Interleukin-1 beta

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Miscellaneous

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• cytokine activity Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 1919436
• integrin binding Source: UniProtKBInferred from direct assayⁱ
  • 29030430
• interleukin-1 receptor binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • 21873635
• protein domain specific binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • 16575408

GO - Biological processⁱ

• activation of MAPK activity Source: BHF-UCLInferred from direct assayⁱ
  • 10748004
• apoptotic process Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 9218611
• cell-cell signaling Source: ProtIncTraceable author statementⁱ
  • 2989698
• cellular response to antibiotic Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• cellular response to drug Source: MGIInferred from direct assayⁱ
  • 19158679
• cellular response to fatty acid Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• cellular response to glucose stimulus Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• cellular response to lipopolysaccharide Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• cellular response to mechanical stimulus Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • 19593445
• cellular response to organic cyclic compound Source: UniProtKBInferred from direct assayⁱ
  • 21147091
• cellular response to organic substance Source: MGIInferred from direct assayⁱ
  • 19158679
• chronic inflammatory response to antigenic stimulus Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• cytokine-mediated signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • 10748004
• ectopic germ cell programmed cell death Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• embryo implantation Source: BHF-UCLTraceable author statementⁱ
  • 16720713
• extrinsic apoptotic signaling pathway in absence of ligand Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• fever generation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• hyaluronan biosynthetic process Source: UniProtKBInferred from direct assayⁱ
  • 15100360
• inflammatory response Source: UniProtKBInferred from direct assayⁱ
  • 21147091
• interleukin-1 beta production Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• interleukin-1-mediated signaling pathway Source: Reactome
• interleukin-6 production Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• lipopolysaccharide-mediated signaling pathway Source: UniProtKBInferred from direct assayⁱ
  • 21147091
• MAPK cascade Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 21147091
• memory Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• monocyte aggregation Source: UniProtKBInferred from direct assayⁱ
  • 15100360
• negative regulation of adiponectin secretion Source: BHF-UCL <p>Inferred from Sequence or Structural Similarity <br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • 16865359
• negative regulation of branching morphogenesis of a nerve Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• negative regulation of cell proliferation Source: BHF-UCLInferred from direct assayⁱ
  • 3493774
• negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCLInferred from direct assayⁱ
  • 10748004
• negative regulation of glucose transmembrane transport Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • 16865359
• negative regulation of glutamate secretion Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• negative regulation of insulin receptor signaling pathway Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • 16865359
• negative regulation of lipid catabolic process Source: BHF-UCLInferred from direct assayⁱ
  • 19032770
• negative regulation of lipid metabolic process Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • 16865359
• negative regulation of MAP kinase activity Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • 16865359
• negative regulation of neural precursor cell proliferation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• negative regulation of neurogenesis Source: ARUK-UCLTraceable author statementⁱ
  • 20018408
• negative regulation of neuron differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• negative regulation of synaptic transmission Source: ARUK-UCL
• negative regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• neutrophil chemotaxis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• ovulation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of angiogenesis Source: BHF-UCLInferred from direct assayⁱ
  • 25204733
• positive regulation of astrocyte differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of calcidiol 1-monooxygenase activity Source: BHF-UCLInferred from direct assayⁱ
  • 16720713
  • 17023519
• positive regulation of cell adhesion molecule production Source: BHF-UCL <p>Non-traceable Author Statement</p> <p>Used for statements in the abstract, introduction or discussion of a paper that cannot be traced back to another publication.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#nas">GO evidence code guide</a></p> Non-traceable author statementⁱ
  • 19281832
• positive regulation of cell division Source: UniProtKB-KW
• positive regulation of cell migration Source: BHF-UCLInferred from direct assayⁱ
  • 25204733
• positive regulation of cell proliferation Source: BHF-UCLInferred from direct assayⁱ
  • 25204733
• positive regulation of chemokine biosynthetic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of cytosolic calcium ion concentration Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of DNA-binding transcription factor activity Source: BHF-UCLInferred from direct assayⁱ
  • 10748004
• positive regulation of epithelial to mesenchymal transition Source: BHF-UCLInferred from direct assayⁱ
  • 25204733
• positive regulation of ERK1 and ERK2 cascade Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of estradiol secretion Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of fever generation Source: BHF-UCL
• positive regulation of gene expression Source: UniProtKBInferred from direct assayⁱ
  • 23817958
• positive regulation of glial cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of glial cell proliferation Source: ARUK-UCL <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 1752215
• positive regulation of granulocyte macrophage colony-stimulating factor production Source: BHF-UCLInferred from direct assayⁱ
  • 20027291
• positive regulation of heterotypic cell-cell adhesion Source: UniProtKBInferred from direct assayⁱ
  • 15100360
• positive regulation of histone acetylation Source: BHF-UCLNon-traceable author statementⁱ
  • 20018936
• positive regulation of histone phosphorylation Source: BHF-UCLNon-traceable author statementⁱ
  • 20018936
• positive regulation of I-kappaB kinase/NF-kappaB signaling Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of immature T cell proliferation in thymus Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of interferon-gamma production Source: UniProtKBInferred from direct assayⁱ
  • 10653850
• positive regulation of interleukin-2 biosynthetic process Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 2989698
• positive regulation of interleukin-6 biosynthetic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of interleukin-6 production Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of interleukin-6 secretion Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of interleukin-8 production Source: UniProtKBInferred from direct assayⁱ
  • 19524870
• positive regulation of JNK cascade Source: ARUK-UCL
• positive regulation of JUN kinase activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of lipid catabolic process Source: BHF-UCLInferred from sequence or structural similarityⁱ
  • 16865359
• positive regulation of membrane protein ectodomain proteolysis Source: BHF-UCLInferred from direct assayⁱ
  • 18373975
• positive regulation of mitotic nuclear division Source: BHF-UCLInferred from mutant phenotypeⁱ
  • 2989698
• positive regulation of monocyte chemotactic protein-1 production Source: UniProtKBInferred from direct assayⁱ
  • 19524870
• positive regulation of myosin light chain kinase activity Source: BHF-UCLInferred from direct assayⁱ
  • 18390750
• positive regulation of neuroinflammatory response Source: ARUK-UCLTraceable author statementⁱ
  • 26753638
• positive regulation of neuron apoptotic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of neutrophil chemotaxis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of NF-kappaB transcription factor activity Source: BHF-UCLInferred from direct assayⁱ
  • 10383454
  • 12958148
• positive regulation of NIK/NF-kappaB signaling Source: BHF-UCLInferred from direct assayⁱ
  • 18390750
• positive regulation of nitric oxide biosynthetic process Source: BHF-UCLInferred from direct assayⁱ
  • 8383325
• positive regulation of p38MAPK cascade Source: ARUK-UCL
• positive regulation of phagocytosis Source: AgBaseInferred from mutant phenotypeⁱ
  • 18201371
• positive regulation of prostaglandin secretion Source: BHF-UCL
• positive regulation of protein export from nucleus Source: BHF-UCLNon-traceable author statementⁱ
  • 19281832
• positive regulation of protein phosphorylation Source: BHF-UCLInferred from direct assayⁱ
  • 10748004
• positive regulation of T cell mediated immunity Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence <br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • 1919436
• positive regulation of T cell proliferation Source: BHF-UCLInferred from direct assayⁱ
  • 1919436
• positive regulation of T-helper 1 cell cytokine production Source: UniProtKBInferred from direct assayⁱ
  • 10653850
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • 15100360
• positive regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• positive regulation of vascular endothelial growth factor production Source: BHF-UCLInferred from direct assayⁱ
  • 12958148
• positive regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCLInferred by curatorⁱ
  • 12958148
• protein kinase B signaling Source: UniProtKBInferred from mutant phenotypeⁱ
  • 21147091
• regulation of defense response to virus by host Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• regulation of ERK1 and ERK2 cascade Source: BHF-UCLInferred from direct assayⁱ
  • 25204733
• regulation of establishment of endothelial barrier Source: UniProtKBInferred from direct assayⁱ
  • 25816133
• regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCLInferred from direct assayⁱ
  • 10748004
• regulation of insulin secretion Source: BHF-UCLInferred from direct assayⁱ
  • 8383325
• regulation of neurogenesis Source: ARUK-UCL
• regulation of nitric-oxide synthase activity Source: UniProtKBInferred from direct assayⁱ
  • 15899045
• response to ATP Source: Ensembl
• response to dexamethasone Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to drug Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to estradiol Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to ethanol Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to gamma radiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to glucocorticoid Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to heat Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to hypoxia Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to immobilization stress Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to L-ascorbic acid Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to morphine Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to organic cyclic compound Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to ozone Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to peptide hormone Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to stilbenoid Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• response to vitamin D Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• sequestering of triglyceride Source: BHF-UCLInferred from direct assayⁱ
  • 19032770
• signal transduction Source: ProtIncTraceable author statementⁱ
  • 10786823
  • 9218611
• smooth muscle adaptation Source: BHF-UCLNon-traceable author statementⁱ
  • 16477012
• social behavior Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• wound healing Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• cytokine activity Source: BHF-UCLInferred from direct assayⁱ
  • 1919436
• integrin binding Source: UniProtKBInferred from direct assayⁱ
  • 29030430
• interleukin-1 receptor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • 21873635
• protein domain specific binding Source: UniProtKBInferred from physical interactionⁱ
  • 16575408

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL 
        60         70         80         90        100
RISDHHYSKG FRQAASVVVA MDKLRKMLVP CPQTFQENDL STFFPFIFEE 
       110        120        130        140        150
EPIFFDTWDN EAYVHDAPVR SLNCTLRDSQ QKSLVMSGPY ELKALHLQGQ 
       160        170        180        190        200
DMEQQVVFSM SFVQGEESND KIPVALGLKE KNLYLSCVLK DDKPTLQLES 
       210        220        230        240        250
VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST SQAENMPVFL 
       260 
GGTKGGQDIT DFTMQFVSS                                   

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. Human chromosome 2
   Human chromosome 2: entries, gene names and cross-references to MIM
3. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
4. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
5. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
6. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references