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Protein

Immunoglobulin J chain

Gene

JCHAIN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.By similarity

GO - Molecular functioni

  • antigen binding Source: UniProtKB
  • IgA binding Source: UniProtKB
  • immunoglobulin receptor binding Source: GO_Central
  • protein binding, bridging Source: Ensembl
  • protein homodimerization activity Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2168880 Scavenging of heme from plasma

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin J chain
Alternative name(s):
Joining chain of multimeric IgA and IgMImported
Gene namesi
Name:JCHAINImported
Synonyms:IGCJ, IGJ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000132465.10
HGNCiHGNC:5713 JCHAIN
MIMi147790 gene
neXtProtiNX_P01591

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3512
OpenTargetsiENSG00000132465
PharmGKBiPA29733

Polymorphism and mutation databases

BioMutaiIGJ

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 221 PublicationAdd BLAST22
ChainiPRO_000008417423 – 159Immunoglobulin J chainAdd BLAST137

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23Pyrrolidone carboxylic acid2 Publications1
Disulfide bondi35 ↔ 1231 Publication
Disulfide bondi37Interchain (with heavy chain)1 Publication
GlycosylationiCAR_00016771N-linked (GlcNAc...) (complex) asparagine6 Publications1
Disulfide bondi91Interchain (with heavy chain)1 Publication
Disulfide bondi94 ↔ 1141 Publication
Disulfide bondi131 ↔ 1561 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP01591
MaxQBiP01591
PaxDbiP01591
PeptideAtlasiP01591
PRIDEiP01591
ProteomicsDBi51394

2D gel databases

SWISS-2DPAGEiP01591

PTM databases

GlyConnecti277
iPTMnetiP01591
PhosphoSitePlusiP01591
UniCarbKBiP01591

Expressioni

Gene expression databases

BgeeiENSG00000132465 Expressed in 169 organ(s), highest expression level in caecum
CleanExiHS_IGJ
ExpressionAtlasiP01591 baseline and differential
GenevisibleiP01591 HS

Organism-specific databases

HPAiCAB034436
HPA044132

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109732, 25 interactors
IntActiP01591, 4 interactors
MINTiP01591
STRINGi9606.ENSP00000254801

Structurei

3D structure databases

ProteinModelPortaliP01591
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYAZ Eukaryota
ENOG410YX96 LUCA
GeneTreeiENSGT00390000012791
HOGENOMiHOG000113012
HOVERGENiHBG006138
InParanoidiP01591
OMAiKCYTNRV
OrthoDBiEOG091G0RP0
PhylomeDBiP01591
TreeFamiTF335878

Family and domain databases

InterProiView protein in InterPro
IPR024110 Ig_J
PANTHERiPTHR10070 PTHR10070, 1 hit
PfamiView protein in Pfam
PF15097 Ig_J_chain, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD021296 PD021296, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P01591-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKNHLLFWGV LAVFIKAVHV KAQEDERIVL VDNKCKCARI TSRIIRSSED
60 70 80 90 100
PNEDIVERNI RIIVPLNNRE NISDPTSPLR TRFVYHLSDL CKKCDPTEVE
110 120 130 140 150
LDNQIVTATQ SNICDEDSAT ETCYTYDRNK CYTAVVPLVY GGETKMVETA

LTPDACYPD
Length:159
Mass (Da):18,099
Last modified:October 13, 2009 - v4
Checksum:iB7835C02CCC0CB05
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JA05C9JA05_HUMAN
Immunoglobulin J chain
JCHAIN
70Annotation score:
D6RHJ6D6RHJ6_HUMAN
Immunoglobulin J chain
JCHAIN
157Annotation score:
D6RD17D6RD17_HUMAN
Immunoglobulin J chain
JCHAIN
157Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312014 mRNA Translation: BAG34952.1
M12759, M12378 Genomic DNA Translation: AAA58902.1
CCDSiCCDS3545.1
PIRiA01859 JIHU
RefSeqiNP_653247.1, NM_144646.3
XP_006714274.1, XM_006714211.2
XP_006714275.1, XM_006714212.2
XP_011530227.1, XM_011531925.1
XP_011530228.1, XM_011531926.1
UniGeneiHs.643431

Genome annotation databases

EnsembliENST00000254801; ENSP00000254801; ENSG00000132465
ENST00000510437; ENSP00000426687; ENSG00000132465
ENST00000543780; ENSP00000440066; ENSG00000132465
GeneIDi3512
KEGGihsa:3512
UCSCiuc003hfn.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK312014 mRNA Translation: BAG34952.1
M12759, M12378 Genomic DNA Translation: AAA58902.1
CCDSiCCDS3545.1
PIRiA01859 JIHU
RefSeqiNP_653247.1, NM_144646.3
XP_006714274.1, XM_006714211.2
XP_006714275.1, XM_006714212.2
XP_011530227.1, XM_011531925.1
XP_011530228.1, XM_011531926.1
UniGeneiHs.643431

3D structure databases

ProteinModelPortaliP01591
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109732, 25 interactors
IntActiP01591, 4 interactors
MINTiP01591
STRINGi9606.ENSP00000254801

PTM databases

GlyConnecti277
iPTMnetiP01591
PhosphoSitePlusiP01591
UniCarbKBiP01591

Polymorphism and mutation databases

BioMutaiIGJ

2D gel databases

SWISS-2DPAGEiP01591

Proteomic databases

EPDiP01591
MaxQBiP01591
PaxDbiP01591
PeptideAtlasiP01591
PRIDEiP01591
ProteomicsDBi51394

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254801; ENSP00000254801; ENSG00000132465
ENST00000510437; ENSP00000426687; ENSG00000132465
ENST00000543780; ENSP00000440066; ENSG00000132465
GeneIDi3512
KEGGihsa:3512
UCSCiuc003hfn.5 human

Organism-specific databases

CTDi3512
DisGeNETi3512
EuPathDBiHostDB:ENSG00000132465.10
GeneCardsiJCHAIN
HGNCiHGNC:5713 JCHAIN
HPAiCAB034436
HPA044132
MIMi147790 gene
neXtProtiNX_P01591
OpenTargetsiENSG00000132465
PharmGKBiPA29733
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYAZ Eukaryota
ENOG410YX96 LUCA
GeneTreeiENSGT00390000012791
HOGENOMiHOG000113012
HOVERGENiHBG006138
InParanoidiP01591
OMAiKCYTNRV
OrthoDBiEOG091G0RP0
PhylomeDBiP01591
TreeFamiTF335878

Enzyme and pathway databases

ReactomeiR-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-2168880 Scavenging of heme from plasma

Miscellaneous databases

ChiTaRSiJCHAIN human
GeneWikiiIGJ
GenomeRNAii3512
PROiPR:P01591
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132465 Expressed in 169 organ(s), highest expression level in caecum
CleanExiHS_IGJ
ExpressionAtlasiP01591 baseline and differential
GenevisibleiP01591 HS

Family and domain databases

InterProiView protein in InterPro
IPR024110 Ig_J
PANTHERiPTHR10070 PTHR10070, 1 hit
PfamiView protein in Pfam
PF15097 Ig_J_chain, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD021296 PD021296, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIGJ_HUMAN
AccessioniPrimary (citable) accession number: P01591
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 13, 2009
Last modified: November 7, 2018
This is version 157 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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