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Protein

Thy-1 membrane glycoprotein

Gene

Thy1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

GO - Molecular functioni

  • enzyme binding Source: MGI
  • GPI anchor binding Source: UniProtKB
  • GTPase activator activity Source: UniProtKB
  • integrin binding Source: UniProtKB
  • protein kinase binding Source: MGI

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Thy-1 membrane glycoprotein
Alternative name(s):
Thy-1 antigen
CD_antigen: CD90
Gene namesi
Name:Thy1
Synonyms:Thy-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:98747 Thy1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001497720 – 131Thy-1 membrane glycoproteinAdd BLAST112
PropeptideiPRO_0000014978132 – 162Removed in mature formAdd BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi28 ↔ 131AlternatePROSITE-ProRule annotation1 Publication
Disulfide bondi38 ↔ 105PROSITE-ProRule annotation1 Publication
Glycosylationi42N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi94N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi118N-linked (GlcNAc...) asparagine1 Publication1
Lipidationi131GPI-anchor amidated cysteine; alternate1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP01831
MaxQBiP01831
PaxDbiP01831
PeptideAtlasiP01831
PRIDEiP01831

PTM databases

iPTMnetiP01831
PhosphoSitePlusiP01831
SwissPalmiP01831

Expressioni

Gene expression databases

BgeeiENSMUSG00000032011 Expressed in 240 organ(s), highest expression level in thymus
CleanExiMM_THY1
ExpressionAtlasiP01831 baseline and differential
GenevisibleiP01831 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204188, 3 interactors
IntActiP01831, 9 interactors
MINTiP01831
STRINGi10090.ENSMUSP00000110489

Structurei

3D structure databases

ProteinModelPortaliP01831
SMRiP01831
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 127Ig-like V-typeAdd BLAST108

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IVXA Eukaryota
ENOG410YYC2 LUCA
GeneTreeiENSGT00390000012352
HOGENOMiHOG000048719
HOVERGENiHBG002958
InParanoidiP01831
KOiK06514
OMAiTCELRLS
OrthoDBiEOG091G0RWU
PhylomeDBiP01831
TreeFamiTF336059

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
IPR013151 Immunoglobulin
IPR033292 THY1
PANTHERiPTHR19226 PTHR19226, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
SMARTiView protein in SMART
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

P01831-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPAISVALL LSVLQVSRGQ KVTSLTACLV NQNLRLDCRH ENNTKDNSIQ
60 70 80 90 100
HEFSLTREKR KHVLSGTLGI PEHTYRSRVT LSNQPYIKVL TLANFTTKDE
110 120 130 140 150
GDYFCELQVS GANPMSSNKS ISVYRDKLVK CGGISLLVQN TSWMLLLLLS
160
LSLLQALDFI SL
Length:162
Mass (Da):18,080
Last modified:July 21, 1986 - v1
Checksum:i397BF7D3A9F2C77B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SUX8A0A1L1SUX8_MOUSE
Thy-1 membrane glycoprotein
Thy1
125Annotation score:
A0A1L1ST40A0A1L1ST40_MOUSE
Thy-1 membrane glycoprotein
Thy1
37Annotation score:
A0A1L1SRS7A0A1L1SRS7_MOUSE
Thy-1 membrane glycoprotein
Thy1
40Annotation score:

Polymorphismi

There are two major alleles; Thy-1.1 (CD90.1) and Thy-1.2 (CD90.2).4 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti108Q → R in allele Thy-1.1. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03151 Genomic DNA Translation: CAA26930.1
X02771 Genomic DNA Translation: CAA26548.1
X02772 Genomic DNA Translation: CAA26549.1 Sequence problems.
X02773 Genomic DNA Translation: CAA26550.1 Sequence problems.
M10246 Genomic DNA Translation: AAA40440.1
M11160 Genomic DNA Translation: AAA40441.1
M12379 Genomic DNA Translation: AAA40443.1
BC054436 mRNA Translation: AAH54436.1
CCDSiCCDS23093.1
PIRiA94278 TDMS
RefSeqiNP_033408.1, NM_009382.3
UniGeneiMm.3951

Genome annotation databases

EnsembliENSMUST00000114840; ENSMUSP00000110489; ENSMUSG00000032011
GeneIDi21838
KEGGimmu:21838
UCSCiuc009pbl.1 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTHY1_MOUSE
AccessioniPrimary (citable) accession number: P01831
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 12, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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