UniProtKB - P01569 (IFNA5_HUMAN)
Protein
Interferon alpha-5
Gene
IFNA5
Organism
Homo sapiens (Human)
Status
Functioni
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
GO - Molecular functioni
- cytokine activity Source: GO_Central
- cytokine receptor binding Source: ProtInc
- type I interferon receptor binding Source: GO_Central
GO - Biological processi
- adaptive immune response Source: GO_Central
- B cell differentiation Source: GO_Central
- B cell proliferation Source: GO_Central
- blood coagulation Source: Reactome
- cytokine-mediated signaling pathway Source: GO_Central
- defense response to virus Source: UniProtKB-KW
- humoral immune response Source: GO_Central
- natural killer cell activation involved in immune response Source: GO_Central
- positive regulation of peptidyl-serine phosphorylation of STAT protein Source: GO_Central
- response to exogenous dsRNA Source: GO_Central
- T cell activation involved in immune response Source: GO_Central
- type I interferon signaling pathway Source: Reactome
Keywordsi
Molecular function | Cytokine |
Biological process | Antiviral defense |
Enzyme and pathway databases
PathwayCommonsi | P01569 |
Reactomei | R-HSA-909733, Interferon alpha/beta signaling R-HSA-912694, Regulation of IFNA signaling R-HSA-933541, TRAF6 mediated IRF7 activation R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
Names & Taxonomyi
Protein namesi | Recommended name: Interferon alpha-5Short name: IFN-alpha-5 Alternative name(s): Interferon alpha-61 Interferon alpha-G Short name: LeIF G |
Gene namesi | Name:IFNA5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000147873.5 |
HGNCi | HGNC:5426, IFNA5 |
MIMi | 147565, gene |
neXtProti | NX_P01569 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 3442 |
OpenTargetsi | ENSG00000147873 |
PharmGKBi | PA29665 |
Miscellaneous databases
Pharosi | P01569, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3856161 |
Polymorphism and mutation databases
BioMutai | IFNA5 |
DMDMi | 124457 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | 1 PublicationAdd BLAST | 21 | |
ChainiPRO_0000016362 | 22 – 189 | Interferon alpha-5Add BLAST | 168 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 24 ↔ 122 | By similarity | ||
Disulfide bondi | 52 ↔ 162 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
MassIVEi | P01569 |
PaxDbi | P01569 |
PeptideAtlasi | P01569 |
PRIDEi | P01569 |
ProteomicsDBi | 51385 |
PTM databases
iPTMneti | P01569 |
PhosphoSitePlusi | P01569 |
Expressioni
Gene expression databases
Bgeei | ENSG00000147873, Expressed in sural nerve and 24 other tissues |
Genevisiblei | P01569, HS |
Organism-specific databases
HPAi | ENSG00000147873, Tissue enhanced (epididymis) |
Interactioni
GO - Molecular functioni
- cytokine activity Source: GO_Central
- cytokine receptor binding Source: ProtInc
- type I interferon receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 109665, 15 interactors |
DIPi | DIP-6019N |
IntActi | P01569, 10 interactors |
STRINGi | 9606.ENSP00000484479 |
Miscellaneous databases
RNActi | P01569, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the alpha/beta interferon family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SQAC, Eukaryota |
GeneTreei | ENSGT01000000214611 |
HOGENOMi | CLU_109427_0_0_1 |
InParanoidi | P01569 |
OMAi | RRTLMIM |
OrthoDBi | 1358010at2759 |
PhylomeDBi | P01569 |
TreeFami | TF336177 |
Family and domain databases
CDDi | cd00095, IFab, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000471, Interferon_alpha/beta/delta |
PANTHERi | PTHR11691, PTHR11691, 1 hit |
Pfami | View protein in Pfam PF00143, Interferon, 1 hit |
PRINTSi | PR00266, INTERFERONAB |
SMARTi | View protein in SMART SM00076, IFabd, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00252, INTERFERON_A_B_D, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P01569-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALPFVLLMA LVVLNCKSIC SLGCDLPQTH SLSNRRTLMI MAQMGRISPF
60 70 80 90 100
SCLKDRHDFG FPQEEFDGNQ FQKAQAISVL HEMIQQTFNL FSTKDSSATW
110 120 130 140 150
DETLLDKFYT ELYQQLNDLE ACMMQEVGVE DTPLMNVDSI LTVRKYFQRI
160 170 180
TLYLTEKKYS PCAWEVVRAE IMRSFSLSAN LQERLRRKE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X02956 Genomic DNA Translation: CAA26702.1 AL162420 Genomic DNA No translation available. BC093755 mRNA Translation: AAH93755.1 BC093757 mRNA Translation: AAH93757.1 V00541 mRNA Translation: CAA23802.1 |
CCDSi | CCDS6502.1 |
PIRi | D25843 S43716, IVHUA7 |
RefSeqi | NP_002160.1, NM_002169.2 |
Genome annotation databases
Ensembli | ENST00000610521; ENSP00000484479; ENSG00000147873 |
GeneIDi | 3442 |
KEGGi | hsa:3442 |
UCSCi | uc011lnh.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X02956 Genomic DNA Translation: CAA26702.1 AL162420 Genomic DNA No translation available. BC093755 mRNA Translation: AAH93755.1 BC093757 mRNA Translation: AAH93757.1 V00541 mRNA Translation: CAA23802.1 |
CCDSi | CCDS6502.1 |
PIRi | D25843 S43716, IVHUA7 |
RefSeqi | NP_002160.1, NM_002169.2 |
3D structure databases
SMRi | P01569 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109665, 15 interactors |
DIPi | DIP-6019N |
IntActi | P01569, 10 interactors |
STRINGi | 9606.ENSP00000484479 |
Chemistry databases
ChEMBLi | CHEMBL3856161 |
PTM databases
iPTMneti | P01569 |
PhosphoSitePlusi | P01569 |
Polymorphism and mutation databases
BioMutai | IFNA5 |
DMDMi | 124457 |
Proteomic databases
MassIVEi | P01569 |
PaxDbi | P01569 |
PeptideAtlasi | P01569 |
PRIDEi | P01569 |
ProteomicsDBi | 51385 |
Protocols and materials databases
ABCDi | P01569, 4 sequenced antibodies |
Antibodypediai | 24866, 218 antibodies |
Genome annotation databases
Ensembli | ENST00000610521; ENSP00000484479; ENSG00000147873 |
GeneIDi | 3442 |
KEGGi | hsa:3442 |
UCSCi | uc011lnh.3, human |
Organism-specific databases
CTDi | 3442 |
DisGeNETi | 3442 |
EuPathDBi | HostDB:ENSG00000147873.5 |
GeneCardsi | IFNA5 |
HGNCi | HGNC:5426, IFNA5 |
HPAi | ENSG00000147873, Tissue enhanced (epididymis) |
MIMi | 147565, gene |
neXtProti | NX_P01569 |
OpenTargetsi | ENSG00000147873 |
PharmGKBi | PA29665 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SQAC, Eukaryota |
GeneTreei | ENSGT01000000214611 |
HOGENOMi | CLU_109427_0_0_1 |
InParanoidi | P01569 |
OMAi | RRTLMIM |
OrthoDBi | 1358010at2759 |
PhylomeDBi | P01569 |
TreeFami | TF336177 |
Enzyme and pathway databases
PathwayCommonsi | P01569 |
Reactomei | R-HSA-909733, Interferon alpha/beta signaling R-HSA-912694, Regulation of IFNA signaling R-HSA-933541, TRAF6 mediated IRF7 activation R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
Miscellaneous databases
BioGRID-ORCSi | 3442, 31 hits in 818 CRISPR screens |
GeneWikii | IFNA5 |
GenomeRNAii | 3442 |
Pharosi | P01569, Tbio |
PROi | PR:P01569 |
RNActi | P01569, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000147873, Expressed in sural nerve and 24 other tissues |
Genevisiblei | P01569, HS |
Family and domain databases
CDDi | cd00095, IFab, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000471, Interferon_alpha/beta/delta |
PANTHERi | PTHR11691, PTHR11691, 1 hit |
Pfami | View protein in Pfam PF00143, Interferon, 1 hit |
PRINTSi | PR00266, INTERFERONAB |
SMARTi | View protein in SMART SM00076, IFabd, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00252, INTERFERON_A_B_D, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IFNA5_HUMAN | |
Accessioni | P01569Primary (citable) accession number: P01569 Secondary accession number(s): Q52LX3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | August 13, 1987 | |
Last modified: | December 2, 2020 | |
This is version 175 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families