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Protein

Immunoglobulin J chain

Gene

Jchain

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.1 Publication

GO - Molecular functioni

  • antigen binding Source: MGI
  • IgA binding Source: UniProtKB
  • immunoglobulin receptor binding Source: Ensembl
  • peptidoglycan binding Source: Ensembl
  • phosphatidylcholine binding Source: Ensembl
  • protein binding, bridging Source: GO_Central
  • protein homodimerization activity Source: MGI
  • single-stranded DNA binding Source: Ensembl

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-2168880 Scavenging of heme from plasma

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin J chainImported
Gene namesi
Name:JchainImported
Synonyms:Igj
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:96493 Jchain

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000002148622 – 159Immunoglobulin J chainAdd BLAST138

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 123By similarity
Disulfide bondi36Interchain (with heavy chain)By similarity
Glycosylationi70N-linked (GlcNAc...) (complex) asparagineBy similarity1
Disulfide bondi90Interchain (with heavy chain)By similarity
Disulfide bondi93 ↔ 113By similarity
Disulfide bondi131 ↔ 156By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP01592
MaxQBiP01592
PaxDbiP01592
PeptideAtlasiP01592
PRIDEiP01592

PTM databases

GlyConnecti694
iPTMnetiP01592
PhosphoSitePlusiP01592

Expressioni

Gene expression databases

BgeeiENSMUSG00000067149
CleanExiMM_IGJ
GenevisibleiP01592 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200579, 1 interactor
STRINGi10090.ENSMUSP00000084259

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYAZ Eukaryota
ENOG410YX96 LUCA
GeneTreeiENSGT00390000012791
HOGENOMiHOG000113012
HOVERGENiHBG006138
InParanoidiP01592
OMAiKCYTNRV
OrthoDBiEOG091G0RP0
PhylomeDBiP01592
TreeFamiTF335878

Family and domain databases

InterProiView protein in InterPro
IPR024110 Ig_J
PANTHERiPTHR10070 PTHR10070, 1 hit
PfamiView protein in Pfam
PF15097 Ig_J_chain, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD021296 PD021296, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01592-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTHLLLWGV LAIFVKAVLV TGDDEATILA DNKCMCTRVT SRIIPSTEDP
60 70 80 90 100
NEDIVERNIR IVVPLNNREN ISDPTSPLRR NFVYHLSDVC KKCDPVEVEL
110 120 130 140 150
EDQVVTATQS NICNEDDGVP ETCYMYDRNK CYTTMVPLRY HGETKMVQAA

LTPDSCYPD
Length:159
Mass (Da):18,014
Last modified:February 1, 2005 - v4
Checksum:iB75269C634470384
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17A → V in AAA38674 (PubMed:3079912).Curated1
Sequence conflicti42R → K in AAA38674 (PubMed:3079912).Curated1
Sequence conflicti89V → L in AAA38673 (PubMed:6815655).Curated1
Sequence conflicti138 – 139LR → PG in AAA38673 (PubMed:6815655).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12557, M12555, M12556 Genomic DNA Translation: AAA38674.1
J00544 mRNA Translation: AAA38673.1 Sequence problems.
M90766 mRNA Translation: AAA37918.1
CCDSiCCDS19401.1
PIRiA25963 JIMS
RefSeqiNP_690052.2, NM_152839.3
UniGeneiMm.1192

Genome annotation databases

EnsembliENSMUST00000087033; ENSMUSP00000084259; ENSMUSG00000067149
GeneIDi16069
KEGGimmu:16069
UCSCiuc008xzu.2 mouse

Similar proteinsi

Entry informationi

Entry nameiIGJ_MOUSE
AccessioniPrimary (citable) accession number: P01592
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 1, 2005
Last modified: April 25, 2018
This is version 117 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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