IL2RA

Functionⁱ

Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.2 Publications

GO - Molecular functionⁱ

interleukin-2 binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
interleukin-2 receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
Ras guanyl-nucleotide exchange factor activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation-induced cell death of T cells Source: Ensembl
apoptotic process
Source: ProtInc
Traceable author statementⁱ
- 9096364
cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 2983318
cell surface receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 2983318
cytokine-mediated signaling pathway Source: Reactome
immune response
Source: ProtInc
Traceable author statementⁱ
- 9096364
inflammatory response to antigenic stimulus Source: Ensembl
interleukin-2-mediated signaling pathway Source: Reactome
MAPK cascade Source: Reactome
negative regulation of defense response to virus Source: Ensembl
negative regulation of immune response Source: Ensembl
negative regulation of inflammatory response Source: Ensembl
negative regulation of T cell proliferation Source: Ensembl
Notch signaling pathway Source: Ensembl
positive regulation of activated T cell proliferation Source: Ensembl
positive regulation of T cell differentiation Source: Ensembl
regulation of regulatory T cell differentiation Source: Reactome
regulation of T cell homeostatic proliferation Source: Ensembl
regulation of T cell tolerance induction
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23416241

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5673001 RAF/MAP kinase cascade R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-9020558 Interleukin-2 signaling R-HSA-912526 Interleukin receptor SHC signaling
SIGNORⁱ	P01589

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interleukin-2 receptor subunit alpha Short name: IL-2 receptor subunit alpha Short name: IL-2-RA Short name: IL-2R subunit alpha Short name: IL2-RA Alternative name(s): TAC antigen p55 CD_antigen: CD25
Gene namesⁱ	Name:IL2RA
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000134460.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6008 IL2RA
MIMⁱ	147730 gene
neXtProtⁱ	NX_P01589

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	22 – 240	ExtracellularSequence analysisAdd BLAST	219
Transmembraneⁱ	241 – 259	HelicalSequence analysisAdd BLAST	19
Topological domainⁱ	260 – 272	CytoplasmicSequence analysisAdd BLAST	13

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Diabetes mellitus, insulin-dependent, 10 (IDDM10)1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder of immune dysregulation characterized by recurrent viral, fungal, and bacterial infections, lymphadenopathy, and variable autoimmune features, such as autoimmune enteropathy and eczematous skin lesions.

Keywords - Diseaseⁱ

Diabetes mellitus, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3559
MalaCards human disease database More...MalaCardsⁱ	IL2RA
MIMⁱ	601942 phenotype 606367 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000134460
Orphanetⁱ	169100 Immunodeficiency due to CD25 deficiency 85410 Oligoarticular juvenile idiopathic arthritis 85408 Rheumatoid factor-negative juvenile idiopathic arthritis
PharmGKBⁱ	PA29828

Chemistry databases

ChEMBLⁱ	CHEMBL1778
Drug and drug target database More...DrugBankⁱ	DB00041 Aldesleukin DB00074 Basiliximab DB00111 Daclizumab DB00004 Denileukin diftitox
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1695

Polymorphism and mutation databases

BioMutaⁱ	IL2RA
DMDMⁱ	124317

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	Add BLAST		21
ChainⁱPRO_0000011024	22 – 272	Interleukin-2 receptor subunit alphaAdd BLAST		251

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	24 ↔ 168
Disulfide bondⁱ	49 ↔ 80
Disulfide bondⁱ	51 ↔ 82
Disulfide bondⁱ	67 ↔ 125
Glycosylationⁱ	70	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	89	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	152 ↔ 184
Glycosylationⁱ	218	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	224	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	229	O-linked (GalNAc...) threonine1 Publication	1
Glycosylationⁱ	237	O-linked (GalNAc...) threonine1 Publication	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P01589
PeptideAtlas More...PeptideAtlasⁱ	P01589
PRIDEⁱ	P01589
ProteomicsDBⁱ	51393

PTM databases

iPTMnetⁱ	P01589
PhosphoSitePlusⁱ	P01589

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000134460 Expressed in 103 organ(s), highest expression level in lymph node
CleanExⁱ	HS_IL2RA
ExpressionAtlasⁱ	P01589 baseline and differential
Genevisibleⁱ	P01589 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002419 HPA054622

HPAⁱ

CAB002419
HPA054622

Interactionⁱ

Subunit structureⁱ

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
IL2	P60568	3	EBI-8614302,EBI-12508717

With

Entry

#Exp.

IntAct

Notes

IL2

P60568

3

EBI-8614302,EBI-12508717

GO - Molecular functionⁱ

interleukin-2 binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
Ras guanyl-nucleotide exchange factor activity Source: Reactome

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109774, 4 interactors
CORUMⁱ	P01589
Database of interacting proteins More...DIPⁱ	DIP-1080N
IntActⁱ	P01589, 2 interactors
Molecular INTeraction database More...MINTⁱ	P01589
STRINGⁱ	9606.ENSP00000369293

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	34 – 37	Combined sources	4
Beta strandⁱ	39 – 41	Combined sources	3
Beta strandⁱ	46 – 48	Combined sources	3
Beta strandⁱ	55 – 57	Combined sources	3
Beta strandⁱ	63 – 67	Combined sources	5
Beta strandⁱ	74 – 77	Combined sources	4
Beta strandⁱ	82 – 84	Combined sources	3
Beta strandⁱ	135 – 137	Combined sources	3
Beta strandⁱ	143 – 145	Combined sources	3
Beta strandⁱ	147 – 152	Combined sources	6
Beta strandⁱ	157 – 162	Combined sources	6
Beta strandⁱ	164 – 170	Combined sources	7
Beta strandⁱ	172 – 174	Combined sources	3
Beta strandⁱ	175 – 177	Combined sources	3
Beta strandⁱ	182 – 185	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	P01589
SMRⁱ	P01589
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P01589

EvolutionaryTraceⁱ

P01589

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	22 – 84	Sushi 1PROSITE-ProRule annotationAdd BLAST		63
Domainⁱ	123 – 186	Sushi 2PROSITE-ProRule annotationAdd BLAST		64

Keywords - Domainⁱ

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410J24B Eukaryota ENOG41116U7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000018872
HOGENOMⁱ	HOG000113044
HOVERGENⁱ	HBG052109
InParanoidⁱ	P01589
KEGG Orthology (KO) More...KOⁱ	K05068
OMAⁱ	HYQCIQG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NHH
PhylomeDBⁱ	P01589
TreeFamⁱ	TF337408

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00033 CCP, 1 hit
InterProⁱ	View protein in InterPro IPR015486 IL-2_rcpt_alpha IPR035976 Sushi/SCR/CCP_sf IPR000436 Sushi_SCR_CCP_dom
PANTHERⁱ	PTHR10573 PTHR10573, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00084 Sushi, 1 hit
SMARTⁱ	View protein in SMART SM00032 CCP, 2 hits
SUPFAMⁱ	SSF57535 SSF57535, 2 hits
PROSITEⁱ	View protein in PROSITE PS50923 SUSHI, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

P01589-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDSYLLMWGL LTFIMVPGCQ AELCDDDPPE IPHATFKAMA YKEGTMLNCE 
        60         70         80         90        100
CKRGFRRIKS GSLYMLCTGN SSHSSWDNQC QCTSSATRNT TKQVTPQPEE 
       110        120        130        140        150
QKERKTTEMQ SPMQPVDQAS LPGHCREPPP WENEATERIY HFVVGQMVYY 
       160        170        180        190        200
QCVQGYRALH RGPAESVCKM THGKTRWTQP QLICTGEMET SQFPGEEKPQ 
       210        220        230        240        250
ASPEGRPESE TSCLVTTTDF QIQTEMAATM ETSIFTTEYQ VAVAGCVFLL 
       260        270 
ISVLLLSGLT WQRRQRKSRR TI

Length:272

Mass (Da):30,819

Last modified:July 21, 1986 - v1

Checksum:ⁱ83D907C8C81D2C0E

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

Q5W006	Q5W006_HUMAN	Interleukin-2 receptor subunit alph... Interleukin-2 receptor subunit alpha	IL2RA	263	Annotation score:
Q5W005	Q5W005_HUMAN	Interleukin 2 receptor, alpha, isof... Interleukin 2 receptor, alpha, isoform CRA_b (Interleukin-2 receptor subunit alpha)	IL2RA hCG_23482	200	Annotation score:
H0Y5Z0	H0Y5Z0_HUMAN	Interleukin-2 receptor subunit alph... Interleukin-2 receptor subunit alpha	IL2RA	109	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_074641	41	Y → S in IMD41. 1 PublicationCorresponds to variant dbSNP:rs796051888EnsemblClinVar.	1
Natural variantⁱVAR_074642	166	S → N in IMD41; the receptor does not localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs796051887EnsemblClinVar.	1
Natural variantⁱVAR_019280	272	I → T1 PublicationCorresponds to variant dbSNP:rs12722712Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X01057 mRNA Translation: CAA25525.1 X03131 X03138 Genomic DNA Translation: CAA26906.1 K03122 mRNA Translation: AAB59535.1 Sequence problems. M11066 M11065 Genomic DNA Translation: AAA67527.1 AY563103 Genomic DNA Translation: AAS55572.1 AL157395 Genomic DNA No translation available. AL137186 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86414.1 M15864 Genomic DNA Translation: AAA59162.1 BN000945 Genomic DNA Translation: CAK26553.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS7076.1
PIRⁱ	A44186 UHHU2
NCBI Reference Sequences More...RefSeqⁱ	NP_000408.1, NM_000417.2 NP_001295171.1, NM_001308242.1 NP_001295172.1, NM_001308243.1
UniGeneⁱ	Hs.231367

Genome annotation databases

Ensemblⁱ	ENST00000379959; ENSP00000369293; ENSG00000134460
GeneIDⁱ	3559
KEGGⁱ	hsa:3559
UCSC genome browser More...UCSCⁱ	uc001iiz.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01589	Interleukin 2 receptor, alpha chain variant (Fragment)		HUMAN		272	UniRef90_P01589
IL2RA isoform 1		PANTR		272
IL2RA isoform 1		PONAB		272
Interleukin 2 receptor subunit alpha		GORGO		272
cDNA, FLJ94475, highly similar to Homo sapiens interleukin 2 receptor, alpha (IL2RA), mRNA		HUMAN		272
+7

Protein	Similar proteins		Species	Score	Length	Source
P01589	Interleukin-2 receptor subunit alpha		FELCA		275	UniRef50_P01589
Interleukin-2 receptor subunit alpha		MOUSE		268
Interleukin-2 receptor subunit alpha		RAT		267
Interleukin 2 receptor subunit alpha		GORGO		272
IL2RA isoform 1		PONAB		272
+84

Cross-referencesⁱ

Web resourcesⁱ

IL2RAbase

IL2RA mutation db

SeattleSNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X01057 mRNA Translation: CAA25525.1 X03131 X03138 Genomic DNA Translation: CAA26906.1 K03122 mRNA Translation: AAB59535.1 Sequence problems. M11066 M11065 Genomic DNA Translation: AAA67527.1 AY563103 Genomic DNA Translation: AAS55572.1 AL157395 Genomic DNA No translation available. AL137186 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW86414.1 M15864 Genomic DNA Translation: AAA59162.1 BN000945 Genomic DNA Translation: CAK26553.1
CCDSⁱ	CCDS7076.1
PIRⁱ	A44186 UHHU2
RefSeqⁱ	NP_000408.1, NM_000417.2 NP_001295171.1, NM_001308242.1 NP_001295172.1, NM_001308243.1
UniGeneⁱ	Hs.231367

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1ILM	model	-	A	23-83	[»]
	1ILN	model	-	A	23-83	[»]
	1Z92	X-ray	2.80	B	22-238	[»]
	2B5I	X-ray	2.30	D	22-238	[»]
	2ERJ	X-ray	3.00	A/E	22-233	[»]
	3IU3	X-ray	2.90	I/J/K	22-238	[»]
	3NFP	X-ray	2.86	I/K	22-238	[»]
ProteinModelPortalⁱ	P01589
SMRⁱ	P01589
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109774, 4 interactors
CORUMⁱ	P01589
DIPⁱ	DIP-1080N
IntActⁱ	P01589, 2 interactors
MINTⁱ	P01589
STRINGⁱ	9606.ENSP00000369293

Chemistry databases

ChEMBLⁱ	CHEMBL1778
DrugBankⁱ	DB00041 Aldesleukin DB00074 Basiliximab DB00111 Daclizumab DB00004 Denileukin diftitox
GuidetoPHARMACOLOGYⁱ	1695

PTM databases

iPTMnetⁱ	P01589
PhosphoSitePlusⁱ	P01589

Polymorphism and mutation databases

BioMutaⁱ	IL2RA
DMDMⁱ	124317

Proteomic databases

PaxDbⁱ	P01589
PeptideAtlasⁱ	P01589
PRIDEⁱ	P01589
ProteomicsDBⁱ	51393

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3559
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000379959; ENSP00000369293; ENSG00000134460
GeneIDⁱ	3559
KEGGⁱ	hsa:3559
UCSCⁱ	uc001iiz.3 human

Organism-specific databases

CTDⁱ	3559
DisGeNETⁱ	3559
EuPathDBⁱ	HostDB:ENSG00000134460.15
GeneCardsⁱ	IL2RA
HGNCⁱ	HGNC:6008 IL2RA
HPAⁱ	CAB002419 HPA054622
MalaCardsⁱ	IL2RA
MIMⁱ	147730 gene 601942 phenotype 606367 phenotype
neXtProtⁱ	NX_P01589
OpenTargetsⁱ	ENSG00000134460
Orphanetⁱ	169100 Immunodeficiency due to CD25 deficiency 85410 Oligoarticular juvenile idiopathic arthritis 85408 Rheumatoid factor-negative juvenile idiopathic arthritis
PharmGKBⁱ	PA29828
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J24B Eukaryota ENOG41116U7 LUCA
GeneTreeⁱ	ENSGT00390000018872
HOGENOMⁱ	HOG000113044
HOVERGENⁱ	HBG052109
InParanoidⁱ	P01589
KOⁱ	K05068
OMAⁱ	HYQCIQG
OrthoDBⁱ	EOG091G0NHH
PhylomeDBⁱ	P01589
TreeFamⁱ	TF337408

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5673001 RAF/MAP kinase cascade R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) R-HSA-9020558 Interleukin-2 signaling R-HSA-912526 Interleukin receptor SHC signaling
SIGNORⁱ	P01589

Miscellaneous databases

ChiTaRSⁱ	IL2RA human
EvolutionaryTraceⁱ	P01589
GeneWikiⁱ	IL2RA
GenomeRNAiⁱ	3559
Protein Ontology More...PROⁱ	PR:P01589
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000134460 Expressed in 103 organ(s), highest expression level in lymph node
CleanExⁱ	HS_IL2RA
ExpressionAtlasⁱ	P01589 baseline and differential
Genevisibleⁱ	P01589 HS

Family and domain databases

CDDⁱ	cd00033 CCP, 1 hit
InterProⁱ	View protein in InterPro IPR015486 IL-2_rcpt_alpha IPR035976 Sushi/SCR/CCP_sf IPR000436 Sushi_SCR_CCP_dom
PANTHERⁱ	PTHR10573 PTHR10573, 1 hit
Pfamⁱ	View protein in Pfam PF00084 Sushi, 1 hit
SMARTⁱ	View protein in SMART SM00032 CCP, 2 hits
SUPFAMⁱ	SSF57535 SSF57535, 2 hits
PROSITEⁱ	View protein in PROSITE PS50923 SUSHI, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IL2RA_HUMAN
Accessionⁱ	P01589Primary (citable) accession number: P01589 Secondary accession number(s): Q5W007
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	July 21, 1986
	Last modified:	November 7, 2018
	This is version 197 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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UniProtKB - P01589 (IL2RA_HUMAN)

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Interleukin-2 receptor subunit alpha

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ