UniProtKB - P01602 (KV105_HUMAN)
Protein
Immunoglobulin kappa variable 1-5
Gene
IGKV1-5
Organism
Homo sapiens (Human)
Status
Functioni
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).4 Publications
Caution
For an example of a full-length immunoglobulin kappa light chain see AC P0DOX7.Curated
GO - Molecular functioni
- antigen binding Source: UniProtKB
GO - Biological processi
- complement activation Source: Reactome
- complement activation, classical pathway Source: Reactome
- Fc-epsilon receptor signaling pathway Source: Reactome
- Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
- immune response Source: GO_Central
- immunoglobulin production Source: GO_Central
- leukocyte migration Source: Reactome
- receptor-mediated endocytosis Source: Reactome
- regulation of complement activation Source: Reactome
- regulation of immune response Source: Reactome
Keywordsi
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
PathwayCommonsi | P01602 |
Reactomei | R-HSA-166663, Initial triggering of complement R-HSA-173623, Classical antibody-mediated complement activation R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-2029481, FCGR activation R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485, Role of phospholipids in phagocytosis R-HSA-2168880, Scavenging of heme from plasma R-HSA-2454202, Fc epsilon receptor (FCERI) signaling R-HSA-2730905, Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796, FCERI mediated MAPK activation R-HSA-2871809, FCERI mediated Ca+2 mobilization R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-5690714, CD22 mediated BCR regulation R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-9664422, FCGR3A-mediated phagocytosis R-HSA-977606, Regulation of Complement cascade R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
Protein family/group databases
IMGT/GENE-DB | IGKV1-5 |
Names & Taxonomyi
Protein namesi | Recommended name: Immunoglobulin kappa variable 1-52 PublicationsAlternative name(s): Ig kappa chain V-I region CAR1 Publication Ig kappa chain V-I region EU1 Publication Ig kappa chain V-I region HK1021 Publication Ig kappa chain V-I region Kue1 Publication |
Gene namesi | Name:IGKV1-52 Publications |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000243466.1 |
HGNCi | HGNC:5741, IGKV1-5 |
neXtProti | NX_P01602 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications
Extracellular region or secreted
- Secreted 2 Publications
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- immunoglobulin complex Source: UniProtKB-KW
Keywords - Cellular componenti
Cell membrane, Immunoglobulin, Membrane, SecretedPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000243466 |
Miscellaneous databases
Pharosi | P01602, Tdark |
Polymorphism and mutation databases
BioMutai | IGKV1-5 |
DMDMi | 125760 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | 3 PublicationsAdd BLAST | 22 | |
ChainiPRO_0000015169 | 23 – 117 | Immunoglobulin kappa variable 1-53 PublicationsAdd BLAST | 95 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 45 ↔ 110 | PROSITE-ProRule annotation1 Publication |
Keywords - PTMi
Disulfide bondProteomic databases
jPOSTi | P01602 |
MassIVEi | P01602 |
PeptideAtlasi | P01602 |
PRIDEi | P01602 |
ProteomicsDBi | 51398 51400 51404 51406 |
PTM databases
GlyConnecti | 1388, 3 N-Linked glycans (1 site) 2049, 1 N-Linked glycan (1 site) |
iPTMneti | P01602 |
PhosphoSitePlusi | P01602 |
Expressioni
Gene expression databases
Bgeei | ENSG00000243466, Expressed in urinary bladder and 105 other tissues |
Interactioni
Subunit structurei
Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
1 PublicationProtein-protein interaction databases
IntActi | P01602, 7 interactors |
Miscellaneous databases
RNActi | P01602, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – ›117 | Ig-likePROSITE-ProRule annotationAdd BLAST | ›94 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 23 – 45 | Framework-11 PublicationAdd BLAST | 23 | |
Regioni | 46 – 56 | Complementarity-determining-11 PublicationAdd BLAST | 11 | |
Regioni | 57 – 71 | Framework-21 PublicationAdd BLAST | 15 | |
Regioni | 72 – 78 | Complementarity-determining-21 Publication | 7 | |
Regioni | 79 – 110 | Framework-31 PublicationAdd BLAST | 32 | |
Regioni | 111 – ›117 | Complementarity-determining-31 Publication | ›7 |
Keywords - Domaini
Immunoglobulin domain, SignalPhylogenomic databases
GeneTreei | ENSGT00940000153048 |
InParanoidi | P01602 |
OMAi | IANYFCL |
PhylomeDBi | P01602 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P01602-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDMRVPAQLL GLLLLWLPGA KCDIQMTQSP STLSASVGDR VTITCRASQS
60 70 80 90 100
ISSWLAWYQQ KPGKAPKLLI YKASSLESGV PSRFSGSGSG TEFTLTISSL
110
QPDDFATYYC QQYNSYS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 33 – 34 | LS → QP AA sequence (PubMed:112021).Curated | 2 | |
Sequence conflicti | 42 | T → A AA sequence (PubMed:4216454).Curated | 1 | |
Sequence conflicti | 50 | S → N AA sequence (PubMed:4216454).Curated | 1 | |
Sequence conflicti | 52 – 53 | SS → NI AA sequence (PubMed:112021).Curated | 2 | |
Sequence conflicti | 52 – 53 | SS → NT AA sequence (PubMed:5489770).Curated | 2 | |
Sequence conflicti | 63 | G → E AA sequence (PubMed:112021).Curated | 1 | |
Sequence conflicti | 68 | L → V AA sequence (PubMed:4216454).Curated | 1 | |
Sequence conflicti | 70 | I → M AA sequence (PubMed:5489770).Curated | 1 | |
Sequence conflicti | 73 | A → S AA sequence (PubMed:4216454).Curated | 1 | |
Sequence conflicti | 75 – 78 | SLES → TLET AA sequence (PubMed:112021).Curated | 4 | |
Sequence conflicti | 85 | S → I AA sequence (PubMed:5489770).Curated | 1 | |
Sequence conflicti | 92 | E → D AA sequence (PubMed:4216454).Curated | 1 | |
Sequence conflicti | 98 | S → N AA sequence (PubMed:112021).Curated | 1 | |
Sequence conflicti | 114 – 117 | NSYS → SRYP AA sequence (PubMed:112021).Curated | 4 | |
Sequence conflicti | 115 – 117 | SYS → TFF AA sequence (PubMed:4216454).Curated | 3 | |
Sequence conflicti | 116 | Y → D AA sequence (PubMed:5489770).Curated | 1 | |
Non-terminal residuei | 117 | 1 |
Polymorphismi
There are several alleles. The sequence shown is that of IMGT allele IGKV1-5*03.
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073349 | 72 | K → D in IMGT allele IGKV1-5*01; requires 2 nucleotide substitutions. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J00245 Genomic DNA Translation: AAA59087.1 Z00001 Genomic DNA Translation: CAA77292.1 AC243970 Genomic DNA No translation available. |
PIRi | A01864, K1HUAR A01870, K1HUKU A01882, K1HU12 A90562, K1HUEU |
Genome annotation databases
Ensembli | ENST00000496168; ENSP00000420436; ENSG00000243466 ENST00000632205; ENSP00000488639; ENSG00000282801 |
UCSCi | uc061lqk.1, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | J00245 Genomic DNA Translation: AAA59087.1 Z00001 Genomic DNA Translation: CAA77292.1 AC243970 Genomic DNA No translation available. |
PIRi | A01864, K1HUAR A01870, K1HUKU A01882, K1HU12 A90562, K1HUEU |
3D structure databases
SMRi | P01602 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P01602, 7 interactors |
Protein family/group databases
IMGT/GENE-DB | IGKV1-5 |
PTM databases
GlyConnecti | 1388, 3 N-Linked glycans (1 site) 2049, 1 N-Linked glycan (1 site) |
iPTMneti | P01602 |
PhosphoSitePlusi | P01602 |
Polymorphism and mutation databases
BioMutai | IGKV1-5 |
DMDMi | 125760 |
Proteomic databases
jPOSTi | P01602 |
MassIVEi | P01602 |
PeptideAtlasi | P01602 |
PRIDEi | P01602 |
ProteomicsDBi | 51398 51400 51404 51406 |
Genome annotation databases
Ensembli | ENST00000496168; ENSP00000420436; ENSG00000243466 ENST00000632205; ENSP00000488639; ENSG00000282801 |
UCSCi | uc061lqk.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000243466.1 |
GeneCardsi | IGKV1-5 |
HGNCi | HGNC:5741, IGKV1-5 |
neXtProti | NX_P01602 |
OpenTargetsi | ENSG00000243466 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000153048 |
InParanoidi | P01602 |
OMAi | IANYFCL |
PhylomeDBi | P01602 |
Enzyme and pathway databases
PathwayCommonsi | P01602 |
Reactomei | R-HSA-166663, Initial triggering of complement R-HSA-173623, Classical antibody-mediated complement activation R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-2029481, FCGR activation R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485, Role of phospholipids in phagocytosis R-HSA-2168880, Scavenging of heme from plasma R-HSA-2454202, Fc epsilon receptor (FCERI) signaling R-HSA-2730905, Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796, FCERI mediated MAPK activation R-HSA-2871809, FCERI mediated Ca+2 mobilization R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-5690714, CD22 mediated BCR regulation R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-9664422, FCGR3A-mediated phagocytosis R-HSA-977606, Regulation of Complement cascade R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
Miscellaneous databases
ChiTaRSi | IGKV1-5, human |
Pharosi | P01602, Tdark |
PROi | PR:P01602 |
RNActi | P01602, protein |
Gene expression databases
Bgeei | ENSG00000243466, Expressed in urinary bladder and 105 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KV105_HUMAN | |
Accessioni | P01602Primary (citable) accession number: P01602 Secondary accession number(s): A0A075B6S8 P01604 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | June 24, 2015 | |
Last modified: | December 2, 2020 | |
This is version 151 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations