Csf2

Functionⁱ

Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

GO - Molecular functionⁱ

cytokine activity
Source: MGI
Inferred from direct assayⁱ
- 10652277
- 1350248
granulocyte macrophage colony-stimulating factor receptor binding Source: InterPro
growth factor activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to granulocyte macrophage colony-stimulating factor stimulus Source: MGI
dendritic cell differentiation Source: MGI
embryonic placenta development
Source: MGI
Inferred from mutant phenotypeⁱ
- 19228596
epithelial fluid transport Source: MGI
histamine secretion Source: MGI
immune response Source: InterPro
macrophage activation Source: MGI
monocyte differentiation
Source: MGI
Inferred from direct assayⁱ
- 19109256
myeloid dendritic cell differentiation
Source: MGI
Inferred from direct assayⁱ
- 12021780
negative regulation of cytolysis Source: MGI
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
negative regulation of transcription, DNA-templated Source: MGI
neutrophil differentiation
Source: MGI
Inferred from direct assayⁱ
- 19109256
positive regulation of cell proliferation
Source: MGI
Inferred from direct assayⁱ
- 10652277
- 1350248
positive regulation of gene expression Source: MGI
positive regulation of interleukin-23 production Source: MGI
positive regulation of macrophage derived foam cell differentiation Source: MGI
positive regulation of podosome assembly Source: MGI
positive regulation of tyrosine phosphorylation of STAT protein Source: MGI
regulation of cell proliferation
Source: MGI
Inferred from genetic interactionⁱ
- 10678181
regulation of circadian sleep/wake cycle, sleep Source: MGI
regulation of gene expression
Source: MGI
Inferred from direct assayⁱ
- 9697835

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine, Growth factor

Molecular function

Cytokine, Growth factor

Enzyme and pathway databases

Reactomeⁱ	R-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling R-MMU-5673001 RAF/MAP kinase cascade R-MMU-912526 Interleukin receptor SHC signaling

Reactomeⁱ

R-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-912526 Interleukin receptor SHC signaling

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Granulocyte-macrophage colony-stimulating factor Short name: GM-CSF Alternative name(s): Colony-stimulating factor Short name: CSF
Gene namesⁱ	Name:Csf2 Synonyms:Csfgm
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:1339752 Csf2

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	38	E → P: Reduction in bioactivity. 1 Publication	1
Mutagenesisⁱ	73	L → P: 25-fold reduction in bioactivity. 1 Publication	1
Mutagenesisⁱ	77	E → P: 50-fold reduction in bioactivity. 1 Publication	1
Mutagenesisⁱ	80	L → P: 450-fold reduction in bioactivity. 1 Publication	1
Mutagenesisⁱ	124	L → P: 5500-fold reduction in bioactivity. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 17	Add BLAST		17
ChainⁱPRO_0000005866	18 – 141	Granulocyte-macrophage colony-stimulating factorAdd BLAST		124

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	22	O-linked (GalNAc...) serineBy similarity	1
Glycosylationⁱ	27	O-linked (GalNAc...) threonineBy similarity	1
Disulfide bondⁱ	68 ↔ 110	1 Publication
Glycosylationⁱ	83	N-linked (GlcNAc...) asparagine	1
Glycosylationⁱ	92	N-linked (GlcNAc...) asparagine	1
Disulfide bondⁱ	102 ↔ 135	1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P01587
PRIDEⁱ	P01587

PTM databases

PhosphoSitePlusⁱ	P01587

PhosphoSitePlusⁱ

P01587

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000018916 Expressed in 24 organ(s), highest expression level in left lung lobe
ExpressionAtlasⁱ	P01587 baseline and differential
Genevisibleⁱ	P01587 MM

Interactionⁱ

Subunit structureⁱ

Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits (By similarity).By similarity

GO - Molecular functionⁱ

cytokine activity
Source: MGI
Inferred from direct assayⁱ
- 10652277
- 1350248
granulocyte macrophage colony-stimulating factor receptor binding Source: InterPro
growth factor activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000019060

STRINGⁱ

10090.ENSMUSP00000019060

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P01587
SMRⁱ	P01587
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the GM-CSF family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410JBQ7 Eukaryota ENOG411164J LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000013425
HOGENOMⁱ	HOG000037940
HOVERGENⁱ	HBG000532
InParanoidⁱ	P01587
KEGG Orthology (KO) More...KOⁱ	K05427
OMAⁱ	MWLQNLL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0XFL
PhylomeDBⁱ	P01587
TreeFamⁱ	TF338611

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00040 CSF2, 1 hit
InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR000773 GM_colony-stim-fac
PANTHERⁱ	PTHR10059 PTHR10059, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01109 GM_CSF, 1 hit
PRINTSⁱ	PR00693 GMCSFACTOR
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD007349 GM_colony-stim-fac, 1 hit
SMARTⁱ	View protein in SMART SM00040 CSF2, 1 hit
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00702 GM_CSF, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P01587-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MWLQNLLFLG IVVYSLSAPT RSPITVTRPW KHVEAIKEAL NLLDDMPVTL 
        60         70         80         90        100
NEEVEVVSNE FSFKKLTCVQ TRLKIFEQGL RGNFTKLKGA LNMTASYYQT 
       110        120        130        140 
YCPPTPETDC ETQVTTYADF IDSLKTFLTD IPFECKKPGQ K

Length:141

Mass (Da):16,091

Last modified:April 1, 1988 - v1

Checksum:ⁱ209C7CBB4FF77349

GO

Sequence cautionⁱ

The sequence CAA26192 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	25	T → I in CAA29336 (PubMed:6610831).Curated	1
Sequence conflictⁱ	25	T → I AA sequence (PubMed:3871523).Curated	1
Sequence conflictⁱ	114	V → A in AAA37483 (PubMed:3898082).Curated	1
Sequence conflictⁱ	139	G → S in CAA29336 (PubMed:6610831).Curated	1
Sequence conflictⁱ	139	G → V in CAA26820 (PubMed:3876931).Curated	1
Sequence conflictⁱ	139	G → V no nucleotide entry (PubMed:3902470).Curated	1
Sequence conflictⁱ	139	G → V in CAA26192 (PubMed:3874057).Curated	1
Sequence conflictⁱ	139	G → V in CAA26193 (PubMed:3874057).Curated	1
Sequence conflictⁱ	139	G → V in AAA37483 (PubMed:3898082).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03020 Genomic DNA Translation: CAA26821.1 X03019 mRNA Translation: CAA26820.1 X02333 mRNA Translation: CAA26193.1 X02333 mRNA Translation: CAA26192.1 Different initiation. X05906 mRNA Translation: CAA29336.1 M11848 mRNA Translation: AAA37483.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24692.1
PIRⁱ	I48368 FQMSGM
NCBI Reference Sequences More...RefSeqⁱ	NP_034099.2, NM_009969.4
UniGeneⁱ	Mm.4922

Genome annotation databases

Ensemblⁱ	ENSMUST00000019060; ENSMUSP00000019060; ENSMUSG00000018916
GeneIDⁱ	12981
KEGGⁱ	mmu:12981
UCSC genome browser More...UCSCⁱ	uc007ixm.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01587	Colony stimulating factor 2 (Granulocyte-macrophage)		MOUSE		141	UniRef100_P01587

Protein	Similar proteins		Species	Score	Length	Source
P01587	Colony stimulating factor 2 (Granulocyte-macrophage)		MOUSE		141	UniRef90_P01587
UPI000A3134FD		MUSPA		141
UPI000A31A50D		MUSCR		141
Colony stimulating factor 2 (Granulocyte-macrophage)		MOUSE		141

Protein	Similar proteins		Species	Score	Length	Source
P01587	Granulocyte-macrophage colony-stimulating factor		RAT		144	UniRef50_P01587
Colony stimulating factor 2 (Granulocyte-macrophage)		MOUSE		141
Uncharacterized protein		ICTTR		138
Granulocyte-macrophage colony stimulating factor		MARMO		138
Uncharacterized protein		NEOLE		142
+34

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X03020 Genomic DNA Translation: CAA26821.1 X03019 mRNA Translation: CAA26820.1 X02333 mRNA Translation: CAA26193.1 X02333 mRNA Translation: CAA26192.1 Different initiation. X05906 mRNA Translation: CAA29336.1 M11848 mRNA Translation: AAA37483.1
CCDSⁱ	CCDS24692.1
PIRⁱ	I48368 FQMSGM
RefSeqⁱ	NP_034099.2, NM_009969.4
UniGeneⁱ	Mm.4922

3D structure databases

ProteinModelPortalⁱ	P01587
SMRⁱ	P01587
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000019060

STRINGⁱ

10090.ENSMUSP00000019060

PTM databases

PhosphoSitePlusⁱ	P01587

PhosphoSitePlusⁱ

P01587

Proteomic databases

PaxDbⁱ	P01587
PRIDEⁱ	P01587

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000019060; ENSMUSP00000019060; ENSMUSG00000018916
GeneIDⁱ	12981
KEGGⁱ	mmu:12981
UCSCⁱ	uc007ixm.1 mouse

Organism-specific databases

CTDⁱ	1437
MGIⁱ	MGI:1339752 Csf2

Phylogenomic databases

eggNOGⁱ	ENOG410JBQ7 Eukaryota ENOG411164J LUCA
GeneTreeⁱ	ENSGT00390000013425
HOGENOMⁱ	HOG000037940
HOVERGENⁱ	HBG000532
InParanoidⁱ	P01587
KOⁱ	K05427
OMAⁱ	MWLQNLL
OrthoDBⁱ	EOG091G0XFL
PhylomeDBⁱ	P01587
TreeFamⁱ	TF338611

Enzyme and pathway databases

Reactomeⁱ	R-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling R-MMU-5673001 RAF/MAP kinase cascade R-MMU-912526 Interleukin receptor SHC signaling

Reactomeⁱ

R-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-912526 Interleukin receptor SHC signaling

Miscellaneous databases

ChiTaRSⁱ	Csf2 mouse
Protein Ontology More...PROⁱ	PR:P01587
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000018916 Expressed in 24 organ(s), highest expression level in left lung lobe
ExpressionAtlasⁱ	P01587 baseline and differential
Genevisibleⁱ	P01587 MM

Family and domain databases

CDDⁱ	cd00040 CSF2, 1 hit
InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR000773 GM_colony-stim-fac
PANTHERⁱ	PTHR10059 PTHR10059, 1 hit
Pfamⁱ	View protein in Pfam PF01109 GM_CSF, 1 hit
PRINTSⁱ	PR00693 GMCSFACTOR
ProDomⁱ	View protein in ProDom or Entries sharing at least one domain PD007349 GM_colony-stim-fac, 1 hit
SMARTⁱ	View protein in SMART SM00040 CSF2, 1 hit
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00702 GM_CSF, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CSF2_MOUSE
Accessionⁱ	P01587Primary (citable) accession number: P01587
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	April 1, 1988
	Last modified:	September 12, 2018
	This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P01587 (CSF2_MOUSE)

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Granulocyte-macrophage colony-stimulating factor

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ