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Protein

Interleukin-2 receptor subunit alpha

Gene

Il2ra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.By similarity

GO - Molecular functioni

  • interleukin-2 binding Source: GO_Central
  • interleukin-2 receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processImmunity

Enzyme and pathway databases

ReactomeiR-MMU-5673001 RAF/MAP kinase cascade
R-MMU-9020558 Interleukin-2 signaling
R-MMU-912526 Interleukin receptor SHC signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2 receptor subunit alpha
Short name:
IL-2 receptor subunit alpha
Short name:
IL-2-RA
Short name:
IL-2R subunit alpha
Short name:
IL2-RA
Alternative name(s):
p55
CD_antigen: CD25
Gene namesi
Name:Il2ra
Synonyms:Il2r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96549 Il2ra

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 236ExtracellularSequence analysisAdd BLAST215
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 268CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3287

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001102622 – 268Interleukin-2 receptor subunit alphaAdd BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 66PROSITE-ProRule annotation
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi49 ↔ 75PROSITE-ProRule annotation
Disulfide bondi51 ↔ 77PROSITE-ProRule annotation
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi121 ↔ 164PROSITE-ProRule annotation
Disulfide bondi148 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP01590
PaxDbiP01590
PRIDEiP01590

PTM databases

PhosphoSitePlusiP01590

Expressioni

Gene expression databases

BgeeiENSMUSG00000026770 Expressed in 32 organ(s), highest expression level in bone marrow
CleanExiMM_IL2RA
ExpressionAtlasiP01590 baseline and differential
GenevisibleiP01590 MM

Interactioni

Subunit structurei

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028111

Chemistry databases

BindingDBiP01590

Structurei

3D structure databases

ProteinModelPortaliP01590
SMRiP01590
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 79Sushi 1PROSITE-ProRule annotationAdd BLAST58
Domaini119 – 182Sushi 2PROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J24B Eukaryota
ENOG41116U7 LUCA
GeneTreeiENSGT00390000018872
HOGENOMiHOG000113044
HOVERGENiHBG052109
InParanoidiP01590
KOiK05068
OMAiHYQCIQG
OrthoDBiEOG091G0NHH
PhylomeDBiP01590
TreeFamiTF337408

Family and domain databases

CDDicd00033 CCP, 1 hit
InterProiView protein in InterPro
IPR015486 IL-2_rcpt_alpha
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR10573 PTHR10573, 1 hit
PfamiView protein in Pfam
PF00084 Sushi, 1 hit
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SUPFAMiSSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P01590-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPRLLMLGF LSLTIVPSCR AELCLYDPPE VPNATFKALS YKNGTILNCE
60 70 80 90 100
CKRGFRRLKE LVYMRCLGNS WSSNCQCTSN SHDKSRKQVT AQLEHQKEQQ
110 120 130 140 150
TTTDMQKPTQ SMHQENLTGH CREPPPWKHE DSKRIYHFVE GQSVHYECIP
160 170 180 190 200
GYKALQRGPA ISICKMKCGK TGWTQPQLTC VDEREHHRFL ASEESQGSRN
210 220 230 240 250
SSPESETSCP ITTTDFPQPT ETTAMTETFV LTMEYKVAVA SCLFLLISIL
260
LLSGLTWQHR WRKSRRTI
Length:268
Mass (Da):30,723
Last modified:July 21, 1986 - v1
Checksum:i20C8F712B719192D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3THW2Q3THW2_MOUSE
Interleukin 2 receptor, alpha chain...
Il2ra mCG_9569
44Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 4MEPR → MCQEDGAT in AAA39290 (Ref. 3) Curated4
Sequence conflicti7M → T in AAA39282 (PubMed:2987826).Curated1
Sequence conflicti118T → A in AAA39282 (PubMed:2987826).Curated1
Sequence conflicti140E → V in AAA39282 (PubMed:2987826).Curated1
Sequence conflicti216F → L in AAA39282 (PubMed:2987826).Curated1
Sequence conflicti227E → V in AAA39282 (PubMed:2987826).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02891 mRNA Translation: AAA39285.1
M30856 mRNA Translation: AAA39282.1
M54934 mRNA Translation: AAA39290.1
M21977 mRNA Translation: AAA39288.1
M21978 mRNA Translation: AAA39287.1
CCDSiCCDS15685.1
PIRiA01857 UHMS2
RefSeqiNP_032393.3, NM_008367.3
UniGeneiMm.915

Genome annotation databases

EnsembliENSMUST00000028111; ENSMUSP00000028111; ENSMUSG00000026770
GeneIDi16184
KEGGimmu:16184
UCSCiuc008iiq.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02891 mRNA Translation: AAA39285.1
M30856 mRNA Translation: AAA39282.1
M54934 mRNA Translation: AAA39290.1
M21977 mRNA Translation: AAA39288.1
M21978 mRNA Translation: AAA39287.1
CCDSiCCDS15685.1
PIRiA01857 UHMS2
RefSeqiNP_032393.3, NM_008367.3
UniGeneiMm.915

3D structure databases

ProteinModelPortaliP01590
SMRiP01590
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028111

Chemistry databases

BindingDBiP01590
ChEMBLiCHEMBL3287

PTM databases

PhosphoSitePlusiP01590

Proteomic databases

EPDiP01590
PaxDbiP01590
PRIDEiP01590

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028111; ENSMUSP00000028111; ENSMUSG00000026770
GeneIDi16184
KEGGimmu:16184
UCSCiuc008iiq.2 mouse

Organism-specific databases

CTDi3559
MGIiMGI:96549 Il2ra

Phylogenomic databases

eggNOGiENOG410J24B Eukaryota
ENOG41116U7 LUCA
GeneTreeiENSGT00390000018872
HOGENOMiHOG000113044
HOVERGENiHBG052109
InParanoidiP01590
KOiK05068
OMAiHYQCIQG
OrthoDBiEOG091G0NHH
PhylomeDBiP01590
TreeFamiTF337408

Enzyme and pathway databases

ReactomeiR-MMU-5673001 RAF/MAP kinase cascade
R-MMU-9020558 Interleukin-2 signaling
R-MMU-912526 Interleukin receptor SHC signaling

Miscellaneous databases

ChiTaRSiIl2ra mouse
PROiPR:P01590
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026770 Expressed in 32 organ(s), highest expression level in bone marrow
CleanExiMM_IL2RA
ExpressionAtlasiP01590 baseline and differential
GenevisibleiP01590 MM

Family and domain databases

CDDicd00033 CCP, 1 hit
InterProiView protein in InterPro
IPR015486 IL-2_rcpt_alpha
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR10573 PTHR10573, 1 hit
PfamiView protein in Pfam
PF00084 Sushi, 1 hit
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SUPFAMiSSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIL2RA_MOUSE
AccessioniPrimary (citable) accession number: P01590
Secondary accession number(s): Q61731
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 7, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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