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Protein

Immunoglobulin kappa variable 1D-16

Gene

IGKV1D-16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).4 Publications

Caution

For an example of a full-length immunoglobulin kappa light chain see AC P0DOX7.Curated

GO - Molecular functioni

  • antigen binding Source: UniProtKB
  • serine-type endopeptidase activity Source: Reactome

GO - Biological processi

Keywordsi

Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-977606 Regulation of Complement cascade
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Protein family/group databases

IMGT/GENE-DBIGKV1D-16

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin kappa variable 1D-162 Publications
Alternative name(s):
Ig kappa chain V-I region HK1461 Publication
Ig kappa chain V-I region HK1891 Publication
Gene namesi
Name:IGKV1D-162 Publications
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000241244.1
HGNCiHGNC:5748 IGKV1D-16
neXtProtiNX_P01601

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000241244

Polymorphism and mutation databases

DMDMi125765

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001516823 – 117Immunoglobulin kappa variable 1D-16Sequence analysisAdd BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 110PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PeptideAtlasiP01601
PRIDEiP01601
ProteomicsDBi51403

PTM databases

iPTMnetiP01601
PhosphoSitePlusiP01601

Expressioni

Gene expression databases

BgeeiENSG00000241244 Expressed in 70 organ(s), highest expression level in lymph node

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP01601
SMRiP01601
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – ›117Ig-likePROSITE-ProRule annotationAdd BLAST›94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 45Framework-11 PublicationAdd BLAST23
Regioni46 – 56Complementarity-determining-11 PublicationAdd BLAST11
Regioni57 – 71Framework-21 PublicationAdd BLAST15
Regioni72 – 78Complementarity-determining-21 Publication7
Regioni79 – 110Framework-31 PublicationAdd BLAST32
Regioni111 – ›117Complementarity-determining-31 Publication›7

Keywords - Domaini

Immunoglobulin domain, Immunoglobulin V region, Signal

Phylogenomic databases

GeneTreeiENSGT00920000148960
HOGENOMiHOG000059537
HOVERGENiHBG018013
OMAiCRSSEDI
PhylomeDBiP01601

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01601-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDMRVLAQLL GLLLLCFPGA RCDIQMTQSP SSLSASVGDR VTITCRASQG
60 70 80 90 100
ISSWLAWYQQ KPEKAPKSLI YAASSLQSGV PSRFSGSGSG TDFTLTISSL
110
QPEDFATYYC QQYNSYP
Length:117
Mass (Da):12,730
Last modified:June 24, 2015 - v2
Checksum:iD694BA3718CF4437
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1171

Polymorphismi

There are several alleles. The sequence shown is that of IMGT allele IGKV1D-16*01.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07337648S → R in IMGT allele IGKV1D-16*02. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00558 Genomic DNA Translation: CAA23824.1
K01322 Genomic DNA Translation: AAA58930.1
K01324 Genomic DNA Translation: AAA58932.1
AC243981 Genomic DNA No translation available.
PIRiA01881 K1HU11
UniGeneiHs.449609

Genome annotation databases

EnsembliENST00000492446; ENSP00000418200; ENSG00000241244

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00558 Genomic DNA Translation: CAA23824.1
K01322 Genomic DNA Translation: AAA58930.1
K01324 Genomic DNA Translation: AAA58932.1
AC243981 Genomic DNA No translation available.
PIRiA01881 K1HU11
UniGeneiHs.449609

3D structure databases

ProteinModelPortaliP01601
SMRiP01601
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

IMGT/GENE-DBIGKV1D-16

PTM databases

iPTMnetiP01601
PhosphoSitePlusiP01601

Polymorphism and mutation databases

DMDMi125765

Proteomic databases

PeptideAtlasiP01601
PRIDEiP01601
ProteomicsDBi51403

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000492446; ENSP00000418200; ENSG00000241244

Organism-specific databases

EuPathDBiHostDB:ENSG00000241244.1
GeneCardsiIGKV1D-16
H-InvDBiHIX0114302
HGNCiHGNC:5748 IGKV1D-16
neXtProtiNX_P01601
OpenTargetsiENSG00000241244
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00920000148960
HOGENOMiHOG000059537
HOVERGENiHBG018013
OMAiCRSSEDI
PhylomeDBiP01601

Enzyme and pathway databases

ReactomeiR-HSA-166663 Initial triggering of complement
R-HSA-173623 Classical antibody-mediated complement activation
R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2029481 FCGR activation
R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-HSA-2029485 Role of phospholipids in phagocytosis
R-HSA-2168880 Scavenging of heme from plasma
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-2871796 FCERI mediated MAPK activation
R-HSA-2871809 FCERI mediated Ca+2 mobilization
R-HSA-2871837 FCERI mediated NF-kB activation
R-HSA-5690714 CD22 mediated BCR regulation
R-HSA-977606 Regulation of Complement cascade
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Miscellaneous databases

PROiPR:P01601

Gene expression databases

BgeeiENSG00000241244 Expressed in 70 organ(s), highest expression level in lymph node

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00406 IGv, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKVD16_HUMAN
AccessioniPrimary (citable) accession number: P01601
Secondary accession number(s): A0A0B4J1Z3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: June 24, 2015
Last modified: November 7, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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Main funding by: National Institutes of Health

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