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UniProtKB - P01587 (CSF2_MOUSE)
Protein
Granulocyte-macrophage colony-stimulating factor
Gene
Csf2
Organism
Mus musculus (Mouse)
Status
Functioni
Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.
GO - Molecular functioni
- cytokine activity Source: MGI
- granulocyte macrophage colony-stimulating factor receptor binding Source: InterPro
- growth factor activity Source: UniProtKB-KW
GO - Biological processi
- cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: MGI
- dendritic cell differentiation Source: MGI
- embryonic placenta development Source: MGI
- epithelial fluid transport Source: MGI
- granulocyte-macrophage colony-stimulating factor signaling pathway Source: Ensembl
- histamine secretion Source: MGI
- immune response Source: InterPro
- macrophage activation Source: MGI
- macrophage differentiation Source: MGI
- monocyte differentiation Source: MGI
- myeloid cell differentiation Source: GO_Central
- myeloid dendritic cell differentiation Source: MGI
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
- negative regulation of transcription, DNA-templated Source: MGI
- neutrophil differentiation Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of gene expression Source: MGI
- positive regulation of interleukin-23 production Source: MGI
- positive regulation of leukocyte proliferation Source: Ensembl
- positive regulation of macrophage derived foam cell differentiation Source: MGI
- positive regulation of podosome assembly Source: MGI
- positive regulation of tyrosine phosphorylation of STAT protein Source: MGI
- protein phosphorylation Source: Ensembl
- receptor signaling pathway via JAK-STAT Source: Ensembl
- regulation of cell population proliferation Source: MGI
- regulation of circadian sleep/wake cycle, sleep Source: MGI
- regulation of gene expression Source: MGI
Keywordsi
Molecular function | Cytokine, Growth factor |
Enzyme and pathway databases
Reactomei | R-MMU-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling R-MMU-5673001, RAF/MAP kinase cascade R-MMU-912526, Interleukin receptor SHC signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Granulocyte-macrophage colony-stimulating factorShort name: GM-CSF Alternative name(s): Colony-stimulating factor Short name: CSF |
Gene namesi | Name:Csf2 Synonyms:Csfgm |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1339752, Csf2 |
VEuPathDBi | HostDB:ENSMUSG00000018916 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: MGI
Plasma Membrane
Other locations
- intracellular membrane-bounded organelle Source: MGI
Keywords - Cellular componenti
SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 38 | E → P: Reduction in bioactivity. 1 Publication | 1 | |
Mutagenesisi | 73 | L → P: 25-fold reduction in bioactivity. 1 Publication | 1 | |
Mutagenesisi | 77 | E → P: 50-fold reduction in bioactivity. 1 Publication | 1 | |
Mutagenesisi | 80 | L → P: 450-fold reduction in bioactivity. 1 Publication | 1 | |
Mutagenesisi | 124 | L → P: 5500-fold reduction in bioactivity. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 17 | Add BLAST | 17 | |
ChainiPRO_0000005866 | 18 – 141 | Granulocyte-macrophage colony-stimulating factorAdd BLAST | 124 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 22 | O-linked (GalNAc...) serineBy similarity | 1 | |
Glycosylationi | 27 | O-linked (GalNAc...) threonineBy similarity | 1 | |
Disulfide bondi | 68 ↔ 110 | 1 Publication | ||
Glycosylationi | 83 | N-linked (GlcNAc...) asparagine | 1 | |
Glycosylationi | 92 | N-linked (GlcNAc...) asparagine | 1 | |
Disulfide bondi | 102 ↔ 135 | 1 Publication |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P01587 |
PRIDEi | P01587 |
PTM databases
GlyGeni | P01587, 4 sites |
PhosphoSitePlusi | P01587 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000018916, Expressed in lung and 42 other tissues |
ExpressionAtlasi | P01587, baseline and differential |
Genevisiblei | P01587, MM |
Interactioni
Subunit structurei
Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits (By similarity).
By similarityGO - Molecular functioni
- cytokine activity Source: MGI
- granulocyte macrophage colony-stimulating factor receptor binding Source: InterPro
- growth factor activity Source: UniProtKB-KW
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000019060 |
Miscellaneous databases
RNActi | P01587, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the GM-CSF family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502TDUI, Eukaryota |
GeneTreei | ENSGT00390000013425 |
HOGENOMi | CLU_152286_0_0_1 |
InParanoidi | P01587 |
OMAi | VTRPWKH |
PhylomeDBi | P01587 |
TreeFami | TF338611 |
Family and domain databases
CDDi | cd00040, CSF2, 1 hit |
Gene3Di | 1.20.1250.10, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000773, GM_colony-stim-fac |
PANTHERi | PTHR10059, PTHR10059, 1 hit |
Pfami | View protein in Pfam PF01109, GM_CSF, 1 hit |
PRINTSi | PR00693, GMCSFACTOR |
SMARTi | View protein in SMART SM00040, CSF2, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00702, GM_CSF, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P01587-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWLQNLLFLG IVVYSLSAPT RSPITVTRPW KHVEAIKEAL NLLDDMPVTL
60 70 80 90 100
NEEVEVVSNE FSFKKLTCVQ TRLKIFEQGL RGNFTKLKGA LNMTASYYQT
110 120 130 140
YCPPTPETDC ETQVTTYADF IDSLKTFLTD IPFECKKPGQ K
Sequence cautioni
The sequence CAA26192 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 25 | T → I in CAA29336 (PubMed:6610831).Curated | 1 | |
Sequence conflicti | 25 | T → I AA sequence (PubMed:3871523).Curated | 1 | |
Sequence conflicti | 114 | V → A in AAA37483 (PubMed:3898082).Curated | 1 | |
Sequence conflicti | 139 | G → S in CAA29336 (PubMed:6610831).Curated | 1 | |
Sequence conflicti | 139 | G → V in CAA26820 (PubMed:3876931).Curated | 1 | |
Sequence conflicti | 139 | G → V no nucleotide entry (PubMed:3902470).Curated | 1 | |
Sequence conflicti | 139 | G → V in CAA26192 (PubMed:3874057).Curated | 1 | |
Sequence conflicti | 139 | G → V in CAA26193 (PubMed:3874057).Curated | 1 | |
Sequence conflicti | 139 | G → V in AAA37483 (PubMed:3898082).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03020 Genomic DNA Translation: CAA26821.1 X03019 mRNA Translation: CAA26820.1 X02333 mRNA Translation: CAA26193.1 X02333 mRNA Translation: CAA26192.1 Different initiation. X05906 mRNA Translation: CAA29336.1 M11848 mRNA Translation: AAA37483.1 |
CCDSi | CCDS24692.1 |
PIRi | I48368, FQMSGM |
RefSeqi | NP_034099.2, NM_009969.4 |
Genome annotation databases
Ensembli | ENSMUST00000019060; ENSMUSP00000019060; ENSMUSG00000018916 |
GeneIDi | 12981 |
KEGGi | mmu:12981 |
UCSCi | uc007ixm.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X03020 Genomic DNA Translation: CAA26821.1 X03019 mRNA Translation: CAA26820.1 X02333 mRNA Translation: CAA26193.1 X02333 mRNA Translation: CAA26192.1 Different initiation. X05906 mRNA Translation: CAA29336.1 M11848 mRNA Translation: AAA37483.1 |
CCDSi | CCDS24692.1 |
PIRi | I48368, FQMSGM |
RefSeqi | NP_034099.2, NM_009969.4 |
3D structure databases
SMRi | P01587 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000019060 |
PTM databases
GlyGeni | P01587, 4 sites |
PhosphoSitePlusi | P01587 |
Proteomic databases
PaxDbi | P01587 |
PRIDEi | P01587 |
Protocols and materials databases
Antibodypediai | 14363, 1881 antibodies from 48 providers |
DNASUi | 12981 |
Genome annotation databases
Ensembli | ENSMUST00000019060; ENSMUSP00000019060; ENSMUSG00000018916 |
GeneIDi | 12981 |
KEGGi | mmu:12981 |
UCSCi | uc007ixm.1, mouse |
Organism-specific databases
CTDi | 1437 |
MGIi | MGI:1339752, Csf2 |
VEuPathDBi | HostDB:ENSMUSG00000018916 |
Phylogenomic databases
eggNOGi | ENOG502TDUI, Eukaryota |
GeneTreei | ENSGT00390000013425 |
HOGENOMi | CLU_152286_0_0_1 |
InParanoidi | P01587 |
OMAi | VTRPWKH |
PhylomeDBi | P01587 |
TreeFami | TF338611 |
Enzyme and pathway databases
Reactomei | R-MMU-512988, Interleukin-3, Interleukin-5 and GM-CSF signaling R-MMU-5673001, RAF/MAP kinase cascade R-MMU-912526, Interleukin receptor SHC signaling |
Miscellaneous databases
BioGRID-ORCSi | 12981, 0 hits in 67 CRISPR screens |
ChiTaRSi | Csf2, mouse |
PROi | PR:P01587 |
RNActi | P01587, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000018916, Expressed in lung and 42 other tissues |
ExpressionAtlasi | P01587, baseline and differential |
Genevisiblei | P01587, MM |
Family and domain databases
CDDi | cd00040, CSF2, 1 hit |
Gene3Di | 1.20.1250.10, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000773, GM_colony-stim-fac |
PANTHERi | PTHR10059, PTHR10059, 1 hit |
Pfami | View protein in Pfam PF01109, GM_CSF, 1 hit |
PRINTSi | PR00693, GMCSFACTOR |
SMARTi | View protein in SMART SM00040, CSF2, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00702, GM_CSF, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CSF2_MOUSE | |
Accessioni | P01587Primary (citable) accession number: P01587 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | April 1, 1988 | |
Last modified: | February 23, 2022 | |
This is version 166 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families