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Protein

Granulocyte-macrophage colony-stimulating factor

Gene

Csf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-912526 Interleukin receptor SHC signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Granulocyte-macrophage colony-stimulating factor
Short name:
GM-CSF
Alternative name(s):
Colony-stimulating factor
Short name:
CSF
Gene namesi
Name:Csf2
Synonyms:Csfgm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1339752 Csf2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi38E → P: Reduction in bioactivity. 1 Publication1
Mutagenesisi73L → P: 25-fold reduction in bioactivity. 1 Publication1
Mutagenesisi77E → P: 50-fold reduction in bioactivity. 1 Publication1
Mutagenesisi80L → P: 450-fold reduction in bioactivity. 1 Publication1
Mutagenesisi124L → P: 5500-fold reduction in bioactivity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Add BLAST17
ChainiPRO_000000586618 – 141Granulocyte-macrophage colony-stimulating factorAdd BLAST124

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22O-linked (GalNAc...) serineBy similarity1
Glycosylationi27O-linked (GalNAc...) threonineBy similarity1
Disulfide bondi68 ↔ 1101 Publication
Glycosylationi83N-linked (GlcNAc...) asparagine1
Glycosylationi92N-linked (GlcNAc...) asparagine1
Disulfide bondi102 ↔ 1351 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01587
PRIDEiP01587

PTM databases

PhosphoSitePlusiP01587

Expressioni

Gene expression databases

BgeeiENSMUSG00000018916 Expressed in 24 organ(s), highest expression level in left lung lobe
ExpressionAtlasiP01587 baseline and differential
GenevisibleiP01587 MM

Interactioni

Subunit structurei

Monomer. The signaling GM-CSF receptor complex is a dodecamer of two head-to-head hexamers of two alpha, two beta, and two ligand subunits (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019060

Structurei

3D structure databases

ProteinModelPortaliP01587
SMRiP01587
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GM-CSF family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JBQ7 Eukaryota
ENOG411164J LUCA
GeneTreeiENSGT00390000013425
HOGENOMiHOG000037940
HOVERGENiHBG000532
InParanoidiP01587
KOiK05427
OMAiMWLQNLL
OrthoDBiEOG091G0XFL
PhylomeDBiP01587
TreeFamiTF338611

Family and domain databases

CDDicd00040 CSF2, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000773 GM_colony-stim-fac
PANTHERiPTHR10059 PTHR10059, 1 hit
PfamiView protein in Pfam
PF01109 GM_CSF, 1 hit
PRINTSiPR00693 GMCSFACTOR
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007349 GM_colony-stim-fac, 1 hit
SMARTiView protein in SMART
SM00040 CSF2, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00702 GM_CSF, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01587-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWLQNLLFLG IVVYSLSAPT RSPITVTRPW KHVEAIKEAL NLLDDMPVTL
60 70 80 90 100
NEEVEVVSNE FSFKKLTCVQ TRLKIFEQGL RGNFTKLKGA LNMTASYYQT
110 120 130 140
YCPPTPETDC ETQVTTYADF IDSLKTFLTD IPFECKKPGQ K
Length:141
Mass (Da):16,091
Last modified:April 1, 1988 - v1
Checksum:i209C7CBB4FF77349
GO

Sequence cautioni

The sequence CAA26192 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25T → I in CAA29336 (PubMed:6610831).Curated1
Sequence conflicti25T → I AA sequence (PubMed:3871523).Curated1
Sequence conflicti114V → A in AAA37483 (PubMed:3898082).Curated1
Sequence conflicti139G → S in CAA29336 (PubMed:6610831).Curated1
Sequence conflicti139G → V in CAA26820 (PubMed:3876931).Curated1
Sequence conflicti139G → V no nucleotide entry (PubMed:3902470).Curated1
Sequence conflicti139G → V in CAA26192 (PubMed:3874057).Curated1
Sequence conflicti139G → V in CAA26193 (PubMed:3874057).Curated1
Sequence conflicti139G → V in AAA37483 (PubMed:3898082).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03020 Genomic DNA Translation: CAA26821.1
X03019 mRNA Translation: CAA26820.1
X02333 mRNA Translation: CAA26193.1
X02333 mRNA Translation: CAA26192.1 Different initiation.
X05906 mRNA Translation: CAA29336.1
M11848 mRNA Translation: AAA37483.1
CCDSiCCDS24692.1
PIRiI48368 FQMSGM
RefSeqiNP_034099.2, NM_009969.4
UniGeneiMm.4922

Genome annotation databases

EnsembliENSMUST00000019060; ENSMUSP00000019060; ENSMUSG00000018916
GeneIDi12981
KEGGimmu:12981
UCSCiuc007ixm.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03020 Genomic DNA Translation: CAA26821.1
X03019 mRNA Translation: CAA26820.1
X02333 mRNA Translation: CAA26193.1
X02333 mRNA Translation: CAA26192.1 Different initiation.
X05906 mRNA Translation: CAA29336.1
M11848 mRNA Translation: AAA37483.1
CCDSiCCDS24692.1
PIRiI48368 FQMSGM
RefSeqiNP_034099.2, NM_009969.4
UniGeneiMm.4922

3D structure databases

ProteinModelPortaliP01587
SMRiP01587
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019060

PTM databases

PhosphoSitePlusiP01587

Proteomic databases

PaxDbiP01587
PRIDEiP01587

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019060; ENSMUSP00000019060; ENSMUSG00000018916
GeneIDi12981
KEGGimmu:12981
UCSCiuc007ixm.1 mouse

Organism-specific databases

CTDi1437
MGIiMGI:1339752 Csf2

Phylogenomic databases

eggNOGiENOG410JBQ7 Eukaryota
ENOG411164J LUCA
GeneTreeiENSGT00390000013425
HOGENOMiHOG000037940
HOVERGENiHBG000532
InParanoidiP01587
KOiK05427
OMAiMWLQNLL
OrthoDBiEOG091G0XFL
PhylomeDBiP01587
TreeFamiTF338611

Enzyme and pathway databases

ReactomeiR-MMU-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-MMU-5673001 RAF/MAP kinase cascade
R-MMU-912526 Interleukin receptor SHC signaling

Miscellaneous databases

ChiTaRSiCsf2 mouse
PROiPR:P01587
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018916 Expressed in 24 organ(s), highest expression level in left lung lobe
ExpressionAtlasiP01587 baseline and differential
GenevisibleiP01587 MM

Family and domain databases

CDDicd00040 CSF2, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000773 GM_colony-stim-fac
PANTHERiPTHR10059 PTHR10059, 1 hit
PfamiView protein in Pfam
PF01109 GM_CSF, 1 hit
PRINTSiPR00693 GMCSFACTOR
ProDomiView protein in ProDom or Entries sharing at least one domain
PD007349 GM_colony-stim-fac, 1 hit
SMARTiView protein in SMART
SM00040 CSF2, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00702 GM_CSF, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSF2_MOUSE
AccessioniPrimary (citable) accession number: P01587
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1988
Last modified: September 12, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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