IGKV3-20

Functionⁱ

V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).4 Publications

Caution

For an example of a full-length immunoglobulin kappa light chain see AC P0DOX7.Curated

GO - Molecular functionⁱ

antigen binding
Source: UniProtKB
Non-traceable author statementⁱ
- Ref.1
  "Human immunoglobulin kappa light chain genes of subgroups II and III."
  Klobeck H.G., Meindl A., Combriato G., Solomon A., Zachau H.G.
  Nucleic Acids Res. 13:6499-6513(1985) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
- Ref.8
  "Amino acid sequence of a light chain variable region of a human rheumatoid factor of the Wa idiotypic group, in part predicted by its reactivity with antipeptide antibodies."
  Newkirk M., Chen P.P., Carson D.A., Posnett D., Capra J.D.
  Mol. Immunol. 23:239-244(1986) [PubMed] [Europe PMC] [Abstract]
  Cited for: PROTEIN SEQUENCE OF 21-116.
- Ref.2
  "Autoantibody-associated kappa light chain variable region gene expressed in chronic lymphocytic leukemia with little or no somatic mutation. Implications for etiology and immunotherapy."
  Kipps T.J., Tomhave E., Chen P.P., Carson D.A.
  J. Exp. Med. 167:840-852(1988) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA].
- Ref.6
  "Rule of antibody structure. The primary structure of a monoclonal immunoglobulin L-chain of kappa-type, subgroup 3 (Bence-Jones protein Ti). IV. The complete amino acid sequence and its significance for the mechanism of antibody production."
  Suter L., Barnikol H.U., Watanabe S., Hilschmann N.
  Hoppe-Seyler's Z. Physiol. Chem. 353:189-208(1972) [PubMed] [Europe PMC] [Abstract]
  Cited for: PROTEIN SEQUENCE OF 21-116.
- Ref.4
  "Most kappa immunoglobulin mRNA in human lymphocytes is homologous to a small family of germ-line V genes."
  Bentley D.L.
  Nature 307:77-80(1984) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 17-116.
- Ref.7
  "Amino acid sequence of the variable regions of light chains from two idiotypically cross-reactive human IgM anti-gamma-globulins of the Wa group."
  Andrews D.W., Capra J.D.
  Biochemistry 20:5816-5822(1981) [PubMed] [Europe PMC] [Abstract]
  Cited for: PROTEIN SEQUENCE OF 21-116.

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Adaptive immunity, Immunity

Biological process

Adaptive immunity, Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166663 Initial triggering of complement R-HSA-173623 Classical antibody-mediated complement activation R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-2029481 FCGR activation R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485 Role of phospholipids in phagocytosis R-HSA-2168880 Scavenging of heme from plasma R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796 FCERI mediated MAPK activation R-HSA-2871809 FCERI mediated Ca+2 mobilization R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-5690714 CD22 mediated BCR regulation R-HSA-977606 Regulation of Complement cascade R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Reactomeⁱ

R-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-977606 Regulation of Complement cascade
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Protein family/group databases

IMGT/GENE-DB	IGKV3-20

IMGT/GENE-DB

IGKV3-20

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Immunoglobulin kappa variable 3-202 Publications Alternative name(s): Ig kappa chain V-III region B61 Publication Ig kappa chain V-III region GOL1 Publication Ig kappa chain V-III region HAH1 Publication Ig kappa chain V-III region HIC1 Publication Ig kappa chain V-III region IARC/BL411 Publication Ig kappa chain V-III region NG91 Publication Ig kappa chain V-III region SIE1 Publication Ig kappa chain V-III region Ti1 Publication Ig kappa chain V-III region WOL1 Publication
Gene namesⁱ	Name:IGKV3-202 Publications
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000239951.1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5817 IGKV3-20
neXtProtⁱ	NX_P01619

Keywords - Cellular componentⁱ

Cell membrane, Immunoglobulin, Membrane, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	28912
Open Targets More...OpenTargetsⁱ	ENSG00000239951

Miscellaneous databases

Pharosⁱ

P01619 Tbio

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB09130 Copper DB01593 Zinc DB14487 Zinc acetate DB14533 Zinc chloride

DrugBankⁱ

DB09130 Copper
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

Polymorphism and mutation databases

BioMutaⁱ	IGKV3-20
DMDMⁱ	125801

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 20	4 PublicationsAdd BLAST		20
ChainⁱPRO_0000059762	21 – 116	Immunoglobulin kappa variable 3-204 PublicationsAdd BLAST		96

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	43 ↔ 109	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

jPOSTⁱ	P01619
MassIVEⁱ	P01619
PeptideAtlas More...PeptideAtlasⁱ	P01619
PRIDEⁱ	P01619
ProteomicsDBⁱ	51420 51421 51422 51423 51424 51678 51885 53550 53551
TopDownProteomicsⁱ	P01619

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000239951 Expressed in 139 organ(s), highest expression level in lymph node

Bgeeⁱ

ENSG00000239951 Expressed in 139 organ(s), highest expression level in lymph node

Interactionⁱ

Subunit structureⁱ

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.

1 Publication

Protein-protein interaction databases

IntActⁱ	P01619, 2 interactors
Molecular INTeraction database More...MINTⁱ	P01619

Miscellaneous databases

RNActⁱ	P01619 protein

RNActⁱ

P01619 protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	24 – 27	Combined sources	4
Beta strandⁱ	29 – 33	Combined sources	5
Beta strandⁱ	39 – 47	Combined sources	9
Helixⁱ	50 – 52	Combined sources	3
Beta strandⁱ	54 – 59	Combined sources	6
Beta strandⁱ	66 – 70	Combined sources	5
Turnⁱ	71 – 73	Combined sources	3
Beta strandⁱ	83 – 88	Combined sources	6
Beta strandⁱ	91 – 98	Combined sources	8
Helixⁱ	101 – 103	Combined sources	3
Beta strandⁱ	105 – 111	Combined sources	7
Beta strandⁱ	113 – 116	Combined sources	4

Show more details

3D structure databases

SMRⁱ	P01619
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	21 – ›116	Ig-likePROSITE-ProRule annotationAdd BLAST		›96

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	21 – 43	Framework-11 PublicationAdd BLAST	23
Regionⁱ	44 – 55	Complementarity-determining-11 PublicationAdd BLAST	12
Regionⁱ	56 – 70	Framework-21 PublicationAdd BLAST	15
Regionⁱ	71 – 77	Complementarity-determining-21 Publication	7
Regionⁱ	78 – 109	Framework-31 PublicationAdd BLAST	32
Regionⁱ	110 – ›116	Complementarity-determining-31 Publication	›7

Keywords - Domainⁱ

Immunoglobulin domain, Signal

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000154413
OMAⁱ	LNSYFRS
PhylomeDBⁱ	P01619

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P01619-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
METPAQLLFL LLLWLPDTTG EIVLTQSPGT LSLSPGERAT LSCRASQSVS 
        60         70         80         90        100
SSYLAWYQQK PGQAPRLLIY GASSRATGIP DRFSGSGSGT DFTLTISRLE 
       110 
PEDFAVYYCQ QYGSSP

Length:116

Mass (Da):12,557

Last modified:November 2, 2016 - v2

Checksum:ⁱFAC198A8B24553DD

GO

Sequence cautionⁱ

The sequence CAA77316 differs from that shown. Chimeric DNA. A chimeric DNA corresponding to regions V and J of immunoglobulin kappa light chain.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	17 – 19	DTT → VPS (PubMed:6419127).Curated	3
Sequence conflictⁱ	38	R → S in CAA77316 (PubMed:2997711).Curated	1
Sequence conflictⁱ	40	T → A AA sequence (PubMed:11946339).Curated	1
Sequence conflictⁱ	46 – 52	SQSVSSS → ALLSSRG AA sequence (PubMed:3086710).Curated	7
Sequence conflictⁱ	49 – 52	VSSS → LSGN AA sequence (PubMed:11946339).Curated	4
Sequence conflictⁱ	51	S → N AA sequence (PubMed:6794615).Curated	1
Sequence conflictⁱ	51	S → N AA sequence (PubMed:5027703).Curated	1
Sequence conflictⁱ	52 – 53	SY → N in CAA77316 (PubMed:2997711).Curated	2
Sequence conflictⁱ	52	S → G AA sequence (PubMed:6794615).Curated	1
Sequence conflictⁱ	53	Y → F AA sequence (PubMed:5027703).Curated	1
Sequence conflictⁱ	55	A → G AA sequence (PubMed:6794615).Curated	1
Sequence conflictⁱ	61	P → R in CAA77316 (PubMed:2997711).Curated	1
Sequence conflictⁱ	64	A → S in CAA77316 (PubMed:2997711).Curated	1
Sequence conflictⁱ	69	I → M AA sequence (PubMed:11946339).Curated	1
Sequence conflictⁱ	69	I → M AA sequence (PubMed:3086710).Curated	1
Sequence conflictⁱ	70 – 71	YG → RD in CAA77316 (PubMed:2997711).Curated	2
Sequence conflictⁱ	71	G → V AA sequence (PubMed:5027703).Curated	1
Sequence conflictⁱ	72	A → V AA sequence (PubMed:11946339).Curated	1
Sequence conflictⁱ	73	S → T (PubMed:6419127).Curated	1
Sequence conflictⁱ	77	T → N in CAA77316 (PubMed:2997711).Curated	1
Sequence conflictⁱ	87	G → A (PubMed:6419127).Curated	1
Sequence conflictⁱ	90	T → A AA sequence (PubMed:11946339).Curated	1
Sequence conflictⁱ	95	T → I in CAA77316 (PubMed:2997711).Curated	1
Sequence conflictⁱ	102	E → D AA sequence (PubMed:6794615).Curated	1
Sequence conflictⁱ	113	G → S in CAA77316 (PubMed:2997711).Curated	1
Sequence conflictⁱ	114 – 116	SSP → NSQ (PubMed:6419127).Curated	3
Sequence conflictⁱ	114	S → T (PubMed:3127527).Curated	1
Sequence conflictⁱ	114	S → T in CAA77316 (PubMed:2997711).Curated	1
Sequence conflictⁱ	115 – 116	SP → LG AA sequence (PubMed:6794615).Curated	2
Non-terminal residueⁱ	116		1

Polymorphismⁱ

There are several alleles. The sequence shown is that of IMGT allele IGKV3-20*01.

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z00021 Genomic DNA Translation: CAA77316.1 Sequence problems. AC245015 Genomic DNA No translation available.
PIRⁱ	A01891 K3HUB6 A01892 K3HUSI A01893 K3HUGO A01894 K3HUNG A01895 K3HUTI A01896 K3HUWL A01899 K3HU41 C27594 E30607 PL0021 K3HUHI PL0022 K3HUHA

Genome annotation databases

Ensemblⁱ	ENST00000492167; ENSP00000418649; ENSG00000239951 ENST00000632822; ENSP00000487628; ENSG00000282402

Ensemblⁱ

ENST00000492167; ENSP00000418649; ENSG00000239951
ENST00000632822; ENSP00000487628; ENSG00000282402

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01619	Immunoglobulin kappa variable 3D-20		HUMAN		116	UniRef90_P01619
Ig-like domain-containing protein		MACNE		141
Ig-like domain-containing protein		MACFA		120
Ig-like domain-containing protein		MACNE		120
Ig-like domain-containing protein (Fragment)		MACFA		115
+1

Protein	Similar proteins		Species	Score	Length	Source
P01619	Immunoglobulin kappa variable 3D-20		HUMAN		116	UniRef50_P01619
Ig-like domain-containing protein		MACNE		141
Ig-like domain-containing protein		MACFA		120
Ig-like domain-containing protein		MARMO		133
Ig-like domain-containing protein		PANTR		132
+25

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z00021 Genomic DNA Translation: CAA77316.1 Sequence problems. AC245015 Genomic DNA No translation available.
PIRⁱ	A01891 K3HUB6 A01892 K3HUSI A01893 K3HUGO A01894 K3HUNG A01895 K3HUTI A01896 K3HUWL A01899 K3HU41 C27594 E30607 PL0021 K3HUHI PL0022 K3HUHA

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1DH5	model	-	L	21-116	[»]
	4LRN	X-ray	1.89	L	21-116	[»]
	4M62	X-ray	1.80	L/M	21-116	[»]
	4M8Q	X-ray	2.89	B/L	21-116	[»]
	4OB5	X-ray	1.70	L	21-116	[»]
	4ODX	X-ray	3.10	B/L	21-116	[»]
SMRⁱ	P01619
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P01619, 2 interactors
MINTⁱ	P01619

Chemistry databases

DrugBankⁱ	DB09130 Copper DB01593 Zinc DB14487 Zinc acetate DB14533 Zinc chloride

DrugBankⁱ

DB09130 Copper
DB01593 Zinc
DB14487 Zinc acetate
DB14533 Zinc chloride

Protein family/group databases

IMGT/GENE-DB	IGKV3-20

IMGT/GENE-DB

IGKV3-20

Polymorphism and mutation databases

BioMutaⁱ	IGKV3-20
DMDMⁱ	125801

Proteomic databases

jPOSTⁱ	P01619
MassIVEⁱ	P01619
PeptideAtlasⁱ	P01619
PRIDEⁱ	P01619
ProteomicsDBⁱ	51420 51421 51422 51423 51424 51678 51885 53550 53551
TopDownProteomicsⁱ	P01619

Genome annotation databases

Ensemblⁱ	ENST00000492167; ENSP00000418649; ENSG00000239951 ENST00000632822; ENSP00000487628; ENSG00000282402

Ensemblⁱ

ENST00000492167; ENSP00000418649; ENSG00000239951
ENST00000632822; ENSP00000487628; ENSG00000282402

Organism-specific databases

DisGeNETⁱ	28912
EuPathDBⁱ	HostDB:ENSG00000239951.1
GeneCardsⁱ	IGKV3-20
HGNCⁱ	HGNC:5817 IGKV3-20
neXtProtⁱ	NX_P01619
OpenTargetsⁱ	ENSG00000239951
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00940000154413
OMAⁱ	LNSYFRS
PhylomeDBⁱ	P01619

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166663 Initial triggering of complement R-HSA-173623 Classical antibody-mediated complement activation R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-2029481 FCGR activation R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485 Role of phospholipids in phagocytosis R-HSA-2168880 Scavenging of heme from plasma R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796 FCERI mediated MAPK activation R-HSA-2871809 FCERI mediated Ca+2 mobilization R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-5690714 CD22 mediated BCR regulation R-HSA-977606 Regulation of Complement cascade R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Reactomeⁱ

R-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-977606 Regulation of Complement cascade
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

Pharosⁱ	P01619 Tbio
Protein Ontology More...PROⁱ	PR:P01619
RNActⁱ	P01619 protein

Gene expression databases

Bgeeⁱ	ENSG00000239951 Expressed in 139 organ(s), highest expression level in lymph node

Bgeeⁱ

ENSG00000239951 Expressed in 139 organ(s), highest expression level in lymph node

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set
Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KV320_HUMAN
Accessionⁱ	P01619Primary (citable) accession number: P01619 Secondary accession number(s): A0A0B4J1Z6 P18136
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	November 2, 2016
	Last modified:	December 11, 2019
	This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P01619 (KV320_HUMAN)

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Immunoglobulin kappa variable 3-20

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Plasma membrane

Extracellular region or secreted

Plasma Membrane

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Miscellaneous databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

Polymorphism and mutation databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ