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Protein

Thy-1 membrane glycoprotein

Gene

Thy1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.

GO - Molecular functioni

  • enzyme binding Source: RGD
  • GPI anchor binding Source: UniProtKB
  • GTPase activator activity Source: UniProtKB
  • integrin binding Source: UniProtKB
  • protein kinase binding Source: RGD

GO - Biological processi

  • angiogenesis Source: UniProtKB
  • cell-cell adhesion Source: UniProtKB
  • cell-cell signaling Source: UniProtKB
  • cytoskeleton organization Source: UniProtKB
  • focal adhesion assembly Source: UniProtKB
  • integrin-mediated signaling pathway Source: UniProtKB
  • mast cell activation Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of axonogenesis Source: UniProtKB
  • negative regulation of cell migration Source: UniProtKB
  • negative regulation of fibroblast proliferation Source: UniProtKB
  • negative regulation of neuron projection regeneration Source: UniProtKB
  • negative regulation of protein kinase activity Source: UniProtKB
  • negative regulation of protein tyrosine kinase activity Source: UniProtKB
  • negative regulation of T cell receptor signaling pathway Source: UniProtKB
  • positive regulation of cellular extravasation Source: Ensembl
  • positive regulation of focal adhesion assembly Source: UniProtKB
  • positive regulation of GTPase activity Source: UniProtKB
  • positive regulation of heterotypic cell-cell adhesion Source: Ensembl
  • positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  • positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
  • positive regulation of T cell activation Source: UniProtKB
  • protein autophosphorylation Source: CACAO
  • receptor clustering Source: UniProtKB
  • regulation of Rho-dependent protein serine/threonine kinase activity Source: UniProtKB
  • retinal cone cell development Source: UniProtKB
  • T cell receptor signaling pathway Source: UniProtKB

Keywordsi

LigandSialic acid

Enzyme and pathway databases

ReactomeiR-RNO-163125 Post-translational modification: synthesis of GPI-anchored proteins

Names & Taxonomyi

Protein namesi
Recommended name:
Thy-1 membrane glycoprotein
Alternative name(s):
Thy-1 antigen
CD_antigen: CD90
Gene namesi
Name:Thy1
Synonyms:Thy-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi3860 Thy1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 191 PublicationAdd BLAST19
ChainiPRO_000001497920 – 130Thy-1 membrane glycoproteinAdd BLAST111
PropeptideiPRO_0000014980131 – 161Removed in mature formAdd BLAST31

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei20Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi28 ↔ 130AlternatePROSITE-ProRule annotation1 Publication
Disulfide bondi38 ↔ 104PROSITE-ProRule annotation1 Publication
Glycosylationi42N-linked (GlcNAc...) (complex) asparagine; alternate1 Publication1
Glycosylationi42N-linked (GlcNAc...) (high mannose) asparagine; alternate1 Publication1
Glycosylationi42N-linked (GlcNAc...) asparagine; alternateCombined sources1
Glycosylationi42N-linked (HexNAc...) asparagine; alternate1
Modified residuei82PhosphoserineCombined sources1
Glycosylationi93N-linked (GlcNAc...) (complex) asparagine; alternate1 Publication1
Glycosylationi93N-linked (GlcNAc...) asparagine; alternateCombined sources1
Glycosylationi93N-linked (HexNAc...) asparagine; alternate1
Glycosylationi117N-linked (GlcNAc...) (high mannose) asparagine; in brain; alternate1 Publication1
Glycosylationi117N-linked (GlcNAc...) (hybrid) asparagine; in brain; alternate1 Publication1
Lipidationi130GPI-anchor amidated cysteine; alternate1

Post-translational modificationi

Glycosylation is tissue specific. Sialylation of N-glycans at Asn-93 in brain and at Asn-42, Asn-93 and Asn-117 in thymus.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP01830
PRIDEiP01830

PTM databases

iPTMnetiP01830
PhosphoSitePlusiP01830
SwissPalmiP01830
UniCarbKBiP01830

Expressioni

Tissue specificityi

Abundant in lymphoid tissues.

Gene expression databases

BgeeiENSRNOG00000006604
GenevisibleiP01830 RN

Interactioni

GO - Molecular functioni

  • enzyme binding Source: RGD
  • integrin binding Source: UniProtKB
  • protein kinase binding Source: RGD

Protein-protein interaction databases

BioGridi246951, 2 interactors
DIPiDIP-1031N
IntActiP01830, 2 interactors
STRINGi10116.ENSRNOP00000008685

Structurei

3D structure databases

ProteinModelPortaliP01830
SMRiP01830
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 126Ig-like V-typeAdd BLAST107

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiENOG410IVXA Eukaryota
ENOG410YYC2 LUCA
GeneTreeiENSGT00390000012352
HOGENOMiHOG000048719
HOVERGENiHBG002958
InParanoidiP01830
KOiK06514
OMAiTCELRLS
OrthoDBiEOG091G0RWU
PhylomeDBiP01830
TreeFamiTF336059

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
IPR013151 Immunoglobulin
IPR033292 THY1
PANTHERiPTHR19226 PTHR19226, 1 hit
PfamiView protein in Pfam
PF00047 ig, 1 hit
SMARTiView protein in SMART
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01830-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPVISITLL LSVLQMSRGQ RVISLTACLV NQNLRLDCRH ENNTNLPIQH
60 70 80 90 100
EFSLTREKKK HVLSGTLGVP EHTYRSRVNL FSDRFIKVLT LANFTTKDEG
110 120 130 140 150
DYMCELRVSG QNPTSSNKTI NVIRDKLVKC GGISLLVQNT SWLLLLLLSL
160
SFLQATDFIS L
Length:161
Mass (Da):18,172
Last modified:August 13, 1987 - v1
Checksum:i3285748F3C2C5AB2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71E → Q in CAA26931 (PubMed:2864289).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03152 Genomic DNA Translation: CAA26931.1
X03150 mRNA Translation: CAA26929.1
X02002 Genomic DNA Translation: CAA26033.1
M18002 mRNA Translation: AAA42243.1
M10666 mRNA Translation: AAA42242.1
PIRiB45909 TDRT
RefSeqiNP_036805.1, NM_012673.2
UniGeneiRn.108198

Genome annotation databases

EnsembliENSRNOT00000008685; ENSRNOP00000008685; ENSRNOG00000006604
GeneIDi24832
KEGGirno:24832
UCSCiRGD:3860 rat

Similar proteinsi

Entry informationi

Entry nameiTHY1_RAT
AccessioniPrimary (citable) accession number: P01830
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: June 20, 2018
This is version 158 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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