Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interferon gamma

Gene

IFNG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • interferon-gamma receptor binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense, Growth regulation

Enzyme and pathway databases

ReactomeiR-HSA-877300 Interferon gamma signaling
R-HSA-877312 Regulation of IFNG signaling
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SignaLinkiP01579
SIGNORiP01579

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon gamma
Short name:
IFN-gamma
Alternative name(s):
Immune interferon
Gene namesi
Name:IFNG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000111537.4
HGNCiHGNC:5438 IFNG
MIMi147570 gene
neXtProtiNX_P01579

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Aplastic anemia (AA)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA form of anemia in which the bone marrow fails to produce adequate numbers of peripheral blood elements. It is characterized by peripheral pancytopenia and marrow hypoplasia.
See also OMIM:609135

Pharmaceutical usei

Available under the name Actimmune (Genentech). Used for reducing the frequency and severity of serious infections associated with chronic granulomatous disease (CGD).

Organism-specific databases

DisGeNETi3458
MalaCardsiIFNG
MIMi609135 phenotype
OpenTargetsiENSG00000111537
Orphaneti88 Idiopathic aplastic anemia
PharmGKBiPA29674

Chemistry databases

ChEMBLiCHEMBL3286073
DrugBankiDB05676 Apremilast
DB05111 Fontolizumab
DB01296 Glucosamine
DB01250 Olsalazine
DB05110 VIR201

Polymorphism and mutation databases

BioMutaiIFNG
DMDMi124479

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 232 PublicationsAdd BLAST23
ChainiPRO_000001644424 – 161Interferon gammaAdd BLAST138
PropeptideiPRO_0000259481162 – 1665

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acid2 Publications1
Glycosylationi48N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi120N-linked (GlcNAc...) asparagine; in dimeric form1 Publication1

Post-translational modificationi

Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

EPDiP01579
PaxDbiP01579
PeptideAtlasiP01579
PRIDEiP01579
ProteomicsDBi51389

PTM databases

GlyConnecti287
iPTMnetiP01579
PhosphoSitePlusiP01579
UniCarbKBiP01579

Miscellaneous databases

PMAP-CutDBiP01579

Expressioni

Tissue specificityi

Released primarily from activated T lymphocytes.

Gene expression databases

BgeeiENSG00000111537 Expressed in 68 organ(s), highest expression level in leukocyte
CleanExiHS_IFNG
GenevisibleiP01579 HS

Organism-specific databases

HPAiCAB010344

Interactioni

Subunit structurei

Homodimer.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109680, 5 interactors
DIPiDIP-483N
IntActiP01579, 3 interactors
STRINGi9606.ENSP00000229135

Chemistry databases

BindingDBiP01579

Structurei

Secondary structure

1166
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP01579
SMRiP01579
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01579

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWSY Eukaryota
ENOG410Z8I5 LUCA
GeneTreeiENSGT00390000007831
HOGENOMiHOG000254784
HOVERGENiHBG056912
InParanoidiP01579
KOiK04687
OMAiWKEESDK
OrthoDBiEOG091G0ZH0
PhylomeDBiP01579
TreeFamiTF336308

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002069 Interferon_gamma
PANTHERiPTHR11419 PTHR11419, 1 hit
PfamiView protein in Pfam
PF00714 IFN-gamma, 1 hit
PIRSFiPIRSF001936 IFN-gamma, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002435 Interferon_gamma, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01579-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKYTSYILAF QLCIVLGSLG CYCQDPYVKE AENLKKYFNA GHSDVADNGT
60 70 80 90 100
LFLGILKNWK EESDRKIMQS QIVSFYFKLF KNFKDDQSIQ KSVETIKEDM
110 120 130 140 150
NVKFFNSNKK KRDDFEKLTN YSVTDLNVQR KAIHELIQVM AELSPAAKTG
160
KRKRSQMLFR GRRASQ
Length:166
Mass (Da):19,348
Last modified:April 1, 1988 - v1
Checksum:i1514E8F785FD81AA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00401729K → Q. 1
Natural variantiVAR_004018160R → Q1 PublicationCorresponds to variant dbSNP:rs201359065Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13274 mRNA Translation: CAA31639.1
J00219 Genomic DNA Translation: AAB59534.1
X01992 mRNA Translation: CAA26022.1
V00543 mRNA Translation: CAA23804.1
AY255837 mRNA Translation: AAP20098.1
AF375790 Genomic DNA Translation: AAK53058.1
AB451324 mRNA Translation: BAG70138.1
AB451453 mRNA Translation: BAG70267.1
CH471054 Genomic DNA Translation: EAW97180.1
BC070256 mRNA Translation: AAH70256.1
CCDSiCCDS8980.1
PIRiA93284 IVHUG
RefSeqiNP_000610.2, NM_000619.2
UniGeneiHs.856

Genome annotation databases

EnsembliENST00000229135; ENSP00000229135; ENSG00000111537
GeneIDi3458
KEGGihsa:3458
UCSCiuc001stw.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Interferon gamma entry

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13274 mRNA Translation: CAA31639.1
J00219 Genomic DNA Translation: AAB59534.1
X01992 mRNA Translation: CAA26022.1
V00543 mRNA Translation: CAA23804.1
AY255837 mRNA Translation: AAP20098.1
AF375790 Genomic DNA Translation: AAK53058.1
AB451324 mRNA Translation: BAG70138.1
AB451453 mRNA Translation: BAG70267.1
CH471054 Genomic DNA Translation: EAW97180.1
BC070256 mRNA Translation: AAH70256.1
CCDSiCCDS8980.1
PIRiA93284 IVHUG
RefSeqiNP_000610.2, NM_000619.2
UniGeneiHs.856

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EKUX-ray2.90A/B26-161[»]
1FG9X-ray2.90A/B24-156[»]
1FYHX-ray2.04A/D28-156[»]
1HIGX-ray3.50A/B/C/D24-161[»]
3BESX-ray2.20L24-161[»]
ProteinModelPortaliP01579
SMRiP01579
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109680, 5 interactors
DIPiDIP-483N
IntActiP01579, 3 interactors
STRINGi9606.ENSP00000229135

Chemistry databases

BindingDBiP01579
ChEMBLiCHEMBL3286073
DrugBankiDB05676 Apremilast
DB05111 Fontolizumab
DB01296 Glucosamine
DB01250 Olsalazine
DB05110 VIR201

PTM databases

GlyConnecti287
iPTMnetiP01579
PhosphoSitePlusiP01579
UniCarbKBiP01579

Polymorphism and mutation databases

BioMutaiIFNG
DMDMi124479

Proteomic databases

EPDiP01579
PaxDbiP01579
PeptideAtlasiP01579
PRIDEiP01579
ProteomicsDBi51389

Protocols and materials databases

DNASUi3458
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000229135; ENSP00000229135; ENSG00000111537
GeneIDi3458
KEGGihsa:3458
UCSCiuc001stw.2 human

Organism-specific databases

CTDi3458
DisGeNETi3458
EuPathDBiHostDB:ENSG00000111537.4
GeneCardsiIFNG
HGNCiHGNC:5438 IFNG
HPAiCAB010344
MalaCardsiIFNG
MIMi147570 gene
609135 phenotype
neXtProtiNX_P01579
OpenTargetsiENSG00000111537
Orphaneti88 Idiopathic aplastic anemia
PharmGKBiPA29674
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWSY Eukaryota
ENOG410Z8I5 LUCA
GeneTreeiENSGT00390000007831
HOGENOMiHOG000254784
HOVERGENiHBG056912
InParanoidiP01579
KOiK04687
OMAiWKEESDK
OrthoDBiEOG091G0ZH0
PhylomeDBiP01579
TreeFamiTF336308

Enzyme and pathway databases

ReactomeiR-HSA-877300 Interferon gamma signaling
R-HSA-877312 Regulation of IFNG signaling
R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SignaLinkiP01579
SIGNORiP01579

Miscellaneous databases

EvolutionaryTraceiP01579
GeneWikiiInterferon-gamma
GenomeRNAii3458
PMAP-CutDBiP01579
PROiPR:P01579
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000111537 Expressed in 68 organ(s), highest expression level in leukocyte
CleanExiHS_IFNG
GenevisibleiP01579 HS

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR002069 Interferon_gamma
PANTHERiPTHR11419 PTHR11419, 1 hit
PfamiView protein in Pfam
PF00714 IFN-gamma, 1 hit
PIRSFiPIRSF001936 IFN-gamma, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002435 Interferon_gamma, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFNG_HUMAN
AccessioniPrimary (citable) accession number: P01579
Secondary accession number(s): B5BU88, Q53ZV4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1988
Last modified: November 7, 2018
This is version 212 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Pharmaceutical, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again