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Protein

Ig kappa chain V-V region L7

Gene

Gm10881

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

There appears to be two possible splice junctions at the 3' end of the intron. The alternate would code for a protein lacking residues 17-19.

GO - Molecular functioni

GO - Biological processi

  • immune response Source: GO_Central
  • immunoglobulin production Source: GO_Central

Names & Taxonomyi

Protein namesi
Recommended name:
Ig kappa chain V-V region L7
Gene namesi
Name:Gm10881
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:3642817 Gm10881

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Add BLAST20
ChainiPRO_000001519621 – ›115Ig kappa chain V-V region L7Add BLAST›95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 108PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP01642
PeptideAtlasiP01642
PRIDEiP01642

Expressioni

Gene expression databases

BgeeiENSMUSG00000076563 Expressed in 14 organ(s), highest expression level in colon
ExpressionAtlasiP01642 baseline and differential

Structurei

Secondary structure

1115
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP01642
SMRiP01642
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01642

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 43Framework-1Add BLAST23
Regioni44 – 54Complementarity-determining-1Add BLAST11
Regioni55 – 69Framework-2Add BLAST15
Regioni70 – 76Complementarity-determining-27
Regioni77 – 108Framework-3Add BLAST32
Regioni109 – ›115Complementarity-determining-3›7

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

GeneTreeiENSGT00920000149150
HOGENOMiHOG000059537
HOVERGENiHBG018013
InParanoidiP01642
OMAiLWVPASK

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P01642-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVSTPQFLVF LLFWIPASRG DILLTQSPAI LSVSPGERVS FSCRASQSIG
60 70 80 90 100
TSIHWYQQRT NGSPRLLIKY ASESISGIPS RFSGSGSGTD FTLSINSVES
110
EDIADYYCQQ SNSWP
Length:115
Mass (Da):12,615
Last modified:July 21, 1986 - v1
Checksum:iC17BEC758C577E00
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140T8N2A0A140T8N2_MOUSE
Protein Igkv5-48
Igkv5-48
115Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1151

Sequence databases

PIRiA01925 KVMSL7

Genome annotation databases

EnsembliENSMUST00000103364; ENSMUSP00000100165; ENSMUSG00000076563

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiA01925 KVMSL7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1C08X-ray2.30A21-115[»]
1IC4X-ray2.50L21-115[»]
1IC5X-ray2.30L21-115[»]
1IC7X-ray2.10L21-115[»]
1J1OX-ray1.80L21-115[»]
1J1PX-ray1.80L21-115[»]
1J1XX-ray1.80L21-115[»]
2OZ4X-ray2.70L21-115[»]
4CKDelectron microscopy13.00L/M/N/O21-115[»]
ProteinModelPortaliP01642
SMRiP01642
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiP01642
PeptideAtlasiP01642
PRIDEiP01642

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000103364; ENSMUSP00000100165; ENSMUSG00000076563

Organism-specific databases

MGIiMGI:3642817 Gm10881

Phylogenomic databases

GeneTreeiENSGT00920000149150
HOGENOMiHOG000059537
HOVERGENiHBG018013
InParanoidiP01642
OMAiLWVPASK

Miscellaneous databases

EvolutionaryTraceiP01642
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000076563 Expressed in 14 organ(s), highest expression level in colon
ExpressionAtlasiP01642 baseline and differential

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKV5A9_MOUSE
AccessioniPrimary (citable) accession number: P01642
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 12, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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