IGHV2-5

Functionⁱ

V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).4 Publications

Caution

For examples of full-length immunoglobulin heavy chains (of different isotypes) see AC P0DOX2, AC P0DOX3, AC P0DOX4, AC P0DOX5 and AC P0DOX6.Curated

GO - Molecular functionⁱ

antigen binding
Source: UniProtKB
Non-traceable author statementⁱ
- 5264153
- 6780622
serine-type endopeptidase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

complement activation Source: Reactome
complement activation, classical pathway Source: Reactome
Fc-epsilon receptor signaling pathway Source: Reactome
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
immune response
Source: UniProtKB
Non-traceable author statementⁱ
- 5264153
- 6780622
leukocyte migration Source: Reactome
receptor-mediated endocytosis Source: Reactome
regulation of complement activation Source: Reactome
regulation of immune response Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Adaptive immunity, Immunity

Biological process

Adaptive immunity, Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166663 Initial triggering of complement R-HSA-173623 Classical antibody-mediated complement activation R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-2029481 FCGR activation R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485 Role of phospholipids in phagocytosis R-HSA-2168880 Scavenging of heme from plasma R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796 FCERI mediated MAPK activation R-HSA-2871809 FCERI mediated Ca+2 mobilization R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-5690714 CD22 mediated BCR regulation R-HSA-977606 Regulation of Complement cascade R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Reactomeⁱ

R-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-977606 Regulation of Complement cascade
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Protein family/group databases

IMGT/GENE-DB	IGHV2-5

IMGT/GENE-DB

IGHV2-5

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Immunoglobulin heavy variable 2-52 Publications Alternative name(s): Ig heavy chain V-II region HE1 Publication Ig heavy chain V-II region MCE1 Publication
Gene namesⁱ	Name:IGHV2-52 Publications
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000211937.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5576 IGHV2-5
neXtProtⁱ	NX_P01817

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000211937

OpenTargetsⁱ

ENSG00000211937

Polymorphism and mutation databases

DMDMⁱ	123825 123826

DMDMⁱ

123825
123826

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	2 PublicationsAdd BLAST		19
ChainⁱPRO_0000059910	20 – 119	Immunoglobulin heavy variable 2-52 PublicationsAdd BLAST		100

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	20	Pyrrolidone carboxylic acid2 Publications		1
Disulfide bondⁱ	41 ↔ 116	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	P01817
PRIDEⁱ	P01817
ProteomicsDBⁱ	51485 51486

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000211937

Bgeeⁱ

ENSG00000211937

Interactionⁱ

Subunit structureⁱ

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P01817
SMRⁱ	P01817
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	20 – ›119	Ig-likePROSITE-ProRule annotationAdd BLAST		›100

Keywords - Domainⁱ

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144057
HOVERGENⁱ	HBG018013
OMAⁱ	CARRPQR

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013106 Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P01817-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDTLCSTLLL LTIPSWVLSQ ITLKESGPTL VKPTQTLTLT CTFSGFSLST 
        60         70         80         90        100
SGVGVGWIRQ PPGKALEWLA LIYWDDDKRY SPSLKSRLTI TKDTSKNQVV 
       110 
LTMTNMDPVD TATYYCAHR

Length:119

Mass (Da):13,231

Last modified:September 7, 2016 - v2

Checksum:ⁱ7403E23CE450BA92

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	21 – 26	ITLKES → VTLKEN AA sequence (PubMed:5264153).Curated	6
Sequence conflictⁱ	35	Q → E AA sequence (PubMed:6780622).Curated	1
Sequence conflictⁱ	35	Q → E AA sequence (PubMed:5264153).Curated	1
Sequence conflictⁱ	43 – 54	FSGFS…TSGVG → LSGLSLTTDGVA AA sequence (PubMed:5264153).CuratedAdd BLAST	12
Sequence conflictⁱ	61 – 64	PPGK → GPGR AA sequence (PubMed:5264153).Curated	4
Sequence conflictⁱ	61	P → R AA sequence (PubMed:6780622).Curated	1
Sequence conflictⁱ	71 – 78	LIYWDDDK → FINWDDDN AA sequence (PubMed:6780622).Curated	8
Sequence conflictⁱ	71 – 72	LI → WLL AA sequence (PubMed:5264153).Curated	2
Sequence conflictⁱ	80	Y → F AA sequence (PubMed:5264153).Curated	1
Sequence conflictⁱ	85	K → R AA sequence (PubMed:6780622).Curated	1
Sequence conflictⁱ	90 – 92	ITK → VTR AA sequence (PubMed:5264153).Curated	3
Sequence conflictⁱ	90	I → G AA sequence (PubMed:6780622).Curated	1
Sequence conflictⁱ	96	K → R AA sequence (PubMed:6780622).Curated	1
Sequence conflictⁱ	103	M → I AA sequence (PubMed:6780622).Curated	1
Sequence conflictⁱ	117	A → V AA sequence (PubMed:5264153).Curated	1
Non-terminal residueⁱ	119		1

Polymorphismⁱ

There are several alleles. The sequence shown is that of IMGT allele IGHV2-5*02.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC244226 Genomic DNA No translation available.
PIRⁱ	A02092 MHHUMC A02093 G1HUHE

Genome annotation databases

Ensemblⁱ	ENST00000390597; ENSP00000375006; ENSG00000211937 ENST00000560724; ENSP00000473889; ENSG00000277318
UCSC genome browser More...UCSCⁱ	uc059gfq.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P01817	IGHV2-5 isoform 1 (Fragment)		PONAB		119
IGHV2-5 isoform 1 (Fragment)		PANTR		119

Protein	Similar proteins		Species	Score	Length
P01817	IGHV2-5 isoform 1 (Fragment)		PONAB		119
IGHV2-5 isoform 1 (Fragment)		PANTR		119
Immunoglobulin heavy variable 2-5		SAIBB		115
IGHV2-26 protein (Fragment)		HUMAN		98
Immunoglobulin heavy variable V8-4		MOUSE		98
+10

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC244226 Genomic DNA No translation available.
PIRⁱ	A02092 MHHUMC A02093 G1HUHE

3D structure databases

ProteinModelPortalⁱ	P01817
SMRⁱ	P01817
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein family/group databases

IMGT/GENE-DB	IGHV2-5

IMGT/GENE-DB

IGHV2-5

Polymorphism and mutation databases

DMDMⁱ	123825 123826

DMDMⁱ

123825
123826

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	P01817
PRIDEⁱ	P01817
ProteomicsDBⁱ	51485 51486

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000390597; ENSP00000375006; ENSG00000211937 ENST00000560724; ENSP00000473889; ENSG00000277318
UCSC genome browser More...UCSCⁱ	uc059gfq.1 human

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000211937.3
GeneCardsⁱ	IGHV2-5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5576 IGHV2-5
neXtProtⁱ	NX_P01817
Open Targets More...OpenTargetsⁱ	ENSG00000211937
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144057
HOVERGENⁱ	HBG018013
OMAⁱ	CARRPQR

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166663 Initial triggering of complement R-HSA-173623 Classical antibody-mediated complement activation R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-2029481 FCGR activation R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485 Role of phospholipids in phagocytosis R-HSA-2168880 Scavenging of heme from plasma R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796 FCERI mediated MAPK activation R-HSA-2871809 FCERI mediated Ca+2 mobilization R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-5690714 CD22 mediated BCR regulation R-HSA-977606 Regulation of Complement cascade R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Reactomeⁱ

R-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-977606 Regulation of Complement cascade
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P01817

PROⁱ

PR:P01817

Gene expression databases

Bgeeⁱ	ENSG00000211937

Bgeeⁱ

ENSG00000211937

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013106 Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HV205_HUMAN
Accessionⁱ	P01817Primary (citable) accession number: P01817 Secondary accession number(s): A0A0A0MS10, P01818
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	September 7, 2016
	Last modified:	June 20, 2018
	This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P01817 (HV205_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Immunoglobulin heavy variable 2-5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Plasma membrane

Extracellular region or secreted

Plasma Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein family/group databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ