PROSITE-ProRule annotation1 Publication
Disulfide bondi56 ↔ 64PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi83N-linked (GlcNAc...) asparagine4 Publications1
Glycosylationi90N-linked (GlcNAc...) asparagine5 Publications1
Glycosylationi135N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi152 ↔ 220PROSITE-ProRule annotation1 Publication
Glycosylationi186N-linked (GlcNAc...) asparagine3 Publications1
Disulfide bondi257 ↔ 325PROSITE-ProRule annotation1 Publication
Disulfide bondi271 ↔ 279PROSITE-ProRule annotation1 Publication
Disulfide bondi371 ↔ 441PROSITE-ProRule annotation1 Publication
Disulfide bondi385 ↔ 395PROSITE-ProRule annotation1 Publication
Glycosylationi421N-linked (GlcNAc...) asparagine6 Publications1
Glycosylationi469N-linked (GlcNAc...) (complex) asparagine7 Publications1
Disulfide bondi482 ↔ 544PROSITE-ProRule annotation1 Publication
Disulfide bondi486 ↔ 520PROSITE-ProRule annotation1 Publication
Disulfide bondi496 ↔ 503PROSITE-ProRule annotation1 Publication
Glycosylationi499N-linked (GlcNAc...) asparagine3 Publications1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei673PhosphoserineBy similarity1
Modified residuei682PhosphoserineBy similarity1
Modified residuei689PhosphoserineBy similarity1
Modified residuei735PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylation is not necessary for Ig binding.7 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P01833

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01833

PeptideAtlas

More...
PeptideAtlasi
P01833

PRoteomics IDEntifications database

More...
PRIDEi
P01833

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51489

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
550

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01833

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01833

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P01833

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000162896 Expressed in 148 organ(s), highest expression level in parotid gland

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01833 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009454
HPA006154
HPA012012

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111302, 34 interactors

Protein interaction database and analysis system

More...
IntActi
P01833, 7 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000348888

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1764
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XEDX-ray1.90A/B/C/D/E/F19-127[»]
2OCWX-ray-A19-603[»]
3CHNOther1.00J353-458[»]
S19-603[»]
3CM9Other1.00J353-458[»]
S19-603[»]
5D4KX-ray2.60A/B19-565[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P01833

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P01833

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01833

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini19 – 120Ig-like V-type 1Add BLAST102
Domaini145 – 237Ig-like V-type 2Add BLAST93
Domaini250 – 352Ig-like V-type 3Add BLAST103
Domaini364 – 458Ig-like V-type 4Add BLAST95
Domaini462 – 561Ig-like V-type 5Add BLAST100

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IHXB Eukaryota
ENOG41128ZA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161667

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115545

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG008199

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01833

KEGG Orthology (KO)

More...
KOi
K13073

Identification of Orthologs from Complete Genome Data

More...
OMAi
YWCGVKQ

Database of Orthologous Groups

More...
OrthoDBi
1319689at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01833

TreeFam database of animal gene trees

More...
TreeFami
TF334441

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07686 V-set, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 5 hits
SM00406 IGv, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P01833-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLFVLTCLL AVFPAISTKS PIFGPEEVNS VEGNSVSITC YYPPTSVNRH
60 70 80 90 100
TRKYWCRQGA RGGCITLISS EGYVSSKYAG RANLTNFPEN GTFVVNIAQL
110 120 130 140 150
SQDDSGRYKC GLGINSRGLS FDVSLEVSQG PGLLNDTKVY TVDLGRTVTI
160 170 180 190 200
NCPFKTENAQ KRKSLYKQIG LYPVLVIDSS GYVNPNYTGR IRLDIQGTGQ
210 220 230 240 250
LLFSVVINQL RLSDAGQYLC QAGDDSNSNK KNADLQVLKP EPELVYEDLR
260 270 280 290 300
GSVTFHCALG PEVANVAKFL CRQSSGENCD VVVNTLGKRA PAFEGRILLN
310 320 330 340 350
PQDKDGSFSV VITGLRKEDA GRYLCGAHSD GQLQEGSPIQ AWQLFVNEES
360 370 380 390 400
TIPRSPTVVK GVAGGSVAVL CPYNRKESKS IKYWCLWEGA QNGRCPLLVD
410 420 430 440 450
SEGWVKAQYE GRLSLLEEPG NGTFTVILNQ LTSRDAGFYW CLTNGDTLWR
460 470 480 490 500
TTVEIKIIEG EPNLKVPGNV TAVLGETLKV PCHFPCKFSS YEKYWCKWNN
510 520 530 540 550
TGCQALPSQD EGPSKAFVNC DENSRLVSLT LNLVTRADEG WYWCGVKQGH
560 570 580 590 600
FYGETAAVYV AVEERKAAGS RDVSLAKADA APDEKVLDSG FREIENKAIQ
610 620 630 640 650
DPRLFAEEKA VADTRDQADG SRASVDSGSS EEQGGSSRAL VSTLVPLGLV
660 670 680 690 700
LAVGAVAVGV ARARHRKNVD RVSIRSYRTD ISMSDFENSR EFGANDNMGA
710 720 730 740 750
SSITQETSLG GKEEFVATTE STTETKEPKK AKRSSKEEAE MAYKDFLLQS
760
STVAAEAQDG PQEA
Length:764
Mass (Da):83,284
Last modified:June 26, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i927461F4EB3B05C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti136D → Q AA sequence (PubMed:6526384).Curated1
Sequence conflicti136D → Q AA sequence (PubMed:1859628).Curated1
Sequence conflicti158N → D AA sequence (PubMed:6526384).Curated1
Sequence conflicti158N → D AA sequence (PubMed:1859628).Curated1
Sequence conflicti208 – 209NQ → DE AA sequence (PubMed:6526384).Curated2
Sequence conflicti208 – 209NQ → DE AA sequence (PubMed:1859628).Curated2
Sequence conflicti229Missing AA sequence (PubMed:6526384).Curated1
Sequence conflicti229Missing AA sequence (PubMed:1859628).Curated1
Sequence conflicti234D → N AA sequence (PubMed:6526384).Curated1
Sequence conflicti234D → N AA sequence (PubMed:1859628).Curated1
Sequence conflicti241E → Q AA sequence (PubMed:6526384).Curated1
Sequence conflicti241E → Q AA sequence (PubMed:1859628).Curated1
Sequence conflicti262E → Q AA sequence (PubMed:6526384).Curated1
Sequence conflicti262E → Q AA sequence (PubMed:1859628).Curated1
Sequence conflicti280D → N AA sequence (PubMed:6526384).Curated1
Sequence conflicti280D → N AA sequence (PubMed:1859628).Curated1
Sequence conflicti392N → D AA sequence (PubMed:6526384).Curated1
Sequence conflicti392N → D AA sequence (PubMed:1859628).Curated1
Sequence conflicti500N → D AA sequence (PubMed:6526384).Curated1
Sequence conflicti500N → D AA sequence (PubMed:1859628).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025283365G → S6 PublicationsCorresponds to variant dbSNP:rs2275531Ensembl.1
Natural variantiVAR_032822555T → I. Corresponds to variant dbSNP:rs7542760Ensembl.1
Natural variantiVAR_003920580A → V. Corresponds to variant dbSNP:rs291102EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S62403 mRNA Translation: AAB20203.1
S43449
, S43437, S43441, S43442, S43443, S43444, S43445, S43446, S43447, S43448 Genomic DNA Translation: AAB23176.1
AF272149 mRNA Translation: AAN65630.1
CR749533 mRNA Translation: CAH18339.1
M24559 mRNA Translation: AAA36102.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1474.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A46537 QRHUGS

NCBI Reference Sequences

More...
RefSeqi
NP_002635.2, NM_002644.3
XP_011507931.1, XM_011509629.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.497589

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000356495; ENSP00000348888; ENSG00000162896

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5284

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5284

UCSC genome browser

More...
UCSCi
uc001hez.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62403 mRNA Translation: AAB20203.1
S43449
, S43437, S43441, S43442, S43443, S43444, S43445, S43446, S43447, S43448 Genomic DNA Translation: AAB23176.1
AF272149 mRNA Translation: AAN65630.1
CR749533 mRNA Translation: CAH18339.1
M24559 mRNA Translation: AAA36102.1
CCDSiCCDS1474.1
PIRiA46537 QRHUGS
RefSeqiNP_002635.2, NM_002644.3
XP_011507931.1, XM_011509629.1
UniGeneiHs.497589

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XEDX-ray1.90A/B/C/D/E/F19-127[»]
2OCWX-ray-A19-603[»]
3CHNOther1.00J353-458[»]
S19-603[»]
3CM9Other1.00J353-458[»]
S19-603[»]
5D4KX-ray2.60A/B19-565[»]
ProteinModelPortaliP01833
SMRiP01833
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111302, 34 interactors
IntActiP01833, 7 interactors
STRINGi9606.ENSP00000348888

PTM databases

GlyConnecti550
iPTMnetiP01833
PhosphoSitePlusiP01833
UniCarbKBiP01833

Polymorphism and mutation databases

BioMutaiPIGR
DMDMi150421625

Proteomic databases

jPOSTiP01833
PaxDbiP01833
PeptideAtlasiP01833
PRIDEiP01833
ProteomicsDBi51489

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356495; ENSP00000348888; ENSG00000162896
GeneIDi5284
KEGGihsa:5284
UCSCiuc001hez.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5284
DisGeNETi5284
EuPathDBiHostDB:ENSG00000162896.5

GeneCards: human genes, protein and diseases

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GeneCardsi
PIGR

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0028583
HGNCiHGNC:8968 PIGR
HPAiCAB009454
HPA006154
HPA012012
MIMi173880 gene
neXtProtiNX_P01833
OpenTargetsiENSG00000162896
PharmGKBiPA33300

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IHXB Eukaryota
ENOG41128ZA LUCA
GeneTreeiENSGT00940000161667
HOGENOMiHOG000115545
HOVERGENiHBG008199
InParanoidiP01833
KOiK13073
OMAiYWCGVKQ
OrthoDBi1319689at2759
PhylomeDBiP01833
TreeFamiTF334441

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PIGR human
EvolutionaryTraceiP01833

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Polymeric_immunoglobulin_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5284

Protein Ontology

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PROi
PR:P01833

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000162896 Expressed in 148 organ(s), highest expression level in parotid gland
GenevisibleiP01833 HS

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 5 hits
SMARTiView protein in SMART
SM00409 IG, 5 hits
SM00406 IGv, 4 hits
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPIGR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01833
Secondary accession number(s): Q68D81, Q8IZY7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 26, 2007
Last modified: February 13, 2019
This is version 190 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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