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Entry version 208 (18 Sep 2019)
Sequence version 1 (21 Jul 1986)
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Protein

Interleukin-1 alpha

Gene

IL1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine, Mitogen, Pyrogen
Biological processInflammatory response

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-448706 Interleukin-1 processing
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9020702 Interleukin-1 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P01583

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01583

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.109.1.1 the interleukin 1 (il1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-1 alpha
Short name:
IL-1 alpha
Alternative name(s):
Hematopoietin-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IL1A
Synonyms:IL1F1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5991 IL1A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
147760 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01583

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3552

Open Targets

More...
OpenTargetsi
ENSG00000115008

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29807

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3580496

Drug and drug target database

More...
DrugBanki
DB06372 Rilonacept

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IL1A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124297

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_00000152651 – 1121 PublicationAdd BLAST112
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000015266113 – 271Interleukin-1 alphaAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi82N6-myristoyl lysine1 Publication1
Lipidationi83N6-myristoyl lysine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei87PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P01583

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P01583

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01583

PeptideAtlas

More...
PeptideAtlasi
P01583

PRoteomics IDEntifications database

More...
PRIDEi
P01583

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51390

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01583

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01583

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P01583

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P01583

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115008 Expressed in 90 organ(s), highest expression level in smooth muscle tissue

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01583 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109768, 19 interactors

Database of interacting proteins

More...
DIPi
DIP-40550N

Protein interaction database and analysis system

More...
IntActi
P01583, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000263339

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1271
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P01583

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01583

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JAAI Eukaryota
ENOG411151X LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013353

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000113034

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01583

KEGG Orthology (KO)

More...
KOi
K04383

Identification of Orthologs from Complete Genome Data

More...
OMAi
NQKSFYD

Database of Orthologous Groups

More...
OrthoDBi
1513671at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01583

TreeFam database of animal gene trees

More...
TreeFami
TF300203

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003295 IL-1_alpha
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003502 IL-1_propep
IPR008996 IL1/FGF

The PANTHER Classification System

More...
PANTHERi
PTHR10078:SF33 PTHR10078:SF33, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00340 IL1, 1 hit
PF02394 IL1_propep, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00264 INTERLEUKIN1
PR01358 INTRLEUKIN1A

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50353 SSF50353, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P01583-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKVPDMFED LKNCYSENEE DSSSIDHLSL NQKSFYHVSY GPLHEGCMDQ
60 70 80 90 100
SVSLSISETS KTSKLTFKES MVVVATNGKV LKKRRLSLSQ SITDDDLEAI
110 120 130 140 150
ANDSEEEIIK PRSAPFSFLS NVKYNFMRII KYEFILNDAL NQSIIRANDQ
160 170 180 190 200
YLTAAALHNL DEAVKFDMGA YKSSKDDAKI TVILRISKTQ LYVTAQDEDQ
210 220 230 240 250
PVLLKEMPEI PKTITGSETN LLFFWETHGT KNYFTSVAHP NLFIATKQDY
260 270
WVCLAGGPPS ITDFQILENQ A
Length:271
Mass (Da):30,607
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCBCCC49569D9ED40
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01430485R → Q1 PublicationCorresponds to variant dbSNP:rs3783531Ensembl.1
Natural variantiVAR_014305114A → S3 PublicationsCorresponds to variant dbSNP:rs17561Ensembl.1
Natural variantiVAR_014600125N → D. Corresponds to variant dbSNP:rs17562Ensembl.1
Natural variantiVAR_014306138D → N1 PublicationCorresponds to variant dbSNP:rs3783581Ensembl.1
Natural variantiVAR_014601176D → H. Corresponds to variant dbSNP:rs1801715Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X02531 mRNA Translation: CAA26371.1
X03833 Genomic DNA Translation: CAA27448.1
X02851 mRNA Translation: CAA26604.1
X56086 mRNA Translation: CAA39566.1
M28983 mRNA Translation: AAA59134.1
M15329 mRNA Translation: AAA59133.1
BN000002 Genomic DNA Translation: CAD29871.1
BT007014 mRNA Translation: AAP35660.1
CR457414 mRNA Translation: CAG33695.1
AF536338 Genomic DNA Translation: AAM96189.1
AK314850 mRNA Translation: BAG37367.1
AC112235 Genomic DNA Translation: AAX93054.1
CH471217 Genomic DNA Translation: EAW73604.1
BC013142 mRNA Translation: AAH13142.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2101.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A23385 ICHU1A

NCBI Reference Sequences

More...
RefSeqi
NP_000566.3, NM_000575.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000263339; ENSP00000263339; ENSG00000115008

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3552

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3552

UCSC genome browser

More...
UCSCi
uc002tig.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Interleukin-1 entry

SeattleSNPs
SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02531 mRNA Translation: CAA26371.1
X03833 Genomic DNA Translation: CAA27448.1
X02851 mRNA Translation: CAA26604.1
X56086 mRNA Translation: CAA39566.1
M28983 mRNA Translation: AAA59134.1
M15329 mRNA Translation: AAA59133.1
BN000002 Genomic DNA Translation: CAD29871.1
BT007014 mRNA Translation: AAP35660.1
CR457414 mRNA Translation: CAG33695.1
AF536338 Genomic DNA Translation: AAM96189.1
AK314850 mRNA Translation: BAG37367.1
AC112235 Genomic DNA Translation: AAX93054.1
CH471217 Genomic DNA Translation: EAW73604.1
BC013142 mRNA Translation: AAH13142.1
CCDSiCCDS2101.1
PIRiA23385 ICHU1A
RefSeqiNP_000566.3, NM_000575.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ITAmodel-A121-271[»]
2ILAX-ray2.30A117-271[»]
2KKINMR-A121-271[»]
2L5XNMR-A/D121-271[»]
5UC6X-ray2.10A113-271[»]
SMRiP01583
ModBaseiSearch...

Protein-protein interaction databases

BioGridi109768, 19 interactors
DIPiDIP-40550N
IntActiP01583, 6 interactors
STRINGi9606.ENSP00000263339

Chemistry databases

ChEMBLiCHEMBL3580496
DrugBankiDB06372 Rilonacept

DrugCentral

More...
DrugCentrali
P01583

Protein family/group databases

TCDBi1.A.109.1.1 the interleukin 1 (il1) family

PTM databases

iPTMnetiP01583
PhosphoSitePlusiP01583
SwissPalmiP01583

Polymorphism and mutation databases

BioMutaiIL1A
DMDMi124297

Proteomic databases

EPDiP01583
MassIVEiP01583
PaxDbiP01583
PeptideAtlasiP01583
PRIDEiP01583
ProteomicsDBi51390

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P01583

The DNASU plasmid repository

More...
DNASUi
3552
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263339; ENSP00000263339; ENSG00000115008
GeneIDi3552
KEGGihsa:3552
UCSCiuc002tig.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3552
DisGeNETi3552

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IL1A
HGNCiHGNC:5991 IL1A
MIMi147760 gene
neXtProtiNX_P01583
OpenTargetsiENSG00000115008
PharmGKBiPA29807

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410JAAI Eukaryota
ENOG411151X LUCA
GeneTreeiENSGT00390000013353
HOGENOMiHOG000113034
InParanoidiP01583
KOiK04383
OMAiNQKSFYD
OrthoDBi1513671at2759
PhylomeDBiP01583
TreeFamiTF300203

Enzyme and pathway databases

ReactomeiR-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-448706 Interleukin-1 processing
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-9020702 Interleukin-1 signaling
SignaLinkiP01583
SIGNORiP01583

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
IL1A human
EvolutionaryTraceiP01583

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
IL1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3552

Pharos

More...
Pharosi
P01583
PMAP-CutDBiP01583

Protein Ontology

More...
PROi
PR:P01583

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000115008 Expressed in 90 organ(s), highest expression level in smooth muscle tissue
GenevisibleiP01583 HS

Family and domain databases

InterProiView protein in InterPro
IPR003295 IL-1_alpha
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003502 IL-1_propep
IPR008996 IL1/FGF
PANTHERiPTHR10078:SF33 PTHR10078:SF33, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PF02394 IL1_propep, 1 hit
PRINTSiPR00264 INTERLEUKIN1
PR01358 INTRLEUKIN1A
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIL1A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01583
Secondary accession number(s): Q53QF9, Q7RU02
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 18, 2019
This is version 208 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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