IFNA5

Functionⁱ

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Molecular functionⁱ

cytokine activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cytokine receptor binding
Source: ProtInc
Traceable author statementⁱ
- 6163083
type I interferon receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adaptive immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
B cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
B cell proliferation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
blood coagulation Source: Reactome
cytokine-mediated signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
defense response to virus Source: UniProtKB-KW
humoral immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
natural killer cell activation involved in immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of peptidyl-serine phosphorylation of STAT protein
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to exogenous dsRNA
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
T cell activation involved in immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
type I interferon signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine
Biological process	Antiviral defense

Enzyme and pathway databases

Reactomeⁱ	R-HSA-909733 Interferon alpha/beta signaling R-HSA-912694 Regulation of IFNA signaling R-HSA-933541 TRAF6 mediated IRF7 activation R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Reactomeⁱ

R-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Interferon alpha-5 Short name: IFN-alpha-5 Alternative name(s): Interferon alpha-61 Interferon alpha-G Short name: LeIF G
Gene namesⁱ	Name:IFNA5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000147873.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5426 IFNA5
MIMⁱ	147565 gene
neXtProtⁱ	NX_P01569

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3442
Open Targets More...OpenTargetsⁱ	ENSG00000147873
PharmGKBⁱ	PA29665

Chemistry databases

ChEMBLⁱ	CHEMBL3856161

ChEMBLⁱ

CHEMBL3856161

Polymorphism and mutation databases

BioMutaⁱ	IFNA5
DMDMⁱ	124457

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	1 PublicationAdd BLAST		21
ChainⁱPRO_0000016362	22 – 189	Interferon alpha-5Add BLAST		168

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	24 ↔ 122	By similarity
Disulfide bondⁱ	52 ↔ 162	By similarity

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	P01569
PeptideAtlas More...PeptideAtlasⁱ	P01569
PRIDEⁱ	P01569
ProteomicsDBⁱ	51385

PTM databases

iPTMnetⁱ	P01569
PhosphoSitePlusⁱ	P01569

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000147873 Expressed in 17 organ(s), highest expression level in lower esophagus muscularis layer
CleanExⁱ	HS_IFNA5
Genevisibleⁱ	P01569 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA047557

HPAⁱ

HPA047557

Interactionⁱ

GO - Molecular functionⁱ

cytokine activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cytokine receptor binding
Source: ProtInc
Traceable author statementⁱ
- 6163083
type I interferon receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109665, 15 interactors
Database of interacting proteins More...DIPⁱ	DIP-6019N
STRINGⁱ	9606.ENSP00000259555

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P01569
SMRⁱ	P01569
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the alpha/beta interferon family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J735 Eukaryota ENOG410ZH91 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119150
HOGENOMⁱ	HOG000230500
HOVERGENⁱ	HBG052086
InParanoidⁱ	P01569
KEGG Orthology (KO) More...KOⁱ	K05414
OMAⁱ	EACMMQE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MJ6
PhylomeDBⁱ	P01569
TreeFamⁱ	TF336177

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00095 IFab, 1 hit
InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR000471 Interferon_alpha/beta/delta
PANTHERⁱ	PTHR11691 PTHR11691, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00143 Interferon, 1 hit
PRINTSⁱ	PR00266 INTERFERONAB
SMARTⁱ	View protein in SMART SM00076 IFabd, 1 hit
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00252 INTERFERON_A_B_D, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P01569-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALPFVLLMA LVVLNCKSIC SLGCDLPQTH SLSNRRTLMI MAQMGRISPF 
        60         70         80         90        100
SCLKDRHDFG FPQEEFDGNQ FQKAQAISVL HEMIQQTFNL FSTKDSSATW 
       110        120        130        140        150
DETLLDKFYT ELYQQLNDLE ACMMQEVGVE DTPLMNVDSI LTVRKYFQRI 
       160        170        180 
TLYLTEKKYS PCAWEVVRAE IMRSFSLSAN LQERLRRKE

Length:189

Mass (Da):21,942

Last modified:August 13, 1987 - v1

Checksum:ⁱC605992FE2E78043

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X02956 Genomic DNA Translation: CAA26702.1 AL162420 Genomic DNA No translation available. BC093755 mRNA Translation: AAH93755.1 BC093757 mRNA Translation: AAH93757.1 V00541 mRNA Translation: CAA23802.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6502.1
PIRⁱ	D25843 S43716 IVHUA7
NCBI Reference Sequences More...RefSeqⁱ	NP_002160.1, NM_002169.2
UniGeneⁱ	Hs.37113

Genome annotation databases

Ensemblⁱ	ENST00000610521; ENSP00000484479; ENSG00000147873
GeneIDⁱ	3442
KEGGⁱ	hsa:3442
UCSC genome browser More...UCSCⁱ	uc011lnh.3 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P01569	IFNA5 isoform 1		PANTR		189	UniRef90_P01569
Interferon alpha 5		PONAB		189
Uncharacterized protein		PANPA		189
Uncharacterized protein		NOMLE		189
UPI0001FA6B50		GORGO		189
+2

Protein	Similar proteins		Species	Score	Length	Source
P01569	Interferon alpha-2	)	HUMAN		188	UniRef50_P01563
Interferon alpha-2		HORSE		184
IFNA2 isoform 1		PONAB		188
IFNA2 isoform 1		PANTR		188
Interferon alpha 2		PANPA		170
+153

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X02956 Genomic DNA Translation: CAA26702.1 AL162420 Genomic DNA No translation available. BC093755 mRNA Translation: AAH93755.1 BC093757 mRNA Translation: AAH93757.1 V00541 mRNA Translation: CAA23802.1
CCDSⁱ	CCDS6502.1
PIRⁱ	D25843 S43716 IVHUA7
RefSeqⁱ	NP_002160.1, NM_002169.2
UniGeneⁱ	Hs.37113

3D structure databases

ProteinModelPortalⁱ	P01569
SMRⁱ	P01569
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109665, 15 interactors
DIPⁱ	DIP-6019N
STRINGⁱ	9606.ENSP00000259555

Chemistry databases

ChEMBLⁱ	CHEMBL3856161

ChEMBLⁱ

CHEMBL3856161

PTM databases

iPTMnetⁱ	P01569
PhosphoSitePlusⁱ	P01569

Polymorphism and mutation databases

BioMutaⁱ	IFNA5
DMDMⁱ	124457

Proteomic databases

PaxDbⁱ	P01569
PeptideAtlasⁱ	P01569
PRIDEⁱ	P01569
ProteomicsDBⁱ	51385

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000610521; ENSP00000484479; ENSG00000147873
GeneIDⁱ	3442
KEGGⁱ	hsa:3442
UCSCⁱ	uc011lnh.3 human

Organism-specific databases

CTDⁱ	3442
DisGeNETⁱ	3442
EuPathDBⁱ	HostDB:ENSG00000147873.5
GeneCardsⁱ	IFNA5
HGNCⁱ	HGNC:5426 IFNA5
HPAⁱ	HPA047557
MIMⁱ	147565 gene
neXtProtⁱ	NX_P01569
OpenTargetsⁱ	ENSG00000147873
PharmGKBⁱ	PA29665
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410J735 Eukaryota ENOG410ZH91 LUCA
GeneTreeⁱ	ENSGT00760000119150
HOGENOMⁱ	HOG000230500
HOVERGENⁱ	HBG052086
InParanoidⁱ	P01569
KOⁱ	K05414
OMAⁱ	EACMMQE
OrthoDBⁱ	EOG091G0MJ6
PhylomeDBⁱ	P01569
TreeFamⁱ	TF336177

Enzyme and pathway databases

Reactomeⁱ	R-HSA-909733 Interferon alpha/beta signaling R-HSA-912694 Regulation of IFNA signaling R-HSA-933541 TRAF6 mediated IRF7 activation R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Reactomeⁱ

R-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

GeneWikiⁱ	IFNA5
GenomeRNAiⁱ	3442
Protein Ontology More...PROⁱ	PR:P01569
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000147873 Expressed in 17 organ(s), highest expression level in lower esophagus muscularis layer
CleanExⁱ	HS_IFNA5
Genevisibleⁱ	P01569 HS

Family and domain databases

CDDⁱ	cd00095 IFab, 1 hit
InterProⁱ	View protein in InterPro IPR009079 4_helix_cytokine-like_core IPR000471 Interferon_alpha/beta/delta
PANTHERⁱ	PTHR11691 PTHR11691, 1 hit
Pfamⁱ	View protein in Pfam PF00143 Interferon, 1 hit
PRINTSⁱ	PR00266 INTERFERONAB
SMARTⁱ	View protein in SMART SM00076 IFabd, 1 hit
SUPFAMⁱ	SSF47266 SSF47266, 1 hit
PROSITEⁱ	View protein in PROSITE PS00252 INTERFERON_A_B_D, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IFNA5_HUMAN
Accessionⁱ	P01569Primary (citable) accession number: P01569 Secondary accession number(s): Q52LX3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	August 13, 1987
	Last modified:	November 7, 2018
	This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

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Annotation systems

Supporting data

UniProtKB - P01569 (IFNA5_HUMAN)

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Interferon alpha-5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ