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Protein

Interleukin-2 receptor subunit alpha

Gene

IL2RA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.2 Publications

GO - Molecular functioni

  • interleukin-2 binding Source: GO_Central
  • interleukin-2 receptor activity Source: GO_Central
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processImmunity

Enzyme and pathway databases

ReactomeiR-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-HSA-9020558 Interleukin-2 signaling
R-HSA-912526 Interleukin receptor SHC signaling
SIGNORiP01589

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2 receptor subunit alpha
Short name:
IL-2 receptor subunit alpha
Short name:
IL-2-RA
Short name:
IL-2R subunit alpha
Short name:
IL2-RA
Alternative name(s):
TAC antigen
p55
CD_antigen: CD25
Gene namesi
Name:IL2RA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000134460.15
HGNCiHGNC:6008 IL2RA
MIMi147730 gene
neXtProtiNX_P01589

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 240ExtracellularSequence analysisAdd BLAST219
Transmembranei241 – 259HelicalSequence analysisAdd BLAST19
Topological domaini260 – 272CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Diabetes mellitus, insulin-dependent, 10 (IDDM10)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
See also OMIM:601942
Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of immune dysregulation characterized by recurrent viral, fungal, and bacterial infections, lymphadenopathy, and variable autoimmune features, such as autoimmune enteropathy and eczematous skin lesions.
See also OMIM:606367
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07464141Y → S in IMD41. 1 PublicationCorresponds to variant dbSNP:rs796051888EnsemblClinVar.1
Natural variantiVAR_074642166S → N in IMD41; the receptor does not localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs796051887EnsemblClinVar.1

Keywords - Diseasei

Diabetes mellitus, Disease mutation

Organism-specific databases

DisGeNETi3559
MalaCardsiIL2RA
MIMi601942 phenotype
606367 phenotype
OpenTargetsiENSG00000134460
Orphaneti169100 Immunodeficiency due to CD25 deficiency
85410 Oligoarticular juvenile idiopathic arthritis
85408 Rheumatoid factor-negative juvenile idiopathic arthritis
PharmGKBiPA29828

Chemistry databases

ChEMBLiCHEMBL1778
DrugBankiDB00041 Aldesleukin
DB00074 Basiliximab
DB00111 Daclizumab
DB00004 Denileukin diftitox
GuidetoPHARMACOLOGYi1695

Polymorphism and mutation databases

BioMutaiIL2RA
DMDMi124317

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001102422 – 272Interleukin-2 receptor subunit alphaAdd BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 168
Disulfide bondi49 ↔ 80
Disulfide bondi51 ↔ 82
Disulfide bondi67 ↔ 125
Glycosylationi70N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi89N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi152 ↔ 184
Glycosylationi218O-linked (GalNAc...) threonine1 Publication1
Glycosylationi224O-linked (GalNAc...) threonine1 Publication1
Glycosylationi229O-linked (GalNAc...) threonine1 Publication1
Glycosylationi237O-linked (GalNAc...) threonine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01589
PeptideAtlasiP01589
PRIDEiP01589
ProteomicsDBi51393

PTM databases

iPTMnetiP01589
PhosphoSitePlusiP01589

Expressioni

Gene expression databases

BgeeiENSG00000134460 Expressed in 103 organ(s), highest expression level in lymph node
CleanExiHS_IL2RA
ExpressionAtlasiP01589 baseline and differential
GenevisibleiP01589 HS

Organism-specific databases

HPAiCAB002419
HPA054622

Interactioni

Subunit structurei

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IL2P605683EBI-8614302,EBI-12508717

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109774, 4 interactors
CORUMiP01589
DIPiDIP-1080N
IntActiP01589, 2 interactors
MINTiP01589
STRINGi9606.ENSP00000369293

Structurei

Secondary structure

1272
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP01589
SMRiP01589
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01589

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 84Sushi 1PROSITE-ProRule annotationAdd BLAST63
Domaini123 – 186Sushi 2PROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J24B Eukaryota
ENOG41116U7 LUCA
GeneTreeiENSGT00390000018872
HOGENOMiHOG000113044
HOVERGENiHBG052109
InParanoidiP01589
KOiK05068
OMAiHYQCIQG
OrthoDBiEOG091G0NHH
PhylomeDBiP01589
TreeFamiTF337408

Family and domain databases

CDDicd00033 CCP, 1 hit
InterProiView protein in InterPro
IPR015486 IL-2_rcpt_alpha
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR10573 PTHR10573, 1 hit
PfamiView protein in Pfam
PF00084 Sushi, 1 hit
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SUPFAMiSSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P01589-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSYLLMWGL LTFIMVPGCQ AELCDDDPPE IPHATFKAMA YKEGTMLNCE
60 70 80 90 100
CKRGFRRIKS GSLYMLCTGN SSHSSWDNQC QCTSSATRNT TKQVTPQPEE
110 120 130 140 150
QKERKTTEMQ SPMQPVDQAS LPGHCREPPP WENEATERIY HFVVGQMVYY
160 170 180 190 200
QCVQGYRALH RGPAESVCKM THGKTRWTQP QLICTGEMET SQFPGEEKPQ
210 220 230 240 250
ASPEGRPESE TSCLVTTTDF QIQTEMAATM ETSIFTTEYQ VAVAGCVFLL
260 270
ISVLLLSGLT WQRRQRKSRR TI
Length:272
Mass (Da):30,819
Last modified:July 21, 1986 - v1
Checksum:i83D907C8C81D2C0E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5W006Q5W006_HUMAN
Interleukin-2 receptor subunit alph...
IL2RA
263Annotation score:
Q5W005Q5W005_HUMAN
Interleukin 2 receptor, alpha, isof...
IL2RA hCG_23482
200Annotation score:
H0Y5Z0H0Y5Z0_HUMAN
Interleukin-2 receptor subunit alph...
IL2RA
109Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07464141Y → S in IMD41. 1 PublicationCorresponds to variant dbSNP:rs796051888EnsemblClinVar.1
Natural variantiVAR_074642166S → N in IMD41; the receptor does not localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs796051887EnsemblClinVar.1
Natural variantiVAR_019280272I → T1 PublicationCorresponds to variant dbSNP:rs12722712Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01057 mRNA Translation: CAA25525.1
X03131
, X03132, X03133, X03134, X03135, X03136, X03137, X03138 Genomic DNA Translation: CAA26906.1
K03122 mRNA Translation: AAB59535.1 Sequence problems.
M11066
, M10322, M11060, M11061, M11062, M11063, M11064, M11065 Genomic DNA Translation: AAA67527.1
AY563103 Genomic DNA Translation: AAS55572.1
AL157395 Genomic DNA No translation available.
AL137186 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86414.1
M15864 Genomic DNA Translation: AAA59162.1
BN000945 Genomic DNA Translation: CAK26553.1
CCDSiCCDS7076.1
PIRiA44186 UHHU2
RefSeqiNP_000408.1, NM_000417.2
NP_001295171.1, NM_001308242.1
NP_001295172.1, NM_001308243.1
UniGeneiHs.231367

Genome annotation databases

EnsembliENST00000379959; ENSP00000369293; ENSG00000134460
GeneIDi3559
KEGGihsa:3559
UCSCiuc001iiz.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

IL2RAbase

IL2RA mutation db

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01057 mRNA Translation: CAA25525.1
X03131
, X03132, X03133, X03134, X03135, X03136, X03137, X03138 Genomic DNA Translation: CAA26906.1
K03122 mRNA Translation: AAB59535.1 Sequence problems.
M11066
, M10322, M11060, M11061, M11062, M11063, M11064, M11065 Genomic DNA Translation: AAA67527.1
AY563103 Genomic DNA Translation: AAS55572.1
AL157395 Genomic DNA No translation available.
AL137186 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86414.1
M15864 Genomic DNA Translation: AAA59162.1
BN000945 Genomic DNA Translation: CAK26553.1
CCDSiCCDS7076.1
PIRiA44186 UHHU2
RefSeqiNP_000408.1, NM_000417.2
NP_001295171.1, NM_001308242.1
NP_001295172.1, NM_001308243.1
UniGeneiHs.231367

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ILMmodel-A23-83[»]
1ILNmodel-A23-83[»]
1Z92X-ray2.80B22-238[»]
2B5IX-ray2.30D22-238[»]
2ERJX-ray3.00A/E22-233[»]
3IU3X-ray2.90I/J/K22-238[»]
3NFPX-ray2.86I/K22-238[»]
ProteinModelPortaliP01589
SMRiP01589
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109774, 4 interactors
CORUMiP01589
DIPiDIP-1080N
IntActiP01589, 2 interactors
MINTiP01589
STRINGi9606.ENSP00000369293

Chemistry databases

ChEMBLiCHEMBL1778
DrugBankiDB00041 Aldesleukin
DB00074 Basiliximab
DB00111 Daclizumab
DB00004 Denileukin diftitox
GuidetoPHARMACOLOGYi1695

PTM databases

iPTMnetiP01589
PhosphoSitePlusiP01589

Polymorphism and mutation databases

BioMutaiIL2RA
DMDMi124317

Proteomic databases

PaxDbiP01589
PeptideAtlasiP01589
PRIDEiP01589
ProteomicsDBi51393

Protocols and materials databases

DNASUi3559
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379959; ENSP00000369293; ENSG00000134460
GeneIDi3559
KEGGihsa:3559
UCSCiuc001iiz.3 human

Organism-specific databases

CTDi3559
DisGeNETi3559
EuPathDBiHostDB:ENSG00000134460.15
GeneCardsiIL2RA
HGNCiHGNC:6008 IL2RA
HPAiCAB002419
HPA054622
MalaCardsiIL2RA
MIMi147730 gene
601942 phenotype
606367 phenotype
neXtProtiNX_P01589
OpenTargetsiENSG00000134460
Orphaneti169100 Immunodeficiency due to CD25 deficiency
85410 Oligoarticular juvenile idiopathic arthritis
85408 Rheumatoid factor-negative juvenile idiopathic arthritis
PharmGKBiPA29828
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J24B Eukaryota
ENOG41116U7 LUCA
GeneTreeiENSGT00390000018872
HOGENOMiHOG000113044
HOVERGENiHBG052109
InParanoidiP01589
KOiK05068
OMAiHYQCIQG
OrthoDBiEOG091G0NHH
PhylomeDBiP01589
TreeFamiTF337408

Enzyme and pathway databases

ReactomeiR-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-HSA-9020558 Interleukin-2 signaling
R-HSA-912526 Interleukin receptor SHC signaling
SIGNORiP01589

Miscellaneous databases

ChiTaRSiIL2RA human
EvolutionaryTraceiP01589
GeneWikiiIL2RA
GenomeRNAii3559
PROiPR:P01589
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134460 Expressed in 103 organ(s), highest expression level in lymph node
CleanExiHS_IL2RA
ExpressionAtlasiP01589 baseline and differential
GenevisibleiP01589 HS

Family and domain databases

CDDicd00033 CCP, 1 hit
InterProiView protein in InterPro
IPR015486 IL-2_rcpt_alpha
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR10573 PTHR10573, 1 hit
PfamiView protein in Pfam
PF00084 Sushi, 1 hit
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SUPFAMiSSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiIL2RA_HUMAN
AccessioniPrimary (citable) accession number: P01589
Secondary accession number(s): Q5W007
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 7, 2018
This is version 197 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  6. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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