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Entry version 210 (07 Oct 2020)
Sequence version 1 (21 Jul 1986)
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Protein

Interleukin-2 receptor subunit alpha

Gene

IL2RA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processImmunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
P01589

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5673001, RAF/MAP kinase cascade
R-HSA-8877330, RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-HSA-9020558, Interleukin-2 signaling
R-HSA-912526, Interleukin receptor SHC signaling

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01589

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-2 receptor subunit alpha
Short name:
IL-2 receptor subunit alpha
Short name:
IL-2-RA
Short name:
IL-2R subunit alpha
Short name:
IL2-RA
Alternative name(s):
TAC antigen
p55
CD_antigen: CD25
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL2RA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000134460.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6008, IL2RA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
147730, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01589

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 240ExtracellularSequence analysisAdd BLAST219
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei241 – 259HelicalSequence analysisAdd BLAST19
Topological domaini260 – 272CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diabetes mellitus, insulin-dependent, 10 (IDDM10)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Related information in OMIM
Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of immune dysregulation characterized by recurrent viral, fungal, and bacterial infections, lymphadenopathy, and variable autoimmune features, such as autoimmune enteropathy and eczematous skin lesions.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07464141Y → S in IMD41. 1 PublicationCorresponds to variant dbSNP:rs796051888EnsemblClinVar.1
Natural variantiVAR_074642166S → N in IMD41; the receptor does not localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs796051887Ensembl.1

Keywords - Diseasei

Diabetes mellitus, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
3559

MalaCards human disease database

More...
MalaCardsi
IL2RA
MIMi601942, phenotype
606367, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000134460

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
169100, Immunodeficiency due to CD25 deficiency
85410, Oligoarticular juvenile idiopathic arthritis
85408, Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29828

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P01589, Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1778

Drug and drug target database

More...
DrugBanki
DB00041, Aldesleukin
DB00074, Basiliximab
DB00111, Daclizumab
DB00004, Denileukin diftitox

DrugCentral

More...
DrugCentrali
P01589

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
1695

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL2RA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124317

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Add BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001102422 – 272Interleukin-2 receptor subunit alphaAdd BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi24 ↔ 168
Disulfide bondi49 ↔ 80
Disulfide bondi51 ↔ 82
Disulfide bondi67 ↔ 125
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi70N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi89N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi152 ↔ 184
Glycosylationi218O-linked (GalNAc...) threonine1 Publication1
Glycosylationi224O-linked (GalNAc...) threonine1 Publication1
Glycosylationi229O-linked (GalNAc...) threonine1 Publication1
Glycosylationi237O-linked (GalNAc...) threonine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P01589

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01589

PeptideAtlas

More...
PeptideAtlasi
P01589

PRoteomics IDEntifications database

More...
PRIDEi
P01589

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
51393

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
P01589, 6 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01589

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01589

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000134460, Expressed in lymph node and 127 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P01589, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P01589, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000134460, Group enriched (adipose tissue, blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
109774, 4 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P01589

Database of interacting proteins

More...
DIPi
DIP-1080N

Protein interaction database and analysis system

More...
IntActi
P01589, 2 interactors

Molecular INTeraction database

More...
MINTi
P01589

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000369293

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P01589, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1272
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01589

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01589

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 84Sushi 1PROSITE-ProRule annotationAdd BLAST63
Domaini123 – 186Sushi 2PROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SUAG, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018872

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01589

KEGG Orthology (KO)

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KOi
K05068

Identification of Orthologs from Complete Genome Data

More...
OMAi
HYQCIQG

Database of Orthologous Groups

More...
OrthoDBi
1236351at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01589

TreeFam database of animal gene trees

More...
TreeFami
TF337408

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00033, CCP, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015486, IL-2_rcpt_alpha
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10573, PTHR10573, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00084, Sushi, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00032, CCP, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57535, SSF57535, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50923, SUSHI, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P01589-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSYLLMWGL LTFIMVPGCQ AELCDDDPPE IPHATFKAMA YKEGTMLNCE
60 70 80 90 100
CKRGFRRIKS GSLYMLCTGN SSHSSWDNQC QCTSSATRNT TKQVTPQPEE
110 120 130 140 150
QKERKTTEMQ SPMQPVDQAS LPGHCREPPP WENEATERIY HFVVGQMVYY
160 170 180 190 200
QCVQGYRALH RGPAESVCKM THGKTRWTQP QLICTGEMET SQFPGEEKPQ
210 220 230 240 250
ASPEGRPESE TSCLVTTTDF QIQTEMAATM ETSIFTTEYQ VAVAGCVFLL
260 270
ISVLLLSGLT WQRRQRKSRR TI
Length:272
Mass (Da):30,819
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83D907C8C81D2C0E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5W006Q5W006_HUMAN
Interleukin-2 receptor subunit alph...
IL2RA
263Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5W005Q5W005_HUMAN
Interleukin 2 receptor, alpha, isof...
IL2RA hCG_23482
200Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5Z0H0Y5Z0_HUMAN
Interleukin-2 receptor subunit alph...
IL2RA
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07464141Y → S in IMD41. 1 PublicationCorresponds to variant dbSNP:rs796051888EnsemblClinVar.1
Natural variantiVAR_074642166S → N in IMD41; the receptor does not localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs796051887Ensembl.1
Natural variantiVAR_019280272I → T1 PublicationCorresponds to variant dbSNP:rs12722712Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X01057 mRNA Translation: CAA25525.1
X03131 X03138 Genomic DNA Translation: CAA26906.1
K03122 mRNA Translation: AAB59535.1 Sequence problems.
M11066 M11065 Genomic DNA Translation: AAA67527.1
AY563103 Genomic DNA Translation: AAS55572.1
AL157395 Genomic DNA No translation available.
AL137186 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86414.1
M15864 Genomic DNA Translation: AAA59162.1
BN000945 Genomic DNA Translation: CAK26553.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7076.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A44186, UHHU2

NCBI Reference Sequences

More...
RefSeqi
NP_000408.1, NM_000417.2
NP_001295171.1, NM_001308242.1
NP_001295172.1, NM_001308243.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000379959; ENSP00000369293; ENSG00000134460

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3559

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3559

UCSC genome browser

More...
UCSCi
uc001iiz.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

IL2RAbase

IL2RA mutation db

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01057 mRNA Translation: CAA25525.1
X03131 X03138 Genomic DNA Translation: CAA26906.1
K03122 mRNA Translation: AAB59535.1 Sequence problems.
M11066 M11065 Genomic DNA Translation: AAA67527.1
AY563103 Genomic DNA Translation: AAS55572.1
AL157395 Genomic DNA No translation available.
AL137186 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86414.1
M15864 Genomic DNA Translation: AAA59162.1
BN000945 Genomic DNA Translation: CAK26553.1
CCDSiCCDS7076.1
PIRiA44186, UHHU2
RefSeqiNP_000408.1, NM_000417.2
NP_001295171.1, NM_001308242.1
NP_001295172.1, NM_001308243.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ILMmodel-A23-83[»]
1ILNmodel-A23-83[»]
1Z92X-ray2.80B22-238[»]
2B5IX-ray2.30D22-238[»]
2ERJX-ray3.00A/E22-233[»]
3IU3X-ray2.90I/J/K22-238[»]
3NFPX-ray2.86I/K22-238[»]
6VWUX-ray3.40A22-186[»]
SMRiP01589
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109774, 4 interactors
CORUMiP01589
DIPiDIP-1080N
IntActiP01589, 2 interactors
MINTiP01589
STRINGi9606.ENSP00000369293

Chemistry databases

ChEMBLiCHEMBL1778
DrugBankiDB00041, Aldesleukin
DB00074, Basiliximab
DB00111, Daclizumab
DB00004, Denileukin diftitox
DrugCentraliP01589
GuidetoPHARMACOLOGYi1695

PTM databases

GlyGeniP01589, 6 sites
iPTMnetiP01589
PhosphoSitePlusiP01589

Polymorphism and mutation databases

BioMutaiIL2RA
DMDMi124317

Proteomic databases

MassIVEiP01589
PaxDbiP01589
PeptideAtlasiP01589
PRIDEiP01589
ProteomicsDBi51393

Protocols and materials databases

ABCD curated depository of sequenced antibodies

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ABCDi
P01589, 11 sequenced antibodies

Antibodypedia a portal for validated antibodies

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Antibodypediai
3715, 3034 antibodies

The DNASU plasmid repository

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DNASUi
3559

Genome annotation databases

EnsembliENST00000379959; ENSP00000369293; ENSG00000134460
GeneIDi3559
KEGGihsa:3559
UCSCiuc001iiz.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3559
DisGeNETi3559
EuPathDBiHostDB:ENSG00000134460.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IL2RA
HGNCiHGNC:6008, IL2RA
HPAiENSG00000134460, Group enriched (adipose tissue, blood, lymphoid tissue)
MalaCardsiIL2RA
MIMi147730, gene
601942, phenotype
606367, phenotype
neXtProtiNX_P01589
OpenTargetsiENSG00000134460
Orphaneti169100, Immunodeficiency due to CD25 deficiency
85410, Oligoarticular juvenile idiopathic arthritis
85408, Rheumatoid factor-negative polyarticular juvenile idiopathic arthritis
PharmGKBiPA29828

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502SUAG, Eukaryota
GeneTreeiENSGT00390000018872
InParanoidiP01589
KOiK05068
OMAiHYQCIQG
OrthoDBi1236351at2759
PhylomeDBiP01589
TreeFamiTF337408

Enzyme and pathway databases

PathwayCommonsiP01589
ReactomeiR-HSA-5673001, RAF/MAP kinase cascade
R-HSA-8877330, RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-HSA-9020558, Interleukin-2 signaling
R-HSA-912526, Interleukin receptor SHC signaling
SIGNORiP01589

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
3559, 14 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IL2RA, human
EvolutionaryTraceiP01589

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
IL2RA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3559
PharosiP01589, Tclin

Protein Ontology

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PROi
PR:P01589
RNActiP01589, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000134460, Expressed in lymph node and 127 other tissues
ExpressionAtlasiP01589, baseline and differential
GenevisibleiP01589, HS

Family and domain databases

CDDicd00033, CCP, 1 hit
InterProiView protein in InterPro
IPR015486, IL-2_rcpt_alpha
IPR035976, Sushi/SCR/CCP_sf
IPR000436, Sushi_SCR_CCP_dom
PANTHERiPTHR10573, PTHR10573, 1 hit
PfamiView protein in Pfam
PF00084, Sushi, 1 hit
SMARTiView protein in SMART
SM00032, CCP, 2 hits
SUPFAMiSSF57535, SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS50923, SUSHI, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL2RA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01589
Secondary accession number(s): Q5W007
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 7, 2020
This is version 210 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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