Jchain

Functionⁱ

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers. It also helps to bind these immunoglobulins to secretory component.

1 Publication

GO - Molecular functionⁱ

antigen binding
Source: MGI
Inferred from sequence or structural similarityⁱ
- Ref.1
  "Immunoglobulin J chain gene from the mouse."
  Matsuuchi L., Cann G.M., Koshland M.E.
  Proc. Natl. Acad. Sci. U.S.A. 83:456-460(1986) [PubMed] [Europe PMC] [Abstract]
  Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
IgA binding
Source: UniProtKB
Inferred from direct assayⁱ
- "Secretory antibody formation: conserved binding interactions between J chain and polymeric Ig receptor from humans and amphibians."
  Braathen R., Hohman V.S., Brandtzaeg P., Johansen F.E.
  J Immunol 178:1589-1597(2007) [PubMed] [Europe PMC] [Abstract]
immunoglobulin receptor binding Source: Ensembl
peptidoglycan binding Source: Ensembl
phosphatidylcholine binding Source: Ensembl
protein homodimerization activity Source: MGI
protein-macromolecule adaptor activity
Source: GO_Central
Inferred from direct assayⁱ
- "Secretory antibody formation: conserved binding interactions between J chain and polymeric Ig receptor from humans and amphibians."
  Braathen R., Hohman V.S., Brandtzaeg P., Johansen F.E.
  J Immunol 178:1589-1597(2007) [PubMed] [Europe PMC] [Abstract]
single-stranded DNA binding Source: Ensembl

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-202733, Cell surface interactions at the vascular wall R-MMU-2168880, Scavenging of heme from plasma

Reactomeⁱ

R-MMU-202733, Cell surface interactions at the vascular wall
R-MMU-2168880, Scavenging of heme from plasma

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Immunoglobulin J chainImported
Gene namesⁱ	Name:JchainImported Synonyms:Igj
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:96493, Jchain
VEuPathDBⁱ	HostDB:ENSMUSG00000067149

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	Add BLAST		21
ChainⁱPRO_0000021486	22 – 159	Immunoglobulin J chainAdd BLAST		138

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	34 ↔ 123	By similarity
Disulfide bondⁱ	36	Interchain (with heavy chain)By similarity
Glycosylationⁱ	70	N-linked (GlcNAc...) (complex) asparagineBy similarity	1
Disulfide bondⁱ	90	Interchain (with heavy chain)By similarity
Disulfide bondⁱ	93 ↔ 113	By similarity
Disulfide bondⁱ	131 ↔ 156	By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal More...CPTACⁱ	non-CPTAC-3651 non-CPTAC-3920
EPDⁱ	P01592
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P01592
PaxDbⁱ	P01592
PeptideAtlas More...PeptideAtlasⁱ	P01592
PRIDEⁱ	P01592
ProteomicsDBⁱ	269385

PTM databases

GlyConnectⁱ	694, 2 N-Linked glycans (1 site)
GlyGenⁱ	P01592, 1 site, 4 N-linked glycans (1 site)
iPTMnetⁱ	P01592
PhosphoSitePlusⁱ	P01592

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000067149, Expressed in spleen and 153 other tissues
Genevisibleⁱ	P01592, MM

Interactionⁱ

Subunit structureⁱ

Part of the secretory IgA (sIgA) complex that consists of two, four or five IgA monomers, and two additional non-Ig polypeptides, namely the JCHAIN and the secretory component (the proteoytic product of PIGR).

By similarity

GO - Molecular functionⁱ

immunoglobulin receptor binding Source: Ensembl
protein homodimerization activity Source: MGI

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	200579, 1 interactor
IntActⁱ	P01592, 1 interactor
Molecular INTeraction database More...MINTⁱ	P01592
STRINGⁱ	10090.ENSMUSP00000084259

Miscellaneous databases

RNActⁱ	P01592, protein

RNActⁱ

P01592, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	27 – 30	Combined sources	4
Turnⁱ	33 – 36	Combined sources	4
Beta strandⁱ	37 – 45	Combined sources	9
Beta strandⁱ	53 – 66	Combined sources	14
Beta strandⁱ	74 – 76	Combined sources	3
Beta strandⁱ	81 – 85	Combined sources	5
Helixⁱ	86 – 89	Combined sources	4
Beta strandⁱ	96 – 100	Combined sources	5
Beta strandⁱ	103 – 108	Combined sources	6
Beta strandⁱ	125 – 127	Combined sources	3
Beta strandⁱ	133 – 140	Combined sources	8
Beta strandⁱ	143 – 152	Combined sources	10
Beta strandⁱ	153 – 155	Combined sources	3

Show more details

3D structure databases

SMRⁱ	P01592
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Family & Domainsⁱ

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG502RZF4, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012791
HOGENOMⁱ	CLU_1651635_0_0_1
InParanoidⁱ	P01592
OMAⁱ	YTNRVPL
Database of Orthologous Groups More...OrthoDBⁱ	1400263at2759
PhylomeDBⁱ	P01592
TreeFamⁱ	TF335878

Family and domain databases

InterProⁱ	View protein in InterPro IPR024110, Ig_J
PANTHERⁱ	PTHR10070, PTHR10070, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15097, Ig_J_chain, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P01592-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKTHLLLWGV LAIFVKAVLV TGDDEATILA DNKCMCTRVT SRIIPSTEDP 
        60         70         80         90        100
NEDIVERNIR IVVPLNNREN ISDPTSPLRR NFVYHLSDVC KKCDPVEVEL 
       110        120        130        140        150
EDQVVTATQS NICNEDDGVP ETCYMYDRNK CYTTMVPLRY HGETKMVQAA 

LTPDSCYPD

Length:159

Mass (Da):18,014

Last modified:February 1, 2005 - v4

Checksum:ⁱB75269C634470384

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	17	A → V in AAA38674 (PubMed:3079912).Curated	1
Sequence conflictⁱ	42	R → K in AAA38674 (PubMed:3079912).Curated	1
Sequence conflictⁱ	89	V → L in AAA38673 (PubMed:6815655).Curated	1
Sequence conflictⁱ	138 – 139	LR → PG in AAA38673 (PubMed:6815655).Curated	2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M12557, M12555, M12556 Genomic DNA Translation: AAA38674.1 J00544 mRNA Translation: AAA38673.1 Sequence problems. M90766 mRNA Translation: AAA37918.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19401.1
PIRⁱ	A25963, JIMS
NCBI Reference Sequences More...RefSeqⁱ	NP_690052.2, NM_152839.3

Genome annotation databases

Ensemblⁱ	ENSMUST00000087033; ENSMUSP00000084259; ENSMUSG00000067149
GeneIDⁱ	16069
KEGGⁱ	mmu:16069
UCSC genome browser More...UCSCⁱ	uc008xzu.2, mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01592	immunoglobulin J chain		MUSCR		159	UniRef90_P01592
+3

Protein	Similar proteins		Species	Score	Length	Source
P01592	Immunoglobulin J chain		RABIT		136	UniRef50_P01592
immunoglobulin J chain		MUSCR		159
IGJ protein (Fragment)		Eurystomus gularis		142
IGJ protein (Fragment)		SULDA		142
IGJ protein (Fragment)		ANHAN		152
+408

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M12557, M12555, M12556 Genomic DNA Translation: AAA38674.1 J00544 mRNA Translation: AAA38673.1 Sequence problems. M90766 mRNA Translation: AAA37918.1
CCDSⁱ	CCDS19401.1
PIRⁱ	A25963, JIMS
RefSeqⁱ	NP_690052.2, NM_152839.3

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	7JG1	electron microscopy	3.30	J	23-159	[»]
	7JG2	electron microscopy	3.30	J	23-159	[»]
SMRⁱ	P01592
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	200579, 1 interactor
IntActⁱ	P01592, 1 interactor
MINTⁱ	P01592
STRINGⁱ	10090.ENSMUSP00000084259

PTM databases

GlyConnectⁱ	694, 2 N-Linked glycans (1 site)
GlyGenⁱ	P01592, 1 site, 4 N-linked glycans (1 site)
iPTMnetⁱ	P01592
PhosphoSitePlusⁱ	P01592

Proteomic databases

CPTACⁱ	non-CPTAC-3651 non-CPTAC-3920
EPDⁱ	P01592
MaxQBⁱ	P01592
PaxDbⁱ	P01592
PeptideAtlasⁱ	P01592
PRIDEⁱ	P01592
ProteomicsDBⁱ	269385

Protocols and materials databases

Antibodypediaⁱ	12875, 343 antibodies
The DNASU plasmid repository More...DNASUⁱ	16069

Genome annotation databases

Ensemblⁱ	ENSMUST00000087033; ENSMUSP00000084259; ENSMUSG00000067149
GeneIDⁱ	16069
KEGGⁱ	mmu:16069
UCSCⁱ	uc008xzu.2, mouse

Organism-specific databases

CTDⁱ	3512
MGIⁱ	MGI:96493, Jchain
VEuPathDBⁱ	HostDB:ENSMUSG00000067149

Phylogenomic databases

eggNOGⁱ	ENOG502RZF4, Eukaryota
GeneTreeⁱ	ENSGT00390000012791
HOGENOMⁱ	CLU_1651635_0_0_1
InParanoidⁱ	P01592
OMAⁱ	YTNRVPL
OrthoDBⁱ	1400263at2759
PhylomeDBⁱ	P01592
TreeFamⁱ	TF335878

Enzyme and pathway databases

Reactomeⁱ	R-MMU-202733, Cell surface interactions at the vascular wall R-MMU-2168880, Scavenging of heme from plasma

Reactomeⁱ

R-MMU-202733, Cell surface interactions at the vascular wall
R-MMU-2168880, Scavenging of heme from plasma

Miscellaneous databases

BioGRID-ORCSⁱ	16069, 0 hits in 61 CRISPR screens
ChiTaRSⁱ	Jchain, mouse
Protein Ontology More...PROⁱ	PR:P01592
RNActⁱ	P01592, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000067149, Expressed in spleen and 153 other tissues
Genevisibleⁱ	P01592, MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR024110, Ig_J
PANTHERⁱ	PTHR10070, PTHR10070, 1 hit
Pfamⁱ	View protein in Pfam PF15097, Ig_J_chain, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IGJ_MOUSE
Accessionⁱ	P01592Primary (citable) accession number: P01592
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	February 1, 2005
	Last modified:	September 29, 2021
	This is version 136 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P01592 (IGJ_MOUSE)

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Immunoglobulin J chain

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ