Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interleukin-3

Gene

Il3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.
This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.

GO - Molecular functioni

  • cytokine activity Source: MGI
  • growth factor activity Source: MGI
  • interleukin-1 receptor binding Source: GO_Central
  • interleukin-3 receptor binding Source: MGI

GO - Biological processi

  • activation of Janus kinase activity Source: MGI
  • cytokine-mediated signaling pathway Source: MGI
  • extrinsic apoptotic signaling pathway in absence of ligand Source: MGI
  • fever generation Source: GO_Central
  • hemopoiesis Source: MGI
  • immune response Source: InterPro
  • interleukin-3-mediated signaling pathway Source: MGI
  • monocyte differentiation Source: MGI
  • myeloid cell apoptotic process Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of autophagy Source: MGI
  • negative regulation of mast cell apoptotic process Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of JNK cascade Source: MGI
  • positive regulation of mast cell proliferation Source: MGI
  • positive regulation of myeloid leukocyte differentiation Source: MGI
  • positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  • positive regulation of protein phosphorylation Source: MGI
  • regulation of cell growth Source: MGI
  • regulation of gene expression Source: MGI
  • regulation of glycolytic process Source: MGI
  • regulation of protein dephosphorylation Source: MGI
  • response to hormone Source: MGI
  • response to hypoxia Source: MGI

Keywordsi

Molecular functionCytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-3
Short name:
IL-3
Alternative name(s):
Hematopoietic growth factor
Mast cell growth factor
Short name:
MCGF
Multipotential colony-stimulating factor
P-cell-stimulating factor
Gene namesi
Name:Il3
Synonyms:Csfmu, Il-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96552 Il3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Add BLAST26
ChainiPRO_000001551927 – 166Interleukin-3Add BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi42N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi43 ↔ 1061 Publication
Disulfide bondi105 ↔ 1661 Publication
Glycosylationi112N-linked (GlcNAc...) asparagine; partial1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01586
PRIDEiP01586

PTM databases

iPTMnetiP01586

Expressioni

Tissue specificityi

Activated T-cells, mast cells, natural killer cells.

Gene expression databases

BgeeiENSMUSG00000018914
CleanExiMM_IL3
ExpressionAtlasiP01586 baseline and differential
GenevisibleiP01586 MM

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

  • cytokine activity Source: MGI
  • growth factor activity Source: MGI
  • interleukin-1 receptor binding Source: GO_Central
  • interleukin-3 receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019058

Structurei

Secondary structure

1166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi37 – 41Combined sources5
Helixi44 – 53Combined sources10
Helixi67 – 69Combined sources3
Turni71 – 73Combined sources3
Helixi74 – 85Combined sources12
Turni86 – 88Combined sources3
Helixi90 – 93Combined sources4
Helixi97 – 106Combined sources10
Helixi124 – 137Combined sources14
Beta strandi140 – 142Combined sources3
Beta strandi151 – 153Combined sources3

3D structure databases

ProteinModelPortaliP01586
SMRiP01586
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00520000059953
HOGENOMiHOG000113051
HOVERGENiHBG006148
InParanoidiP01586
KOiK04736
OMAiSGRDTHR
OrthoDBiEOG091G15R6
PhylomeDBiP01586
TreeFamiTF338567

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002183 IL-3
PfamiView protein in Pfam
PF02059 IL3, 1 hit
PIRSFiPIRSF001939 IL-3, 1 hit
PRINTSiPR00430 INTERLEUKIN3
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01586-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLASSTTSI HTMLLLLLML FHLGLQASIS GRDTHRLTRT LNCSSIVKEI
60 70 80 90 100
IGKLPEPELK TDDEGPSLRN KSFRRVNLSK FVESQGEVDP EDRYVIKSNL
110 120 130 140 150
QKLNCCLPTS ANDSALPGVF IRDLDDFRKK LRFYMVHLND LETVLTSRPP
160
QPASGSVSPN RGTVEC
Length:166
Mass (Da):18,540
Last modified:July 21, 1986 - v1
Checksum:iF38EE7A9E361CAA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01850 mRNA Translation: AAA39291.1
K01668 mRNA Translation: AAA39507.1
K03233 Genomic DNA Translation: AAA39293.1
X02732 Genomic DNA Translation: CAA26514.1
M20128, M14394 Genomic DNA Translation: AAA39308.1
CCDSiCCDS24693.1
PIRiA25481 ICMS3
RefSeqiNP_034686.2, NM_010556.4
UniGeneiMm.983

Genome annotation databases

EnsembliENSMUST00000019058; ENSMUSP00000019058; ENSMUSG00000018914
GeneIDi16187
KEGGimmu:16187
UCSCiuc007ixn.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIL3_MOUSE
AccessioniPrimary (citable) accession number: P01586
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 20, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health