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Entry version 207 (18 Sep 2019)
Sequence version 1 (21 Jul 1986)
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Protein

Interferon beta

Gene

IFNB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has antiviral, antibacterial and anticancer activities.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chloramphenicol O-acetyltransferase activity Source: AgBase
  • cytokine activity Source: BHF-UCL
  • type I interferon receptor binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-918233 TRAF3-dependent IRF activation pathway
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P01574

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01574

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon beta
Short name:
IFN-beta
Alternative name(s):
Fibroblast interferon
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IFNB1
Synonyms:IFB, IFNB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5434 IFNB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
147640 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01574

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the use of a protein as a pharmaceutical drug. It indicates the name of the drug, the name of the firm that commercializes it and explains in a few words in which context the drug is used. In some cases, drugs that are under development are also described.<p><a href='/help/pharmaceutical_use' target='_top'>More...</a></p>Pharmaceutical usei

Available under the names Avonex (Biogen), Betaseron (Berlex) and Rebif (Serono). Used in the treatment of multiple sclerosis (MS). Betaseron is a slightly modified form of IFNB1 with two residue substitutions.

Organism-specific databases

DisGeNET

More...
DisGeNETi
3456

Open Targets

More...
OpenTargetsi
ENSG00000171855

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29672

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
9875 Hom s IFN beta

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02379 Beta-D-Glucose

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IFNB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124469

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Add BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001640022 – 187Interferon betaAdd BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei24PhosphotyrosineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi52 ↔ 1621 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi101N-linked (GlcNAc...) asparagine1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P01574

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01574

PeptideAtlas

More...
PeptideAtlasi
P01574

PRoteomics IDEntifications database

More...
PRIDEi
P01574

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51388

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P01574

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
291

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01574

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01574

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P01574

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P01574

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000171855 Expressed in 3 organ(s), highest expression level in upper lobe of left lung

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01574 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB009386

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109678, 2 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P01574

Database of interacting proteins

More...
DIPi
DIP-6018N

Protein interaction database and analysis system

More...
IntActi
P01574, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000369581

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1187
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P01574

Database of comparative protein structure models

More...
ModBasei
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01574

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J0RY Eukaryota
ENOG41113EJ LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182853

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230501

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01574

KEGG Orthology (KO)

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KOi
K05415

Identification of Orthologs from Complete Genome Data

More...
OMAi
CLKDRMN

Database of Orthologous Groups

More...
OrthoDBi
870903at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01574

TreeFam database of animal gene trees

More...
TreeFami
TF336177

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00095 IFab, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
IPR015588 Interferon_beta

The PANTHER Classification System

More...
PANTHERi
PTHR11691 PTHR11691, 1 hit
PTHR11691:SF68 PTHR11691:SF68, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00143 Interferon, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00266 INTERFERONAB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00076 IFabd, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47266 SSF47266, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P01574-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTNKCLLQIA LLLCFSTTAL SMSYNLLGFL QRSSNFQCQK LLWQLNGRLE
60 70 80 90 100
YCLKDRMNFD IPEEIKQLQQ FQKEDAALTI YEMLQNIFAI FRQDSSSTGW
110 120 130 140 150
NETIVENLLA NVYHQINHLK TVLEEKLEKE DFTRGKLMSS LHLKRYYGRI
160 170 180
LHYLKAKEYS HCAWTIVRVE ILRNFYFINR LTGYLRN
Length:187
Mass (Da):22,294
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B013D4087723CEC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_004016162C → Y Variant found in a clone obtained from a fibroblast cell line; does not form the essential disulfide bond; results in loss of antiviral activity. 1 Publication1
Natural variantiVAR_036330164W → C in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
V00534 Genomic DNA Translation: CAA23795.1
V00535 Genomic DNA Translation: CAA23796.1
V00546 mRNA Translation: CAA23807.1
V00547 mRNA Translation: CAA23808.1
M28622 mRNA Translation: AAA36040.1
EF064725 Genomic DNA Translation: ABK41908.1
AB451323 mRNA Translation: BAG70137.1
AB451452 mRNA Translation: BAG70266.1
CH471071 Genomic DNA Translation: EAW58625.1
BC069314 mRNA Translation: AAH69314.1
BC096150 mRNA Translation: AAH96150.1
BC096151 mRNA Translation: AAH96151.1
BC096152 mRNA Translation: AAH96152.1
BC096153 mRNA Translation: AAH96153.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6495.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A93721 IVHUB1

NCBI Reference Sequences

More...
RefSeqi
NP_002167.1, NM_002176.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000380232; ENSP00000369581; ENSG00000171855

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3456

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3456

UCSC genome browser

More...
UCSCi
uc003zok.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Avonex

Clinical information on Avonex

Betaseron

Clinical information on Betaseron

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00534 Genomic DNA Translation: CAA23795.1
V00535 Genomic DNA Translation: CAA23796.1
V00546 mRNA Translation: CAA23807.1
V00547 mRNA Translation: CAA23808.1
M28622 mRNA Translation: AAA36040.1
EF064725 Genomic DNA Translation: ABK41908.1
AB451323 mRNA Translation: BAG70137.1
AB451452 mRNA Translation: BAG70266.1
CH471071 Genomic DNA Translation: EAW58625.1
BC069314 mRNA Translation: AAH69314.1
BC096150 mRNA Translation: AAH96150.1
BC096151 mRNA Translation: AAH96151.1
BC096152 mRNA Translation: AAH96152.1
BC096153 mRNA Translation: AAH96153.1
CCDSiCCDS6495.1
PIRiA93721 IVHUB1
RefSeqiNP_002167.1, NM_002176.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AU1X-ray2.20A/B22-187[»]
SMRiP01574
ModBaseiSearch...

Protein-protein interaction databases

BioGridi109678, 2 interactors
CORUMiP01574
DIPiDIP-6018N
IntActiP01574, 2 interactors
STRINGi9606.ENSP00000369581

Chemistry databases

DrugBankiDB02379 Beta-D-Glucose

Protein family/group databases

Allergomei9875 Hom s IFN beta

PTM databases

GlyConnecti291
iPTMnetiP01574
PhosphoSitePlusiP01574
UniCarbKBiP01574

Polymorphism and mutation databases

BioMutaiIFNB1
DMDMi124469

Proteomic databases

MassIVEiP01574
PaxDbiP01574
PeptideAtlasiP01574
PRIDEiP01574
ProteomicsDBi51388
TopDownProteomicsiP01574

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380232; ENSP00000369581; ENSG00000171855
GeneIDi3456
KEGGihsa:3456
UCSCiuc003zok.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3456
DisGeNETi3456

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IFNB1
HGNCiHGNC:5434 IFNB1
HPAiCAB009386
MIMi147640 gene
neXtProtiNX_P01574
OpenTargetsiENSG00000171855
PharmGKBiPA29672

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J0RY Eukaryota
ENOG41113EJ LUCA
GeneTreeiENSGT00950000182853
HOGENOMiHOG000230501
InParanoidiP01574
KOiK05415
OMAiCLKDRMN
OrthoDBi870903at2759
PhylomeDBiP01574
TreeFamiTF336177

Enzyme and pathway databases

ReactomeiR-HSA-2559580 Oxidative Stress Induced Senescence
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-918233 TRAF3-dependent IRF activation pathway
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkiP01574
SIGNORiP01574

Miscellaneous databases

EvolutionaryTraceiP01574

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
IFNB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3456

Pharos

More...
Pharosi
P01574
PMAP-CutDBiP01574

Protein Ontology

More...
PROi
PR:P01574

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000171855 Expressed in 3 organ(s), highest expression level in upper lobe of left lung
GenevisibleiP01574 HS

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
IPR015588 Interferon_beta
PANTHERiPTHR11691 PTHR11691, 1 hit
PTHR11691:SF68 PTHR11691:SF68, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIFNB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01574
Secondary accession number(s): Q5VWC9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 18, 2019
This is version 207 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Pharmaceutical, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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