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Protein

Interferon alpha-7

Gene

IFNA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • type I interferon receptor binding Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-7
Short name:
IFN-alpha-7
Alternative name(s):
Interferon alpha-J
Short name:
LeIF J
Interferon alpha-J1
Short name:
IFN-alpha-J1
Gene namesi
Name:IFNA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000214042.1
HGNCiHGNC:5428 IFNA7
MIMi147567 gene
neXtProtiNX_P01567

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3444
OpenTargetsiENSG00000214042
PharmGKBiPA29667

Chemistry databases

ChEMBLiCHEMBL3856161

Polymorphism and mutation databases

BioMutaiIFNA7
DMDMi124442

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001636424 – 189Interferon alpha-7Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 162By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP01567
PeptideAtlasiP01567
PRIDEiP01567
ProteomicsDBi51383

PTM databases

iPTMnetiP01567
PhosphoSitePlusiP01567

Expressioni

Gene expression databases

BgeeiENSG00000214042 Expressed in 2 organ(s), highest expression level in blood
CleanExiHS_IFNA7
GenevisibleiP01567 HS

Organism-specific databases

HPAiHPA047557

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109667, 7 interactors
STRINGi9606.ENSP00000239347

Structurei

3D structure databases

ProteinModelPortaliP01567
SMRiP01567
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J735 Eukaryota
ENOG410ZH91 LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230500
HOVERGENiHBG052086
InParanoidiP01567
KOiK05414
OMAiHEFRFPE
OrthoDBiEOG091G0PSY
PhylomeDBiP01567
TreeFamiTF336177

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01567-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARSFSLLMV VLVLSYKSIC SLGCDLPQTH SLRNRRALIL LAQMGRISPF
60 70 80 90 100
SCLKDRHEFR FPEEEFDGHQ FQKTQAISVL HEMIQQTFNL FSTEDSSAAW
110 120 130 140 150
EQSLLEKFST ELYQQLNDLE ACVIQEVGVE ETPLMNEDFI LAVRKYFQRI
160 170 180
TLYLMEKKYS PCAWEVVRAE IMRSFSFSTN LKKGLRRKD
Length:189
Mass (Da):22,107
Last modified:July 21, 1986 - v1
Checksum:i9DF6F5C81E339A42
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10V → A in AAA36039 (PubMed:2995168).Curated1
Sequence conflicti155M → T in AAA36039 (PubMed:2995168).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00531 Genomic DNA Translation: CAA23792.1
X02960 Genomic DNA Translation: CAA26706.1
M34913 mRNA Translation: AAA36039.1
AL512606 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58620.1
BC074991 mRNA Translation: AAH74991.1
BC074992 mRNA Translation: AAH74992.1
BC113994 mRNA Translation: AAI13995.1
BC114000 mRNA Translation: AAI14001.1
CCDSiCCDS34995.1
PIRiA01831 IVHUA0
F25843
I53102
RefSeqiNP_066401.2, NM_021057.2
UniGeneiHs.282274

Genome annotation databases

EnsembliENST00000239347; ENSP00000239347; ENSG00000214042
GeneIDi3444
KEGGihsa:3444
UCSCiuc003zop.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00531 Genomic DNA Translation: CAA23792.1
X02960 Genomic DNA Translation: CAA26706.1
M34913 mRNA Translation: AAA36039.1
AL512606 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58620.1
BC074991 mRNA Translation: AAH74991.1
BC074992 mRNA Translation: AAH74992.1
BC113994 mRNA Translation: AAI13995.1
BC114000 mRNA Translation: AAI14001.1
CCDSiCCDS34995.1
PIRiA01831 IVHUA0
F25843
I53102
RefSeqiNP_066401.2, NM_021057.2
UniGeneiHs.282274

3D structure databases

ProteinModelPortaliP01567
SMRiP01567
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109667, 7 interactors
STRINGi9606.ENSP00000239347

Chemistry databases

ChEMBLiCHEMBL3856161

PTM databases

iPTMnetiP01567
PhosphoSitePlusiP01567

Polymorphism and mutation databases

BioMutaiIFNA7
DMDMi124442

Proteomic databases

PaxDbiP01567
PeptideAtlasiP01567
PRIDEiP01567
ProteomicsDBi51383

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000239347; ENSP00000239347; ENSG00000214042
GeneIDi3444
KEGGihsa:3444
UCSCiuc003zop.1 human

Organism-specific databases

CTDi3444
DisGeNETi3444
EuPathDBiHostDB:ENSG00000214042.1
GeneCardsiIFNA7
HGNCiHGNC:5428 IFNA7
HPAiHPA047557
MIMi147567 gene
neXtProtiNX_P01567
OpenTargetsiENSG00000214042
PharmGKBiPA29667
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J735 Eukaryota
ENOG410ZH91 LUCA
GeneTreeiENSGT00760000119150
HOGENOMiHOG000230500
HOVERGENiHBG052086
InParanoidiP01567
KOiK05414
OMAiHEFRFPE
OrthoDBiEOG091G0PSY
PhylomeDBiP01567
TreeFamiTF336177

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

Miscellaneous databases

GeneWikiiIFNA7
GenomeRNAii3444
PROiPR:P01567
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000214042 Expressed in 2 organ(s), highest expression level in blood
CleanExiHS_IFNA7
GenevisibleiP01567 HS

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFNA7_HUMAN
AccessioniPrimary (citable) accession number: P01567
Secondary accession number(s): Q14607, Q5VV14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 12, 2018
This is version 164 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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