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Protein

Beta-mammal toxin Cn2

Gene
N/A
Organism
Centruroides noxius (Mexican scorpion)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mammal beta-toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the activation voltage to more negative potentials. This toxin is active against mammals.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-mammal toxin Cn2
Short name:
Toxin 2
Alternative name(s):
Toxin II.9.2.2
OrganismiCentruroides noxius (Mexican scorpion)
Taxonomic identifieri6878 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeCentruroides

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

LD50 is 20 µg/kg in mice.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 162 PublicationsAdd BLAST›16
ChainiPRO_000003528017 – 82Beta-mammal toxin Cn2Add BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 81PROSITE-ProRule annotation1 Publication
Disulfide bondi32 ↔ 57PROSITE-ProRule annotation1 Publication
Disulfide bondi41 ↔ 62PROSITE-ProRule annotation1 Publication
Disulfide bondi45 ↔ 64PROSITE-ProRule annotation1 Publication
Modified residuei82Serine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Structurei

Secondary structure

184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP01495
SMRiP01495
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01495

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 82LCN-type CS-alpha/betaPROSITE-ProRule annotationAdd BLAST66

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR003614 Scorpion_toxin-like
IPR036574 Scorpion_toxin-like_sf
IPR018218 Scorpion_toxinL
IPR002061 Scorpion_toxinL/defensin
PfamiView protein in Pfam
PF00537 Toxin_3, 1 hit
PRINTSiPR00285 SCORPNTOXIN
SMARTiView protein in SMART
SM00505 Knot1, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS51863 LCN_CSAB, 1 hit

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01495-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LLIITACLAL IGTVWAKEGY LVDKNTGCKY ECLKLGDNDY CLRECKQQYG
60 70 80
KGAGGYCYAF ACWCTHLYEQ AIVWPLPNKR CSGK
Length:84
Mass (Da):9,436
Last modified:November 1, 1997 - v3
Checksum:i9784E065D37E2383
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti24Missing in AAR08045 (Ref. 3) Curated1
Sequence conflicti49 – 50YG → GY AA sequence (PubMed:1371253).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81096 mRNA Translation: AAB36086.1
AY351310 Genomic DNA Translation: AAR08045.1
PIRiT10893 NTSR2N

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S81096 mRNA Translation: AAB36086.1
AY351310 Genomic DNA Translation: AAR08045.1
PIRiT10893 NTSR2N

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CN2NMR-A17-82[»]
2YBRX-ray2.55C/F/I17-82[»]
2YC1X-ray1.90C/F17-82[»]
4V1DX-ray3.10C17-82[»]
ProteinModelPortaliP01495
SMRiP01495
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP01495

Family and domain databases

Gene3Di3.30.30.10, 1 hit
InterProiView protein in InterPro
IPR003614 Scorpion_toxin-like
IPR036574 Scorpion_toxin-like_sf
IPR018218 Scorpion_toxinL
IPR002061 Scorpion_toxinL/defensin
PfamiView protein in Pfam
PF00537 Toxin_3, 1 hit
PRINTSiPR00285 SCORPNTOXIN
SMARTiView protein in SMART
SM00505 Knot1, 1 hit
SUPFAMiSSF57095 SSF57095, 1 hit
PROSITEiView protein in PROSITE
PS51863 LCN_CSAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSCX2_CENNO
AccessioniPrimary (citable) accession number: P01495
Secondary accession number(s): Q26461, Q6V4Y0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1997
Last modified: July 18, 2018
This is version 112 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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