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Protein

Enterotoxin type B

Gene

entB

Organism
Staphylococcus aureus
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Staphylococcal enterotoxins cause the intoxication staphylococcal food poisoning syndrome. The illness characterized by high fever, hypotension, diarrhea, shock, and in some cases death.

GO - Molecular functioni

Keywordsi

Molecular functionEnterotoxin, Superantigen, Toxin

Protein family/group databases

UniLectiniP01552

Names & Taxonomyi

Protein namesi
Recommended name:
Enterotoxin type B
Alternative name(s):
SEB
Gene namesi
Name:entB
OrganismiStaphylococcus aureus
Taxonomic identifieri1280 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2140 Sta a SEB

Chemistry databases

DrugBankiDB02379 Beta-D-Glucose
DB04465 Lactose
DB03721 N-acetyl-alpha-neuraminic acid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 271 PublicationAdd BLAST27
ChainiPRO_000003560628 – 266Enterotoxin type BAdd BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi120 ↔ 140

Keywords - PTMi

Disulfide bond

Interactioni

Binary interactionsi

Protein-protein interaction databases

DIPiDIP-35541N
IntActiP01552, 3 interactors

Structurei

Secondary structure

1266
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP01552
SMRiP01552
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01552

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR008992 Enterotoxin
IPR006126 Staph/Strept_toxin_CS
IPR006173 Staph_tox_OB
IPR016091 SuperAg_toxin_C
IPR013307 Superantigen_bac
IPR006123 Toxin_b-grasp_Staph/Strep
IPR006177 Toxin_bac
PfamiView protein in Pfam
PF02876 Stap_Strp_tox_C, 1 hit
PF01123 Stap_Strp_toxin, 1 hit
PRINTSiPR00279 BACTRLTOXIN
PR01898 SAGSUPRFAMLY
SUPFAMiSSF50203 SSF50203, 1 hit
SSF54334 SSF54334, 1 hit
PROSITEiView protein in PROSITE
PS00277 STAPH_STREP_TOXIN_1, 1 hit
PS00278 STAPH_STREP_TOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01552-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYKRLFISHV ILIFALILVI STPNVLAESQ PDPKPDELHK SSKFTGLMEN
60 70 80 90 100
MKVLYDDNHV SAINVKSIDQ FLYFDLIYSI KDTKLGNYDN VRVEFKNKDL
110 120 130 140 150
ADKYKDKYVD VFGANYYYQC YFSKKTNDIN SHQTDKRKTC MYGGVTEHNG
160 170 180 190 200
NQLDKYRSIT VRVFEDGKNL LSFDVQTNKK KVTAQELDYL TRHYLVKNKK
210 220 230 240 250
LYEFNNSPYE TGYIKFIENE NSFWYDMMPA PGDKFDQSKY LMMYNDNKMV
260
DSKDVKIEVY LTTKKK
Length:266
Mass (Da):31,436
Last modified:August 13, 1987 - v1
Checksum:iB6D417F61CF018B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56 – 58DDN → NND AA sequence (PubMed:5470821).Curated3
Sequence conflicti69 – 77DQFLYFDLI → NEFFDLIYL AA sequence (PubMed:5470821).Curated9
Sequence conflicti118Missing AA sequence (PubMed:5470821).Curated1
Sequence conflicti128 – 130DIN → NID AA sequence (PubMed:5470821).Curated3
Sequence conflicti133 – 135QTD → ENT AA sequence (PubMed:5470821).Curated3
Sequence conflicti149 – 150NG → GN AA sequence (PubMed:5470821).Curated2
Sequence conflicti156Y → YY AA sequence (PubMed:5470821).Curated1
Sequence conflicti185 – 186QE → EQ AA sequence (PubMed:5470821).Curated2
Sequence conflicti233D → N AA sequence (PubMed:5470821).Curated1
Sequence conflicti246 – 247DN → ND AA sequence (PubMed:5470821).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11118 Genomic DNA Translation: AAA88550.1
PIRiS27360 ENSAB6
RefSeqiWP_000278085.1, NZ_UHCI01000002.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11118 Genomic DNA Translation: AAA88550.1
PIRiS27360 ENSAB6
RefSeqiWP_000278085.1, NZ_UHCI01000002.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1D5MX-ray2.00C28-266[»]
1D5XX-ray2.45C28-266[»]
1D5ZX-ray2.00C28-266[»]
1D6EX-ray2.45C28-266[»]
1GOZX-ray2.00A/B28-266[»]
1SBBX-ray2.40B/D28-266[»]
1SE3X-ray2.30A28-266[»]
1SE4X-ray1.90A28-266[»]
1SEBX-ray2.70D/H29-262[»]
2SEBX-ray2.50D28-266[»]
3GP7X-ray1.90A/B28-266[»]
3R8BX-ray2.95A/C/E/G/I/K/M/O28-266[»]
3SEBX-ray1.48A28-265[»]
3W2DX-ray3.10A28-266[»]
4C56X-ray2.90C/I29-266[»]
4RGMX-ray2.69A/S28-266[»]
4RGNX-ray2.70A/S28-266[»]
4RGOX-ray1.80S28-266[»]
ProteinModelPortaliP01552
SMRiP01552
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-35541N
IntActiP01552, 3 interactors

Chemistry databases

DrugBankiDB02379 Beta-D-Glucose
DB04465 Lactose
DB03721 N-acetyl-alpha-neuraminic acid

Protein family/group databases

Allergomei2140 Sta a SEB
UniLectiniP01552

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP01552
PROiPR:P01552

Family and domain databases

InterProiView protein in InterPro
IPR008992 Enterotoxin
IPR006126 Staph/Strept_toxin_CS
IPR006173 Staph_tox_OB
IPR016091 SuperAg_toxin_C
IPR013307 Superantigen_bac
IPR006123 Toxin_b-grasp_Staph/Strep
IPR006177 Toxin_bac
PfamiView protein in Pfam
PF02876 Stap_Strp_tox_C, 1 hit
PF01123 Stap_Strp_toxin, 1 hit
PRINTSiPR00279 BACTRLTOXIN
PR01898 SAGSUPRFAMLY
SUPFAMiSSF50203 SSF50203, 1 hit
SSF54334 SSF54334, 1 hit
PROSITEiView protein in PROSITE
PS00277 STAPH_STREP_TOXIN_1, 1 hit
PS00278 STAPH_STREP_TOXIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiETXB_STAAU
AccessioniPrimary (citable) accession number: P01552
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: November 7, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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