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Protein

Apamin

Gene
N/A
Organism
Apis mellifera (Honeybee)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Neurotoxin that blocks voltage-independent calcium-activated potassium channels (KCa2.1/KCNN1/SK1, KCa2.2/KCNN2/SK2, KCa2.3/KCNN3/SK3).

GO - Molecular functioni

Keywordsi

Molecular functionCalcium-activated potassium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Apamin3 Publications
Alternative name(s):
Apamine1 Publication
OrganismiApis mellifera (Honeybee)
Taxonomic identifieri7460 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaHymenopteraApocritaAculeataApoideaApidaeApis
Proteomesi
  • UP000005203 Componenti: Linkage group 12

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 272 PublicationsAdd BLAST27
PeptideiPRO_000001861128 – 45Apamin2 PublicationsAdd BLAST18

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 382 Publications
Disulfide bondi30 ↔ 422 Publications
Modified residuei45Histidine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Proteomic databases

PaxDbiP01500

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP01500
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni40 – 41Essential for toxin activity2

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000033980

Family and domain databases

InterProiView protein in InterPro
IPR035361 Bee_toxin
PfamiView protein in Pfam
PF17454 Bee_toxin, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD026566 PD026566, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01500-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
MISMLRCIYL FLSVILITSY FVTPVMPCNC KAPETALCAR RCQQHG
Length:46
Mass (Da):5,223
Last modified:October 1, 1996 - v2
Checksum:i92694A07501AEE33
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78458 mRNA Translation: AAB34402.1
PIRiA56710 AMHB
RefSeqiNP_001011612.1, NM_001011612.1
UniGeneiAme.1216

Genome annotation databases

EnsemblMetazoaiGB40697-RA; GB40697-PA; GB40697
GeneIDi406135
KEGGiame:406135

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S78458 mRNA Translation: AAB34402.1
PIRiA56710 AMHB
RefSeqiNP_001011612.1, NM_001011612.1
UniGeneiAme.1216

3D structure databases

ProteinModelPortaliP01500
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiP01500

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiGB40697-RA; GB40697-PA; GB40697
GeneIDi406135
KEGGiame:406135

Organism-specific databases

CTDi406135

Phylogenomic databases

HOGENOMiHOG000033980

Family and domain databases

InterProiView protein in InterPro
IPR035361 Bee_toxin
PfamiView protein in Pfam
PF17454 Bee_toxin, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD026566 PD026566, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPAM_APIME
AccessioniPrimary (citable) accession number: P01500
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1996
Last modified: October 10, 2018
This is version 93 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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