We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - P01567 (IFNA7_HUMAN)
Protein
Interferon alpha-7
Gene
IFNA7
Organism
Homo sapiens (Human)
Status
Functioni
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
GO - Molecular functioni
- cytokine activity Source: GO_Central
- type I interferon receptor binding Source: GO_Central
GO - Biological processi
- adaptive immune response Source: GO_Central
- B cell differentiation Source: GO_Central
- B cell proliferation Source: GO_Central
- cell-cell signaling Source: ProtInc
- cellular response to virus Source: ComplexPortal
- cytokine-mediated signaling pathway Source: GO_Central
- defense response to virus Source: UniProtKB-KW
- humoral immune response Source: GO_Central
- natural killer cell activation involved in immune response Source: GO_Central
- positive regulation of peptidyl-serine phosphorylation of STAT protein Source: GO_Central
- response to exogenous dsRNA Source: GO_Central
- response to virus Source: ProtInc
- T cell activation involved in immune response Source: GO_Central
- type I interferon signaling pathway Source: ComplexPortal
Keywordsi
Molecular function | Cytokine |
Biological process | Antiviral defense |
Enzyme and pathway databases
PathwayCommonsi | P01567 |
Reactomei | R-HSA-909733, Interferon alpha/beta signaling R-HSA-912694, Regulation of IFNA signaling R-HSA-933541, TRAF6 mediated IRF7 activation R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SignaLinki | P01567 |
Names & Taxonomyi
Protein namesi | Recommended name: Interferon alpha-7Short name: IFN-alpha-7 Alternative name(s): Interferon alpha-J Short name: LeIF J Interferon alpha-J1 Short name: IFN-alpha-J1 |
Gene namesi | Name:IFNA7 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5428, IFNA7 |
MIMi | 147567, gene |
neXtProti | NX_P01567 |
VEuPathDBi | HostDB:ENSG00000214042 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 3444 |
OpenTargetsi | ENSG00000214042 |
PharmGKBi | PA29667 |
Miscellaneous databases
Pharosi | P01567, Tdark |
Chemistry databases
ChEMBLi | CHEMBL3856161 |
Genetic variation databases
BioMutai | IFNA7 |
DMDMi | 124442 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | 1 PublicationAdd BLAST | 23 | |
ChainiPRO_0000016364 | 24 – 189 | Interferon alpha-7Add BLAST | 166 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 24 ↔ 122 | By similarity | ||
Disulfide bondi | 52 ↔ 162 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
MassIVEi | P01567 |
PaxDbi | P01567 |
PeptideAtlasi | P01567 |
PRIDEi | P01567 |
PTM databases
iPTMneti | P01567 |
PhosphoSitePlusi | P01567 |
Expressioni
Gene expression databases
Bgeei | ENSG00000214042, Expressed in sural nerve and 4 other tissues |
Genevisiblei | P01567, HS |
Organism-specific databases
HPAi | ENSG00000214042, Not detected |
Interactioni
GO - Molecular functioni
- cytokine activity Source: GO_Central
- type I interferon receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 109667, 10 interactors |
ComplexPortali | CPX-5997, Interferon alpha receptor-ligand complex, IFNA7 variant |
IntActi | P01567, 1 interactor |
STRINGi | 9606.ENSP00000239347 |
Miscellaneous databases
RNActi | P01567, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the alpha/beta interferon family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502SQAC, Eukaryota |
GeneTreei | ENSGT01000000214430 |
HOGENOMi | CLU_109427_0_0_1 |
InParanoidi | P01567 |
OMAi | WHEDSRN |
OrthoDBi | 1358010at2759 |
PhylomeDBi | P01567 |
TreeFami | TF336177 |
Family and domain databases
CDDi | cd00095, IFab, 1 hit |
Gene3Di | 1.20.1250.10, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000471, Interferon_alpha/beta/delta |
PANTHERi | PTHR11691, PTHR11691, 1 hit |
Pfami | View protein in Pfam PF00143, Interferon, 1 hit |
PRINTSi | PR00266, INTERFERONAB |
SMARTi | View protein in SMART SM00076, IFabd, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00252, INTERFERON_A_B_D, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P01567-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MARSFSLLMV VLVLSYKSIC SLGCDLPQTH SLRNRRALIL LAQMGRISPF
60 70 80 90 100
SCLKDRHEFR FPEEEFDGHQ FQKTQAISVL HEMIQQTFNL FSTEDSSAAW
110 120 130 140 150
EQSLLEKFST ELYQQLNDLE ACVIQEVGVE ETPLMNEDFI LAVRKYFQRI
160 170 180
TLYLMEKKYS PCAWEVVRAE IMRSFSFSTN LKKGLRRKD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 | V → A in AAA36039 (PubMed:2995168).Curated | 1 | |
Sequence conflicti | 155 | M → T in AAA36039 (PubMed:2995168).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00531 Genomic DNA Translation: CAA23792.1 X02960 Genomic DNA Translation: CAA26706.1 M34913 mRNA Translation: AAA36039.1 AL512606 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58620.1 BC074991 mRNA Translation: AAH74991.1 BC074992 mRNA Translation: AAH74992.1 BC113994 mRNA Translation: AAI13995.1 BC114000 mRNA Translation: AAI14001.1 |
CCDSi | CCDS34995.1 |
PIRi | A01831, IVHUA0 F25843 I53102 |
RefSeqi | NP_066401.2, NM_021057.2 |
Genome annotation databases
Ensembli | ENST00000239347.3; ENSP00000239347.3; ENSG00000214042.1 |
GeneIDi | 3444 |
KEGGi | hsa:3444 |
MANE-Selecti | ENST00000239347.3; ENSP00000239347.3; NM_021057.2; NP_066401.2 |
UCSCi | uc003zop.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | V00531 Genomic DNA Translation: CAA23792.1 X02960 Genomic DNA Translation: CAA26706.1 M34913 mRNA Translation: AAA36039.1 AL512606 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58620.1 BC074991 mRNA Translation: AAH74991.1 BC074992 mRNA Translation: AAH74992.1 BC113994 mRNA Translation: AAI13995.1 BC114000 mRNA Translation: AAI14001.1 |
CCDSi | CCDS34995.1 |
PIRi | A01831, IVHUA0 F25843 I53102 |
RefSeqi | NP_066401.2, NM_021057.2 |
3D structure databases
AlphaFoldDBi | P01567 |
SMRi | P01567 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109667, 10 interactors |
ComplexPortali | CPX-5997, Interferon alpha receptor-ligand complex, IFNA7 variant |
IntActi | P01567, 1 interactor |
STRINGi | 9606.ENSP00000239347 |
Chemistry databases
ChEMBLi | CHEMBL3856161 |
PTM databases
iPTMneti | P01567 |
PhosphoSitePlusi | P01567 |
Genetic variation databases
BioMutai | IFNA7 |
DMDMi | 124442 |
Proteomic databases
MassIVEi | P01567 |
PaxDbi | P01567 |
PeptideAtlasi | P01567 |
PRIDEi | P01567 |
Protocols and materials databases
ABCDi | P01567, 3 sequenced antibodies |
Antibodypediai | 24856, 98 antibodies from 20 providers |
DNASUi | 3444 |
Genome annotation databases
Ensembli | ENST00000239347.3; ENSP00000239347.3; ENSG00000214042.1 |
GeneIDi | 3444 |
KEGGi | hsa:3444 |
MANE-Selecti | ENST00000239347.3; ENSP00000239347.3; NM_021057.2; NP_066401.2 |
UCSCi | uc003zop.1, human |
Organism-specific databases
CTDi | 3444 |
DisGeNETi | 3444 |
GeneCardsi | IFNA7 |
HGNCi | HGNC:5428, IFNA7 |
HPAi | ENSG00000214042, Not detected |
MIMi | 147567, gene |
neXtProti | NX_P01567 |
OpenTargetsi | ENSG00000214042 |
PharmGKBi | PA29667 |
VEuPathDBi | HostDB:ENSG00000214042 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502SQAC, Eukaryota |
GeneTreei | ENSGT01000000214430 |
HOGENOMi | CLU_109427_0_0_1 |
InParanoidi | P01567 |
OMAi | WHEDSRN |
OrthoDBi | 1358010at2759 |
PhylomeDBi | P01567 |
TreeFami | TF336177 |
Enzyme and pathway databases
PathwayCommonsi | P01567 |
Reactomei | R-HSA-909733, Interferon alpha/beta signaling R-HSA-912694, Regulation of IFNA signaling R-HSA-933541, TRAF6 mediated IRF7 activation R-HSA-983231, Factors involved in megakaryocyte development and platelet production |
SignaLinki | P01567 |
Miscellaneous databases
BioGRID-ORCSi | 3444, 9 hits in 1000 CRISPR screens |
GeneWikii | IFNA7 |
GenomeRNAii | 3444 |
Pharosi | P01567, Tdark |
PROi | PR:P01567 |
RNActi | P01567, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000214042, Expressed in sural nerve and 4 other tissues |
Genevisiblei | P01567, HS |
Family and domain databases
CDDi | cd00095, IFab, 1 hit |
Gene3Di | 1.20.1250.10, 1 hit |
InterProi | View protein in InterPro IPR009079, 4_helix_cytokine-like_core IPR000471, Interferon_alpha/beta/delta |
PANTHERi | PTHR11691, PTHR11691, 1 hit |
Pfami | View protein in Pfam PF00143, Interferon, 1 hit |
PRINTSi | PR00266, INTERFERONAB |
SMARTi | View protein in SMART SM00076, IFabd, 1 hit |
SUPFAMi | SSF47266, SSF47266, 1 hit |
PROSITEi | View protein in PROSITE PS00252, INTERFERON_A_B_D, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IFNA7_HUMAN | |
Accessioni | P01567Primary (citable) accession number: P01567 Secondary accession number(s): Q14607, Q5VV14 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | May 25, 2022 | |
This is version 184 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families