UniProtKB - P01584 (IL1B_HUMAN)
Interleukin-1 beta
IL1B
Functioni
Potent proinflammatory cytokine (PubMed:3920526, PubMed:10653850, PubMed:12794819).
Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production (PubMed:3920526).
Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells (PubMed:10653850).
Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6 (PubMed:12794819).
Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33377178, PubMed:33883744).
5 PublicationsMiscellaneous
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 120 | Involved in receptor binding | 1 | |
Sitei | 171 | Important for interaction with integrin1 Publication | 1 | |
Sitei | 179 | Important for interaction with integrin1 Publication | 1 | |
Sitei | 181 | Important for interaction with integrin1 Publication | 1 | |
Sitei | 190 | Important for interaction with integrin1 Publication | 1 | |
Sitei | 204 | Important for interaction with integrin1 Publication | 1 |
GO - Molecular functioni
- cytokine activity Source: BHF-UCL
- integrin binding Source: UniProtKB
- interleukin-1 receptor binding Source: UniProtKB
- protein domain specific binding Source: UniProtKB
GO - Biological processi
- apoptotic process Source: ProtInc
- astrocyte activation Source: Ensembl
- cell-cell signaling Source: ProtInc
- cellular response to lipopolysaccharide Source: GO_Central
- cellular response to mechanical stimulus Source: UniProtKB
- cellular response to organic cyclic compound Source: UniProtKB
- cellular response to organic substance Source: MGI
- cellular response to xenobiotic stimulus Source: MGI
- cytokine-mediated signaling pathway Source: BHF-UCL
- ectopic germ cell programmed cell death Source: Ensembl
- embryo implantation Source: BHF-UCL
- extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
- fever generation Source: UniProtKB-KW
- hyaluronan biosynthetic process Source: UniProtKB
- immune response Source: InterPro
- inflammatory response Source: UniProtKB
- interleukin-1-mediated signaling pathway Source: BHF-UCL
- lipopolysaccharide-mediated signaling pathway Source: UniProtKB
- MAPK cascade Source: UniProtKB
- monocyte aggregation Source: UniProtKB
- negative regulation of adiponectin secretion Source: BHF-UCL
- negative regulation of cell population proliferation Source: BHF-UCL
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
- negative regulation of gap junction assembly Source: ARUK-UCL
- negative regulation of glucose transmembrane transport Source: BHF-UCL
- negative regulation of insulin receptor signaling pathway Source: BHF-UCL
- negative regulation of lipid catabolic process Source: BHF-UCL
- negative regulation of lipid metabolic process Source: BHF-UCL
- negative regulation of MAP kinase activity Source: BHF-UCL
- negative regulation of neurogenesis Source: ARUK-UCL
- negative regulation of synaptic transmission Source: ARUK-UCL
- neutrophil chemotaxis Source: Ensembl
- positive regulation of angiogenesis Source: BHF-UCL
- positive regulation of calcidiol 1-monooxygenase activity Source: BHF-UCL
- positive regulation of cell adhesion molecule production Source: BHF-UCL
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of cell migration Source: BHF-UCL
- positive regulation of cell population proliferation Source: BHF-UCL
- positive regulation of complement activation Source: ARUK-UCL
- positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
- positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
- positive regulation of fever generation Source: BHF-UCL
- positive regulation of gene expression Source: UniProtKB
- positive regulation of glial cell proliferation Source: ARUK-UCL
- positive regulation of granulocyte macrophage colony-stimulating factor production Source: BHF-UCL
- positive regulation of heterotypic cell-cell adhesion Source: UniProtKB
- positive regulation of histone acetylation Source: BHF-UCL
- positive regulation of histone phosphorylation Source: BHF-UCL
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
- positive regulation of immature T cell proliferation in thymus Source: GO_Central
- positive regulation of inflammatory response Source: ARUK-UCL
- positive regulation of interferon-gamma production Source: UniProtKB
- positive regulation of interleukin-2 production Source: BHF-UCL
- positive regulation of interleukin-6 production Source: ARUK-UCL
- positive regulation of interleukin-8 production Source: UniProtKB
- positive regulation of JNK cascade Source: ARUK-UCL
- positive regulation of lipid catabolic process Source: BHF-UCL
- positive regulation of MAP kinase activity Source: BHF-UCL
- positive regulation of membrane protein ectodomain proteolysis Source: BHF-UCL
- positive regulation of mitotic nuclear division Source: BHF-UCL
- positive regulation of monocyte chemotactic protein-1 production Source: UniProtKB
- positive regulation of myosin light chain kinase activity Source: BHF-UCL
- positive regulation of neuroinflammatory response Source: ARUK-UCL
- positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
- positive regulation of NIK/NF-kappaB signaling Source: BHF-UCL
- positive regulation of nitric oxide biosynthetic process Source: BHF-UCL
- positive regulation of p38MAPK cascade Source: ARUK-UCL
- positive regulation of phagocytosis Source: AgBase
- positive regulation of prostaglandin biosynthetic process Source: ARUK-UCL
- positive regulation of prostaglandin secretion Source: BHF-UCL
- positive regulation of protein export from nucleus Source: BHF-UCL
- positive regulation of protein phosphorylation Source: BHF-UCL
- positive regulation of RNA biosynthetic process Source: ARUK-UCL
- positive regulation of T cell mediated immunity Source: BHF-UCL
- positive regulation of T cell proliferation Source: BHF-UCL
- positive regulation of T-helper 1 cell cytokine production Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- positive regulation of vascular endothelial growth factor production Source: BHF-UCL
- positive regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
- protein kinase B signaling Source: UniProtKB
- regulation of defense response to virus by host Source: Ensembl
- regulation of ERK1 and ERK2 cascade Source: BHF-UCL
- regulation of establishment of endothelial barrier Source: UniProtKB
- regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
- regulation of insulin secretion Source: BHF-UCL
- regulation of neurogenesis Source: ARUK-UCL
- regulation of nitric-oxide synthase activity Source: UniProtKB
- response to ATP Source: Ensembl
- response to carbohydrate Source: Ensembl
- response to interleukin-1 Source: ARUK-UCL
- response to lipopolysaccharide Source: ARUK-UCL
- sequestering of triglyceride Source: BHF-UCL
- signal transduction Source: ProtInc
- smooth muscle adaptation Source: BHF-UCL
- vascular endothelial growth factor production Source: UniProtKB
Keywordsi
Molecular function | Cytokine, Mitogen, Pyrogen |
Biological process | Inflammatory response |
Enzyme and pathway databases
PathwayCommonsi | P01584 |
Reactomei | R-HSA-448706, Interleukin-1 processing R-HSA-5620971, Pyroptosis R-HSA-5660668, CLEC7A/inflammasome pathway R-HSA-6783783, Interleukin-10 signaling R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-9020702, Interleukin-1 signaling R-HSA-9660826, Purinergic signaling in leishmaniasis infection |
SignaLinki | P01584 |
SIGNORi | P01584 |
Protein family/group databases
TCDBi | 1.A.109.1.2, the interleukin 1 (il1) family |
Names & Taxonomyi
Protein namesi | Recommended name: Interleukin-1 beta1 PublicationShort name: IL-1 beta1 Publication Alternative name(s): Catabolin |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5992, IL1B |
MIMi | 147720, gene |
neXtProti | NX_P01584 |
VEuPathDBi | HostDB:ENSG00000125538 |
Subcellular locationi
Lysosome
- Lysosome 1 Publication
Cytoplasm and Cytosol
- cytosol 1 Publication
Extracellular region or secreted
- Secreted 3 Publications
- extracellular exosome By similarity
Note: The precursor is cytosolic (PubMed:15192144). In response to inflammasome-activating signals, such as ATP for NLRP3 inflammasome or bacterial flagellin for NLRC4 inflammasome, cleaved and secreted (PubMed:24201029, PubMed:33377178, PubMed:33883744). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:33883744). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (PubMed:33883744). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (PubMed:32272059).5 Publications
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular region Source: BHF-UCL
- extracellular space Source: BHF-UCL
Lysosome
- lysosome Source: UniProtKB-SubCell
Other locations
- secretory granule Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, Lysosome, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 6 – 27 | ELASE…FFEAD → ALASAMMAYYSGNAAALFFA AA: Promotes release of IL1B precursors through the Gasdermin-D (GSDMD) ring-shaped pore complex. 1 PublicationAdd BLAST | 22 | |
Mutagenesisi | 27 | D → A: Loss of activation by CASP1; when associated with A-116. 1 Publication | 1 | |
Mutagenesisi | 87 – 111 | ENDLS…TWDNE → ANDLSTFFPFIFAAAPIFFA TWANA: Promotes release of IL1B precursors through the Gasdermin-D (GSDMD) ring-shaped pore complex. 1 PublicationAdd BLAST | 25 | |
Mutagenesisi | 116 | D → A: Loss of activation by CASP1; when associated with A-27. 1 Publication | 1 | |
Mutagenesisi | 171 | K → E: Suppression of integrin binding; when associated with K-244. Markedly reduced activity; when associated with E-190; E-204 and C-233. 1 Publication | 1 | |
Mutagenesisi | 179 | K → E: Suppression of integrin binding; when associated with E-181 and K-244. Markedly reduced activity; when associated with E-181; E-190; E-204 and C-233. 1 Publication | 1 | |
Mutagenesisi | 181 | K → E: Suppression of integrin binding; when associated with E-179 and K-244. Markedly reduced activity; when associated with E-179; E-190; E-204 and C-233. 1 Publication | 1 | |
Mutagenesisi | 190 | K → E: Suppression of integrin binding; when associated with K-244. Markedly reduced activity; when associated with E-171; E-204 and C-233. Markedly reduced activity; when associated with E-179; E-181; E-204 and C-233. 1 Publication | 1 | |
Mutagenesisi | 204 | K → E: Suppression of integrin binding; when associated with K-244. Markedly reduced activity; when associated with E-171; E-190 and C-233. Markedly reduced activity; when associated with E-179; E-181; E-190 and C-233. 1 Publication | 1 | |
Mutagenesisi | 221 | E → K: Enhanced integrin binding. 1 Publication | 1 | |
Mutagenesisi | 233 | F → C: No effect on binding to IL1R or on IL1B activity. Markedly reduced activity; when associated with E-171; E-190 and E-204. Markedly reduced activity; when associated with E-179; E-181; E-190 and E-204. 1 Publication | 1 | |
Mutagenesisi | 244 | E → K: Increased affinity for integrin ITGAV:ITGB3. Suppression of integrin binding; when associated with E-171; E-190 or E-204. Suppression of integrin binding; when associated with E-179 and E-181. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 3553 |
MalaCardsi | IL1B |
OpenTargetsi | ENSG00000125538 |
PharmGKBi | PA29808 |
Miscellaneous databases
Pharosi | P01584, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1909490 |
DrugBanki | DB05767, Andrographolide DB11967, Binimetinib DB06168, Canakinumab DB12140, Dilmapimod DB00843, Donepezil DB05442, Etiprednol dicloacetate DB10772, Foreskin keratinocyte (neonatal) DB05260, Gallium nitrate DB12119, Gevokizumab DB01017, Minocycline DB06372, Rilonacept DB05412, Talmapimod DB05133, VP025 DB05470, VX-702 DB05507, VX-765 |
DrugCentrali | P01584 |
Genetic variation databases
BioMutai | IL1B |
DMDMi | 62906858 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000015301 | 1 – 116 | Removed in mature form; by CASP12 PublicationsAdd BLAST | 116 | |
ChainiPRO_0000015302 | 117 – 269 | Interleukin-1 beta1 PublicationAdd BLAST | 153 |
Post-translational modificationi
Proteomic databases
EPDi | P01584 |
MassIVEi | P01584 |
MaxQBi | P01584 |
PaxDbi | P01584 |
PeptideAtlasi | P01584 |
PRIDEi | P01584 |
ProteomicsDBi | 51391 |
PTM databases
iPTMneti | P01584 |
PhosphoSitePlusi | P01584 |
SwissPalmi | P01584 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000125538, Expressed in smooth muscle tissue and 190 other tissues |
ExpressionAtlasi | P01584, baseline and differential |
Genevisiblei | P01584, HS |
Organism-specific databases
HPAi | ENSG00000125538, Tissue enhanced (bone marrow, urinary bladder) |
Interactioni
Subunit structurei
Monomer. In its precursor form, weakly interacts with full-length MEFV; the mature cytokine does not interact at all (PubMed:17431422).
Interacts with integrins ITGAV:ITGBV and ITGA5:ITGB1; integrin-binding is required for IL1B signaling (PubMed:29030430).
Interacts with cargo receptor TMED10; the interaction is direct and is required for the secretion of IL1B mature form (PubMed:32272059).
Interacts with HSP90AB1; the interaction facilitates cargo translocation into the ERGIC (PubMed:32272059).
Interacts with HSP90B1; the interaction facilitates cargo translocation into the ERGIC (PubMed:32272059).
4 PublicationsGO - Molecular functioni
- cytokine activity Source: BHF-UCL
- integrin binding Source: UniProtKB
- interleukin-1 receptor binding Source: UniProtKB
- protein domain specific binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109769, 43 interactors |
DIPi | DIP-474N |
IntActi | P01584, 8 interactors |
STRINGi | 9606.ENSP00000263341 |
Chemistry databases
BindingDBi | P01584 |
Miscellaneous databases
RNActi | P01584, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P01584 |
SMRi | P01584 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P01584 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 228 – 241 | Involved in interaction with TMED10 C-terminus1 PublicationAdd BLAST | 14 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502S3E9, Eukaryota |
GeneTreei | ENSGT00950000182943 |
HOGENOMi | CLU_083639_0_0_1 |
InParanoidi | P01584 |
OMAi | RQPVGIT |
OrthoDBi | 1243742at2759 |
PhylomeDBi | P01584 |
TreeFami | TF300203 |
Family and domain databases
InterProi | View protein in InterPro IPR003296, IL-1_beta IPR020877, IL-1_CS IPR000975, IL-1_fam IPR003502, IL-1_propep IPR008996, IL1/FGF |
PANTHERi | PTHR10078, PTHR10078, 1 hit PTHR10078:SF30, PTHR10078:SF30, 1 hit |
Pfami | View protein in Pfam PF00340, IL1, 1 hit PF02394, IL1_propep, 1 hit |
PRINTSi | PR00264, INTERLEUKIN1 |
SUPFAMi | SSF50353, SSF50353, 1 hit |
PROSITEi | View protein in PROSITE PS00253, INTERLEUKIN_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAEVPELASE MMAYYSGNED DLFFEADGPK QMKCSFQDLD LCPLDGGIQL
60 70 80 90 100
RISDHHYSKG FRQAASVVVA MDKLRKMLVP CPQTFQENDL STFFPFIFEE
110 120 130 140 150
EPIFFDTWDN EAYVHDAPVR SLNCTLRDSQ QKSLVMSGPY ELKALHLQGQ
160 170 180 190 200
DMEQQVVFSM SFVQGEESND KIPVALGLKE KNLYLSCVLK DDKPTLQLES
210 220 230 240 250
VDPKNYPKKK MEKRFVFNKI EINNKLEFES AQFPNWYIST SQAENMPVFL
260
GGTKGGQDIT DFTMQFVSS
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JWV2 | C9JWV2_HUMAN | Interleukin-1 beta | IL1B | 143 | Annotation score: | ||
C9JSC2 | C9JSC2_HUMAN | Interleukin-1 beta | IL1B | 125 | Annotation score: | ||
C9JVK0 | C9JVK0_HUMAN | Interleukin-1 beta | IL1B | 111 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 6 | E → K in AAA36106 (PubMed:6083565).Curated | 1 | |
Sequence conflicti | 6 | E → K in AAA59136 (PubMed:6083565).Curated | 1 | |
Sequence conflicti | 6 | E → K in CAG28607 (Ref. 10) Curated | 1 | |
Sequence conflicti | 124 | C → A AA sequence (PubMed:3920526).Curated | 1 | |
Sequence conflicti | 155 | Q → D AA sequence (PubMed:3920526).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_073951 | 141 | E → N Requires 2 nucleotide substitutions. 1 PublicationCorresponds to variant dbSNP:rs144640380Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K02770 mRNA Translation: AAA36106.1 M54933 mRNA Translation: AAA59136.1 Sequence problems. X02532 mRNA Translation: CAA26372.1 X04500 Genomic DNA Translation: CAA28185.1 M15330 mRNA Translation: AAA59135.1 M15840 Genomic DNA Translation: AAA74137.1 X56087 mRNA Translation: CAA39567.1 BN000002 Genomic DNA Translation: CAD29872.1 BT007213 mRNA Translation: AAP35877.1 CR407679 mRNA Translation: CAG28607.1 AY137079 Genomic DNA Translation: AAM88883.1 AC079753 Genomic DNA Translation: AAX88888.1 CH471217 Genomic DNA Translation: EAW73605.1 BC008678 mRNA Translation: AAH08678.1 |
CCDSi | CCDS2102.1 |
PIRi | A21851 A25542, ICHU1B |
RefSeqi | NP_000567.1, NM_000576.2 |
Genome annotation databases
Ensembli | ENST00000263341; ENSP00000263341; ENSG00000125538 |
GeneIDi | 3553 |
KEGGi | hsa:3553 |
MANE-Selecti | ENST00000263341.7; ENSP00000263341.2; NM_000576.3; NP_000567.1 |
UCSCi | uc002tii.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Wikipedia Interleukin-1 entry |
SeattleSNPs |
SHMPD The Singapore human mutation and polymorphism database |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | K02770 mRNA Translation: AAA36106.1 M54933 mRNA Translation: AAA59136.1 Sequence problems. X02532 mRNA Translation: CAA26372.1 X04500 Genomic DNA Translation: CAA28185.1 M15330 mRNA Translation: AAA59135.1 M15840 Genomic DNA Translation: AAA74137.1 X56087 mRNA Translation: CAA39567.1 BN000002 Genomic DNA Translation: CAD29872.1 BT007213 mRNA Translation: AAP35877.1 CR407679 mRNA Translation: CAG28607.1 AY137079 Genomic DNA Translation: AAM88883.1 AC079753 Genomic DNA Translation: AAX88888.1 CH471217 Genomic DNA Translation: EAW73605.1 BC008678 mRNA Translation: AAH08678.1 |
CCDSi | CCDS2102.1 |
PIRi | A21851 A25542, ICHU1B |
RefSeqi | NP_000567.1, NM_000576.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1HIB | X-ray | 2.40 | A | 117-269 | [»] | |
1I1B | X-ray | 2.00 | A | 117-269 | [»] | |
1IOB | X-ray | 2.00 | A | 117-269 | [»] | |
1ITB | X-ray | 2.50 | A | 117-269 | [»] | |
1L2H | X-ray | 1.54 | A | 117-269 | [»] | |
1S0L | X-ray | 2.34 | A | 117-269 | [»] | |
1T4Q | X-ray | 2.10 | A | 117-269 | [»] | |
1TOO | X-ray | 2.10 | A | 117-269 | [»] | |
1TP0 | X-ray | 2.20 | A | 117-269 | [»] | |
1TWE | X-ray | 2.10 | A | 117-269 | [»] | |
1TWM | X-ray | 2.26 | A | 117-269 | [»] | |
21BI | X-ray | 2.00 | A | 117-269 | [»] | |
2I1B | X-ray | 2.00 | A | 117-269 | [»] | |
2KH2 | NMR | - | A | 117-269 | [»] | |
2NVH | X-ray | 1.53 | A | 117-269 | [»] | |
31BI | X-ray | 2.00 | A | 117-269 | [»] | |
3LTQ | X-ray | 2.10 | A | 117-269 | [»] | |
3O4O | X-ray | 3.30 | A | 117-269 | [»] | |
3POK | X-ray | 1.70 | A | 117-269 | [»] | |
41BI | X-ray | 2.90 | A | 117-269 | [»] | |
4DEP | X-ray | 3.10 | A/D | 117-269 | [»] | |
4G6J | X-ray | 2.03 | A | 117-269 | [»] | |
4G6M | X-ray | 1.81 | A | 118-267 | [»] | |
4GAF | X-ray | 2.15 | A | 117-269 | [»] | |
4GAI | X-ray | 1.49 | A/B | 117-269 | [»] | |
4I1B | X-ray | 2.00 | A | 117-269 | [»] | |
5BVP | X-ray | 2.20 | I | 117-269 | [»] | |
5I1B | X-ray | 2.10 | A | 117-269 | [»] | |
5MVZ | X-ray | 2.15 | U/V | 117-269 | [»] | |
5R7W | X-ray | 1.27 | A | 117-269 | [»] | |
5R85 | X-ray | 1.44 | A | 117-269 | [»] | |
5R86 | X-ray | 1.50 | A | 117-269 | [»] | |
5R87 | X-ray | 1.47 | A | 117-269 | [»] | |
5R88 | X-ray | 1.48 | A | 117-269 | [»] | |
5R89 | X-ray | 1.65 | A | 117-269 | [»] | |
5R8A | X-ray | 1.47 | A | 117-269 | [»] | |
5R8B | X-ray | 1.49 | A | 117-269 | [»] | |
5R8C | X-ray | 1.54 | A | 117-269 | [»] | |
5R8D | X-ray | 1.47 | A | 117-269 | [»] | |
5R8E | X-ray | 1.35 | A | 117-269 | [»] | |
5R8F | X-ray | 1.41 | A | 117-269 | [»] | |
5R8G | X-ray | 1.43 | A | 117-269 | [»] | |
5R8H | X-ray | 1.50 | A | 117-269 | [»] | |
5R8I | X-ray | 1.47 | A | 117-269 | [»] | |
5R8J | X-ray | 1.62 | A | 117-269 | [»] | |
5R8K | X-ray | 1.47 | A | 117-269 | [»] | |
5R8L | X-ray | 1.56 | A | 117-269 | [»] | |
5R8M | X-ray | 1.39 | A | 117-269 | [»] | |
5R8N | X-ray | 1.48 | A | 117-269 | [»] | |
5R8O | X-ray | 1.42 | A | 117-269 | [»] | |
5R8P | X-ray | 1.53 | A | 117-269 | [»] | |
5R8Q | X-ray | 1.23 | A | 117-269 | [»] | |
6I1B | NMR | - | A | 117-269 | [»] | |
6Y8I | X-ray | 1.46 | A | 117-269 | [»] | |
6Y8M | X-ray | 1.90 | A | 117-269 | [»] | |
7CHY | X-ray | 2.65 | I | 117-269 | [»] | |
7CHZ | X-ray | 2.50 | I | 117-269 | [»] | |
7I1B | NMR | - | A | 117-269 | [»] | |
9ILB | X-ray | 2.28 | A | 117-269 | [»] | |
BMRBi | P01584 | |||||
SMRi | P01584 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109769, 43 interactors |
DIPi | DIP-474N |
IntActi | P01584, 8 interactors |
STRINGi | 9606.ENSP00000263341 |
Chemistry databases
BindingDBi | P01584 |
ChEMBLi | CHEMBL1909490 |
DrugBanki | DB05767, Andrographolide DB11967, Binimetinib DB06168, Canakinumab DB12140, Dilmapimod DB00843, Donepezil DB05442, Etiprednol dicloacetate DB10772, Foreskin keratinocyte (neonatal) DB05260, Gallium nitrate DB12119, Gevokizumab DB01017, Minocycline DB06372, Rilonacept DB05412, Talmapimod DB05133, VP025 DB05470, VX-702 DB05507, VX-765 |
DrugCentrali | P01584 |
Protein family/group databases
TCDBi | 1.A.109.1.2, the interleukin 1 (il1) family |
PTM databases
iPTMneti | P01584 |
PhosphoSitePlusi | P01584 |
SwissPalmi | P01584 |
Genetic variation databases
BioMutai | IL1B |
DMDMi | 62906858 |
Proteomic databases
EPDi | P01584 |
MassIVEi | P01584 |
MaxQBi | P01584 |
PaxDbi | P01584 |
PeptideAtlasi | P01584 |
PRIDEi | P01584 |
ProteomicsDBi | 51391 |
Protocols and materials databases
ABCDi | P01584, 8 sequenced antibodies |
Antibodypediai | 771, 2426 antibodies from 49 providers |
DNASUi | 3553 |
Genome annotation databases
Ensembli | ENST00000263341; ENSP00000263341; ENSG00000125538 |
GeneIDi | 3553 |
KEGGi | hsa:3553 |
MANE-Selecti | ENST00000263341.7; ENSP00000263341.2; NM_000576.3; NP_000567.1 |
UCSCi | uc002tii.2, human |
Organism-specific databases
CTDi | 3553 |
DisGeNETi | 3553 |
GeneCardsi | IL1B |
HGNCi | HGNC:5992, IL1B |
HPAi | ENSG00000125538, Tissue enhanced (bone marrow, urinary bladder) |
MalaCardsi | IL1B |
MIMi | 147720, gene |
neXtProti | NX_P01584 |
OpenTargetsi | ENSG00000125538 |
PharmGKBi | PA29808 |
VEuPathDBi | HostDB:ENSG00000125538 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S3E9, Eukaryota |
GeneTreei | ENSGT00950000182943 |
HOGENOMi | CLU_083639_0_0_1 |
InParanoidi | P01584 |
OMAi | RQPVGIT |
OrthoDBi | 1243742at2759 |
PhylomeDBi | P01584 |
TreeFami | TF300203 |
Enzyme and pathway databases
PathwayCommonsi | P01584 |
Reactomei | R-HSA-448706, Interleukin-1 processing R-HSA-5620971, Pyroptosis R-HSA-5660668, CLEC7A/inflammasome pathway R-HSA-6783783, Interleukin-10 signaling R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling R-HSA-9020702, Interleukin-1 signaling R-HSA-9660826, Purinergic signaling in leishmaniasis infection |
SignaLinki | P01584 |
SIGNORi | P01584 |
Miscellaneous databases
BioGRID-ORCSi | 3553, 38 hits in 1037 CRISPR screens |
ChiTaRSi | IL1B, human |
EvolutionaryTracei | P01584 |
GeneWikii | IL1B |
GenomeRNAii | 3553 |
Pharosi | P01584, Tclin |
PROi | PR:P01584 |
RNActi | P01584, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125538, Expressed in smooth muscle tissue and 190 other tissues |
ExpressionAtlasi | P01584, baseline and differential |
Genevisiblei | P01584, HS |
Family and domain databases
InterProi | View protein in InterPro IPR003296, IL-1_beta IPR020877, IL-1_CS IPR000975, IL-1_fam IPR003502, IL-1_propep IPR008996, IL1/FGF |
PANTHERi | PTHR10078, PTHR10078, 1 hit PTHR10078:SF30, PTHR10078:SF30, 1 hit |
Pfami | View protein in Pfam PF00340, IL1, 1 hit PF02394, IL1_propep, 1 hit |
PRINTSi | PR00264, INTERLEUKIN1 |
SUPFAMi | SSF50353, SSF50353, 1 hit |
PROSITEi | View protein in PROSITE PS00253, INTERLEUKIN_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IL1B_HUMAN | |
Accessioni | P01584Primary (citable) accession number: P01584 Secondary accession number(s): Q53X59 Q9UCT6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | April 26, 2005 | |
Last modified: | February 23, 2022 | |
This is version 246 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families