UniProtKB - P01593 (KVD33_HUMAN)
Protein
Immunoglobulin kappa variable 1D-33
Gene
IGKV1D-33
Organism
Homo sapiens (Human)
Status
Functioni
V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:20176268, PubMed:17576170).4 Publications
Caution
For an example of a full-length immunoglobulin kappa light chain see AC P0DOX7.Curated
GO - Molecular functioni
- antigen binding Source: UniProtKB
GO - Biological processi
- complement activation Source: Reactome
- complement activation, classical pathway Source: Reactome
- Fc-epsilon receptor signaling pathway Source: Reactome
- Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
- immune response Source: GO_Central
- immunoglobulin production Source: GO_Central
- leukocyte migration Source: Reactome
- receptor-mediated endocytosis Source: Reactome
- regulation of complement activation Source: Reactome
- regulation of immune response Source: Reactome
Keywordsi
Biological process | Adaptive immunity, Immunity |
Enzyme and pathway databases
PathwayCommonsi | P01593 |
Reactomei | R-HSA-166663, Initial triggering of complement R-HSA-173623, Classical antibody-mediated complement activation R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-2029481, FCGR activation R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485, Role of phospholipids in phagocytosis R-HSA-2168880, Scavenging of heme from plasma R-HSA-2454202, Fc epsilon receptor (FCERI) signaling R-HSA-2730905, Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796, FCERI mediated MAPK activation R-HSA-2871809, FCERI mediated Ca+2 mobilization R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-5690714, CD22 mediated BCR regulation R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-9664422, FCGR3A-mediated phagocytosis R-HSA-977606, Regulation of Complement cascade R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
Protein family/group databases
IMGT/GENE-DB | IGKV1D-33 |
Names & Taxonomyi
Protein namesi | Recommended name: Immunoglobulin kappa variable 1D-332 PublicationsAlternative name(s): Ig kappa chain V-I region AG1 Publication Ig kappa chain V-I region Bi1 Publication Ig kappa chain V-I region Lay2 Publications Ig kappa chain V-I region Ni1 Publication Ig kappa chain V-I region Rei1 Publication Ig kappa chain V-I region Roy1 Publication Ig kappa chain V-I region Scw1 Publication Ig kappa chain V-I region WAT2 Publications |
Gene namesi | Name:IGKV1D-332 Publications |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000239975.2 HostDB:ENSG00000242076.2 |
HGNCi | HGNC:5753, IGKV1D-33 |
neXtProti | NX_P01593 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications
Extracellular region or secreted
- Secreted 2 Publications
Extracellular region or secreted
- blood microparticle Source: UniProtKB
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Plasma Membrane
- plasma membrane Source: Reactome
Other locations
- immunoglobulin complex Source: UniProtKB-KW
Keywords - Cellular componenti
Cell membrane, Immunoglobulin, Membrane, SecretedPathology & Biotechi
Miscellaneous databases
Pharosi | P01593, Tdark |
Chemistry databases
DrugBanki | DB04147, Dodecyldimethylamine N-oxide |
Polymorphism and mutation databases
BioMutai | IGKV1D-33 |
DMDMi | 125759 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | 10 PublicationsAdd BLAST | 22 | |
ChainiPRO_0000059737 | 23 – 117 | Immunoglobulin kappa variable 1D-339 PublicationsAdd BLAST | 95 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 45 ↔ 110 | PROSITE-ProRule annotation1 Publication |
Keywords - PTMi
Disulfide bondProteomic databases
jPOSTi | P01593 |
MassIVEi | P01593 |
PeptideAtlasi | P01593 |
PRIDEi | P01593 |
ProteomicsDBi | 51395 51397 51407 51409 51410 51411 51415 57679 |
PTM databases
GlyGeni | P01593, 2 sites, 1 O-linked glycan (2 sites) |
Expressioni
Gene expression databases
Bgeei | ENSG00000239975, Expressed in lymph node and 85 other tissues |
ExpressionAtlasi | P01593, baseline and differential |
Interactioni
Subunit structurei
Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.
1 PublicationProtein-protein interaction databases
IntActi | P01593, 3 interactors |
Miscellaneous databases
RNActi | P01593, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P01593 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – ›117 | Ig-likePROSITE-ProRule annotationAdd BLAST | ›94 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 23 – 45 | Framework-1Add BLAST | 23 | |
Regioni | 46 – 56 | Complementarity-determining-1Add BLAST | 11 | |
Regioni | 57 – 71 | Framework-2Add BLAST | 15 | |
Regioni | 72 – 78 | Complementarity-determining-2 | 7 | |
Regioni | 79 – 110 | Framework-3Add BLAST | 32 | |
Regioni | 111 – 117 | Complementarity-determining-3 | 7 |
Keywords - Domaini
Immunoglobulin domain, SignalPhylogenomic databases
OMAi | YLQSGIP |
PhylomeDBi | P01593 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P01593-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDMRVPAQLL GLLLLWLSGA RCDIQMTQSP SSLSASVGDR VTITCQASQD
60 70 80 90 100
ISNYLNWYQQ KPGKAPKLLI YDASNLETGV PSRFSGSGSG TDFTFTISSL
110
QPEDIATYYC QQYDNLP
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2Q2TTZ9 | A0A2Q2TTZ9_HUMAN | Immunoglobulin kappa variable 1-33 | IGKV1D-33 IGKV1-33 | 108 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 32 | S → P AA sequence (PubMed:4563064).Curated | 1 | |
Sequence conflicti | 35 | A → V AA sequence (PubMed:824717).Curated | 1 | |
Sequence conflicti | 35 | A → V AA sequence (PubMed:2496160).Curated | 1 | |
Sequence conflicti | 36 | S → T AA sequence (PubMed:4709625).Curated | 1 | |
Sequence conflicti | 40 | R → S AA sequence (PubMed:4563064).Curated | 1 | |
Sequence conflicti | 43 – 46 | ITCQ → LLCE AA sequence (PubMed:4709625).Curated | 4 | |
Sequence conflicti | 46 | Q → R AA sequence (PubMed:7993911).Curated | 1 | |
Sequence conflicti | 46 | Q → R AA sequence (PubMed:6167731).Curated | 1 | |
Sequence conflicti | 50 – 56 | DISNYLN → SVLESGNTFLA AA sequence (PubMed:4709625).Curated | 7 | |
Sequence conflicti | 50 – 53 | DISN → NVNA AA sequence (PubMed:824717).Curated | 4 | |
Sequence conflicti | 50 – 53 | DISN → NVNA AA sequence (PubMed:2496160).Curated | 4 | |
Sequence conflicti | 52 – 56 | SNYLN → RNSLI AA sequence (PubMed:4563064).Curated | 5 | |
Sequence conflicti | 52 – 54 | SNY → RKH AA sequence (PubMed:4435756).Curated | 3 | |
Sequence conflicti | 52 – 53 | SN → IK AA sequence (PubMed:809329).Curated | 2 | |
Sequence conflicti | 52 – 53 | SN → NH AA sequence (PubMed:4893682).Curated | 2 | |
Sequence conflicti | 52 | S → T AA sequence (PubMed:7993911).Curated | 1 | |
Sequence conflicti | 52 | S → T AA sequence (PubMed:6167731).Curated | 1 | |
Sequence conflicti | 53 – 54 | NY → IF AA sequence (PubMed:5595110).Curated | 2 | |
Sequence conflicti | 53 | N → D AA sequence (PubMed:6167731).Curated | 1 | |
Sequence conflicti | 55 | L → V AA sequence (PubMed:7993911).Curated | 1 | |
Sequence conflicti | 55 | L → V AA sequence (PubMed:6167731).Curated | 1 | |
Sequence conflicti | 58 | Y → F AA sequence (PubMed:7993911).Curated | 1 | |
Sequence conflicti | 59 | Q → D AA sequence (PubMed:4435756).Curated | 1 | |
Sequence conflicti | 61 | K → G AA sequence (PubMed:4893682).Curated | 1 | |
Sequence conflicti | 61 | K → R AA sequence (PubMed:7993911).Curated | 1 | |
Sequence conflicti | 61 | K → T AA sequence (PubMed:809329).Curated | 1 | |
Sequence conflicti | 63 | G → K AA sequence (PubMed:4709625).Curated | 1 | |
Sequence conflicti | 63 | G → K AA sequence (PubMed:4893682).Curated | 1 | |
Sequence conflicti | 64 | K → L AA sequence (PubMed:824717).Curated | 1 | |
Sequence conflicti | 64 | K → L AA sequence (PubMed:2496160).Curated | 1 | |
Sequence conflicti | 64 | K → Q AA sequence (PubMed:7993911).Curated | 1 | |
Sequence conflicti | 67 | K → R AA sequence (PubMed:4435756).Curated | 1 | |
Sequence conflicti | 68 | L → F AA sequence (PubMed:4563064).Curated | 1 | |
Sequence conflicti | 68 | L → I AA sequence (PubMed:4893682).Curated | 1 | |
Sequence conflicti | 68 | L → V AA sequence (PubMed:7993911).Curated | 1 | |
Sequence conflicti | 72 | D → E AA sequence (PubMed:809329).Curated | 1 | |
Sequence conflicti | 72 | D → G AA sequence (PubMed:7993911).Curated | 1 | |
Sequence conflicti | 72 | D → G AA sequence (PubMed:4435756).Curated | 1 | |
Sequence conflicti | 72 | D → G AA sequence (PubMed:824717).Curated | 1 | |
Sequence conflicti | 72 | D → G AA sequence (PubMed:2496160).Curated | 1 | |
Sequence conflicti | 74 | S → E AA sequence (PubMed:4563064).Curated | 1 | |
Sequence conflicti | 75 | N → I AA sequence (PubMed:7993911).Curated | 1 | |
Sequence conflicti | 75 | N → K AA sequence (PubMed:5595110).Curated | 1 | |
Sequence conflicti | 75 | N → T AA sequence (PubMed:4435756).Curated | 1 | |
Sequence conflicti | 75 | N → T AA sequence (PubMed:824717).Curated | 1 | |
Sequence conflicti | 75 | N → T AA sequence (PubMed:2496160).Curated | 1 | |
Sequence conflicti | 76 | L → R AA sequence (PubMed:824717).Curated | 1 | |
Sequence conflicti | 76 | L → R AA sequence (PubMed:2496160).Curated | 1 | |
Sequence conflicti | 77 | E → Q AA sequence (PubMed:809329).Curated | 1 | |
Sequence conflicti | 78 | T → A AA sequence (PubMed:5595110).Curated | 1 | |
Sequence conflicti | 78 | T → A AA sequence (PubMed:824717).Curated | 1 | |
Sequence conflicti | 78 | T → A AA sequence (PubMed:2496160).Curated | 1 | |
Sequence conflicti | 78 | T → A AA sequence (PubMed:809329).Curated | 1 | |
Sequence conflicti | 78 | T → I AA sequence (PubMed:4563064).Curated | 1 | |
Sequence conflicti | 85 | S → R AA sequence (PubMed:4563064).Curated | 1 | |
Sequence conflicti | 86 | G → E AA sequence (PubMed:4709625).Curated | 1 | |
Sequence conflicti | 87 | S → T AA sequence (PubMed:5595110).Curated | 1 | |
Sequence conflicti | 89 | S → F AA sequence (PubMed:4893682).Curated | 1 | |
Sequence conflicti | 93 | F → Y AA sequence (PubMed:809329).Curated | 1 | |
Sequence conflicti | 94 – 96 | TFT → ALS AA sequence (PubMed:4563064).Curated | 3 | |
Sequence conflicti | 95 | F → L AA sequence (PubMed:4435756).Curated | 1 | |
Sequence conflicti | 99 | S → G AA sequence (PubMed:4893682).Curated | 1 | |
Sequence conflicti | 99 | S → G AA sequence (PubMed:4709625).Curated | 1 | |
Sequence conflicti | 99 | S → T AA sequence (PubMed:4435756).Curated | 1 | |
Sequence conflicti | 105 | I → F AA sequence (PubMed:4563064).Curated | 1 | |
Sequence conflicti | 105 | I → F AA sequence (PubMed:4709625).Curated | 1 | |
Sequence conflicti | 106 – 107 | AT → GN AA sequence (PubMed:4435756).Curated | 2 | |
Sequence conflicti | 107 | T → V AA sequence (PubMed:4709625).Curated | 1 | |
Sequence conflicti | 113 | Y → F AA sequence (PubMed:5595110).Curated | 1 | |
Sequence conflicti | 114 – 116 | DNL → NNW AA sequence (PubMed:824717).Curated | 3 | |
Sequence conflicti | 114 – 116 | DNL → NNW AA sequence (PubMed:2496160).Curated | 3 | |
Sequence conflicti | 114 – 115 | DN → QS AA sequence (PubMed:809329).Curated | 2 | |
Sequence conflicti | 114 | D → Y AA sequence (PubMed:4563064).Curated | 1 | |
Sequence conflicti | 115 | N → T AA sequence (PubMed:7993911).Curated | 1 | |
Sequence conflicti | 115 | N → T AA sequence (PubMed:4709625).Curated | 1 | |
Sequence conflicti | 115 | N → T AA sequence (PubMed:4893682).Curated | 1 | |
Sequence conflicti | 116 | L → V AA sequence (PubMed:4435756).Curated | 1 | |
Non-terminal residuei | 117 | 1 |
Polymorphismi
There are several alleles. The sequence shown is that of IMGT allele IGKV1D-33*01.
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC233264 Genomic DNA No translation available. |
PIRi | A01861, K1HUAG A01863, K1HUBI A01871, K1HULY A01875, K1HUSW A01880, K1HUNY A91638, K1HURY A91663, K1HURE |
Genome annotation databases
Ensembli | ENST00000390265; ENSP00000374800; ENSG00000239975 |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC233264 Genomic DNA No translation available. |
PIRi | A01861, K1HUAG A01863, K1HUBI A01871, K1HULY A01875, K1HUSW A01880, K1HUNY A91638, K1HURY A91663, K1HURE |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1AR2 | X-ray | 2.80 | A | 23-117 | [»] | |
1BWW | X-ray | 1.70 | A/B | 23-117 | [»] | |
1REI | X-ray | 2.00 | A/B | 23-117 | [»] | |
1WTL | X-ray | 1.90 | A/B | 23-117 | [»] | |
4L1H | X-ray | 1.68 | A | 23-117 | [»] | |
5XP1 | X-ray | 2.88 | A/B/C/D/E/F/G/H | 23-117 | [»] | |
SMRi | P01593 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P01593, 3 interactors |
Chemistry databases
DrugBanki | DB04147, Dodecyldimethylamine N-oxide |
Protein family/group databases
IMGT/GENE-DB | IGKV1D-33 |
PTM databases
GlyGeni | P01593, 2 sites, 1 O-linked glycan (2 sites) |
Polymorphism and mutation databases
BioMutai | IGKV1D-33 |
DMDMi | 125759 |
Proteomic databases
jPOSTi | P01593 |
MassIVEi | P01593 |
PeptideAtlasi | P01593 |
PRIDEi | P01593 |
ProteomicsDBi | 51395 51397 51407 51409 51410 51411 51415 57679 |
Genome annotation databases
Ensembli | ENST00000390265; ENSP00000374800; ENSG00000239975 |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000239975.2 HostDB:ENSG00000242076.2 |
GeneCardsi | IGKV1D-33 |
HGNCi | HGNC:5753, IGKV1D-33 |
neXtProti | NX_P01593 |
GenAtlasi | Search... |
Phylogenomic databases
OMAi | YLQSGIP |
PhylomeDBi | P01593 |
Enzyme and pathway databases
PathwayCommonsi | P01593 |
Reactomei | R-HSA-166663, Initial triggering of complement R-HSA-173623, Classical antibody-mediated complement activation R-HSA-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733, Cell surface interactions at the vascular wall R-HSA-2029481, FCGR activation R-HSA-2029482, Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485, Role of phospholipids in phagocytosis R-HSA-2168880, Scavenging of heme from plasma R-HSA-2454202, Fc epsilon receptor (FCERI) signaling R-HSA-2730905, Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796, FCERI mediated MAPK activation R-HSA-2871809, FCERI mediated Ca+2 mobilization R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-5690714, CD22 mediated BCR regulation R-HSA-9664323, FCGR3A-mediated IL10 synthesis R-HSA-9664422, FCGR3A-mediated phagocytosis R-HSA-977606, Regulation of Complement cascade R-HSA-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
Miscellaneous databases
ChiTaRSi | IGKV1D-33, human |
Pharosi | P01593, Tdark |
PROi | PR:P01593 |
RNActi | P01593, protein |
Gene expression databases
Bgeei | ENSG00000239975, Expressed in lymph node and 85 other tissues |
ExpressionAtlasi | P01593, baseline and differential |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit SM00406, IGv, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KVD33_HUMAN | |
Accessioni | P01593Primary (citable) accession number: P01593 Secondary accession number(s): A0A0B4J1U0 P80362 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | November 2, 2016 | |
Last modified: | August 12, 2020 | |
This is version 125 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM