UniProtKB - P01584 (IL1B_HUMAN)

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History
Entry version 223 (18 Jul 2018)
Sequence version 2 (26 Apr 2005)
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Protein

Interleukin-1 beta

Gene

IL1B

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).2 Publications

Miscellaneous

The IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	120	Involved in receptor binding	1
Siteⁱ	171	Important for interaction with integrin1 Publication	1
Siteⁱ	179	Important for interaction with integrin1 Publication	1
Siteⁱ	181	Important for interaction with integrin1 Publication	1
Siteⁱ	190	Important for interaction with integrin1 Publication	1
Siteⁱ	204	Important for interaction with integrin1 Publication	1

GO - Molecular functionⁱ

cytokine activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 1919436
integrin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 29030430
interleukin-1 receptor binding Source: GO_Central
protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16575408

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPK activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 10748004
apoptotic process
Source: ProtInc
Traceable author statementⁱ
- 9218611
cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 2989698
cellular response to drug
Source: MGI
Inferred from direct assayⁱ
- 19158679
cellular response to mechanical stimulus
Source: UniProtKB
Inferred from expression patternⁱ
- 19593445
cellular response to organic cyclic compound
Source: UniProtKB
Inferred from direct assayⁱ
- 21147091
cellular response to organic substance
Source: MGI
Inferred from direct assayⁱ
- 19158679
cytokine-mediated signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 10748004
ectopic germ cell programmed cell death Source: Ensembl
embryo implantation
Source: BHF-UCL
Traceable author statementⁱ
- 16720713
extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
fever generation Source: GO_Central
hyaluronan biosynthetic process
Source: UniProtKB
Inferred from direct assayⁱ
- 15100360
immune response Source: InterPro
inflammatory response
Source: UniProtKB
Inferred from direct assayⁱ
- 21147091
interleukin-1 beta production Source: Ensembl
interleukin-1-mediated signaling pathway Source: Reactome
interleukin-6 production Source: Ensembl
lipopolysaccharide-mediated signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 21147091
MAPK cascade
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21147091
monocyte aggregation
Source: UniProtKB
Inferred from direct assayⁱ
- 15100360
negative regulation of adiponectin secretion
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 16865359
negative regulation of cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 3493774
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
Source: BHF-UCL
Inferred from direct assayⁱ
- 10748004
negative regulation of glucose transmembrane transport
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 16865359
negative regulation of insulin receptor signaling pathway
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 16865359
negative regulation of lipid catabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 19032770
negative regulation of lipid metabolic process
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 16865359
negative regulation of MAP kinase activity
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 16865359
negative regulation of synaptic transmission Source: ARUK-UCL
neutrophil chemotaxis Source: Ensembl
positive regulation of angiogenesis
Source: BHF-UCL
Inferred from direct assayⁱ
- 25204733
positive regulation of calcidiol 1-monooxygenase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 16720713
- 17023519
positive regulation of cell adhesion molecule production
Source: BHF-UCL
Non-traceable author statementⁱ
- 19281832
positive regulation of cell division Source: UniProtKB-KW
positive regulation of cell migration
Source: BHF-UCL
Inferred from direct assayⁱ
- 25204733
positive regulation of cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 25204733
positive regulation of chemokine biosynthetic process Source: Ensembl
positive regulation of DNA binding transcription factor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 10748004
positive regulation of epithelial to mesenchymal transition
Source: BHF-UCL
Inferred from direct assayⁱ
- 25204733
positive regulation of fever generation Source: BHF-UCL
positive regulation of gene expression
Source: UniProtKB
Inferred from direct assayⁱ
- 23817958
positive regulation of granulocyte macrophage colony-stimulating factor production
Source: BHF-UCL
Inferred from direct assayⁱ
- 20027291
positive regulation of heterotypic cell-cell adhesion
Source: UniProtKB
Inferred from direct assayⁱ
- 15100360
positive regulation of histone acetylation
Source: BHF-UCL
Non-traceable author statementⁱ
- 20018936
positive regulation of histone phosphorylation
Source: BHF-UCL
Non-traceable author statementⁱ
- 20018936
positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
positive regulation of interferon-gamma production
Source: UniProtKB
Inferred from direct assayⁱ
- 10653850
positive regulation of interleukin-2 biosynthetic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 2989698
positive regulation of interleukin-6 biosynthetic process Source: Ensembl
positive regulation of interleukin-6 production
Source: BHF-UCL
Traceable author statementⁱ
- 16865359
positive regulation of interleukin-6 secretion Source: Ensembl
positive regulation of interleukin-8 production
Source: UniProtKB
Inferred from direct assayⁱ
- 19524870
positive regulation of JNK cascade Source: ARUK-UCL
positive regulation of lipid catabolic process
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 16865359
positive regulation of membrane protein ectodomain proteolysis
Source: BHF-UCL
Inferred from direct assayⁱ
- 18373975
positive regulation of mitotic nuclear division
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 2989698
positive regulation of monocyte chemotactic protein-1 production
Source: UniProtKB
Inferred from direct assayⁱ
- 19524870
positive regulation of myosin light chain kinase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 18390750
positive regulation of NF-kappaB transcription factor activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 10383454
- 12958148
positive regulation of NIK/NF-kappaB signaling
Source: BHF-UCL
Inferred from direct assayⁱ
- 18390750
positive regulation of nitric oxide biosynthetic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 8383325
positive regulation of p38MAPK cascade Source: ARUK-UCL
positive regulation of phagocytosis
Source: AgBase
Inferred from mutant phenotypeⁱ
- 18201371
positive regulation of prostaglandin secretion Source: BHF-UCL
positive regulation of protein export from nucleus
Source: BHF-UCL
Non-traceable author statementⁱ
- 19281832
positive regulation of protein phosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 10748004
positive regulation of T cell mediated immunity
Source: BHF-UCL
Inferred by curatorⁱ
- 1919436
positive regulation of T cell proliferation
Source: BHF-UCL
Inferred from direct assayⁱ
- 1919436
positive regulation of T-helper 1 cell cytokine production
Source: UniProtKB
Inferred from direct assayⁱ
- 10653850
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 15100360
positive regulation of transcription by RNA polymerase II Source: Ensembl
positive regulation of vascular endothelial growth factor production
Source: BHF-UCL
Inferred from direct assayⁱ
- 12958148
positive regulation of vascular endothelial growth factor receptor signaling pathway
Source: BHF-UCL
Inferred by curatorⁱ
- 12958148
protein kinase B signaling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21147091
regulation of defense response to virus by host Source: Ensembl
regulation of ERK1 and ERK2 cascade
Source: BHF-UCL
Inferred from direct assayⁱ
- 25204733
regulation of establishment of endothelial barrier
Source: UniProtKB
Inferred from direct assayⁱ
- 25816133
regulation of I-kappaB kinase/NF-kappaB signaling
Source: BHF-UCL
Inferred from direct assayⁱ
- 10748004
regulation of insulin secretion
Source: BHF-UCL
Inferred from direct assayⁱ
- 8383325
regulation of nitric-oxide synthase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 15899045
response to ATP Source: Ensembl
response to carbohydrate Source: Ensembl
sequestering of triglyceride
Source: BHF-UCL
Inferred from direct assayⁱ
- 19032770
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 9218611
- 10786823
smooth muscle adaptation
Source: BHF-UCL
Non-traceable author statementⁱ
- 16477012

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine, Mitogen, Pyrogen
Biological process	Inflammatory response

Enzyme and pathway databases

Reactomeⁱ	R-HSA-448706 Interleukin-1 processing R-HSA-5660668 CLEC7A/inflammasome pathway R-HSA-6783783 Interleukin-10 signaling R-HSA-6785807 Interleukin-4 and 13 signaling R-HSA-9020702 Interleukin-1 signaling
SignaLinkⁱ	P01584
SIGNORⁱ	P01584

Protein family/group databases

TCDBⁱ	1.A.109.1.2 the interleukin 1 (il1) family

TCDBⁱ

1.A.109.1.2 the interleukin 1 (il1) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interleukin-1 beta1 Publication Short name: IL-1 beta1 Publication Alternative name(s): Catabolin
Gene namesⁱ	Name:IL1BImported Synonyms:IL1F2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000125538.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5992 IL1B
MIMⁱ	147720 gene
neXtProtⁱ	NX_P01584

Keywords - Cellular componentⁱ

Cytoplasm, Lysosome, Secreted

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	27	D → A: Loss of activation by CASP1; when associated with A-116. 1 Publication	1
Mutagenesisⁱ	116	D → A: Loss of activation by CASP1; when associated with A-27. 1 Publication	1
Mutagenesisⁱ	171	K → E: Suppression of integrin binding; when associated with K-244. Markedly reduced activity; when associated with E-190; E-204 and C-233. 1 Publication	1
Mutagenesisⁱ	179	K → E: Suppression of integrin binding; when associated with E-181 and K-244. Markedly reduced activity; when associated with E-181; E-190; E-204 and C-233. 1 Publication	1
Mutagenesisⁱ	181	K → E: Suppression of integrin binding; when associated with E-179 and K-244. Markedly reduced activity; when associated with E-179; E-190; E-204 and C-233. 1 Publication	1
Mutagenesisⁱ	190	K → E: Suppression of integrin binding; when associated with K-244. Markedly reduced activity; when associated with E-171; E-204 and C-233. Markedly reduced activity; when associated with E-179; E-181; E-204 and C-233. 1 Publication	1
Mutagenesisⁱ	204	K → E: Suppression of integrin binding; when associated with K-244. Markedly reduced activity; when associated with E-171; E-190 and C-233. Markedly reduced activity; when associated with E-179; E-181; E-190 and C-233. 1 Publication	1
Mutagenesisⁱ	221	E → K: Enhanced integrin binding. 1 Publication	1
Mutagenesisⁱ	233	F → C: No effect on binding to IL1R or on IL1B activity. Markedly reduced activity; when associated with E-171; E-190 and E-204. Markedly reduced activity; when associated with E-179; E-181; E-190 and E-204. 1 Publication	1
Mutagenesisⁱ	244	E → K: Increased affinity for integrin ITGAV:ITGB3. Suppression of integrin binding; when associated with E-171; E-190 or E-204. Suppression of integrin binding; when associated with E-179 and E-181. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3553
MalaCards human disease database More...MalaCardsⁱ	IL1B
Open Targets More...OpenTargetsⁱ	ENSG00000125538
PharmGKBⁱ	PA29808

Chemistry databases

ChEMBLⁱ	CHEMBL1909490
Drug and drug target database More...DrugBankⁱ	DB05250 681323 DB05066 AV411 DB06168 Canakinumab DB05442 Etiprednol dicloacetate DB05260 Gallium nitrate DB05767 HMPL-004 DB01017 Minocycline DB06372 Rilonacept DB05412 SCIO-469 DB05133 VP025 DB05470 VX-702 DB05507 VX-765 DB06062 XOMA 052

Polymorphism and mutation databases

BioMutaⁱ	IL1B
DMDMⁱ	62906858

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
PropeptideⁱPRO_0000015301	1 – 116	Removed in mature form; by CASP12 PublicationsAdd BLAST		116
ChainⁱPRO_0000015302	117 – 269	Interleukin-1 beta1 PublicationAdd BLAST		153

Post-translational modificationⁱ

Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated.1 Publication

Proteomic databases

EPDⁱ	P01584
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P01584
PaxDbⁱ	P01584
PeptideAtlas More...PeptideAtlasⁱ	P01584
PRIDEⁱ	P01584
ProteomicsDBⁱ	51391

PTM databases

iPTMnetⁱ	P01584
PhosphoSitePlusⁱ	P01584
SwissPalmⁱ	P01584

Miscellaneous databases

PMAP-CutDBⁱ	P01584

PMAP-CutDBⁱ

P01584

Expressionⁱ

Tissue specificityⁱ

Expressed in activated monocytes/macrophages (at protein level).1 Publication

Inductionⁱ

By LPS (PubMed:15192144). Transcription and translation induced by M.tuberculosis and a number of different M.tuberculosis components in macrophages; EsxA is the most potent activator tested (at protein level) (PubMed:20148899). In pancreatic islets, release is increased by high glucose treatment. In pancreatic islets and macrophages, release is also increased by endocannabinoid anandamide/AEA (PubMed:23955712).3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000125538
CleanExⁱ	HS_IL1B
ExpressionAtlasⁱ	P01584 baseline and differential
Genevisibleⁱ	P01584 HS

Interactionⁱ

Subunit structureⁱ

Monomer. In its precursor form, weakly interacts with full-length MEFV; the mature cytokine does not interact at all (PubMed:17431422). Interacts with integrins ITGAV:ITGBV and ITGA5:ITGB1; integrin-binding is required for IL1B signaling (PubMed:29030430).3 Publications

GO - Molecular functionⁱ

cytokine activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 1919436
integrin binding
Source: UniProtKB
Inferred from direct assayⁱ
- 29030430
interleukin-1 receptor binding Source: GO_Central
protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16575408

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109769, 15 interactors
Database of interacting proteins More...DIPⁱ	DIP-474N
IntActⁱ	P01584, 7 interactors
STRINGⁱ	9606.ENSP00000263341

Chemistry databases

BindingDBⁱ	P01584

BindingDBⁱ

P01584

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	121 – 128	Combined sources	8
Beta strandⁱ	133 – 137	Combined sources	5
Beta strandⁱ	138 – 140	Combined sources	3
Beta strandⁱ	141 – 145	Combined sources	5
Helixⁱ	149 – 154	Combined sources	6
Beta strandⁱ	158 – 162	Combined sources	5
Beta strandⁱ	172 – 178	Combined sources	7
Turnⁱ	179 – 181	Combined sources	3
Beta strandⁱ	183 – 190	Combined sources	8
Beta strandⁱ	193 – 200	Combined sources	8
Turnⁱ	203 – 205	Combined sources	3
Helixⁱ	213 – 215	Combined sources	3
Beta strandⁱ	217 – 222	Combined sources	6
Beta strandⁱ	225 – 233	Combined sources	9
Beta strandⁱ	237 – 240	Combined sources	4
Beta strandⁱ	242 – 247	Combined sources	6
Beta strandⁱ	249 – 252	Combined sources	4
Turnⁱ	254 – 257	Combined sources	4
Beta strandⁱ	262 – 266	Combined sources	5

3D structure databases

ProteinModelPortalⁱ	P01584
SMRⁱ	P01584
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P01584

EvolutionaryTraceⁱ

P01584

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IGSZ Eukaryota ENOG410XU2E LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00510000048687
HOVERGENⁱ	HBG007328
InParanoidⁱ	P01584
KEGG Orthology (KO) More...KOⁱ	K04519
OMAⁱ	QVVFSMS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GR9
PhylomeDBⁱ	P01584
TreeFamⁱ	TF300203

Family and domain databases

InterProⁱ	View protein in InterPro IPR003296 IL-1_beta IPR020877 IL-1_CS IPR000975 IL-1_fam IPR003502 IL-1_propep IPR008996 IL1/FGF
PANTHERⁱ	PTHR44849 PTHR44849, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00340 IL1, 1 hit PF02394 IL1_propep, 1 hit
PRINTSⁱ	PR00264 INTERLEUKIN1
SUPFAMⁱ	SSF50353 SSF50353, 1 hit
PROSITEⁱ	View protein in PROSITE PS00253 INTERLEUKIN_1, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P01584-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL 
        60         70         80         90        100
RISDHHYSKG FRQAASVVVA MDKLRKMLVP CPQTFQENDL STFFPFIFEE 
       110        120        130        140        150
EPIFFDTWDN EAYVHDAPVR SLNCTLRDSQ QKSLVMSGPY ELKALHLQGQ 
       160        170        180        190        200
DMEQQVVFSM SFVQGEESND KIPVALGLKE KNLYLSCVLK DDKPTLQLES 
       210        220        230        240        250
VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST SQAENMPVFL 
       260 
GGTKGGQDIT DFTMQFVSS

Length:269

Mass (Da):30,748

Last modified:April 26, 2005 - v2

Checksum:ⁱ9BF73C3673C6FD66

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	6	E → K in AAA36106 (PubMed:6083565).Curated	1
Sequence conflictⁱ	6	E → K in AAA59136 (PubMed:6083565).Curated	1
Sequence conflictⁱ	6	E → K in CAG28607 (Ref. 9) Curated	1
Sequence conflictⁱ	124	C → A AA sequence (PubMed:3920526).Curated	1
Sequence conflictⁱ	155	Q → D AA sequence (PubMed:3920526).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_073951	141	E → N Requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant dbSNP:rs144640380Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	K02770 mRNA Translation: AAA36106.1 M54933 mRNA Translation: AAA59136.1 Sequence problems. X02532 mRNA Translation: CAA26372.1 X04500 Genomic DNA Translation: CAA28185.1 M15330 mRNA Translation: AAA59135.1 M15840 Genomic DNA Translation: AAA74137.1 X56087 mRNA Translation: CAA39567.1 BN000002 Genomic DNA Translation: CAD29872.1 BT007213 mRNA Translation: AAP35877.1 CR407679 mRNA Translation: CAG28607.1 AY137079 Genomic DNA Translation: AAM88883.1 AC079753 Genomic DNA Translation: AAX88888.1 CH471217 Genomic DNA Translation: EAW73605.1 BC008678 mRNA Translation: AAH08678.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2102.1
PIRⁱ	A21851 A25542 ICHU1B
NCBI Reference Sequences More...RefSeqⁱ	NP_000567.1, NM_000576.2
UniGeneⁱ	Hs.126256

Genome annotation databases

Ensemblⁱ	ENST00000263341; ENSP00000263341; ENSG00000125538
GeneIDⁱ	3553
KEGGⁱ	hsa:3553
UCSC genome browser More...UCSCⁱ	uc002tii.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P01584	UPI000002CF5D		HUMAN		238
Interleukin-1 beta (Fragment)		HUMAN		125
UPI0002A139AD		HUMAN		150
Multifunctional fusion protein (Fragment)		HUMAN		153
Interleukin-1 beta (Fragment)		HUMAN		143
+1

Protein	Similar proteins		Species	Score	Length
P01584	UPI000002CF5D		HUMAN		238
Multifunctional fusion protein		MACFA		302
Multifunctional fusion protein		MACMU		268
UPI00062A6778		NOMLE		286
Interleukin-1 beta		MACNE		269
+41

Protein	Similar proteins		Species	Score	Length
P01584	UPI000002CF5D		HUMAN		238
Multifunctional fusion protein		MACFA		302
Multifunctional fusion protein		MACMU		268
UPI00062A6778		NOMLE		286
Multifunctional fusion protein		CHLSB		269
+194

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1HIB	X-ray	2.40	A	117-269	[»]
1I1B	X-ray	2.00	A	117-269	[»]
1IOB	X-ray	2.00	A	117-269	[»]
1ITB	X-ray	2.50	A	117-269	[»]
1L2H	X-ray	1.54	A	117-269	[»]
1S0L	X-ray	2.34	A	117-269	[»]
1T4Q	X-ray	2.10	A	117-269	[»]
1TOO	X-ray	2.10	A	117-269	[»]
1TP0	X-ray	2.20	A	117-269	[»]
1TWE	X-ray	2.10	A	117-269	[»]
1TWM	X-ray	2.26	A	117-269	[»]
21BI	X-ray	2.00	A	117-269	[»]
2I1B	X-ray	2.00	A	117-269	[»]
2KH2	NMR	-	A	117-269	[»]
2NVH	X-ray	1.53	A	117-269	[»]
31BI	X-ray	2.00	A	117-269	[»]
3LTQ	X-ray	2.10	A	117-269	[»]
3O4O	X-ray	3.30	A	117-269	[»]
3POK	X-ray	1.70	A	117-269	[»]
41BI	X-ray	2.90	A	117-269	[»]
4DEP	X-ray	3.10	A/D	117-269	[»]
4G6J	X-ray	2.03	A	117-269	[»]
4G6M	X-ray	1.81	A	118-267	[»]
4GAF	X-ray	2.15	A	117-269	[»]
4GAI	X-ray	1.49	A/B	117-269	[»]
4I1B	X-ray	2.00	A	117-269	[»]
5BVP	X-ray	2.20	I	117-269	[»]
5I1B	X-ray	2.10	A	117-269	[»]
5MVZ	X-ray	2.15	U/V	117-269	[»]
6I1B	NMR	-	A	117-269	[»]
7I1B	NMR	-	A	117-269	[»]
9ILB	X-ray	2.28	A	117-269	[»]
ProteinModelPortalⁱ	P01584
SMRⁱ	P01584
ModBaseⁱ	Search...
MobiDBⁱ	Search...

BindingDBⁱ	P01584
ChEMBLⁱ	CHEMBL1909490
Drug and drug target database More...DrugBankⁱ	DB05250 681323 DB05066 AV411 DB06168 Canakinumab DB05442 Etiprednol dicloacetate DB05260 Gallium nitrate DB05767 HMPL-004 DB01017 Minocycline DB06372 Rilonacept DB05412 SCIO-469 DB05133 VP025 DB05470 VX-702 DB05507 VX-765 DB06062 XOMA 052

TCDBⁱ	1.A.109.1.2 the interleukin 1 (il1) family

The DNASU plasmid repository More...DNASUⁱ	3553
Structural Biology Knowledgebase	Search...

CTDⁱ	3553
DisGeNET More...DisGeNETⁱ	3553
EuPathDBⁱ	HostDB:ENSG00000125538.11
GeneCardsⁱ	IL1B
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5992 IL1B
MalaCards human disease database More...MalaCardsⁱ	IL1B
MIMⁱ	147720 gene
neXtProtⁱ	NX_P01584
Open Targets More...OpenTargetsⁱ	ENSG00000125538
PharmGKBⁱ	PA29808
GenAtlas: human gene database More...GenAtlasⁱ	Search...

ChiTaRSⁱ	IL1B human
EvolutionaryTraceⁱ	P01584
GeneWikiⁱ	IL1B
GenomeRNAiⁱ	3553
PMAP-CutDBⁱ	P01584
Protein Ontology More...PROⁱ	PR:P01584
SOURCEⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IL1B_HUMAN
Accessionⁱ	P01584Primary (citable) accession number: P01584 Secondary accession number(s): Q53X59 , Q53XX2, Q7M4S7, Q7RU01, Q96HE5, Q9UCT6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	April 26, 2005
	Last modified:	July 18, 2018
	This is version 223 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P01584 (IL1B_HUMAN)

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Interleukin-1 beta

IL1B

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Functionⁱ

GO - Molecular functionⁱ

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Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

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GO - Molecular functionⁱ

Structureⁱ

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