Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Interferon alpha-21

Gene

IFNA21

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.1 Publication

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • cytokine receptor binding Source: ProtInc
  • type I interferon receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-21
Short name:
IFN-alpha-21
Alternative name(s):
Interferon alpha-F
Short name:
LeIF F
Gene namesi
Name:IFNA21
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000137080.4
HGNCiHGNC:5424 IFNA21
MIMi147584 gene
neXtProtiNX_P01568

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3452
OpenTargetsiENSG00000137080
PharmGKBiPA29663

Chemistry databases

ChEMBLiCHEMBL3856161

Polymorphism and mutation databases

BioMutaiIFNA21
DMDMi20178289

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 232 PublicationsAdd BLAST23
ChainiPRO_000001637024 – 189Interferon alpha-21Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01568
PeptideAtlasiP01568
PRIDEiP01568
ProteomicsDBi51384

PTM databases

iPTMnetiP01568
PhosphoSitePlusiP01568

Expressioni

Gene expression databases

BgeeiENSG00000137080
CleanExiHS_IFNA21
GenevisibleiP01568 HS

Organism-specific databases

HPAiHPA047557

Interactioni

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • cytokine receptor binding Source: ProtInc
  • type I interferon receptor binding Source: GO_Central

Protein-protein interaction databases

BioGridi109674, 29 interactors
STRINGi9606.ENSP00000369574

Structurei

3D structure databases

ProteinModelPortaliP01568
SMRiP01568
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J735 Eukaryota
ENOG410ZH91 LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230500
HOVERGENiHBG052086
InParanoidiP01568
KOiK05414
OMAiIAVFHEM
OrthoDBiEOG091G0MJ6
PhylomeDBiP01568
TreeFamiTF336177

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01568-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSFSLLMA VLVLSYKSIC SLGCDLPQTH SLGNRRALIL LAQMGRISPF
60 70 80 90 100
SCLKDRHDFG FPQEEFDGNQ FQKAQAISVL HEMIQQTFNL FSTKDSSATW
110 120 130 140 150
EQSLLEKFST ELNQQLNDLE ACVIQEVGVE ETPLMNVDSI LAVKKYFQRI
160 170 180
TLYLTEKKYS PCAWEVVRAE IMRSFSLSKI FQERLRRKE
Length:189
Mass (Da):21,741
Last modified:April 16, 2002 - v2
Checksum:iF0B6C9C392905802
GO

Sequence cautioni

The sequence AAA36041 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60G → E AA sequence (PubMed:1634550).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_055325119L → M1 PublicationCorresponds to variant dbSNP:rs1053885Ensembl.1
Natural variantiVAR_049638179K → E. Corresponds to variant dbSNP:rs3750478Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00540 mRNA Translation: CAA23801.1
M12350 mRNA Translation: AAA52718.1
X00145 mRNA Translation: CAA24980.1
M28586 mRNA Translation: AAA36041.1 Different initiation.
AL390882 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58623.1
BC069329 mRNA Translation: AAH69329.1
BC069372 mRNA Translation: AAH69372.1
BC069408 mRNA Translation: AAH69408.1
BC096699 mRNA Translation: AAH96699.1
BC101638 mRNA Translation: AAI01639.1
BC101640 mRNA Translation: AAI01641.1
CCDSiCCDS6497.1
PIRiA01832 IVHUF
D42753
E25843
I56313
I84464
RefSeqiNP_002166.2, NM_002175.2
UniGeneiHs.113211

Genome annotation databases

EnsembliENST00000380225; ENSP00000369574; ENSG00000137080
GeneIDi3452
KEGGihsa:3452
UCSCiuc003zom.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIFN21_HUMAN
AccessioniPrimary (citable) accession number: P01568
Secondary accession number(s): Q14608, Q5VWD1, Q7M4Q4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 16, 2002
Last modified: July 18, 2018
This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health