UniProtKB - P01589 (IL2RA_HUMAN)
Interleukin-2 receptor subunit alpha
IL2RA
Functioni
Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
2 PublicationsGO - Molecular functioni
- interleukin-2 binding Source: GO_Central
- interleukin-2 receptor activity Source: ProtInc
GO - Biological processi
- activation-induced cell death of T cells Source: Ensembl
- apoptotic process Source: ProtInc
- cell surface receptor signaling pathway Source: ProtInc
- immune response Source: ProtInc
- inflammatory response Source: GO_Central
- inflammatory response to antigenic stimulus Source: Ensembl
- negative regulation of inflammatory response Source: Ensembl
- negative regulation of T cell proliferation Source: Ensembl
- Notch signaling pathway Source: Ensembl
- positive regulation of activated T cell proliferation Source: Ensembl
- positive regulation of T cell differentiation Source: Ensembl
- regulation of T cell homeostatic proliferation Source: Ensembl
- regulation of T cell tolerance induction Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Biological process | Immunity |
Enzyme and pathway databases
PathwayCommonsi | P01589 |
Reactomei | R-HSA-5673001, RAF/MAP kinase cascade R-HSA-8877330, RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-9020558, Interleukin-2 signaling R-HSA-912526, Interleukin receptor SHC signaling |
SignaLinki | P01589 |
SIGNORi | P01589 |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-2 receptor subunit alphaShort name: IL-2 receptor subunit alpha Short name: IL-2-RA Short name: IL-2R subunit alpha Short name: IL2-RA Alternative name(s): TAC antigen p55 CD_antigen: CD25 |
Gene namesi | Name:IL2RA |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6008, IL2RA |
MIMi | 147730, gene |
neXtProti | NX_P01589 |
VEuPathDBi | HostDB:ENSG00000134460 |
Subcellular locationi
Other locations
Plasma Membrane
- external side of plasma membrane Source: Ensembl
- interleukin-2 receptor complex Source: UniProtKB
- plasma membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 240 | ExtracellularSequence analysisAdd BLAST | 219 | |
Transmembranei | 241 – 259 | HelicalSequence analysisAdd BLAST | 19 | |
Topological domaini | 260 – 272 | CytoplasmicSequence analysisAdd BLAST | 13 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Involvement in diseasei
Diabetes mellitus, insulin-dependent, 10 (IDDM10)1 Publication
Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_074641 | 41 | Y → S in IMD41. 1 PublicationCorresponds to variant dbSNP:rs796051888EnsemblClinVar. | 1 | |
Natural variantiVAR_074642 | 166 | S → N in IMD41; the receptor does not localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs796051887EnsemblClinVar. | 1 |
Keywords - Diseasei
Diabetes mellitus, Disease variantOrganism-specific databases
DisGeNETi | 3559 |
MalaCardsi | IL2RA |
MIMi | 601942, phenotype 606367, phenotype |
OpenTargetsi | ENSG00000134460 |
Orphaneti | 169100, Immunodeficiency due to CD25 deficiency 85410, Oligoarticular juvenile idiopathic arthritis 85408, Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis |
PharmGKBi | PA29828 |
Miscellaneous databases
Pharosi | P01589, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1778 |
DrugBanki | DB00041, Aldesleukin DB00074, Basiliximab DB00111, Daclizumab DB00004, Denileukin diftitox DB15628, Inolimomab |
DrugCentrali | P01589 |
GuidetoPHARMACOLOGYi | 1695 |
Genetic variation databases
BioMutai | IL2RA |
DMDMi | 124317 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Add BLAST | 21 | |
ChainiPRO_0000011024 | 22 – 272 | Interleukin-2 receptor subunit alphaAdd BLAST | 251 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 24 ↔ 168 | |||
Disulfide bondi | 49 ↔ 80 | |||
Disulfide bondi | 51 ↔ 82 | |||
Disulfide bondi | 67 ↔ 125 | |||
Glycosylationi | 70 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 89 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 152 ↔ 184 | |||
Glycosylationi | 218 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 224 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 229 | O-linked (GalNAc...) threonine1 Publication | 1 | |
Glycosylationi | 237 | O-linked (GalNAc...) threonine1 Publication | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P01589 |
PaxDbi | P01589 |
PeptideAtlasi | P01589 |
PRIDEi | P01589 |
ProteomicsDBi | 51393 |
PTM databases
GlyGeni | P01589, 6 sites |
iPTMneti | P01589 |
PhosphoSitePlusi | P01589 |
Expressioni
Gene expression databases
Bgeei | ENSG00000134460, Expressed in lymph node and 128 other tissues |
ExpressionAtlasi | P01589, baseline and differential |
Genevisiblei | P01589, HS |
Organism-specific databases
HPAi | ENSG00000134460, Tissue enhanced (adipose tissue, lymphoid tissue, urinary bladder) |
Interactioni
Subunit structurei
Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
2 PublicationsBinary interactionsi
P01589
With | #Exp. | IntAct |
---|---|---|
IL2 [P60568] | 3 | EBI-8614302,EBI-12508717 |
GO - Molecular functioni
- interleukin-2 binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 109774, 83 interactors |
CORUMi | P01589 |
DIPi | DIP-1080N |
IntActi | P01589, 2 interactors |
MINTi | P01589 |
STRINGi | 9606.ENSP00000369293 |
Chemistry databases
BindingDBi | P01589 |
Miscellaneous databases
RNActi | P01589, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | P01589 |
SMRi | P01589 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P01589 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 22 – 84 | Sushi 1PROSITE-ProRule annotationAdd BLAST | 63 | |
Domaini | 123 – 186 | Sushi 2PROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 87 – 123 | DisorderedSequence analysisAdd BLAST | 37 | |
Regioni | 190 – 212 | DisorderedSequence analysisAdd BLAST | 23 |
Keywords - Domaini
Repeat, Signal, Sushi, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502SUAG, Eukaryota |
GeneTreei | ENSGT00390000018872 |
InParanoidi | P01589 |
OMAi | HYQCIQG |
OrthoDBi | 1236351at2759 |
PhylomeDBi | P01589 |
TreeFami | TF337408 |
Family and domain databases
CDDi | cd00033, CCP, 1 hit |
InterProi | View protein in InterPro IPR015486, IL-2_rcpt_alpha IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
PANTHERi | PTHR10573, PTHR10573, 1 hit |
Pfami | View protein in Pfam PF00084, Sushi, 1 hit |
SMARTi | View protein in SMART SM00032, CCP, 2 hits |
SUPFAMi | SSF57535, SSF57535, 2 hits |
PROSITEi | View protein in PROSITE PS50923, SUSHI, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MDSYLLMWGL LTFIMVPGCQ AELCDDDPPE IPHATFKAMA YKEGTMLNCE
60 70 80 90 100
CKRGFRRIKS GSLYMLCTGN SSHSSWDNQC QCTSSATRNT TKQVTPQPEE
110 120 130 140 150
QKERKTTEMQ SPMQPVDQAS LPGHCREPPP WENEATERIY HFVVGQMVYY
160 170 180 190 200
QCVQGYRALH RGPAESVCKM THGKTRWTQP QLICTGEMET SQFPGEEKPQ
210 220 230 240 250
ASPEGRPESE TSCLVTTTDF QIQTEMAATM ETSIFTTEYQ VAVAGCVFLL
260 270
ISVLLLSGLT WQRRQRKSRR TI
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ5W006 | Q5W006_HUMAN | Interleukin-2 receptor subunit alph... | IL2RA | 263 | Annotation score: | ||
Q5W005 | Q5W005_HUMAN | Interleukin 2 receptor, alpha, isof... | IL2RA hCG_23482 | 200 | Annotation score: | ||
H0Y5Z0 | H0Y5Z0_HUMAN | Interleukin-2 receptor subunit alph... | IL2RA | 109 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_074641 | 41 | Y → S in IMD41. 1 PublicationCorresponds to variant dbSNP:rs796051888EnsemblClinVar. | 1 | |
Natural variantiVAR_074642 | 166 | S → N in IMD41; the receptor does not localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs796051887EnsemblClinVar. | 1 | |
Natural variantiVAR_019280 | 272 | I → T1 PublicationCorresponds to variant dbSNP:rs12722712Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X01057 mRNA Translation: CAA25525.1 X03131 , X03132, X03133, X03134, X03135, X03136, X03137, X03138 Genomic DNA Translation: CAA26906.1 K03122 mRNA Translation: AAB59535.1 Sequence problems. M11066 , M10322, M11060, M11061, M11062, M11063, M11064, M11065 Genomic DNA Translation: AAA67527.1 AY563103 Genomic DNA Translation: AAS55572.1 AL157395 Genomic DNA No translation available. AL137186 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86414.1 M15864 Genomic DNA Translation: AAA59162.1 BN000945 Genomic DNA Translation: CAK26553.1 |
CCDSi | CCDS7076.1 |
PIRi | A44186, UHHU2 |
RefSeqi | NP_000408.1, NM_000417.2 NP_001295171.1, NM_001308242.1 NP_001295172.1, NM_001308243.1 |
Genome annotation databases
Ensembli | ENST00000379959.8; ENSP00000369293.3; ENSG00000134460.18 |
GeneIDi | 3559 |
KEGGi | hsa:3559 |
MANE-Selecti | ENST00000379959.8; ENSP00000369293.3; NM_000417.3; NP_000408.1 |
UCSCi | uc001iiz.3, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
IL2RAbase IL2RA mutation db |
SeattleSNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X01057 mRNA Translation: CAA25525.1 X03131 , X03132, X03133, X03134, X03135, X03136, X03137, X03138 Genomic DNA Translation: CAA26906.1 K03122 mRNA Translation: AAB59535.1 Sequence problems. M11066 , M10322, M11060, M11061, M11062, M11063, M11064, M11065 Genomic DNA Translation: AAA67527.1 AY563103 Genomic DNA Translation: AAS55572.1 AL157395 Genomic DNA No translation available. AL137186 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86414.1 M15864 Genomic DNA Translation: AAA59162.1 BN000945 Genomic DNA Translation: CAK26553.1 |
CCDSi | CCDS7076.1 |
PIRi | A44186, UHHU2 |
RefSeqi | NP_000408.1, NM_000417.2 NP_001295171.1, NM_001308242.1 NP_001295172.1, NM_001308243.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1Z92 | X-ray | 2.80 | B | 22-238 | [»] | |
2B5I | X-ray | 2.30 | D | 22-238 | [»] | |
2ERJ | X-ray | 3.00 | A/E | 22-233 | [»] | |
3IU3 | X-ray | 2.90 | I/J/K | 22-238 | [»] | |
3NFP | X-ray | 2.86 | I/K | 22-238 | [»] | |
6VWU | X-ray | 3.40 | A | 22-186 | [»] | |
6YIO | X-ray | 1.83 | B | 22-213 | [»] | |
7F9W | electron microscopy | 3.20 | A | 26-186 | [»] | |
AlphaFoldDBi | P01589 | |||||
SMRi | P01589 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109774, 83 interactors |
CORUMi | P01589 |
DIPi | DIP-1080N |
IntActi | P01589, 2 interactors |
MINTi | P01589 |
STRINGi | 9606.ENSP00000369293 |
Chemistry databases
BindingDBi | P01589 |
ChEMBLi | CHEMBL1778 |
DrugBanki | DB00041, Aldesleukin DB00074, Basiliximab DB00111, Daclizumab DB00004, Denileukin diftitox DB15628, Inolimomab |
DrugCentrali | P01589 |
GuidetoPHARMACOLOGYi | 1695 |
PTM databases
GlyGeni | P01589, 6 sites |
iPTMneti | P01589 |
PhosphoSitePlusi | P01589 |
Genetic variation databases
BioMutai | IL2RA |
DMDMi | 124317 |
Proteomic databases
MassIVEi | P01589 |
PaxDbi | P01589 |
PeptideAtlasi | P01589 |
PRIDEi | P01589 |
ProteomicsDBi | 51393 |
Protocols and materials databases
ABCDi | P01589, 13 sequenced antibodies |
Antibodypediai | 3715, 3206 antibodies from 52 providers |
DNASUi | 3559 |
Genome annotation databases
Ensembli | ENST00000379959.8; ENSP00000369293.3; ENSG00000134460.18 |
GeneIDi | 3559 |
KEGGi | hsa:3559 |
MANE-Selecti | ENST00000379959.8; ENSP00000369293.3; NM_000417.3; NP_000408.1 |
UCSCi | uc001iiz.3, human |
Organism-specific databases
CTDi | 3559 |
DisGeNETi | 3559 |
GeneCardsi | IL2RA |
HGNCi | HGNC:6008, IL2RA |
HPAi | ENSG00000134460, Tissue enhanced (adipose tissue, lymphoid tissue, urinary bladder) |
MalaCardsi | IL2RA |
MIMi | 147730, gene 601942, phenotype 606367, phenotype |
neXtProti | NX_P01589 |
OpenTargetsi | ENSG00000134460 |
Orphaneti | 169100, Immunodeficiency due to CD25 deficiency 85410, Oligoarticular juvenile idiopathic arthritis 85408, Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis |
PharmGKBi | PA29828 |
VEuPathDBi | HostDB:ENSG00000134460 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SUAG, Eukaryota |
GeneTreei | ENSGT00390000018872 |
InParanoidi | P01589 |
OMAi | HYQCIQG |
OrthoDBi | 1236351at2759 |
PhylomeDBi | P01589 |
TreeFami | TF337408 |
Enzyme and pathway databases
PathwayCommonsi | P01589 |
Reactomei | R-HSA-5673001, RAF/MAP kinase cascade R-HSA-8877330, RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-9020558, Interleukin-2 signaling R-HSA-912526, Interleukin receptor SHC signaling |
SignaLinki | P01589 |
SIGNORi | P01589 |
Miscellaneous databases
BioGRID-ORCSi | 3559, 19 hits in 1067 CRISPR screens |
ChiTaRSi | IL2RA, human |
EvolutionaryTracei | P01589 |
GeneWikii | IL2RA |
GenomeRNAii | 3559 |
Pharosi | P01589, Tclin |
PROi | PR:P01589 |
RNActi | P01589, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134460, Expressed in lymph node and 128 other tissues |
ExpressionAtlasi | P01589, baseline and differential |
Genevisiblei | P01589, HS |
Family and domain databases
CDDi | cd00033, CCP, 1 hit |
InterProi | View protein in InterPro IPR015486, IL-2_rcpt_alpha IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom |
PANTHERi | PTHR10573, PTHR10573, 1 hit |
Pfami | View protein in Pfam PF00084, Sushi, 1 hit |
SMARTi | View protein in SMART SM00032, CCP, 2 hits |
SUPFAMi | SSF57535, SSF57535, 2 hits |
PROSITEi | View protein in PROSITE PS50923, SUSHI, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | IL2RA_HUMAN | |
Accessioni | P01589Primary (citable) accession number: P01589 Secondary accession number(s): Q5W007 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | May 25, 2022 | |
This is version 217 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references