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Protein

Cholera enterotoxin subunit B

Gene

ctxB

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • galactose binding Source: CAFA
  • host cell surface binding Source: TIGR
  • toxin activity Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEnterotoxin, Toxin

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:VC1456-MONOMER
VCHO:VC1456-MONOMER

Protein family/group databases

UniLectin database of carbohydrate-binding proteins

More...
UniLectini
P01556

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cholera enterotoxin subunit B
Alternative name(s):
Cholera enterotoxin B chain
Cholera enterotoxin gamma chain
Choleragenoid
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ctxB
Synonyms:toxB
Ordered Locus Names:VC_1456
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri243277 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000584 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi78H → A: Loss of toxicity. 1

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02802 5-Aminocarbonyl-3-Nitrophenyl-Alpha-D-Galactopyranose
DB02379 Beta-D-Glucose
DB02474 Bmsc-0013
DB04210 BV1
DB02574 BV2
DB02903 BV3
DB02572 BV4
DB02213 Metanitrophenyl-Alpha-D-Galactoside
DB03721 N-acetyl-alpha-neuraminic acid
DB03235 N-{3-[4-(3-Amino-Propyl)-Piperazin-1-Yl]-Propyl}-3-Nitro-5-(Galactopyranosyl)-Alpha-Benzamide
DB04073 N-{3-[4-(3-Amino-Propyl)-Piperazin-1-Yl]-Propyl}-3-Nitro-5-(Galactopyranosyl)-Beta-Benzamide
DB03754 Tris

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 212 PublicationsAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001934422 – 124Cholera enterotoxin subunit BAdd BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi30 ↔ 1071 Publication

Keywords - PTMi

Disulfide bond

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The holotoxin (choleragen) consists of a pentameric ring of B subunits whose central pore is occupied by the A subunit. The A subunit contains two chains, A1 and A2, linked by a disulfide bridge.2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
ctxAP015555EBI-1038383,EBI-1038392

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-6256N

Protein interaction database and analysis system

More...
IntActi
P01556, 5 interactors

Molecular INTeraction database

More...
MINTi
P01556

STRING: functional protein association networks

More...
STRINGi
243277.VC1456

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P01556

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P01556

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01556

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K10929

Identification of Orthologs from Complete Genome Data

More...
OMAi
HIDSQKK

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008992 Enterotoxin
IPR001835 Enterotoxin_B

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01376 Enterotoxin_b, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00772 ENTEROTOXINB

ProDom; a protein domain database

More...
ProDomi
View protein in ProDom or Entries sharing at least one domain
PD012805 Enterotoxin_B, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50203 SSF50203, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P01556-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIKLKFGVFF TVLLSSAYAH GTPQNITDLC AEYHNTQIYT LNDKIFSYTE
60 70 80 90 100
SLAGKREMAI ITFKNGAIFQ VEVPGSQHID SQKKAIERMK DTLRIAYLTE
110 120
AKVEKLCVWN NKTPHAIAAI SMAN
Length:124
Mass (Da):13,957
Last modified:August 13, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9AA393E3EA8E3EBF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti33Y → S in CAA24996 (PubMed:6646234).Curated1
Sequence conflicti39Y → H AA sequence (PubMed:903363).Curated1
Sequence conflicti39Y → H AA sequence (PubMed:903362).Curated1
Sequence conflicti43D → N AA sequence (PubMed:903363).Curated1
Sequence conflicti43D → N AA sequence (PubMed:903362).Curated1
Sequence conflicti68I → T AA sequence (PubMed:903363).Curated1
Sequence conflicti68I → T AA sequence (PubMed:903362).Curated1
Sequence conflicti70Q → E AA sequence (PubMed:903362).Curated1
Sequence conflicti75G → S in CAA24996 (PubMed:6646234).Curated1
Sequence conflicti91D → N AA sequence (PubMed:903363).Curated1
Sequence conflicti91D → N AA sequence (PubMed:903362).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
K01170 Genomic DNA Translation: AAA27573.1
X00171 Genomic DNA Translation: CAA24996.1
X76390 Genomic DNA Translation: CAA53973.1
X76391 Genomic DNA Translation: CAA53976.1
X58786 Genomic DNA Translation: CAA41593.1
D30053 Genomic DNA Translation: BAA06291.1
AE003852 Genomic DNA Translation: AAF94613.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S14624 XVVCB

NCBI Reference Sequences

More...
RefSeqi
NP_231099.1, NC_002505.1
WP_000593522.1, NC_002505.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAF94613; AAF94613; VC_1456

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2613962

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vch:VC1456

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|243277.26.peg.1386

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K01170 Genomic DNA Translation: AAA27573.1
X00171 Genomic DNA Translation: CAA24996.1
X76390 Genomic DNA Translation: CAA53973.1
X76391 Genomic DNA Translation: CAA53976.1
X58786 Genomic DNA Translation: CAA41593.1
D30053 Genomic DNA Translation: BAA06291.1
AE003852 Genomic DNA Translation: AAF94613.1
PIRiS14624 XVVCB
RefSeqiNP_231099.1, NC_002505.1
WP_000593522.1, NC_002505.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CHPX-ray2.00D/E/F/G/H22-124[»]
1CHQX-ray2.10D/E/F/G/H22-124[»]
1CT1X-ray2.30D/E/F/G/H22-124[»]
1FGBX-ray2.40D/E/F/G/H22-124[»]
1G8ZX-ray2.00D/E/F/G/H22-124[»]
1JR0X-ray1.30D/E/F/G/H22-124[»]
1MD2X-ray1.45D/E/F/G/H22-124[»]
1RCVX-ray1.60D/E/F/G/H22-124[»]
1RD9X-ray1.44D/E/F/G/H22-124[»]
1RDPX-ray1.35D/E/F/G/H22-124[»]
1RF2X-ray1.35D/E/F/G/H22-124[»]
1S5BX-ray2.13D/E/F/G/H22-124[»]
1S5CX-ray2.50D/E/F/G/H22-124[»]
1S5DX-ray1.75D/E/F/G/H22-124[»]
1S5EX-ray1.90D/E/F/G/H/J/K/L/M/N22-124[»]
1S5FX-ray2.60D/E/F/G/H22-124[»]
1XTCX-ray2.40D/E/F/G/H22-124[»]
2CHBX-ray2.00D/E/F/G/H22-124[»]
3CHBX-ray1.25D/E/F/G/H22-124[»]
3EFXX-ray1.94D/E/F/G/H/I/J/K/L/M23-124[»]
5ELCX-ray1.50A/B/C/D/E/F/G/H/I/J22-124[»]
5ELEX-ray1.60A/B/C/D/E/F/G/H/I/J22-124[»]
5ELFX-ray1.55A/B/C/D/E/F/G/H/I/J22-124[»]
5LZGX-ray1.13A/B/C/D/E22-124[»]
5LZJX-ray1.20A/B/C/D/E22-124[»]
ProteinModelPortaliP01556
SMRiP01556
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-6256N
IntActiP01556, 5 interactors
MINTiP01556
STRINGi243277.VC1456

Chemistry databases

DrugBankiDB02802 5-Aminocarbonyl-3-Nitrophenyl-Alpha-D-Galactopyranose
DB02379 Beta-D-Glucose
DB02474 Bmsc-0013
DB04210 BV1
DB02574 BV2
DB02903 BV3
DB02572 BV4
DB02213 Metanitrophenyl-Alpha-D-Galactoside
DB03721 N-acetyl-alpha-neuraminic acid
DB03235 N-{3-[4-(3-Amino-Propyl)-Piperazin-1-Yl]-Propyl}-3-Nitro-5-(Galactopyranosyl)-Alpha-Benzamide
DB04073 N-{3-[4-(3-Amino-Propyl)-Piperazin-1-Yl]-Propyl}-3-Nitro-5-(Galactopyranosyl)-Beta-Benzamide
DB03754 Tris

Protein family/group databases

UniLectiniP01556

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2613962
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF94613; AAF94613; VC_1456
GeneIDi2613962
KEGGivch:VC1456
PATRICifig|243277.26.peg.1386

Phylogenomic databases

KOiK10929
OMAiHIDSQKK

Enzyme and pathway databases

BioCyciMetaCyc:VC1456-MONOMER
VCHO:VC1456-MONOMER

Miscellaneous databases

EvolutionaryTraceiP01556

Protein Ontology

More...
PROi
PR:P01556

Family and domain databases

InterProiView protein in InterPro
IPR008992 Enterotoxin
IPR001835 Enterotoxin_B
PfamiView protein in Pfam
PF01376 Enterotoxin_b, 1 hit
PRINTSiPR00772 ENTEROTOXINB
ProDomiView protein in ProDom or Entries sharing at least one domain
PD012805 Enterotoxin_B, 1 hit
SUPFAMiSSF50203 SSF50203, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHTB_VIBCH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01556
Secondary accession number(s): Q9JQ02
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: July 18, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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