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Entry version 135 (16 Oct 2019)
Sequence version 1 (13 Aug 1987)
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Protein

Enterotoxin type B

Gene

entB

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules. In turn, this ternary complex activates a large number of T-lymphocytes initiating a systemic release of proinflammatory cytokines (PubMed:2303780, PubMed:25015819). Causes also the intoxication staphylococcal food poisoning syndrome (By similarity).By similarity2 Publications

Miscellaneous

Lacks the zinc-binding site found in other members of this family, such as staphylococcal enterotoxin A, C2 and D, thus it possesses only one MHC class II binding site.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEnterotoxin, Superantigen, Toxin
Biological processVirulence
LigandMetal-binding

Protein family/group databases

UniLectin database of carbohydrate-binding proteins

More...
UniLectini
P01552

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Enterotoxin type B
Alternative name(s):
SEB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:entB
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStaphylococcus aureus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1280 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
2140 Sta a SEB

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB02379 Beta-D-Glucose
DB04465 Lactose
DB03721 N-acetyl-alpha-neuraminic acid

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 271 PublicationAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003560628 – 266Enterotoxin type BAdd BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi120 ↔ 140Combined sources2 Publications

Keywords - PTMi

Disulfide bond

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MHC class II molecules composed of alpha/HLA-DRA and beta/HLA-DRB1 chains (PubMed:8152483, PubMed:25015819).

Interacts with T-cell receptor beta variable 19/TRBV19 (PubMed:9881971, PubMed:25015819).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-35541N

Protein interaction database and analysis system

More...
IntActi
P01552, 3 interactors

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1266
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01552

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01552

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008992 Enterotoxin
IPR006126 Staph/Strept_toxin_CS
IPR006173 Staph_tox_OB
IPR016091 SuperAg_toxin_C
IPR013307 Superantigen_bac
IPR006123 Toxin_b-grasp_Staph/Strep
IPR006177 Toxin_bac

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02876 Stap_Strp_tox_C, 1 hit
PF01123 Stap_Strp_toxin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00279 BACTRLTOXIN
PR01898 SAGSUPRFAMLY

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50203 SSF50203, 1 hit
SSF54334 SSF54334, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00277 STAPH_STREP_TOXIN_1, 1 hit
PS00278 STAPH_STREP_TOXIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P01552-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYKRLFISHV ILIFALILVI STPNVLAESQ PDPKPDELHK SSKFTGLMEN
60 70 80 90 100
MKVLYDDNHV SAINVKSIDQ FLYFDLIYSI KDTKLGNYDN VRVEFKNKDL
110 120 130 140 150
ADKYKDKYVD VFGANYYYQC YFSKKTNDIN SHQTDKRKTC MYGGVTEHNG
160 170 180 190 200
NQLDKYRSIT VRVFEDGKNL LSFDVQTNKK KVTAQELDYL TRHYLVKNKK
210 220 230 240 250
LYEFNNSPYE TGYIKFIENE NSFWYDMMPA PGDKFDQSKY LMMYNDNKMV
260
DSKDVKIEVY LTTKKK
Length:266
Mass (Da):31,436
Last modified:August 13, 1987 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB6D417F61CF018B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti56 – 58DDN → NND AA sequence (PubMed:5470821).Curated3
Sequence conflicti69 – 77DQFLYFDLI → NEFFDLIYL AA sequence (PubMed:5470821).Curated9
Sequence conflicti118Missing AA sequence (PubMed:5470821).Curated1
Sequence conflicti128 – 130DIN → NID AA sequence (PubMed:5470821).Curated3
Sequence conflicti133 – 135QTD → ENT AA sequence (PubMed:5470821).Curated3
Sequence conflicti149 – 150NG → GN AA sequence (PubMed:5470821).Curated2
Sequence conflicti156Y → YY AA sequence (PubMed:5470821).Curated1
Sequence conflicti185 – 186QE → EQ AA sequence (PubMed:5470821).Curated2
Sequence conflicti233D → N AA sequence (PubMed:5470821).Curated1
Sequence conflicti246 – 247DN → ND AA sequence (PubMed:5470821).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M11118 Genomic DNA Translation: AAA88550.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S27360 ENSAB6

NCBI Reference Sequences

More...
RefSeqi
WP_000278085.1, NZ_VCGD01000033.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11118 Genomic DNA Translation: AAA88550.1
PIRiS27360 ENSAB6
RefSeqiWP_000278085.1, NZ_VCGD01000033.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D5MX-ray2.00C28-266[»]
1D5XX-ray2.45C28-266[»]
1D5ZX-ray2.00C28-266[»]
1D6EX-ray2.45C28-266[»]
1GOZX-ray2.00A/B28-266[»]
1SBBX-ray2.40B/D28-266[»]
1SE3X-ray2.30A28-266[»]
1SE4X-ray1.90A28-266[»]
1SEBX-ray2.70D/H29-262[»]
2SEBX-ray2.50D28-266[»]
3GP7X-ray1.90A/B28-266[»]
3R8BX-ray2.95A/C/E/G/I/K/M/O28-266[»]
3SEBX-ray1.48A28-265[»]
3W2DX-ray3.10A28-266[»]
4C56X-ray2.90C/I29-266[»]
4RGMX-ray2.69A/S28-266[»]
4RGNX-ray2.70A/S28-266[»]
4RGOX-ray1.80S28-266[»]
SMRiP01552
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

DIPiDIP-35541N
IntActiP01552, 3 interactors

Chemistry databases

DrugBankiDB02379 Beta-D-Glucose
DB04465 Lactose
DB03721 N-acetyl-alpha-neuraminic acid

Protein family/group databases

Allergomei2140 Sta a SEB
UniLectiniP01552

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...
ABCDi
P01552

Miscellaneous databases

EvolutionaryTraceiP01552

Protein Ontology

More...
PROi
PR:P01552

Family and domain databases

InterProiView protein in InterPro
IPR008992 Enterotoxin
IPR006126 Staph/Strept_toxin_CS
IPR006173 Staph_tox_OB
IPR016091 SuperAg_toxin_C
IPR013307 Superantigen_bac
IPR006123 Toxin_b-grasp_Staph/Strep
IPR006177 Toxin_bac
PfamiView protein in Pfam
PF02876 Stap_Strp_tox_C, 1 hit
PF01123 Stap_Strp_toxin, 1 hit
PRINTSiPR00279 BACTRLTOXIN
PR01898 SAGSUPRFAMLY
SUPFAMiSSF50203 SSF50203, 1 hit
SSF54334 SSF54334, 1 hit
PROSITEiView protein in PROSITE
PS00277 STAPH_STREP_TOXIN_1, 1 hit
PS00278 STAPH_STREP_TOXIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiETXB_STAAU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01552
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: October 16, 2019
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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