Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alpha-conotoxin MI

Gene
N/A
Organism
Conus magus (Magus cone) (Magician's cone snail)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. Blocks mammalian nAChR composed of alpha-1/delta subunits with high potency and alpha-1/gamma with a low potency.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin MI
Short name:
Alpha-MI
Short name:
CtxMI
Alternative name(s):
M1
OrganismiConus magus (Magus cone) (Magician's cone snail)
Taxonomic identifieri6492 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaNeogastropodaConoideaConidaeConusPionoconus

Organism-specific databases

ConoServeri23 MI

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2R → A: 4-fold loss of activity. 1 Publication1
Mutagenesisi5H → A: 3-fold loss of activity. 1 Publication1
Mutagenesisi6P → A: 73-fold loss of activity. 1 Publication1
Mutagenesisi10K → A: 9-fold loss of activity. 1 Publication1
Mutagenesisi11N → A: 3-fold loss of activity. 1 Publication1
Mutagenesisi12Y → A: 8500-fold loss of activity. 1 Publication1
Mutagenesisi12Y → H: 33-fold loss of activity. 1 Publication1
Mutagenesisi12Y → M: 48-fold loss of activity. 1 Publication1
Mutagenesisi12Y → W: 5-fold loss of activity. 1 Publication1
Mutagenesisi13S → A: No loss of activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PeptideiPRO_00000444611 – 14Alpha-conotoxin MIAdd BLAST14

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi3 ↔ 81 Publication
Disulfide bondi4 ↔ 141 Publication
Modified residuei14Cysteine amide1 Publication1

Post-translational modificationi

Amidated; synthetic peptide with a C-terminus free is 6-fold less active than the amidated peptide.

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha3/5 pattern.

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR018072 Conotoxin_a-typ_CS
PROSITEiView protein in PROSITE
PS60014 ALPHA_CONOTOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Length:14
Mass (Da):1,499
Last modified:July 21, 1986 - v1
Checksum:iDEEE91898BF5E5BD
GO

Sequence databases

PIRiA01784 NTKN1M

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiA01784 NTKN1M

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ConoServeri23 MI

Family and domain databases

InterProiView protein in InterPro
IPR018072 Conotoxin_a-typ_CS
PROSITEiView protein in PROSITE
PS60014 ALPHA_CONOTOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCA1_CONMA
AccessioniPrimary (citable) accession number: P01521
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 12, 2018
This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again