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Protein

Ig heavy chain V region B1-8/186-2

Gene

Ighv1-72

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

The B1-8 mu chain mRNA was cloned from a hybridoma making antibodies to the hapten (4-hydroxy-3-nitrophenyl)acetyl (NPb antibodies).

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ig heavy chain V region B1-8/186-2
Gene namesi
Name:Ighv1-72
Synonyms:Gm16709
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:4439633 Ighv1-72

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000001522020 – 139Ig heavy chain V region B1-8/186-2Add BLAST120

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 115PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP01751
PRIDEiP01751

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP01751, 2 interactors
MINTiP01751

Structurei

Secondary structure

1139
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi22 – 25Combined sources4
Beta strandi29 – 31Combined sources3
Beta strandi37 – 46Combined sources10
Helixi48 – 50Combined sources3
Beta strandi51 – 58Combined sources8
Beta strandi60 – 62Combined sources3
Beta strandi64 – 70Combined sources7
Turni72 – 74Combined sources3
Beta strandi77 – 79Combined sources3
Helixi81 – 83Combined sources3
Turni84 – 86Combined sources3
Beta strandi87 – 92Combined sources6
Turni93 – 96Combined sources4
Beta strandi97 – 102Combined sources6
Helixi107 – 109Combined sources3
Beta strandi111 – 119Combined sources9
Turni120 – 123Combined sources4
Beta strandi126 – 129Combined sources4
Beta strandi133 – 137Combined sources5

3D structure databases

ProteinModelPortaliP01751
SMRiP01751
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01751

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 49Framework-1Add BLAST30
Regioni50 – 54Complementarity-determining-15
Regioni55 – 68Framework-2Add BLAST14
Regioni69 – 85Complementarity-determining-2Add BLAST17
Regioni86 – 117Framework-3Add BLAST32
Regioni118 – 124D segment7
Regioni125 – 139JH2 segmentAdd BLAST15

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

HOGENOMiHOG000154831
HOVERGENiHBG018013
InParanoidiP01751

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01751-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGWSCIMLFL AATATGVHSQ VQLQQPGAEL VKPGASVKLS CKASGYTFTS
60 70 80 90 100
YWMHWVKQRP GRGLEWIGRI DPNSGGTKYN EKFKSKATLT VDKPSSTAYM
110 120 130
QLSSLTSEDS AVYYCARYDY YGSSYFDYWG QGTTLTVSS
Length:139
Mass (Da):15,419
Last modified:July 21, 1986 - v1
Checksum:i1B57DD4FD0C9F465
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1391

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00529 mRNA Translation: AAA38170.1
PIRiA90809 MHMS18
UniGeneiMm.304472
Mm.425791

Similar proteinsi

Entry informationi

Entry nameiHVM07_MOUSE
AccessioniPrimary (citable) accession number: P01751
Secondary accession number(s): P01752
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 18, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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