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Protein

Interferon alpha-14

Gene

IFNA14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.1 Publication

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • cytokine receptor binding Source: ProtInc
  • type I interferon receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-14
Short name:
IFN-alpha-14
Alternative name(s):
Interferon alpha-H
Short name:
LeIF H
Interferon lambda-2-H
Gene namesi
Name:IFNA14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000228083.2
HGNCiHGNC:5420 IFNA14
MIMi147579 gene
neXtProtiNX_P01570

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3448
OpenTargetsiENSG00000228083
PharmGKBiPA29659

Chemistry databases

ChEMBLiCHEMBL3856161

Polymorphism and mutation databases

BioMutaiIFNA14
DMDMi20178265

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 233 PublicationsAdd BLAST23
ChainiPRO_000001636724 – 189Interferon alpha-14Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity
Glycosylationi95N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP01570
PeptideAtlasiP01570
PRIDEiP01570
ProteomicsDBi51386

2D gel databases

REPRODUCTION-2DPAGEiP01570

PTM databases

GlyConnecti288
iPTMnetiP01570
PhosphoSitePlusiP01570
UniCarbKBiP01570

Expressioni

Gene expression databases

BgeeiENSG00000228083 Expressed in 2 organ(s), highest expression level in cortex of kidney
CleanExiHS_IFNA14
GenevisibleiP01570 HS

Organism-specific databases

HPAiHPA047557

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109671, 9 interactors
IntActiP01570, 1 interactor
STRINGi9606.ENSP00000369571

Structurei

3D structure databases

ProteinModelPortaliP01570
SMRiP01570
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J735 Eukaryota
ENOG410ZH91 LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230500
HOVERGENiHBG052086
InParanoidiP01570
KOiK05414
OMAiNNRRTLM
OrthoDBiEOG091G0MJ6
PhylomeDBiP01570
TreeFamiTF336177

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01570-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALPFALMMA LVVLSCKSSC SLGCNLSQTH SLNNRRTLML MAQMRRISPF
60 70 80 90 100
SCLKDRHDFE FPQEEFDGNQ FQKAQAISVL HEMMQQTFNL FSTKNSSAAW
110 120 130 140 150
DETLLEKFYI ELFQQMNDLE ACVIQEVGVE ETPLMNEDSI LAVKKYFQRI
160 170 180
TLYLMEKKYS PCAWEVVRAE IMRSLSFSTN LQKRLRRKD
Length:189
Mass (Da):22,063
Last modified:July 21, 1986 - v3
Checksum:iB6B71E2F0D644FE7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti175L → F in CAA23803 (PubMed:6163083).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00542 mRNA Translation: CAA23803.1
V00533 Genomic DNA Translation: CAA23794.1
X02959 Genomic DNA Translation: CAA26705.1
AL162420 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58616.1
BC074956 mRNA Translation: AAH74956.1
BC104159 mRNA Translation: AAI04160.1
BC104160 mRNA Translation: AAI04161.1
CCDSiCCDS6501.1
PIRiA42753
A92916 IVHU14
RefSeqiNP_002163.2, NM_002172.2
UniGeneiHs.93907

Genome annotation databases

EnsembliENST00000380222; ENSP00000369571; ENSG00000228083
GeneIDi3448
KEGGihsa:3448
UCSCiuc010mis.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00542 mRNA Translation: CAA23803.1
V00533 Genomic DNA Translation: CAA23794.1
X02959 Genomic DNA Translation: CAA26705.1
AL162420 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58616.1
BC074956 mRNA Translation: AAH74956.1
BC104159 mRNA Translation: AAI04160.1
BC104160 mRNA Translation: AAI04161.1
CCDSiCCDS6501.1
PIRiA42753
A92916 IVHU14
RefSeqiNP_002163.2, NM_002172.2
UniGeneiHs.93907

3D structure databases

ProteinModelPortaliP01570
SMRiP01570
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109671, 9 interactors
IntActiP01570, 1 interactor
STRINGi9606.ENSP00000369571

Chemistry databases

ChEMBLiCHEMBL3856161

PTM databases

GlyConnecti288
iPTMnetiP01570
PhosphoSitePlusiP01570
UniCarbKBiP01570

Polymorphism and mutation databases

BioMutaiIFNA14
DMDMi20178265

2D gel databases

REPRODUCTION-2DPAGEiP01570

Proteomic databases

PaxDbiP01570
PeptideAtlasiP01570
PRIDEiP01570
ProteomicsDBi51386

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000380222; ENSP00000369571; ENSG00000228083
GeneIDi3448
KEGGihsa:3448
UCSCiuc010mis.4 human

Organism-specific databases

CTDi3448
DisGeNETi3448
EuPathDBiHostDB:ENSG00000228083.2
GeneCardsiIFNA14
HGNCiHGNC:5420 IFNA14
HPAiHPA047557
MIMi147579 gene
neXtProtiNX_P01570
OpenTargetsiENSG00000228083
PharmGKBiPA29659
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J735 Eukaryota
ENOG410ZH91 LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230500
HOVERGENiHBG052086
InParanoidiP01570
KOiK05414
OMAiNNRRTLM
OrthoDBiEOG091G0MJ6
PhylomeDBiP01570
TreeFamiTF336177

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

GeneWikiiIFNA14
GenomeRNAii3448
PROiPR:P01570
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000228083 Expressed in 2 organ(s), highest expression level in cortex of kidney
CleanExiHS_IFNA14
GenevisibleiP01570 HS

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFN14_HUMAN
AccessioniPrimary (citable) accession number: P01570
Secondary accession number(s): Q5VZ56, Q7M4S1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 7, 2018
This is version 178 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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