UniProtKB - P01764 (HV323_HUMAN)
Protein
Immunoglobulin heavy variable 3-23
Gene
IGHV3-23
Organism
Homo sapiens (Human)
Status
Functioni
V region of the variable domain of immunoglobulin heavy chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).4 Publications
Caution
For examples of full-length immunoglobulin heavy chains (of different isotypes) see AC P0DOX2, AC P0DOX3, AC P0DOX4, AC P0DOX5 and AC P0DOX6.Curated
GO - Molecular functioni
- antigen binding Source: GO_Central
- immunoglobulin receptor binding Source: GO_Central
GO - Biological processi
- B cell receptor signaling pathway Source: GO_Central
- complement activation Source: Reactome
- complement activation, classical pathway Source: GO_Central
- defense response to bacterium Source: GO_Central
- Fc-epsilon receptor signaling pathway Source: Reactome
- Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
- immune response Source: UniProtKB
- innate immune response Source: GO_Central
- leukocyte migration Source: Reactome
- phagocytosis, engulfment Source: GO_Central
- phagocytosis, recognition Source: GO_Central
- positive regulation of B cell activation Source: GO_Central
- receptor-mediated endocytosis Source: Reactome
- regulation of complement activation Source: Reactome
- regulation of immune response Source: Reactome
Keywordsi
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
PathwayCommonsi | P01764 |
Reactomei | R-HSA-166663, Initial triggering of complement R-HSA-173623, Classical antibody-mediated complement activation R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-2029481, FCGR activation R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485, Role of phospholipids in phagocytosis R-HSA-2168880, Scavenging of heme from plasma R-HSA-2454202, Fc epsilon receptor (FCERI) signaling R-HSA-2730905, Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796, FCERI mediated MAPK activation R-HSA-2871809, FCERI mediated Ca+2 mobilization R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-5690714, CD22 mediated BCR regulation R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-9664422, FCGR3A-mediated phagocytosis R-HSA-977606, Regulation of Complement cascade R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
Protein family/group databases
IMGT/GENE-DB | IGHV3-23 |
Names & Taxonomyi
Protein namesi | Recommended name: Immunoglobulin heavy variable 3-232 PublicationsAlternative name(s): Ig heavy chain V-III region LAY1 Publication Ig heavy chain V-III region POM1 Publication Ig heavy chain V-III region TEI1 Publication Ig heavy chain V-III region TIL1 Publication Ig heavy chain V-III region TUR1 Publication Ig heavy chain V-III region VH261 Publication Ig heavy chain V-III region WAS1 Publication Ig heavy chain V-III region ZAP1 Publication |
Gene namesi | Name:IGHV3-232 Publications |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000211949.3 |
HGNCi | HGNC:5588, IGHV3-23 |
neXtProti | NX_P01764 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications
Extracellular region or secreted
- Secreted 2 Publications
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
- immunoglobulin complex, circulating Source: GO_Central
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- plasma membrane Source: Reactome
Keywords - Cellular componenti
Cell membrane, Immunoglobulin, Membrane, SecretedPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000211949 |
Miscellaneous databases
Pharosi | P01764, Tdark |
Chemistry databases
DrugBanki | DB04147, Dodecyldimethylamine N-oxide |
Polymorphism and mutation databases
BioMutai | IGHV3-23 |
DMDMi | 123854 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 3 PublicationsAdd BLAST | 19 | |
ChainiPRO_0000015249 | 20 – 117 | Immunoglobulin heavy variable 3-233 PublicationsAdd BLAST | 98 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 41 ↔ 115 | PROSITE-ProRule annotationCombined sources2 Publications |
Keywords - PTMi
Disulfide bondProteomic databases
jPOSTi | P01764 |
MassIVEi | P01764 |
PeptideAtlasi | P01764 |
PRIDEi | P01764 |
ProteomicsDBi | 51463 51464 51473 51474 51475 51476 51477 51478 |
Expressioni
Gene expression databases
Bgeei | ENSG00000211949, Expressed in tonsil and 142 other tissues |
Interactioni
Subunit structurei
Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
1 PublicationGO - Molecular functioni
- immunoglobulin receptor binding Source: GO_Central
Protein-protein interaction databases
IntActi | P01764, 2 interactors |
Miscellaneous databases
RNActi | P01764, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P01764 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P01764 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – ›117 | Ig-likeAdd BLAST | ›98 |
Keywords - Domaini
Immunoglobulin domain, SignalPhylogenomic databases
GeneTreei | ENSGT01010000222434 |
InParanoidi | P01764 |
OMAi | MEWVGRI |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P01764-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEFGLSWLFL VAILKGVQCE VQLVESGGGL VQPGGSLRLS CAASGFTFSS
60 70 80 90 100
YAMSWVRQAP GKGLEWVSAI SGSGGSTYYA DSVKGRFTIS RDNSKNTLYL
110
QMNSLRAEDT AVYYCAK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 20 | E → A AA sequence (PubMed:4139708).Curated | 1 | |
Sequence conflicti | 29 | G → A AA sequence (PubMed:4522793).Curated | 1 | |
Sequence conflicti | 37 | L → G AA sequence (PubMed:4522793).Curated | 1 | |
Sequence conflicti | 47 – 54 | TFSSYAMS → SFSTDAMY AA sequence (PubMed:4522793).Curated | 8 | |
Sequence conflicti | 50 – 53 | SYAM → RVLS AA sequence (PubMed:4522793).Curated | 4 | |
Sequence conflicti | 50 – 52 | SYA → TYV AA sequence (PubMed:409716).Curated | 3 | |
Sequence conflicti | 50 | S → A AA sequence (PubMed:4139708).Curated | 1 | |
Sequence conflicti | 50 | S → T AA sequence (PubMed:4522793).Curated | 1 | |
Sequence conflicti | 51 – 54 | YAMS → TSAVY AA sequence (PubMed:4522793).Curated | 4 | |
Sequence conflicti | 51 – 54 | YAMS → TTSRF AA sequence (PubMed:4522793).Curated | 4 | |
Sequence conflicti | 51 | Y → S AA sequence (PubMed:4139708).Curated | 1 | |
Sequence conflicti | 68 – 84 | SAISG…ADSVK → AWKYQEASNSHFADTVN AA sequence (PubMed:4522793).CuratedAdd BLAST | 17 | |
Sequence conflicti | 68 – 84 | SAISG…ADSVK → GWRYEGSSLTHYAVSVQ AA sequence (PubMed:4522793).CuratedAdd BLAST | 17 | |
Sequence conflicti | 68 – 78 | SAISGSGGSTY → AWKYENGNDKH AA sequence (PubMed:4139708).CuratedAdd BLAST | 11 | |
Sequence conflicti | 68 – 78 | SAISGSGGSTY → EFRVQGSAISH AA sequence (PubMed:4522793).CuratedAdd BLAST | 11 | |
Sequence conflicti | 68 | S → G AA sequence (PubMed:409716).Curated | 1 | |
Sequence conflicti | 69 – 84 | AISGS…ADSVK → GRLNASSNLHFAVSAQ AA sequence (PubMed:4522793).CuratedAdd BLAST | 16 | |
Sequence conflicti | 71 – 78 | SGSGGSTY → ZGLSVSZS AA sequence (PubMed:409716).Curated | 8 | |
Sequence conflicti | 84 – 85 | KG → QA AA sequence (PubMed:4522793).Curated | 2 | |
Sequence conflicti | 84 | K → N AA sequence (PubMed:4139708).Curated | 1 | |
Sequence conflicti | 92 – 93 | DN → ND AA sequence (PubMed:4139708).Curated | 2 | |
Sequence conflicti | 92 – 93 | DN → ND AA sequence (PubMed:4522793).Curated | 2 | |
Sequence conflicti | 93 – 101 | NSKNTLYLQ → DSKNT AA sequence (PubMed:409716).Curated | 9 | |
Sequence conflicti | 101 | Q → L AA sequence (PubMed:4139708).Curated | 1 | |
Sequence conflicti | 103 – 107 | NSLRA → LSLEP AA sequence (PubMed:4522793).Curated | 5 | |
Sequence conflicti | 103 – 106 | NSLR → LSLQ AA sequence (PubMed:4522793).Curated | 4 | |
Sequence conflicti | 104 – 105 | SL → TG AA sequence (PubMed:4522793).Curated | 2 | |
Sequence conflicti | 104 | S → G AA sequence (PubMed:4139708).Curated | 1 | |
Sequence conflicti | 104 | S → R AA sequence (PubMed:4522793).Curated | 1 | |
Sequence conflicti | 106 | R → E AA sequence (PubMed:4522793).Curated | 1 | |
Sequence conflicti | 106 | R → Q AA sequence (PubMed:4139708).Curated | 1 | |
Sequence conflicti | 109 – 112 | DTAV → VSAI AA sequence (PubMed:4139708).Curated | 4 | |
Sequence conflicti | 112 | V → L AA sequence (PubMed:4522793).Curated | 1 | |
Sequence conflicti | 112 | V → L AA sequence (PubMed:4139708).Curated | 1 | |
Sequence conflicti | 117 | K → R AA sequence (PubMed:4139708).Curated | 1 | |
Sequence conflicti | 117 | K → R AA sequence (PubMed:4522793).Curated | 1 | |
Non-terminal residuei | 117 | 1 |
Polymorphismi
There are several alleles. The sequence shown is that of IMGT allele IGHV3-23*04.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073326 | 24 | V → L in IMGT allele IGHV3-23*02. 1 Publication | 1 | |
Natural variantiVAR_073327 | 80 | A → G in IMGT allele IGHV3-23*02. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M35415 Genomic DNA Translation: AAA58735.1 AC245166 Genomic DNA No translation available. |
PIRi | A02047, H3HU26 A02048, H3HUTL A02057, M3HUPM A02058, M3HULY A02059, G1HUWS A02060, G1HUTE A02061, A1HUZP A02062, A1HUTU |
Genome annotation databases
Ensembli | ENST00000390609; ENSP00000375018; ENSG00000211949 ENST00000632630; ENSP00000487761; ENSG00000281962 |
UCSCi | uc059gga.1, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M35415 Genomic DNA Translation: AAA58735.1 AC245166 Genomic DNA No translation available. |
PIRi | A02047, H3HU26 A02048, H3HUTL A02057, M3HUPM A02058, M3HULY A02059, G1HUWS A02060, G1HUTE A02061, A1HUZP A02062, A1HUTU |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1HOU | model | - | H | 20-117 | [»] | |
1OHQ | X-ray | 2.00 | A/B | 20-116 | [»] | |
3BN9 | X-ray | 2.17 | D/F | 21-116 | [»] | |
3UPC | X-ray | 2.80 | A/B/C/D/E/F/G/H/I/J | 22-117 | [»] | |
3ZHD | X-ray | 1.96 | A/B | 20-116 | [»] | |
3ZHK | X-ray | 1.96 | A/B | 20-116 | [»] | |
3ZHL | X-ray | 2.47 | A | 20-116 | [»] | |
4KFZ | X-ray | 2.80 | C/D | 20-116 | [»] | |
SMRi | P01764 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P01764, 2 interactors |
Chemistry databases
DrugBanki | DB04147, Dodecyldimethylamine N-oxide |
Protein family/group databases
IMGT/GENE-DB | IGHV3-23 |
Polymorphism and mutation databases
BioMutai | IGHV3-23 |
DMDMi | 123854 |
Proteomic databases
jPOSTi | P01764 |
MassIVEi | P01764 |
PeptideAtlasi | P01764 |
PRIDEi | P01764 |
ProteomicsDBi | 51463 51464 51473 51474 51475 51476 51477 51478 |
Genome annotation databases
Ensembli | ENST00000390609; ENSP00000375018; ENSG00000211949 ENST00000632630; ENSP00000487761; ENSG00000281962 |
UCSCi | uc059gga.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000211949.3 |
GeneCardsi | IGHV3-23 |
HGNCi | HGNC:5588, IGHV3-23 |
neXtProti | NX_P01764 |
OpenTargetsi | ENSG00000211949 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT01010000222434 |
InParanoidi | P01764 |
OMAi | MEWVGRI |
Enzyme and pathway databases
PathwayCommonsi | P01764 |
Reactomei | R-HSA-166663, Initial triggering of complement R-HSA-173623, Classical antibody-mediated complement activation R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-2029481, FCGR activation R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485, Role of phospholipids in phagocytosis R-HSA-2168880, Scavenging of heme from plasma R-HSA-2454202, Fc epsilon receptor (FCERI) signaling R-HSA-2730905, Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796, FCERI mediated MAPK activation R-HSA-2871809, FCERI mediated Ca+2 mobilization R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-5690714, CD22 mediated BCR regulation R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-9664422, FCGR3A-mediated phagocytosis R-HSA-977606, Regulation of Complement cascade R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
Miscellaneous databases
ChiTaRSi | IGHV3-23, human |
EvolutionaryTracei | P01764 |
Pharosi | P01764, Tdark |
PROi | PR:P01764 |
RNActi | P01764, protein |
Gene expression databases
Bgeei | ENSG00000211949, Expressed in tonsil and 142 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HV323_HUMAN | |
Accessioni | P01764Primary (citable) accession number: P01764 Secondary accession number(s): A0A087WSX3 P01779 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | May 27, 2015 | |
Last modified: | December 2, 2020 | |
This is version 161 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations