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Protein

Interleukin-1 alpha

Gene

IL1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells.

GO - Molecular functioni

  • copper ion binding Source: UniProtKB
  • cytokine activity Source: BHF-UCL
  • interleukin-1 receptor binding Source: GO_Central

GO - Biological processi

  • apoptotic process Source: ProtInc
  • cell proliferation Source: ProtInc
  • cellular response to heat Source: UniProtKB
  • connective tissue replacement involved in inflammatory response wound healing Source: Ensembl
  • cytokine-mediated signaling pathway Source: BHF-UCL
  • ectopic germ cell programmed cell death Source: Ensembl
  • extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
  • fever generation Source: UniProtKB-KW
  • immune response Source: InterPro
  • inflammatory response Source: ProtInc
  • interleukin-1-mediated signaling pathway Source: Reactome
  • negative regulation of cell proliferation Source: BHF-UCL
  • negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: BHF-UCL
  • positive regulation of angiogenesis Source: BHF-UCL
  • positive regulation of cell division Source: UniProtKB-KW
  • positive regulation of cytokine secretion Source: BHF-UCL
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of interleukin-2 biosynthetic process Source: BHF-UCL
  • positive regulation of interleukin-6 production Source: Ensembl
  • positive regulation of mitotic nuclear division Source: BHF-UCL
  • positive regulation of monocyte chemotactic protein-1 production Source: Ensembl
  • positive regulation of neutrophil extravasation Source: Ensembl
  • positive regulation of protein secretion Source: AgBase
  • positive regulation of transcription by RNA polymerase II Source: Ensembl
  • positive regulation of vascular endothelial growth factor production Source: BHF-UCL
  • response to copper ion Source: UniProtKB

Keywordsi

Molecular functionCytokine, Mitogen, Pyrogen
Biological processInflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-448706 Interleukin-1 processing
R-HSA-6783783 Interleukin-10 signaling
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-9020702 Interleukin-1 signaling
SignaLinkiP01583
SIGNORiP01583

Protein family/group databases

TCDBi1.A.109.1.1 the interleukin 1 (il1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 alpha
Short name:
IL-1 alpha
Alternative name(s):
Hematopoietin-1
Gene namesi
Name:IL1A
Synonyms:IL1F1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000115008.5
HGNCiHGNC:5991 IL1A
MIMi147760 gene
neXtProtiNX_P01583

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3552
OpenTargetsiENSG00000115008
PharmGKBiPA29807

Chemistry databases

ChEMBLiCHEMBL3580496
DrugBankiDB06372 Rilonacept

Polymorphism and mutation databases

BioMutaiIL1A
DMDMi124297

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000152651 – 1121 PublicationAdd BLAST112
ChainiPRO_0000015266113 – 271Interleukin-1 alphaAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi82N6-myristoyl lysine1 Publication1
Lipidationi83N6-myristoyl lysine1 Publication1
Modified residuei87PhosphoserineBy similarity1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiP01583
PaxDbiP01583
PeptideAtlasiP01583
PRIDEiP01583
ProteomicsDBi51390

PTM databases

iPTMnetiP01583
PhosphoSitePlusiP01583
SwissPalmiP01583

Miscellaneous databases

PMAP-CutDBiP01583

Expressioni

Gene expression databases

BgeeiENSG00000115008
CleanExiHS_IL1A
GenevisibleiP01583 HS

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

Show more details

GO - Molecular functioni

  • cytokine activity Source: BHF-UCL
  • interleukin-1 receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi109768, 17 interactors
DIPiDIP-40550N
IntActiP01583, 6 interactors
STRINGi9606.ENSP00000263339

Structurei

Secondary structure

1271
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi123 – 138Combined sources16
Beta strandi143 – 146Combined sources4
Beta strandi148 – 150Combined sources3
Beta strandi152 – 155Combined sources4
Helixi160 – 162Combined sources3
Beta strandi166 – 175Combined sources10
Beta strandi176 – 178Combined sources3
Beta strandi181 – 186Combined sources6
Beta strandi189 – 194Combined sources6
Beta strandi198 – 200Combined sources3
Beta strandi203 – 206Combined sources4
Beta strandi212 – 215Combined sources4
Helixi216 – 221Combined sources6
Beta strandi223 – 228Combined sources6
Beta strandi231 – 239Combined sources9
Beta strandi243 – 246Combined sources4
Beta strandi248 – 251Combined sources4
Beta strandi253 – 257Combined sources5
Beta strandi259 – 261Combined sources3
Beta strandi264 – 267Combined sources4

3D structure databases

ProteinModelPortaliP01583
SMRiP01583
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01583

Family & Domainsi

Domaini

The similarity among the IL-1 precursors suggests that the amino ends of these proteins serve some as yet undefined function.

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410JAAI Eukaryota
ENOG411151X LUCA
GeneTreeiENSGT00390000013353
HOGENOMiHOG000113034
HOVERGENiHBG002432
InParanoidiP01583
KOiK04383
OMAiNQKSFYD
OrthoDBiEOG091G0MAP
PhylomeDBiP01583
TreeFamiTF300203

Family and domain databases

InterProiView protein in InterPro
IPR003295 IL-1_alpha
IPR020877 IL-1_CS
IPR000975 IL-1_fam
IPR003502 IL-1_propep
IPR008996 IL1/FGF
PANTHERiPTHR45409 PTHR45409, 1 hit
PfamiView protein in Pfam
PF00340 IL1, 1 hit
PF02394 IL1_propep, 1 hit
PRINTSiPR00264 INTERLEUKIN1
PR01358 INTRLEUKIN1A
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00253 INTERLEUKIN_1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01583-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVPDMFED LKNCYSENEE DSSSIDHLSL NQKSFYHVSY GPLHEGCMDQ
60 70 80 90 100
SVSLSISETS KTSKLTFKES MVVVATNGKV LKKRRLSLSQ SITDDDLEAI
110 120 130 140 150
ANDSEEEIIK PRSAPFSFLS NVKYNFMRII KYEFILNDAL NQSIIRANDQ
160 170 180 190 200
YLTAAALHNL DEAVKFDMGA YKSSKDDAKI TVILRISKTQ LYVTAQDEDQ
210 220 230 240 250
PVLLKEMPEI PKTITGSETN LLFFWETHGT KNYFTSVAHP NLFIATKQDY
260 270
WVCLAGGPPS ITDFQILENQ A
Length:271
Mass (Da):30,607
Last modified:July 21, 1986 - v1
Checksum:iCBCCC49569D9ED40
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01430485R → Q1 PublicationCorresponds to variant dbSNP:rs3783531Ensembl.1
Natural variantiVAR_014305114A → S3 PublicationsCorresponds to variant dbSNP:rs17561Ensembl.1
Natural variantiVAR_014600125N → D. Corresponds to variant dbSNP:rs17562Ensembl.1
Natural variantiVAR_014306138D → N1 PublicationCorresponds to variant dbSNP:rs3783581Ensembl.1
Natural variantiVAR_014601176D → H. Corresponds to variant dbSNP:rs1801715Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02531 mRNA Translation: CAA26371.1
X03833 Genomic DNA Translation: CAA27448.1
X02851 mRNA Translation: CAA26604.1
X56086 mRNA Translation: CAA39566.1
M28983 mRNA Translation: AAA59134.1
M15329 mRNA Translation: AAA59133.1
BN000002 Genomic DNA Translation: CAD29871.1
BT007014 mRNA Translation: AAP35660.1
CR457414 mRNA Translation: CAG33695.1
AF536338 Genomic DNA Translation: AAM96189.1
AK314850 mRNA Translation: BAG37367.1
AC112235 Genomic DNA Translation: AAX93054.1
CH471217 Genomic DNA Translation: EAW73604.1
BC013142 mRNA Translation: AAH13142.1
CCDSiCCDS2101.1
PIRiA23385 ICHU1A
RefSeqiNP_000566.3, NM_000575.4
UniGeneiHs.1722

Genome annotation databases

EnsembliENST00000263339; ENSP00000263339; ENSG00000115008
GeneIDi3552
KEGGihsa:3552
UCSCiuc002tig.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIL1A_HUMAN
AccessioniPrimary (citable) accession number: P01583
Secondary accession number(s): Q53QF9, Q7RU02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: July 18, 2018
This is version 201 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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