IGHV3-23

Functionⁱ

V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).4 Publications

Caution

For examples of full-length immunoglobulin heavy chains (of different isotypes) see AC P0DOX2, AC P0DOX3, AC P0DOX4, AC P0DOX5 and AC P0DOX6.Curated

GO - Molecular functionⁱ

antigen binding Source: GO_Central
immunoglobulin receptor binding Source: GO_Central
serine-type endopeptidase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

B cell receptor signaling pathway Source: GO_Central
complement activation Source: Reactome
complement activation, classical pathway Source: GO_Central
defense response to bacterium Source: GO_Central
Fc-epsilon receptor signaling pathway Source: Reactome
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
immune response
Source: UniProtKB
Non-traceable author statementⁱ
innate immune response Source: GO_Central
leukocyte migration Source: Reactome
phagocytosis, engulfment Source: GO_Central
phagocytosis, recognition Source: GO_Central
positive regulation of B cell activation Source: GO_Central
receptor-mediated endocytosis Source: Reactome
regulation of complement activation Source: Reactome
regulation of immune response Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Adaptive immunity, Immunity

Biological process

Adaptive immunity, Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166663 Initial triggering of complement R-HSA-173623 Classical antibody-mediated complement activation R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-2029481 FCGR activation R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485 Role of phospholipids in phagocytosis R-HSA-2168880 Scavenging of heme from plasma R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796 FCERI mediated MAPK activation R-HSA-2871809 FCERI mediated Ca+2 mobilization R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-5690714 CD22 mediated BCR regulation R-HSA-977606 Regulation of Complement cascade R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Reactomeⁱ

R-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-977606 Regulation of Complement cascade
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Protein family/group databases

IMGT/GENE-DB	IGHV3-23

IMGT/GENE-DB

IGHV3-23

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Immunoglobulin heavy variable 3-232 Publications Alternative name(s): Ig heavy chain V-III region LAY1 Publication Ig heavy chain V-III region POM1 Publication Ig heavy chain V-III region TEI1 Publication Ig heavy chain V-III region TIL1 Publication Ig heavy chain V-III region TUR1 Publication Ig heavy chain V-III region VH261 Publication Ig heavy chain V-III region WAS1 Publication Ig heavy chain V-III region ZAP1 Publication
Gene namesⁱ	Name:IGHV3-232 Publications
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000211949.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5588 IGHV3-23
neXtProtⁱ	NX_P01764

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	28442
Open Targets More...OpenTargetsⁱ	ENSG00000211949

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB04147 Lauryl Dimethylamine-N-Oxide

DrugBankⁱ

DB04147 Lauryl Dimethylamine-N-Oxide

Polymorphism and mutation databases

DMDMⁱ	123843 123844 123854 123855 123856 123857 123858

DMDMⁱ

123843
123844
123854
123855
123856
123857
123858

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	3 PublicationsAdd BLAST		19
ChainⁱPRO_0000015249	20 – 117	Immunoglobulin heavy variable 3-233 PublicationsAdd BLAST		98

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	41 ↔ 115	PROSITE-ProRule annotationCombined sources2 Publications

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	P01764
PRIDEⁱ	P01764
ProteomicsDBⁱ	51463 51464 51473 51474 51475 51476 51477 51478

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000211949

Bgeeⁱ

ENSG00000211949

Interactionⁱ

Subunit structureⁱ

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

GO - Molecular functionⁱ

immunoglobulin receptor binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	P01764, 1 interactor

IntActⁱ

P01764, 1 interactor

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	22 – 26	Combined sources	5
Beta strandⁱ	29 – 31	Combined sources	3
Beta strandⁱ	37 – 46	Combined sources	10
Helixⁱ	48 – 50	Combined sources	3
Beta strandⁱ	53 – 58	Combined sources	6
Turnⁱ	60 – 62	Combined sources	3
Beta strandⁱ	65 – 70	Combined sources	6
Beta strandⁱ	74 – 79	Combined sources	6
Turnⁱ	81 – 86	Combined sources	6
Beta strandⁱ	87 – 92	Combined sources	6
Turnⁱ	93 – 96	Combined sources	4
Beta strandⁱ	97 – 102	Combined sources	6
Helixⁱ	107 – 109	Combined sources	3
Beta strandⁱ	111 – 117	Combined sources	7

3D structure databases

ProteinModelPortalⁱ	P01764
SMRⁱ	P01764
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P01764

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	20 – ›117	Ig-likeAdd BLAST		›98

Keywords - Domainⁱ

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118963
HOVERGENⁱ	HBG018013
InParanoidⁱ	P01764
OMAⁱ	VSECHYE

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013106 Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P01764-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEFGLSWLFL VAILKGVQCE VQLVESGGGL VQPGGSLRLS CAASGFTFSS 
        60         70         80         90        100
YAMSWVRQAP GKGLEWVSAI SGSGGSTYYA DSVKGRFTIS RDNSKNTLYL 
       110 
QMNSLRAEDT AVYYCAK

Length:117

Mass (Da):12,582

Last modified:May 27, 2015 - v2

Checksum:ⁱE96D8794FA22F0B5

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	20	E → A AA sequence (PubMed:4139708).Curated	1
Sequence conflictⁱ	29	G → A AA sequence (PubMed:4522793).Curated	1
Sequence conflictⁱ	37	L → G AA sequence (PubMed:4522793).Curated	1
Sequence conflictⁱ	47 – 54	TFSSYAMS → SFSTDAMY AA sequence (PubMed:4522793).Curated	8
Sequence conflictⁱ	50 – 53	SYAM → RVLS AA sequence (PubMed:4522793).Curated	4
Sequence conflictⁱ	50 – 52	SYA → TYV AA sequence (PubMed:409716).Curated	3
Sequence conflictⁱ	50	S → A AA sequence (PubMed:4139708).Curated	1
Sequence conflictⁱ	50	S → T AA sequence (PubMed:4522793).Curated	1
Sequence conflictⁱ	51 – 54	YAMS → TSAVY AA sequence (PubMed:4522793).Curated	4
Sequence conflictⁱ	51 – 54	YAMS → TTSRF AA sequence (PubMed:4522793).Curated	4
Sequence conflictⁱ	51	Y → S AA sequence (PubMed:4139708).Curated	1
Sequence conflictⁱ	68 – 84	SAISG…ADSVK → AWKYQEASNSHFADTVN AA sequence (PubMed:4522793).CuratedAdd BLAST	17
Sequence conflictⁱ	68 – 84	SAISG…ADSVK → GWRYEGSSLTHYAVSVQ AA sequence (PubMed:4522793).CuratedAdd BLAST	17
Sequence conflictⁱ	68 – 78	SAISGSGGSTY → AWKYENGNDKH AA sequence (PubMed:4139708).CuratedAdd BLAST	11
Sequence conflictⁱ	68 – 78	SAISGSGGSTY → EFRVQGSAISH AA sequence (PubMed:4522793).CuratedAdd BLAST	11
Sequence conflictⁱ	68	S → G AA sequence (PubMed:409716).Curated	1
Sequence conflictⁱ	69 – 84	AISGS…ADSVK → GRLNASSNLHFAVSAQ AA sequence (PubMed:4522793).CuratedAdd BLAST	16
Sequence conflictⁱ	71 – 78	SGSGGSTY → ZGLSVSZS AA sequence (PubMed:409716).Curated	8
Sequence conflictⁱ	84 – 85	KG → QA AA sequence (PubMed:4522793).Curated	2
Sequence conflictⁱ	84	K → N AA sequence (PubMed:4139708).Curated	1
Sequence conflictⁱ	92 – 93	DN → ND AA sequence (PubMed:4139708).Curated	2
Sequence conflictⁱ	92 – 93	DN → ND AA sequence (PubMed:4522793).Curated	2
Sequence conflictⁱ	93 – 101	NSKNTLYLQ → DSKNT AA sequence (PubMed:409716).Curated	9
Sequence conflictⁱ	101	Q → L AA sequence (PubMed:4139708).Curated	1
Sequence conflictⁱ	103 – 107	NSLRA → LSLEP AA sequence (PubMed:4522793).Curated	5
Sequence conflictⁱ	103 – 106	NSLR → LSLQ AA sequence (PubMed:4522793).Curated	4
Sequence conflictⁱ	104 – 105	SL → TG AA sequence (PubMed:4522793).Curated	2
Sequence conflictⁱ	104	S → G AA sequence (PubMed:4139708).Curated	1
Sequence conflictⁱ	104	S → R AA sequence (PubMed:4522793).Curated	1
Sequence conflictⁱ	106	R → E AA sequence (PubMed:4522793).Curated	1
Sequence conflictⁱ	106	R → Q AA sequence (PubMed:4139708).Curated	1
Sequence conflictⁱ	109 – 112	DTAV → VSAI AA sequence (PubMed:4139708).Curated	4
Sequence conflictⁱ	112	V → L AA sequence (PubMed:4522793).Curated	1
Sequence conflictⁱ	112	V → L AA sequence (PubMed:4139708).Curated	1
Sequence conflictⁱ	117	K → R AA sequence (PubMed:4139708).Curated	1
Sequence conflictⁱ	117	K → R AA sequence (PubMed:4522793).Curated	1
Non-terminal residueⁱ	117		1

Polymorphismⁱ

There are several alleles. The sequence shown is that of IMGT allele IGHV3-23*04.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_073326	24	V → L in IMGT allele IGHV3-23*02. 1 Publication		1
Natural variantⁱVAR_073327	80	A → G in IMGT allele IGHV3-23*02. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M35415 Genomic DNA Translation: AAA58735.1 AC245166 Genomic DNA No translation available.
PIRⁱ	A02047 H3HU26 A02048 H3HUTL A02057 M3HUPM A02058 M3HULY A02059 G1HUWS A02060 G1HUTE A02061 A1HUZP A02062 A1HUTU
UniGeneⁱ	Hs.719895

Genome annotation databases

Ensemblⁱ	ENST00000390609; ENSP00000375018; ENSG00000211949 ENST00000632630; ENSP00000487761; ENSG00000281962
UCSC genome browser More...UCSCⁱ	uc059gga.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P01764	Uncharacterized protein		SAIBB		142
Uncharacterized protein		SAIBB		132
Uncharacterized protein		SAIBB		132

Protein	Similar proteins		Species	Score	Length
P01764	Uncharacterized protein		SAIBB		142
Anti-quaternary epitope monoclonal antibody heavy chain (Fragment)		MACMU		162
Uncharacterized protein		MUSPF		142
Rearranged Ig variable region VDJ (Fragment)		MACFA		163
UPI000595858D		HUMAN		150
+86

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M35415 Genomic DNA Translation: AAA58735.1 AC245166 Genomic DNA No translation available.
PIRⁱ	A02047 H3HU26 A02048 H3HUTL A02057 M3HUPM A02058 M3HULY A02059 G1HUWS A02060 G1HUTE A02061 A1HUZP A02062 A1HUTU
UniGeneⁱ	Hs.719895

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1HOU	model	-	H	20-117	[»]
	1OHQ	X-ray	2.00	A/B	20-116	[»]
	3BN9	X-ray	2.17	D/F	21-116	[»]
	3UPC	X-ray	2.80	A/B/C/D/E/F/G/H/I/J	22-117	[»]
	3ZHD	X-ray	1.96	A/B	20-116	[»]
	3ZHK	X-ray	1.96	A/B	20-116	[»]
	3ZHL	X-ray	2.47	A	20-116	[»]
	4KFZ	X-ray	2.80	C/D	20-116	[»]
ProteinModelPortalⁱ	P01764
SMRⁱ	P01764
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P01764, 1 interactor

IntActⁱ

P01764, 1 interactor

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB04147 Lauryl Dimethylamine-N-Oxide

DrugBankⁱ

DB04147 Lauryl Dimethylamine-N-Oxide

Protein family/group databases

IMGT/GENE-DB	IGHV3-23

IMGT/GENE-DB

IGHV3-23

Polymorphism and mutation databases

DMDMⁱ	123843 123844 123854 123855 123856 123857 123858

DMDMⁱ

123843
123844
123854
123855
123856
123857
123858

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	P01764
PRIDEⁱ	P01764
ProteomicsDBⁱ	51463 51464 51473 51474 51475 51476 51477 51478

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000390609; ENSP00000375018; ENSG00000211949 ENST00000632630; ENSP00000487761; ENSG00000281962
UCSC genome browser More...UCSCⁱ	uc059gga.1 human

Organism-specific databases

DisGeNET More...DisGeNETⁱ	28442
EuPathDBⁱ	HostDB:ENSG00000211949.3
GeneCardsⁱ	IGHV3-23
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5588 IGHV3-23
neXtProtⁱ	NX_P01764
Open Targets More...OpenTargetsⁱ	ENSG00000211949
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118963
HOVERGENⁱ	HBG018013
InParanoidⁱ	P01764
OMAⁱ	VSECHYE

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166663 Initial triggering of complement R-HSA-173623 Classical antibody-mediated complement activation R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-2029481 FCGR activation R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485 Role of phospholipids in phagocytosis R-HSA-2168880 Scavenging of heme from plasma R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796 FCERI mediated MAPK activation R-HSA-2871809 FCERI mediated Ca+2 mobilization R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-5690714 CD22 mediated BCR regulation R-HSA-977606 Regulation of Complement cascade R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Reactomeⁱ

R-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-977606 Regulation of Complement cascade
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

EvolutionaryTraceⁱ	P01764
Protein Ontology More...PROⁱ	PR:P01764

Gene expression databases

Bgeeⁱ	ENSG00000211949

Bgeeⁱ

ENSG00000211949

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013106 Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HV323_HUMAN
Accessionⁱ	P01764Primary (citable) accession number: P01764 Secondary accession number(s): A0A087WSX3 P01779
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	May 27, 2015
	Last modified:	June 20, 2018
	This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

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Supporting data

UniProtKB - P01764 (HV323_HUMAN)

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Immunoglobulin heavy variable 3-23

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Plasma membrane

Extracellular region or secreted

Plasma Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ