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Protein

Interferon alpha-1/13

Gene

IFNA1

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.1 Publication

Miscellaneous

Interferons alpha-1 and alpha-13 have identical protein sequences.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processAntiviral defense

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkiP01562
SIGNORiP01562

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon alpha-1/13
Short name:
IFN-alpha-1/13
Alternative name(s):
Interferon alpha-D
Short name:
LeIF D
Gene namesi
Name:IFNA1
AND
Name:IFNA13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000197919.4
HostDB:ENSG00000233816.3
HGNCiHGNC:5417 IFNA1
HGNC:5419 IFNA13
MIMi147578 gene
147660 gene
neXtProtiNX_P01562

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3439
3447
OpenTargetsiENSG00000197919
PharmGKBiPA29658

Chemistry databases

ChEMBLiCHEMBL3713007

Polymorphism and mutation databases

BioMutaiIFNA1
DMDMi124455

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 232 PublicationsAdd BLAST23
ChainiPRO_000001635924 – 189Interferon alpha-1/13Add BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 122By similarity
Disulfide bondi52 ↔ 1621 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP01562
PaxDbiP01562
PeptideAtlasiP01562
PRIDEiP01562
ProteomicsDBi51380

PTM databases

iPTMnetiP01562
PhosphoSitePlusiP01562

Expressioni

Gene expression databases

BgeeiENSG00000197919 Expressed in 18 organ(s), highest expression level in hypothalamus
CleanExiHS_IFNA1
HS_IFNA13
ExpressionAtlasiP01562 baseline and differential
GenevisibleiP01562 HS

Organism-specific databases

HPAiHPA047557

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109662, 8 interactors
109670, 7 interactors
DIPiDIP-6020N
IntActiP01562, 2 interactors
MINTiP01562
STRINGi9606.ENSP00000276927

Structurei

Secondary structure

1189
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP01562
SMRiP01562
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha/beta interferon family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IR8X Eukaryota
ENOG4110Q1A LUCA
GeneTreeiENSGT00760000119150
HOVERGENiHBG052086
InParanoidiP01562
KOiK05414
OMAiVEEMALV
PhylomeDBiP01562
TreeFamiTF336177

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P01562-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASPFALLMV LVVLSCKSSC SLGCDLPETH SLDNRRTLML LAQMSRISPS
60 70 80 90 100
SCLMDRHDFG FPQEEFDGNQ FQKAPAISVL HELIQQIFNL FTTKDSSAAW
110 120 130 140 150
DEDLLDKFCT ELYQQLNDLE ACVMQEERVG ETPLMNADSI LAVKKYFRRI
160 170 180
TLYLTEKKYS PCAWEVVRAE IMRSLSLSTN LQERLRRKE
Length:189
Mass (Da):21,725
Last modified:July 21, 1986 - v1
Checksum:iF32F9CB969606B69
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WWS6A0A087WWS6_HUMAN
Interferon alpha-1/13
IFNA13
190Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116L → P in AAL35223 (Ref. 14) Curated1
Sequence conflicti172M → V in AAL35223 (Ref. 14) Curated1

Polymorphismi

Two forms exist; alpha-1a (shown here) and alpha-1b (PubMed:11032395).1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02450810V → A3 PublicationsCorresponds to variant dbSNP:rs1758567Ensembl.1
Natural variantiVAR_013000137A → V in alpha-1B. 1 PublicationCorresponds to variant dbSNP:rs2230050Ensembl.1
Natural variantiVAR_025173163A → G1 PublicationCorresponds to variant dbSNP:rs28383794Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00537 mRNA Translation: CAA23798.1
J00210 Genomic DNA Translation: AAB59403.1
V00538 mRNA Translation: CAA23799.1
X00803 Genomic DNA Translation: CAA25381.1
X75934 Genomic DNA Translation: CAA53538.1
AB445100 Genomic DNA Translation: BAI99735.1
DQ185447 Genomic DNA Translation: ABA03167.1
AL353732 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58609.1
BC069427 mRNA Translation: AAH69427.1
BC074928 mRNA Translation: AAH74928.1
BC074929 mRNA Translation: AAH74929.1
BC093988 mRNA Translation: AAH93988.1
BC112002 mRNA Translation: AAI12003.1
BC112300 mRNA Translation: AAI12301.1
BC112302 mRNA Translation: AAI12303.1
M29884 Genomic DNA Translation: AAA52714.1
AF439447 Genomic DNA Translation: AAL35223.1
CCDSiCCDS6508.1
PIRiC23285 IVHUA1
F42753
H42753
RefSeqiNP_008831.3, NM_006900.3
NP_076918.1, NM_024013.2
UniGeneiHs.37026
Hs.533471

Genome annotation databases

EnsembliENST00000276927; ENSP00000276927; ENSG00000197919
ENST00000449498; ENSP00000394494; ENSG00000233816
GeneIDi3439
3447
KEGGihsa:3439
hsa:3447
UCSCiuc003zpd.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00537 mRNA Translation: CAA23798.1
J00210 Genomic DNA Translation: AAB59403.1
V00538 mRNA Translation: CAA23799.1
X00803 Genomic DNA Translation: CAA25381.1
X75934 Genomic DNA Translation: CAA53538.1
AB445100 Genomic DNA Translation: BAI99735.1
DQ185447 Genomic DNA Translation: ABA03167.1
AL353732 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58609.1
BC069427 mRNA Translation: AAH69427.1
BC074928 mRNA Translation: AAH74928.1
BC074929 mRNA Translation: AAH74929.1
BC093988 mRNA Translation: AAH93988.1
BC112002 mRNA Translation: AAI12003.1
BC112300 mRNA Translation: AAI12301.1
BC112302 mRNA Translation: AAI12303.1
M29884 Genomic DNA Translation: AAA52714.1
AF439447 Genomic DNA Translation: AAL35223.1
CCDSiCCDS6508.1
PIRiC23285 IVHUA1
F42753
H42753
RefSeqiNP_008831.3, NM_006900.3
NP_076918.1, NM_024013.2
UniGeneiHs.37026
Hs.533471

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UX9X-ray2.80A/C24-189[»]
ProteinModelPortaliP01562
SMRiP01562
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109662, 8 interactors
109670, 7 interactors
DIPiDIP-6020N
IntActiP01562, 2 interactors
MINTiP01562
STRINGi9606.ENSP00000276927

Chemistry databases

ChEMBLiCHEMBL3713007

PTM databases

iPTMnetiP01562
PhosphoSitePlusiP01562

Polymorphism and mutation databases

BioMutaiIFNA1
DMDMi124455

Proteomic databases

MaxQBiP01562
PaxDbiP01562
PeptideAtlasiP01562
PRIDEiP01562
ProteomicsDBi51380

Protocols and materials databases

DNASUi3439
3447
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276927; ENSP00000276927; ENSG00000197919
ENST00000449498; ENSP00000394494; ENSG00000233816
GeneIDi3439
3447
KEGGihsa:3439
hsa:3447
UCSCiuc003zpd.2 human

Organism-specific databases

CTDi3439
3447
DisGeNETi3439
3447
EuPathDBiHostDB:ENSG00000197919.4
HostDB:ENSG00000233816.3
GeneCardsiIFNA1
IFNA13
HGNCiHGNC:5417 IFNA1
HGNC:5419 IFNA13
HPAiHPA047557
MIMi147578 gene
147660 gene
neXtProtiNX_P01562
OpenTargetsiENSG00000197919
PharmGKBiPA29658
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IR8X Eukaryota
ENOG4110Q1A LUCA
GeneTreeiENSGT00760000119150
HOVERGENiHBG052086
InParanoidiP01562
KOiK05414
OMAiVEEMALV
PhylomeDBiP01562
TreeFamiTF336177

Enzyme and pathway databases

ReactomeiR-HSA-909733 Interferon alpha/beta signaling
R-HSA-912694 Regulation of IFNA signaling
R-HSA-933541 TRAF6 mediated IRF7 activation
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
SignaLinkiP01562
SIGNORiP01562

Miscellaneous databases

GeneWikiiIFNA13
Interferon,_alpha_1
PROiPR:P01562
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197919 Expressed in 18 organ(s), highest expression level in hypothalamus
CleanExiHS_IFNA1
HS_IFNA13
ExpressionAtlasiP01562 baseline and differential
GenevisibleiP01562 HS

Family and domain databases

CDDicd00095 IFab, 1 hit
InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000471 Interferon_alpha/beta/delta
PANTHERiPTHR11691 PTHR11691, 1 hit
PfamiView protein in Pfam
PF00143 Interferon, 1 hit
PRINTSiPR00266 INTERFERONAB
SMARTiView protein in SMART
SM00076 IFabd, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00252 INTERFERON_A_B_D, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIFNA1_HUMAN
AccessioniPrimary (citable) accession number: P01562
Secondary accession number(s): D4Q9M8
, Q14605, Q2M1L8, Q52LB8, Q5VYQ2, Q7M4Q1, Q8WZ68, Q9UMJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 12, 2018
This is version 185 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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