UniProtKB - P01592 (IGJ_MOUSE)
Protein
Immunoglobulin J chain
Gene
Jchain
Organism
Mus musculus (Mouse)
Status
Functioni
Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces dimers and/or larger polymers. It also helps to bind these immunoglobulins to secretory component.1 Publication
GO - Molecular functioni
- antigen binding Source: MGI
- IgA binding Source: UniProtKB
- immunoglobulin receptor binding Source: Ensembl
- peptidoglycan binding Source: Ensembl
- phosphatidylcholine binding Source: Ensembl
- protein homodimerization activity Source: MGI
- protein-macromolecule adaptor activity Source: GO_Central
- single-stranded DNA binding Source: Ensembl
GO - Biological processi
- adaptive immune response Source: MGI
- antibacterial humoral response Source: MGI
- glomerular filtration Source: MGI
- humoral immune response Source: MGI
- innate immune response Source: MGI
- positive regulation of respiratory burst Source: MGI
- protein-containing complex assembly Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-202733, Cell surface interactions at the vascular wall R-MMU-2168880, Scavenging of heme from plasma |
Names & Taxonomyi
Protein namesi | Recommended name: Immunoglobulin J chainImported |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96493, Jchain |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- dimeric IgA immunoglobulin complex Source: UniProtKB
- extracellular space Source: MGI
- monomeric IgA immunoglobulin complex Source: MGI
- pentameric IgM immunoglobulin complex Source: MGI
- secretory dimeric IgA immunoglobulin complex Source: MGI
- secretory IgA immunoglobulin complex Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Add BLAST | 21 | |
ChainiPRO_0000021486 | 22 – 159 | Immunoglobulin J chainAdd BLAST | 138 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 34 ↔ 123 | By similarity | ||
Disulfide bondi | 36 | Interchain (with heavy chain)By similarity | ||
Glycosylationi | 70 | N-linked (GlcNAc...) (complex) asparagineBy similarity | 1 | |
Disulfide bondi | 90 | Interchain (with heavy chain)By similarity | ||
Disulfide bondi | 93 ↔ 113 | By similarity | ||
Disulfide bondi | 131 ↔ 156 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
CPTACi | non-CPTAC-3651 non-CPTAC-3920 |
EPDi | P01592 |
MaxQBi | P01592 |
PaxDbi | P01592 |
PeptideAtlasi | P01592 |
PRIDEi | P01592 |
PTM databases
GlyConnecti | 694, 2 N-Linked glycans (1 site) |
GlyGeni | P01592, 1 site, 2 N-linked glycans (1 site) |
iPTMneti | P01592 |
PhosphoSitePlusi | P01592 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000067149, Expressed in spleen and 143 other tissues |
Genevisiblei | P01592, MM |
Interactioni
Subunit structurei
Part of the secretory IgA (sIgA) complex that consists of two, four or five IgA monomers, and two additional non-Ig polypeptides, namely the JCHAIN and the secretory component (the proteoytic product of PIGR).
By similarityGO - Molecular functioni
- immunoglobulin receptor binding Source: Ensembl
- protein homodimerization activity Source: MGI
Protein-protein interaction databases
BioGRIDi | 200579, 1 interactor |
IntActi | P01592, 1 interactor |
STRINGi | 10090.ENSMUSP00000084259 |
Miscellaneous databases
RNActi | P01592, protein |
Family & Domainsi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502RZF4, Eukaryota |
GeneTreei | ENSGT00390000012791 |
HOGENOMi | CLU_1651635_0_0_1 |
InParanoidi | P01592 |
OMAi | PETCYTY |
OrthoDBi | 1400263at2759 |
PhylomeDBi | P01592 |
TreeFami | TF335878 |
Family and domain databases
InterProi | View protein in InterPro IPR024110, Ig_J |
PANTHERi | PTHR10070, PTHR10070, 1 hit |
Pfami | View protein in Pfam PF15097, Ig_J_chain, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P01592-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKTHLLLWGV LAIFVKAVLV TGDDEATILA DNKCMCTRVT SRIIPSTEDP
60 70 80 90 100
NEDIVERNIR IVVPLNNREN ISDPTSPLRR NFVYHLSDVC KKCDPVEVEL
110 120 130 140 150
EDQVVTATQS NICNEDDGVP ETCYMYDRNK CYTTMVPLRY HGETKMVQAA
LTPDSCYPD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 17 | A → V in AAA38674 (PubMed:3079912).Curated | 1 | |
Sequence conflicti | 42 | R → K in AAA38674 (PubMed:3079912).Curated | 1 | |
Sequence conflicti | 89 | V → L in AAA38673 (PubMed:6815655).Curated | 1 | |
Sequence conflicti | 138 – 139 | LR → PG in AAA38673 (PubMed:6815655).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M12557, M12555, M12556 Genomic DNA Translation: AAA38674.1 J00544 mRNA Translation: AAA38673.1 Sequence problems. M90766 mRNA Translation: AAA37918.1 |
CCDSi | CCDS19401.1 |
PIRi | A25963, JIMS |
RefSeqi | NP_690052.2, NM_152839.3 |
Genome annotation databases
Ensembli | ENSMUST00000087033; ENSMUSP00000084259; ENSMUSG00000067149 |
GeneIDi | 16069 |
KEGGi | mmu:16069 |
UCSCi | uc008xzu.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M12557, M12555, M12556 Genomic DNA Translation: AAA38674.1 J00544 mRNA Translation: AAA38673.1 Sequence problems. M90766 mRNA Translation: AAA37918.1 |
CCDSi | CCDS19401.1 |
PIRi | A25963, JIMS |
RefSeqi | NP_690052.2, NM_152839.3 |
3D structure databases
SMRi | P01592 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200579, 1 interactor |
IntActi | P01592, 1 interactor |
STRINGi | 10090.ENSMUSP00000084259 |
PTM databases
GlyConnecti | 694, 2 N-Linked glycans (1 site) |
GlyGeni | P01592, 1 site, 2 N-linked glycans (1 site) |
iPTMneti | P01592 |
PhosphoSitePlusi | P01592 |
Proteomic databases
CPTACi | non-CPTAC-3651 non-CPTAC-3920 |
EPDi | P01592 |
MaxQBi | P01592 |
PaxDbi | P01592 |
PeptideAtlasi | P01592 |
PRIDEi | P01592 |
Protocols and materials databases
Antibodypediai | 12875, 338 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000087033; ENSMUSP00000084259; ENSMUSG00000067149 |
GeneIDi | 16069 |
KEGGi | mmu:16069 |
UCSCi | uc008xzu.2, mouse |
Organism-specific databases
CTDi | 3512 |
MGIi | MGI:96493, Jchain |
Phylogenomic databases
eggNOGi | ENOG502RZF4, Eukaryota |
GeneTreei | ENSGT00390000012791 |
HOGENOMi | CLU_1651635_0_0_1 |
InParanoidi | P01592 |
OMAi | PETCYTY |
OrthoDBi | 1400263at2759 |
PhylomeDBi | P01592 |
TreeFami | TF335878 |
Enzyme and pathway databases
Reactomei | R-MMU-202733, Cell surface interactions at the vascular wall R-MMU-2168880, Scavenging of heme from plasma |
Miscellaneous databases
BioGRID-ORCSi | 16069, 0 hits in 17 CRISPR screens |
ChiTaRSi | Jchain, mouse |
PROi | PR:P01592 |
RNActi | P01592, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000067149, Expressed in spleen and 143 other tissues |
Genevisiblei | P01592, MM |
Family and domain databases
InterProi | View protein in InterPro IPR024110, Ig_J |
PANTHERi | PTHR10070, PTHR10070, 1 hit |
Pfami | View protein in Pfam PF15097, Ig_J_chain, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IGJ_MOUSE | |
Accessioni | P01592Primary (citable) accession number: P01592 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | February 1, 2005 | |
Last modified: | December 2, 2020 | |
This is version 132 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot