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Protein

Interferon alpha-1

Gene

Ifna1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.1 Publication

Caution

Was named interferon alpha-E (embryonic) based on peptide sequencing (PubMed:9244179). The differences found may be sequencing erros and have not been confirmed by other studies.1 Publication

GO - Molecular functioni

  • cytokine activity Source: MGI
  • type I interferon receptor binding Source: GO_Central

GO - Biological processi

  • adaptive immune response Source: GO_Central
  • B cell differentiation Source: GO_Central
  • B cell proliferation Source: GO_Central
  • defense response to bacterium Source: MGI
  • defense response to virus Source: MGI
  • humoral immune response Source: GO_Central
  • natural killer cell activation involved in immune response Source: MGI
  • positive regulation of peptidyl-serine phosphorylation of STAT protein Source: GO_Central
  • regulation of defense response to virus by host Source: CAFA
  • response to exogenous dsRNA Source: GO_Central
  • T cell activation involved in immune response Source: MGI
  • type I interferon signaling pathway Source: CAFA

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-MMU-909733 Interferon alpha/beta signaling
R-MMU-912694 Regulation of IFNA signaling
R-MMU-933541 TRAF6 mediated IRF7 activation
R-MMU-983231 Factors involved in megakaryocyte development and platelet production
SABIO-RKiP01572

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-1
Short name:
IFN-alpha-1
Gene namesi
Name:Ifna1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:107668 Ifna1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001637524 – 189Interferon alpha-1Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity
Glycosylationi101N-linked (GlcNAc...) asparagine1 Publication1

Post-translational modificationi

Glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01572
PRIDEiP01572

PTM databases

iPTMnetiP01572
PhosphoSitePlusiP01572

Expressioni

Gene expression databases

BgeeiENSMUSG00000095498
CleanExiMM_IFNA1
GenevisibleiP01572 MM

Interactioni

GO - Molecular functioni

  • cytokine activity Source: MGI
  • type I interferon receptor binding Source: GO_Central

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092580

Structurei

3D structure databases

ProteinModelPortaliP01572
SMRiP01572
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J735 Eukaryota
ENOG410ZH91 LUCA
GeneTreeiENSGT00760000119150
HOVERGENiHBG052086
InParanoidiP01572
KOiK05414
OMAiHRRTMML
OrthoDBiEOG091G0MJ6
TreeFamiTF336177

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01572-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLCAFLMV LAVLSYWPTC SLGCDLPQTH NLRNKRALTL LVQMRRLSPL
60 70 80 90 100
SCLKDRKDFG FPQEKVDAQQ IKKAQAIPVL SELTQQILNI FTSKDSSAAW
110 120 130 140 150
NTTLLDSFCN DLHQQLNDLQ GCLMQQVGVQ EFPLTQEDAL LAVRKYFHRI
160 170 180
TVYLREKKHS PCAWEVVRAE VWRALSSSAN VLGRLREEK
Length:189
Mass (Da):21,646
Last modified:February 8, 2011 - v2
Checksum:iD6F4BC96DCE7D67E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14L → M no nucleotide entry (PubMed:6188104).Curated1
Sequence conflicti14L → M in CAA26006 (PubMed:2987811).Curated1
Sequence conflicti102T → A no nucleotide entry (PubMed:6188104).Curated1
Sequence conflicti102T → A in CAA26006 (PubMed:2987811).Curated1
Sequence conflicti126Q → E AA sequence (PubMed:9244179).Curated1
Sequence conflicti132F → P AA sequence (PubMed:9244179).Curated1
Sequence conflicti139A → Y AA sequence (PubMed:9244179).Curated1
Sequence conflicti145K → T AA sequence (PubMed:9244179).Curated1
Sequence conflicti175L → M AA sequence (PubMed:9244179).Curated1
Sequence conflicti180 – 181NV → KL AA sequence (PubMed:9244179).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01974 Genomic DNA Translation: CAA26006.1
AY225950 Genomic DNA Translation: AAO63592.1
BX530016 Genomic DNA Translation: CAM22267.1
CH466527 Genomic DNA Translation: EDL30958.1
CCDSiCCDS18347.1
PIRiA01836 IVMSA1
S62682
RefSeqiNP_034632.2, NM_010502.2
UniGeneiMm.57127

Genome annotation databases

EnsembliENSMUST00000094972; ENSMUSP00000092580; ENSMUSG00000095498
GeneIDi15962
KEGGimmu:15962
UCSCiuc008toc.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIFNA1_MOUSE
AccessioniPrimary (citable) accession number: P01572
Secondary accession number(s): Q7M0A3, Q810G7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 8, 2011
Last modified: December 20, 2017
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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