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Protein

Interferon beta-3

Gene

IFNB3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has antiviral, antibacterial and anticancer activities.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon beta-3
Gene namesi
Name:IFNB3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Add BLAST21
ChainiPRO_000001639822 – 186Interferon beta-3Add BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 161Curated
Glycosylationi131N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01577
PRIDEiP01577

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000056510

Structurei

3D structure databases

ProteinModelPortaliP01577
SMRiP01577
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0RY Eukaryota
ENOG41113EJ LUCA
HOVERGENiHBG052086
InParanoidiP01577
KOiK05415

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
IPR015588 Interferon_beta
PANTHERiPTHR11691 PTHR11691, 1 hit
PTHR11691:SF43 PTHR11691:SF43, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01577-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTYRCLLPMV LLLCFSTTAL SRSYSLLRFQ QRRSAEVCQK LLGQLHSTPQ
60 70 80 90 100
HCLEAKMDFQ VPEEMNQAQQ FRKEDAILVI YEMLQQIFNI LTRDFSSTGW
110 120 130 140 150
SETIIEDLLV ELYGQMNRLQ PIQKEIMQEQ NFTMGDTTVL HLKKYYFNLV
160 170 180
QYLESKEYNR CAWTVVRVQI LTNFSFLMRL TASLRD
Length:186
Mass (Da):22,060
Last modified:July 21, 1986 - v1
Checksum:i1D10111EBEE1A65D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15479 Genomic DNA Translation: AAA30581.1
PIRiA01841 IVBOB3
RefSeqiNP_001107769.1, NM_001114297.1
UniGeneiBt.101633

Genome annotation databases

GeneIDi618946
KEGGibta:618946

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15479 Genomic DNA Translation: AAA30581.1
PIRiA01841 IVBOB3
RefSeqiNP_001107769.1, NM_001114297.1
UniGeneiBt.101633

3D structure databases

ProteinModelPortaliP01577
SMRiP01577
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000056510

Proteomic databases

PaxDbiP01577
PRIDEiP01577

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi618946
KEGGibta:618946

Organism-specific databases

CTDi618946

Phylogenomic databases

eggNOGiENOG410J0RY Eukaryota
ENOG41113EJ LUCA
HOVERGENiHBG052086
InParanoidiP01577
KOiK05415

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
IPR015588 Interferon_beta
PANTHERiPTHR11691 PTHR11691, 1 hit
PTHR11691:SF43 PTHR11691:SF43, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFNB3_BOVIN
AccessioniPrimary (citable) accession number: P01577
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 25, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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