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Protein

Delta-hexatoxin-Ar1a

Gene
N/A
Organism
Atrax robustus (Sydney funnel-web spider)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits tetrodotoxin-sensitive voltage-gated sodium channels (Nav) by binding to site 3. It slows the inactivation, causes a prolongation of action potential duration resulting in repetitive firing in autonomic and motor nerve fibers. Does not depolarize the resting potential. Does not affect tetrodotoxin-resistant sodium channels. This lethal neurotoxin is active on both insect and mammalian voltage-gated sodium channels.4 Publications

Miscellaneous

In this species, the venom of the male is lethal rather than that of the female.

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Toxin, Voltage-gated sodium channel impairing toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-hexatoxin-Ar1aCurated
Short name:
Delta-HXTX-Ar1aCurated
Alternative name(s):
Delta-atracotoxin-Ar12 Publications
Delta-atracotoxin-Ar1a1 Publication
Short name:
Delta-ACTX-Ar1a1 Publication
Robustoxin4 Publications
Short name:
RBX2 Publications
OrganismiAtrax robustus (Sydney funnel-web spider)
Taxonomic identifieri6903 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaAraneaeMygalomorphaeHexathelidaeAtrax

Organism-specific databases

ArachnoServeriAS000305 delta-hexatoxin-Ar1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000876531 – 42Delta-hexatoxin-Ar1a1 PublicationAdd BLAST42

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi1 ↔ 152 PublicationsImported
Disulfide bondi8 ↔ 202 PublicationsImported
Disulfide bondi14 ↔ 312 PublicationsImported
Disulfide bondi16 ↔ 422 PublicationsImported

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP01478

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

Secondary structure

142
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP01478
SMRiP01478
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP01478

Family & Domainsi

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.2 Publications

Sequence similaritiesi

Belongs to the neurotoxin 06 (delta-actx) family.Curated

Keywords - Domaini

Knottin

Family and domain databases

InterProiView protein in InterPro
IPR008017 Atracotoxin_delta
PfamiView protein in Pfam
PF05353 Atracotoxin, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD026455 Atracotoxin, 1 hit
PROSITEiView protein in PROSITE
PS60018 DELTA_ACTX, 1 hit

Sequencei

Sequence statusi: Complete.

P01478-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40 
CAKKRNWCGK NEDCCCPMKC IYAWYNQQGS CQTTITGLFK KC
Length:42
Mass (Da):4,857
Last modified:July 21, 1986 - v1
Checksum:i093CF5D89540E284
GO

Mass spectrometryi

Molecular mass is 4848.7 Da from positions 1 - 42. Determined by ESI. 1 Publication

Sequence databases

PIRiA01738 NTIIRF

Similar proteinsi

Cross-referencesi

Sequence databases

PIRiA01738 NTIIRF

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QDPNMR-A1-42[»]
ProteinModelPortaliP01478
SMRiP01478
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP01478

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

ArachnoServeriAS000305 delta-hexatoxin-Ar1a

Miscellaneous databases

EvolutionaryTraceiP01478

Family and domain databases

InterProiView protein in InterPro
IPR008017 Atracotoxin_delta
PfamiView protein in Pfam
PF05353 Atracotoxin, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD026455 Atracotoxin, 1 hit
PROSITEiView protein in PROSITE
PS60018 DELTA_ACTX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTXDT1_ATRRO
AccessioniPrimary (citable) accession number: P01478
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 20, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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