IGKV1-5

Functionⁱ

V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).4 Publications

Caution

For an example of a full-length immunoglobulin kappa light chain see AC P0DOX7.Curated

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

complement activation Source: Reactome
complement activation, classical pathway Source: Reactome
Fc-epsilon receptor signaling pathway Source: Reactome
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
immune response Source: GO_Central
immunoglobulin production Source: GO_Central
leukocyte migration Source: Reactome
receptor-mediated endocytosis Source: Reactome
regulation of complement activation Source: Reactome
regulation of immune response Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Adaptive immunity, Immunity

Biological process

Adaptive immunity, Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166663 Initial triggering of complement R-HSA-173623 Classical antibody-mediated complement activation R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-2029481 FCGR activation R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485 Role of phospholipids in phagocytosis R-HSA-2168880 Scavenging of heme from plasma R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796 FCERI mediated MAPK activation R-HSA-2871809 FCERI mediated Ca+2 mobilization R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-5690714 CD22 mediated BCR regulation R-HSA-977606 Regulation of Complement cascade R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Reactomeⁱ

R-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-977606 Regulation of Complement cascade
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Protein family/group databases

IMGT/GENE-DB	IGKV1-5

IMGT/GENE-DB

IGKV1-5

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Immunoglobulin kappa variable 1-52 Publications Alternative name(s): Ig kappa chain V-I region CAR1 Publication Ig kappa chain V-I region EU1 Publication Ig kappa chain V-I region HK1021 Publication Ig kappa chain V-I region Kue1 Publication
Gene namesⁱ	Name:IGKV1-52 Publications
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000243466.1
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5741 IGKV1-5
neXtProtⁱ	NX_P01602

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	28299
Open Targets More...OpenTargetsⁱ	ENSG00000243466

Polymorphism and mutation databases

DMDMⁱ	125760 125762 125766 125768

DMDMⁱ

125760
125762
125766
125768

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	3 PublicationsAdd BLAST		22
ChainⁱPRO_0000015169	23 – 117	Immunoglobulin kappa variable 1-53 PublicationsAdd BLAST		95

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	45 ↔ 110	PROSITE-ProRule annotation1 Publication

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	P01602
PRIDEⁱ	P01602
ProteomicsDBⁱ	51398 51400 51404 51406

PTM databases

iPTMnetⁱ	P01602
PhosphoSitePlusⁱ	P01602

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000243466

Bgeeⁱ

ENSG00000243466

Interactionⁱ

Subunit structureⁱ

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

Protein-protein interaction databases

IntActⁱ	P01602, 4 interactors

IntActⁱ

P01602, 4 interactors

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P01602
SMRⁱ	P01602
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	24 – ›117	Ig-likePROSITE-ProRule annotationAdd BLAST		›94

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	23 – 45	Framework-11 PublicationAdd BLAST	23
Regionⁱ	46 – 56	Complementarity-determining-11 PublicationAdd BLAST	11
Regionⁱ	57 – 71	Framework-21 PublicationAdd BLAST	15
Regionⁱ	72 – 78	Complementarity-determining-21 Publication	7
Regionⁱ	79 – 110	Framework-31 PublicationAdd BLAST	32
Regionⁱ	111 – ›117	Complementarity-determining-31 Publication	›7

Keywords - Domainⁱ

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148960
HOGENOMⁱ	HOG000059537
HOVERGENⁱ	HBG018013
InParanoidⁱ	P01602
OMAⁱ	INNYLSW
PhylomeDBⁱ	P01602

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P01602-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDMRVPAQLL GLLLLWLPGA KCDIQMTQSP STLSASVGDR VTITCRASQS 
        60         70         80         90        100
ISSWLAWYQQ KPGKAPKLLI YKASSLESGV PSRFSGSGSG TEFTLTISSL 
       110 
QPDDFATYYC QQYNSYS

Length:117

Mass (Da):12,782

Last modified:June 24, 2015 - v2

Checksum:ⁱ1BCDF3A40AFD9868

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	33 – 34	LS → QP AA sequence (PubMed:112021).Curated	2
Sequence conflictⁱ	42	T → A AA sequence (PubMed:4216454).Curated	1
Sequence conflictⁱ	50	S → N AA sequence (PubMed:4216454).Curated	1
Sequence conflictⁱ	52 – 53	SS → NI AA sequence (PubMed:112021).Curated	2
Sequence conflictⁱ	52 – 53	SS → NT AA sequence (PubMed:5489770).Curated	2
Sequence conflictⁱ	63	G → E AA sequence (PubMed:112021).Curated	1
Sequence conflictⁱ	68	L → V AA sequence (PubMed:4216454).Curated	1
Sequence conflictⁱ	70	I → M AA sequence (PubMed:5489770).Curated	1
Sequence conflictⁱ	73	A → S AA sequence (PubMed:4216454).Curated	1
Sequence conflictⁱ	75 – 78	SLES → TLET AA sequence (PubMed:112021).Curated	4
Sequence conflictⁱ	85	S → I AA sequence (PubMed:5489770).Curated	1
Sequence conflictⁱ	92	E → D AA sequence (PubMed:4216454).Curated	1
Sequence conflictⁱ	98	S → N AA sequence (PubMed:112021).Curated	1
Sequence conflictⁱ	114 – 117	NSYS → SRYP AA sequence (PubMed:112021).Curated	4
Sequence conflictⁱ	115 – 117	SYS → TFF AA sequence (PubMed:4216454).Curated	3
Sequence conflictⁱ	116	Y → D AA sequence (PubMed:5489770).Curated	1
Non-terminal residueⁱ	117		1

Polymorphismⁱ

There are several alleles. The sequence shown is that of IMGT allele IGKV1-5*03.

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_073349	72	K → D in IMGT allele IGKV1-5*01; requires 2 nucleotide substitutions. 2 Publications		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J00245 Genomic DNA Translation: AAA59087.1 Z00001 Genomic DNA Translation: CAA77292.1 AC243970 Genomic DNA No translation available.
PIRⁱ	A01864 K1HUAR A01870 K1HUKU A01882 K1HU12 A90562 K1HUEU
UniGeneⁱ	Hs.449609

Genome annotation databases

Ensemblⁱ	ENST00000496168; ENSP00000420436; ENSG00000243466 ENST00000632205; ENSP00000488639; ENSG00000282801
UCSC genome browser More...UCSCⁱ	uc061lqk.1 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

50% Identity

Protein	Similar proteins		Species	Score	Length
P01602	Immunoglobulin kappa variable 4-55 (Fragment)		MOUSE		117
Uncharacterized protein		PIG		118
UPI0008A09DC2		HUMAN		119
Uncharacterized protein		RHIRO		138
Uncharacterized protein		GORGO		118
+42

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	J00245 Genomic DNA Translation: AAA59087.1 Z00001 Genomic DNA Translation: CAA77292.1 AC243970 Genomic DNA No translation available.
PIRⁱ	A01864 K1HUAR A01870 K1HUKU A01882 K1HU12 A90562 K1HUEU
UniGeneⁱ	Hs.449609

3D structure databases

ProteinModelPortalⁱ	P01602
SMRⁱ	P01602
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P01602, 4 interactors

IntActⁱ

P01602, 4 interactors

Protein family/group databases

IMGT/GENE-DB	IGKV1-5

IMGT/GENE-DB

IGKV1-5

PTM databases

iPTMnetⁱ	P01602
PhosphoSitePlusⁱ	P01602

Polymorphism and mutation databases

DMDMⁱ	125760 125762 125766 125768

DMDMⁱ

125760
125762
125766
125768

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	P01602
PRIDEⁱ	P01602
ProteomicsDBⁱ	51398 51400 51404 51406

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000496168; ENSP00000420436; ENSG00000243466 ENST00000632205; ENSP00000488639; ENSG00000282801
UCSC genome browser More...UCSCⁱ	uc061lqk.1 human

Organism-specific databases

DisGeNET More...DisGeNETⁱ	28299
EuPathDBⁱ	HostDB:ENSG00000243466.1
GeneCardsⁱ	IGKV1-5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5741 IGKV1-5
neXtProtⁱ	NX_P01602
Open Targets More...OpenTargetsⁱ	ENSG00000243466
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148960
HOGENOMⁱ	HOG000059537
HOVERGENⁱ	HBG018013
InParanoidⁱ	P01602
OMAⁱ	INNYLSW
PhylomeDBⁱ	P01602

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166663 Initial triggering of complement R-HSA-173623 Classical antibody-mediated complement activation R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-2029481 FCGR activation R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485 Role of phospholipids in phagocytosis R-HSA-2168880 Scavenging of heme from plasma R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796 FCERI mediated MAPK activation R-HSA-2871809 FCERI mediated Ca+2 mobilization R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-5690714 CD22 mediated BCR regulation R-HSA-977606 Regulation of Complement cascade R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Reactomeⁱ

R-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-977606 Regulation of Complement cascade
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

ChiTaRSⁱ	IGKV1-5 human
Protein Ontology More...PROⁱ	PR:P01602

Gene expression databases

Bgeeⁱ	ENSG00000243466

Bgeeⁱ

ENSG00000243466

Family and domain databases

Gene3Dⁱ	2.60.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR013106 Ig_V-set
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 1 hit SM00406 IGv, 1 hit
SUPFAMⁱ	SSF48726 SSF48726, 1 hit
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KV105_HUMAN
Accessionⁱ	P01602Primary (citable) accession number: P01602 Secondary accession number(s): A0A075B6S8 , P01596, P01598, P01604
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	June 24, 2015
	Last modified:	June 20, 2018
	This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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UniProtKB - P01602 (KV105_HUMAN)

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Immunoglobulin kappa variable 1-5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Plasma membrane

Extracellular region or secreted

Plasma Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ