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Entry version 193 (18 Sep 2019)
Sequence version 1 (21 Jul 1986)
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Protein

Interferon alpha-1/13

Gene

IFNA1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.1 Publication

Miscellaneous

Interferons alpha-1 and alpha-13 have identical protein sequences.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P01562

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01562

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interferon alpha-1/13
Short name:
IFN-alpha-1/13
Alternative name(s):
Interferon alpha-D
Short name:
LeIF D
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IFNA1
AND
Name:IFNA13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:5417 IFNA1
HGNC:5419 IFNA13

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
147578 gene
147660 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01562

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3439
3447

Open Targets

More...
OpenTargetsi
ENSG00000197919

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29658

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P01562

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3713007

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IFNA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
124455

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 232 PublicationsAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001635924 – 189Interferon alpha-1/13Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 1621 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P01562

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P01562

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01562

PeptideAtlas

More...
PeptideAtlasi
P01562

PRoteomics IDEntifications database

More...
PRIDEi
P01562

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
51380

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01562

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01562

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197919 Expressed in 18 organ(s), highest expression level in hypothalamus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P01562 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01562 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047557

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
109662, 8 interactors
109670, 7 interactors

Database of interacting proteins

More...
DIPi
DIP-6020N

Protein interaction database and analysis system

More...
IntActi
P01562, 13 interactors

Molecular INTeraction database

More...
MINTi
P01562

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000276927

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P01562

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR8X Eukaryota
ENOG4110Q1A LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182853

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01562

KEGG Orthology (KO)

More...
KOi
K05414

Identification of Orthologs from Complete Genome Data

More...
OMAi
DSYAAWD

Database of Orthologous Groups

More...
OrthoDBi
1358010at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01562

TreeFam database of animal gene trees

More...
TreeFami
TF336177

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00095 IFab, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta

The PANTHER Classification System

More...
PANTHERi
PTHR11691 PTHR11691, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00143 Interferon, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00266 INTERFERONAB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00076 IFabd, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47266 SSF47266, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P01562-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPFALLMV LVVLSCKSSC SLGCDLPETH SLDNRRTLML LAQMSRISPS
60 70 80 90 100
SCLMDRHDFG FPQEEFDGNQ FQKAPAISVL HELIQQIFNL FTTKDSSAAW
110 120 130 140 150
DEDLLDKFCT ELYQQLNDLE ACVMQEERVG ETPLMNADSI LAVKKYFRRI
160 170 180
TLYLTEKKYS PCAWEVVRAE IMRSLSLSTN LQERLRRKE
Length:189
Mass (Da):21,725
Last modified:July 21, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF32F9CB969606B69
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWS6A0A087WWS6_HUMAN
Interferon alpha-1/13
IFNA13
190Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti116L → P in AAL35223 (Ref. 14) Curated1
Sequence conflicti172M → V in AAL35223 (Ref. 14) Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Two forms exist; alpha-1a (shown here) and alpha-1b (PubMed:11032395).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02450810V → A3 PublicationsCorresponds to variant dbSNP:rs1758567Ensembl.1
Natural variantiVAR_013000137A → V in alpha-1B. 1 PublicationCorresponds to variant dbSNP:rs2230050Ensembl.1
Natural variantiVAR_025173163A → G1 PublicationCorresponds to variant dbSNP:rs28383794Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
V00537 mRNA Translation: CAA23798.1
J00210 Genomic DNA Translation: AAB59403.1
V00538 mRNA Translation: CAA23799.1
X00803 Genomic DNA Translation: CAA25381.1
X75934 Genomic DNA Translation: CAA53538.1
AB445100 Genomic DNA Translation: BAI99735.1
DQ185447 Genomic DNA Translation: ABA03167.1
AL353732 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58609.1
BC069427 mRNA Translation: AAH69427.1
BC074928 mRNA Translation: AAH74928.1
BC074929 mRNA Translation: AAH74929.1
BC093988 mRNA Translation: AAH93988.1
BC112002 mRNA Translation: AAI12003.1
BC112300 mRNA Translation: AAI12301.1
BC112302 mRNA Translation: AAI12303.1
M29884 Genomic DNA Translation: AAA52714.1
AF439447 Genomic DNA Translation: AAL35223.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6508.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C23285 IVHUA1
F42753
H42753

NCBI Reference Sequences

More...
RefSeqi
NP_008831.3, NM_006900.3
NP_076918.1, NM_024013.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000276927; ENSP00000276927; ENSG00000197919
ENST00000449498; ENSP00000394494; ENSG00000233816

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3439
3447

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3439
hsa:3447

UCSC genome browser

More...
UCSCi
uc003zpd.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00537 mRNA Translation: CAA23798.1
J00210 Genomic DNA Translation: AAB59403.1
V00538 mRNA Translation: CAA23799.1
X00803 Genomic DNA Translation: CAA25381.1
X75934 Genomic DNA Translation: CAA53538.1
AB445100 Genomic DNA Translation: BAI99735.1
DQ185447 Genomic DNA Translation: ABA03167.1
AL353732 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58609.1
BC069427 mRNA Translation: AAH69427.1
BC074928 mRNA Translation: AAH74928.1
BC074929 mRNA Translation: AAH74929.1
BC093988 mRNA Translation: AAH93988.1
BC112002 mRNA Translation: AAI12003.1
BC112300 mRNA Translation: AAI12301.1
BC112302 mRNA Translation: AAI12303.1
M29884 Genomic DNA Translation: AAA52714.1
AF439447 Genomic DNA Translation: AAL35223.1
CCDSiCCDS6508.1
PIRiC23285 IVHUA1
F42753
H42753
RefSeqiNP_008831.3, NM_006900.3
NP_076918.1, NM_024013.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UX9X-ray2.80A/C24-189[»]
SMRiP01562
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi109662, 8 interactors
109670, 7 interactors
DIPiDIP-6020N
IntActiP01562, 13 interactors
MINTiP01562
STRINGi9606.ENSP00000276927

Chemistry databases

ChEMBLiCHEMBL3713007

PTM databases

iPTMnetiP01562
PhosphoSitePlusiP01562

Polymorphism and mutation databases

BioMutaiIFNA1
DMDMi124455

Proteomic databases

MassIVEiP01562
MaxQBiP01562
PaxDbiP01562
PeptideAtlasiP01562
PRIDEiP01562
ProteomicsDBi51380

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P01562

The DNASU plasmid repository

More...
DNASUi
3439
3447

Genome annotation databases

EnsembliENST00000276927; ENSP00000276927; ENSG00000197919
ENST00000449498; ENSP00000394494; ENSG00000233816
GeneIDi3439
3447
KEGGihsa:3439
hsa:3447
UCSCiuc003zpd.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3439
3447
DisGeNETi3439
3447

GeneCards: human genes, protein and diseases

More...
GeneCardsi
IFNA1
IFNA13
HGNCiHGNC:5417 IFNA1
HGNC:5419 IFNA13
HPAiHPA047557
MIMi147578 gene
147660 gene
neXtProtiNX_P01562
OpenTargetsiENSG00000197919
PharmGKBiPA29658

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IR8X Eukaryota
ENOG4110Q1A LUCA
GeneTreeiENSGT00950000182853
InParanoidiP01562
KOiK05414
OMAiDSYAAWD
OrthoDBi1358010at2759
PhylomeDBiP01562
TreeFamiTF336177

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkiP01562
SIGNORiP01562

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
IFNA13
Interferon,_alpha_1
PharosiP01562

Protein Ontology

More...
PROi
PR:P01562

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000197919 Expressed in 18 organ(s), highest expression level in hypothalamus
ExpressionAtlasiP01562 baseline and differential
GenevisibleiP01562 HS

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIFNA1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01562
Secondary accession number(s): D4Q9M8
, Q14605, Q2M1L8, Q52LB8, Q5VYQ2, Q7M4Q1, Q8WZ68, Q9UMJ3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 18, 2019
This is version 193 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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