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UniProtKB - P01589 (IL2RA_HUMAN)

Protein

Interleukin-2 receptor subunit alpha

Gene

IL2RA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • interleukin-2 binding Source: GO_Central
  • interleukin-2 receptor activity Source: GO_Central
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processImmunity

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-HSA-9020558 Interleukin-2 signaling
R-HSA-912526 Interleukin receptor SHC signaling

SIGNOR Signaling Network Open Resource

More...SIGNORi		P01589

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-2 receptor subunit alpha
Short name:
IL-2 receptor subunit alpha
Short name:
IL-2-RA
Short name:
IL-2R subunit alpha
Short name:
IL2-RA
Alternative name(s):
TAC antigen
p55
CD_antigen: CD25
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL2RA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000134460.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:6008 IL2RA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		147730 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P01589

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 240ExtracellularSequence analysisAdd BLAST219
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei241 – 259HelicalSequence analysisAdd BLAST19
Topological domaini260 – 272CytoplasmicSequence analysisAdd BLAST13

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Diabetes mellitus, insulin-dependent, 10 (IDDM10)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
See also OMIM:601942
Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder of immune dysregulation characterized by recurrent viral, fungal, and bacterial infections, lymphadenopathy, and variable autoimmune features, such as autoimmune enteropathy and eczematous skin lesions.
See also OMIM:606367
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07464141Y → S in IMD41. 1 PublicationCorresponds to variant dbSNP:rs796051888EnsemblClinVar.1
Natural variantiVAR_074642166S → N in IMD41; the receptor does not localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs796051887EnsemblClinVar.1

Keywords - Diseasei

Diabetes mellitus, Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		3559

MalaCards human disease database

More...MalaCardsi		IL2RA
MIMi601942 phenotype
606367 phenotype

Open Targets

More...OpenTargetsi		ENSG00000134460

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		169100 Immunodeficiency due to CD25 deficiency
85410 Oligoarticular juvenile idiopathic arthritis
85408 Rheumatoid factor-negative juvenile idiopathic arthritis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29828

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1778

Drug and drug target database

More...DrugBanki		DB00041 Aldesleukin
DB00074 Basiliximab
DB00111 Daclizumab
DB00004 Denileukin diftitox

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1695

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IL2RA

Domain mapping of disease mutations (DMDM)

More...DMDMi		124317

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Add BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001102422 – 272Interleukin-2 receptor subunit alphaAdd BLAST251

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi24 ↔ 168
Disulfide bondi49 ↔ 80
Disulfide bondi51 ↔ 82
Disulfide bondi67 ↔ 125
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi70N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi89N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi152 ↔ 184
Glycosylationi218O-linked (GalNAc...) threonine1 Publication1
Glycosylationi224O-linked (GalNAc...) threonine1 Publication1
Glycosylationi229O-linked (GalNAc...) threonine1 Publication1
Glycosylationi237O-linked (GalNAc...) threonine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P01589

PeptideAtlas

More...PeptideAtlasi		P01589

PRoteomics IDEntifications database

More...PRIDEi		P01589

ProteomicsDB human proteome resource

More...ProteomicsDBi		51393

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P01589

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P01589

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000134460 Expressed in 103 organ(s), highest expression level in lymph node

CleanEx database of gene expression profiles

More...CleanExi		HS_IL2RA

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P01589 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P01589 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB002419
HPA054622

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
IL2P605683EBI-8614302,EBI-12508717

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		109774, 4 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P01589

Database of interacting proteins

More...DIPi		DIP-1080N

Protein interaction database and analysis system

More...IntActi		P01589, 2 interactors

Molecular INTeraction database

More...MINTi		P01589

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000369293

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1272
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ILMmodel-A23-83[»]
1ILNmodel-A23-83[»]
1Z92X-ray2.80B22-238[»]
2B5IX-ray2.30D22-238[»]
2ERJX-ray3.00A/E22-233[»]
3IU3X-ray2.90I/J/K22-238[»]
3NFPX-ray2.86I/K22-238[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P01589

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P01589

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P01589

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 84Sushi 1PROSITE-ProRule annotationAdd BLAST63
Domaini123 – 186Sushi 2PROSITE-ProRule annotationAdd BLAST64

Keywords - Domaini

Repeat, Signal, Sushi, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410J24B Eukaryota
ENOG41116U7 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018872

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000113044

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG052109

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P01589

KEGG Orthology (KO)

More...KOi		K05068

Identification of Orthologs from Complete Genome Data

More...OMAi		HYQCIQG

Database of Orthologous Groups

More...OrthoDBi		1236351at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P01589

TreeFam database of animal gene trees

More...TreeFami		TF337408

Family and domain databases

Conserved Domains Database

More...CDDi		cd00033 CCP, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR015486 IL-2_rcpt_alpha
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom

The PANTHER Classification System

More...PANTHERi		PTHR10573 PTHR10573, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00084 Sushi, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00032 CCP, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57535 SSF57535, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50923 SUSHI, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P01589-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDSYLLMWGL LTFIMVPGCQ AELCDDDPPE IPHATFKAMA YKEGTMLNCE 
        60         70         80         90        100
CKRGFRRIKS GSLYMLCTGN SSHSSWDNQC QCTSSATRNT TKQVTPQPEE 
       110        120        130        140        150
QKERKTTEMQ SPMQPVDQAS LPGHCREPPP WENEATERIY HFVVGQMVYY 
       160        170        180        190        200
QCVQGYRALH RGPAESVCKM THGKTRWTQP QLICTGEMET SQFPGEEKPQ 
       210        220        230        240        250
ASPEGRPESE TSCLVTTTDF QIQTEMAATM ETSIFTTEYQ VAVAGCVFLL 
       260        270 
ISVLLLSGLT WQRRQRKSRR TI
Length:272
Mass (Da):30,819
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i83D907C8C81D2C0E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5W006Q5W006_HUMAN
Interleukin-2 receptor subunit alph...
IL2RA
263Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5W005Q5W005_HUMAN
Interleukin 2 receptor, alpha, isof...
IL2RA hCG_23482
200Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5Z0H0Y5Z0_HUMAN
Interleukin-2 receptor subunit alph...
IL2RA
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07464141Y → S in IMD41. 1 PublicationCorresponds to variant dbSNP:rs796051888EnsemblClinVar.1
Natural variantiVAR_074642166S → N in IMD41; the receptor does not localize to the plasma membrane. 1 PublicationCorresponds to variant dbSNP:rs796051887EnsemblClinVar.1
Natural variantiVAR_019280272I → T1 PublicationCorresponds to variant dbSNP:rs12722712Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X01057 mRNA Translation: CAA25525.1
X03131
, X03132, X03133, X03134, X03135, X03136, X03137, X03138 Genomic DNA Translation: CAA26906.1
K03122 mRNA Translation: AAB59535.1 Sequence problems.
M11066
, M10322, M11060, M11061, M11062, M11063, M11064, M11065 Genomic DNA Translation: AAA67527.1
AY563103 Genomic DNA Translation: AAS55572.1
AL157395 Genomic DNA No translation available.
AL137186 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86414.1
M15864 Genomic DNA Translation: AAA59162.1
BN000945 Genomic DNA Translation: CAK26553.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS7076.1

Protein sequence database of the Protein Information Resource

More...PIRi		A44186 UHHU2

NCBI Reference Sequences

More...RefSeqi		NP_000408.1, NM_000417.2
NP_001295171.1, NM_001308242.1
NP_001295172.1, NM_001308243.1

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.231367

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000379959; ENSP00000369293; ENSG00000134460

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3559

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3559

UCSC genome browser

More...UCSCi		uc001iiz.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

IL2RAbase

IL2RA mutation db

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01057 mRNA Translation: CAA25525.1
X03131
, X03132, X03133, X03134, X03135, X03136, X03137, X03138 Genomic DNA Translation: CAA26906.1
K03122 mRNA Translation: AAB59535.1 Sequence problems.
M11066
, M10322, M11060, M11061, M11062, M11063, M11064, M11065 Genomic DNA Translation: AAA67527.1
AY563103 Genomic DNA Translation: AAS55572.1
AL157395 Genomic DNA No translation available.
AL137186 Genomic DNA No translation available.
CH471072 Genomic DNA Translation: EAW86414.1
M15864 Genomic DNA Translation: AAA59162.1
BN000945 Genomic DNA Translation: CAK26553.1
CCDSiCCDS7076.1
PIRiA44186 UHHU2
RefSeqiNP_000408.1, NM_000417.2
NP_001295171.1, NM_001308242.1
NP_001295172.1, NM_001308243.1
UniGeneiHs.231367

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ILMmodel-A23-83[»]
1ILNmodel-A23-83[»]
1Z92X-ray2.80B22-238[»]
2B5IX-ray2.30D22-238[»]
2ERJX-ray3.00A/E22-233[»]
3IU3X-ray2.90I/J/K22-238[»]
3NFPX-ray2.86I/K22-238[»]
ProteinModelPortaliP01589
SMRiP01589
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109774, 4 interactors
CORUMiP01589
DIPiDIP-1080N
IntActiP01589, 2 interactors
MINTiP01589
STRINGi9606.ENSP00000369293

Chemistry databases

ChEMBLiCHEMBL1778
DrugBankiDB00041 Aldesleukin
DB00074 Basiliximab
DB00111 Daclizumab
DB00004 Denileukin diftitox
GuidetoPHARMACOLOGYi1695

PTM databases

iPTMnetiP01589
PhosphoSitePlusiP01589

Polymorphism and mutation databases

BioMutaiIL2RA
DMDMi124317

Proteomic databases

PaxDbiP01589
PeptideAtlasiP01589
PRIDEiP01589
ProteomicsDBi51393

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		3559
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000379959; ENSP00000369293; ENSG00000134460
GeneIDi3559
KEGGihsa:3559
UCSCiuc001iiz.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3559
DisGeNETi3559
EuPathDBiHostDB:ENSG00000134460.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		IL2RA
HGNCiHGNC:6008 IL2RA
HPAiCAB002419
HPA054622
MalaCardsiIL2RA
MIMi147730 gene
601942 phenotype
606367 phenotype
neXtProtiNX_P01589
OpenTargetsiENSG00000134460
Orphaneti169100 Immunodeficiency due to CD25 deficiency
85410 Oligoarticular juvenile idiopathic arthritis
85408 Rheumatoid factor-negative juvenile idiopathic arthritis
PharmGKBiPA29828

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410J24B Eukaryota
ENOG41116U7 LUCA
GeneTreeiENSGT00390000018872
HOGENOMiHOG000113044
HOVERGENiHBG052109
InParanoidiP01589
KOiK05068
OMAiHYQCIQG
OrthoDBi1236351at2759
PhylomeDBiP01589
TreeFamiTF337408

Enzyme and pathway databases

ReactomeiR-HSA-5673001 RAF/MAP kinase cascade
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-HSA-9020558 Interleukin-2 signaling
R-HSA-912526 Interleukin receptor SHC signaling
SIGNORiP01589

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IL2RA human
EvolutionaryTraceiP01589

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		IL2RA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3559

Protein Ontology

More...PROi		PR:P01589

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000134460 Expressed in 103 organ(s), highest expression level in lymph node
CleanExiHS_IL2RA
ExpressionAtlasiP01589 baseline and differential
GenevisibleiP01589 HS

Family and domain databases

CDDicd00033 CCP, 1 hit
InterProiView protein in InterPro
IPR015486 IL-2_rcpt_alpha
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
PANTHERiPTHR10573 PTHR10573, 1 hit
PfamiView protein in Pfam
PF00084 Sushi, 1 hit
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SUPFAMiSSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS50923 SUSHI, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL2RA_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01589
Secondary accession number(s): Q5W007
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: January 16, 2019
This is version 199 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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