Jchain

Functionⁱ

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.1 Publication

GO - Molecular functionⁱ

antigen binding
Source: MGI
Inferred from sequence or structural similarityⁱ
- 3079912
IgA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 17237408
immunoglobulin receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
peptidoglycan binding Source: Ensembl
phosphatidylcholine binding Source: Ensembl
protein binding, bridging
Source: GO_Central
Inferred from direct assayⁱ
- 17237408
protein homodimerization activity Source: MGI
single-stranded DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response Source: MGI
antibacterial humoral response Source: MGI
glomerular filtration Source: MGI
humoral immune response
Source: MGI
Inferred from sequence or structural similarityⁱ
- 3079912
innate immune response Source: MGI
positive regulation of protein oligomerization Source: MGI
positive regulation of respiratory burst Source: MGI

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactomeⁱ	R-MMU-202733 Cell surface interactions at the vascular wall R-MMU-2168880 Scavenging of heme from plasma

Reactomeⁱ

R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-2168880 Scavenging of heme from plasma

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Immunoglobulin J chainImported
Gene namesⁱ	Name:JchainImported Synonyms:Igj
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:96493 Jchain

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	Add BLAST		21
ChainⁱPRO_0000021486	22 – 159	Immunoglobulin J chainAdd BLAST		138

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	34 ↔ 123	By similarity
Disulfide bondⁱ	36	Interchain (with heavy chain)By similarity
Glycosylationⁱ	70	N-linked (GlcNAc...) (complex) asparagineBy similarity	1
Disulfide bondⁱ	90	Interchain (with heavy chain)By similarity
Disulfide bondⁱ	93 ↔ 113	By similarity
Disulfide bondⁱ	131 ↔ 156	By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	P01592
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P01592
PaxDbⁱ	P01592
PeptideAtlas More...PeptideAtlasⁱ	P01592
PRIDEⁱ	P01592

PTM databases

GlyConnectⁱ	694
iPTMnetⁱ	P01592
PhosphoSitePlusⁱ	P01592

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000067149 Expressed in 120 organ(s), highest expression level in spleen
CleanExⁱ	MM_IGJ
Genevisibleⁱ	P01592 MM

Interactionⁱ

GO - Molecular functionⁱ

immunoglobulin receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein binding, bridging
Source: GO_Central
Inferred from direct assayⁱ
- 17237408
protein homodimerization activity Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	200579, 1 interactor
STRINGⁱ	10090.ENSMUSP00000084259

Family & Domainsⁱ

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IYAZ Eukaryota ENOG410YX96 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012791
HOGENOMⁱ	HOG000113012
HOVERGENⁱ	HBG006138
InParanoidⁱ	P01592
OMAⁱ	KCYTNRV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0RP0
PhylomeDBⁱ	P01592
TreeFamⁱ	TF335878

Family and domain databases

InterProⁱ	View protein in InterPro IPR024110 Ig_J
PANTHERⁱ	PTHR10070 PTHR10070, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15097 Ig_J_chain, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD021296 PD021296, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P01592-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKTHLLLWGV LAIFVKAVLV TGDDEATILA DNKCMCTRVT SRIIPSTEDP 
        60         70         80         90        100
NEDIVERNIR IVVPLNNREN ISDPTSPLRR NFVYHLSDVC KKCDPVEVEL 
       110        120        130        140        150
EDQVVTATQS NICNEDDGVP ETCYMYDRNK CYTTMVPLRY HGETKMVQAA 

LTPDSCYPD

Length:159

Mass (Da):18,014

Last modified:February 1, 2005 - v4

Checksum:ⁱB75269C634470384

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	17	A → V in AAA38674 (PubMed:3079912).Curated	1
Sequence conflictⁱ	42	R → K in AAA38674 (PubMed:3079912).Curated	1
Sequence conflictⁱ	89	V → L in AAA38673 (PubMed:6815655).Curated	1
Sequence conflictⁱ	138 – 139	LR → PG in AAA38673 (PubMed:6815655).Curated	2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M12557, M12555, M12556 Genomic DNA Translation: AAA38674.1 J00544 mRNA Translation: AAA38673.1 Sequence problems. M90766 mRNA Translation: AAA37918.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19401.1
PIRⁱ	A25963 JIMS
NCBI Reference Sequences More...RefSeqⁱ	NP_690052.2, NM_152839.3
UniGeneⁱ	Mm.1192

Genome annotation databases

Ensemblⁱ	ENSMUST00000087033; ENSMUSP00000084259; ENSMUSG00000067149
GeneIDⁱ	16069
KEGGⁱ	mmu:16069
UCSC genome browser More...UCSCⁱ	uc008xzu.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01592	Uncharacterized protein		Daphnia magna		159	UniRef100_P01592

Protein	Similar proteins		Species	Score	Length	Source
P01592	Uncharacterized protein		Daphnia magna		159	UniRef90_P01592
UPI000A30DA01		MUSPA		160
UPI000A316695		MUSCR		159

Protein	Similar proteins		Species	Score	Length	Source
P01592	Immunoglobulin J chain		HUMAN		159	UniRef50_P01591
Uncharacterized protein		RHIRO		176
Uncharacterized protein		Cebus capucinus imitator		160
Joining chain of multimeric IgA and IgM		SAIBB		159
Uncharacterized protein		CALJA		159
+109

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M12557, M12555, M12556 Genomic DNA Translation: AAA38674.1 J00544 mRNA Translation: AAA38673.1 Sequence problems. M90766 mRNA Translation: AAA37918.1
CCDSⁱ	CCDS19401.1
PIRⁱ	A25963 JIMS
RefSeqⁱ	NP_690052.2, NM_152839.3
UniGeneⁱ	Mm.1192

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	200579, 1 interactor
STRINGⁱ	10090.ENSMUSP00000084259

PTM databases

GlyConnectⁱ	694
iPTMnetⁱ	P01592
PhosphoSitePlusⁱ	P01592

Proteomic databases

EPDⁱ	P01592
MaxQBⁱ	P01592
PaxDbⁱ	P01592
PeptideAtlasⁱ	P01592
PRIDEⁱ	P01592

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000087033; ENSMUSP00000084259; ENSMUSG00000067149
GeneIDⁱ	16069
KEGGⁱ	mmu:16069
UCSCⁱ	uc008xzu.2 mouse

Organism-specific databases

CTDⁱ	3512
MGIⁱ	MGI:96493 Jchain

Phylogenomic databases

eggNOGⁱ	ENOG410IYAZ Eukaryota ENOG410YX96 LUCA
GeneTreeⁱ	ENSGT00390000012791
HOGENOMⁱ	HOG000113012
HOVERGENⁱ	HBG006138
InParanoidⁱ	P01592
OMAⁱ	KCYTNRV
OrthoDBⁱ	EOG091G0RP0
PhylomeDBⁱ	P01592
TreeFamⁱ	TF335878

Enzyme and pathway databases

Reactomeⁱ	R-MMU-202733 Cell surface interactions at the vascular wall R-MMU-2168880 Scavenging of heme from plasma

Reactomeⁱ

R-MMU-202733 Cell surface interactions at the vascular wall
R-MMU-2168880 Scavenging of heme from plasma

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P01592
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000067149 Expressed in 120 organ(s), highest expression level in spleen
CleanExⁱ	MM_IGJ
Genevisibleⁱ	P01592 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR024110 Ig_J
PANTHERⁱ	PTHR10070 PTHR10070, 1 hit
Pfamⁱ	View protein in Pfam PF15097 Ig_J_chain, 1 hit
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD021296 PD021296, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IGJ_MOUSE
Accessionⁱ	P01592Primary (citable) accession number: P01592
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	February 1, 2005
	Last modified:	November 7, 2018
	This is version 119 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P01592 (IGJ_MOUSE)

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Immunoglobulin J chain

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ