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Protein

Lymphotoxin-alpha

Gene

LTA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM (PubMed:9462508). In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and is cytotoxic for a wide range of tumor cells in vitro and in vivo.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cytokine activity Source: UniProtKB-KW
  • signaling receptor binding Source: ProtInc
  • tumor necrosis factor receptor binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5669034 TNFs bind their physiological receptors
R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01374

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lymphotoxin-alpha
Short name:
LT-alpha
Alternative name(s):
TNF-beta
Tumor necrosis factor ligand superfamily member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LTA
Synonyms:TNFB, TNFSF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000226979.8

Human Gene Nomenclature Database

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HGNCi
HGNC:6709 LTA

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
153440 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01374

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Psoriatic arthritis (PSORAS)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionAn inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoid like pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
See also OMIM:607507

Organism-specific databases

DisGeNET

More...
DisGeNETi
4049

MalaCards human disease database

More...
MalaCardsi
LTA
MIMi607507 phenotype
610988 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000226979

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30474

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2059

Drug and drug target database

More...
DrugBanki
DB00005 Etanercept

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LTA

Domain mapping of disease mutations (DMDM)

More...
DMDMi
135940

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 34Add BLAST34
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003446335 – 205Lymphotoxin-alphaAdd BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi41O-linked (GalNAc...) threonine; partial1 Publication1
GlycosylationiCAR_00004896N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P01374

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01374

PeptideAtlas

More...
PeptideAtlasi
P01374

PRoteomics IDEntifications database

More...
PRIDEi
P01374

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51378

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
354

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01374

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
P01374

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000226979 Expressed in 86 organ(s), highest expression level in dorsal plus ventral thalamus

CleanEx database of gene expression profiles

More...
CleanExi
HS_LTA

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P01374 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01374 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA007729

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits. Interacts with TNFRSF14 (PubMed:9462508).1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110227, 8 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P01374

Database of interacting proteins

More...
DIPi
DIP-2910N

Protein interaction database and analysis system

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IntActi
P01374, 8 interactors

Molecular INTeraction database

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MINTi
P01374

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000403495

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P01374

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1205
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TNRX-ray2.85A62-205[»]
4MXVX-ray3.20A/B/D62-205[»]
4MXWX-ray3.60A/X62-205[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P01374

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01374

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01374

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IWT9 Eukaryota
ENOG410YQC4 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153265

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000048729

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG012516

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P01374

KEGG Orthology (KO)

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KOi
K05468

Identification of Orthologs from Complete Genome Data

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OMAi
FPKATPT

Database of Orthologous Groups

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OrthoDBi
1124938at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01374

TreeFam database of animal gene trees

More...
TreeFami
TF332169

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00184 TNF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.40, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR006053 TNF
IPR002960 TNF_beta
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00229 TNF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01234 TNECROSISFCT
PR01236 TNFBETA

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00207 TNF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49842 SSF49842, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P01374-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPPERLFLP RVCGTTLHLL LLGLLLVLLP GAQGLPGVGL TPSAAQTARQ
60 70 80 90 100
HPKMHLAHST LKPAAHLIGD PSKQNSLLWR ANTDRAFLQD GFSLSNNSLL
110 120 130 140 150
VPTSGIYFVY SQVVFSGKAY SPKATSSPLY LAHEVQLFSS QYPFHVPLLS
160 170 180 190 200
SQKMVYPGLQ EPWLHSMYHG AAFQLTQGDQ LSTHTDGIPH LVLSPSTVFF

GAFAL
Length:205
Mass (Da):22,297
Last modified:July 1, 1989 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1BBD5E7D496A3A82
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q6FG55Q6FG55_HUMAN
LTA
LTA
205Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q5ST95Q5ST95_HUMAN
LTA
LTA
205Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

A polymorphism in LTA accounts, in part, for susceptibility to leprosy linked to chromosome 6p21.3 (LPRS4) [MIMi:610988].

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01302313C → R3 PublicationsCorresponds to variant dbSNP:rs2229094Ensembl.1
Natural variantiVAR_01302451H → P2 PublicationsCorresponds to variant dbSNP:rs2229092Ensembl.1
Natural variantiVAR_00751160T → N in allele TNFB*2. 4 PublicationsCorresponds to variant dbSNP:rs1041981EnsemblClinVar.1
Natural variantiVAR_007512125T → P in allele 8.1. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X01393 mRNA Translation: CAA25649.1
X02911 Genomic DNA Translation: CAA26670.1
D00102 mRNA Translation: BAA00064.1
M16441 Genomic DNA Translation: AAA61199.1
D12614 mRNA Translation: BAA02139.1
M55913 Genomic DNA Translation: AAB59455.1
Z15026 Genomic DNA Translation: CAA78746.1
Y14768 Genomic DNA Translation: CAA75071.1
AF129756 Genomic DNA Translation: AAD18092.1
BA000025 Genomic DNA Translation: BAB63397.1
AY070490 Genomic DNA Translation: AAL49956.1
AY216498 Genomic DNA Translation: AAO21135.1
BC034729 mRNA Translation: AAH34729.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4701.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A92755 QWHUX

NCBI Reference Sequences

More...
RefSeqi
NP_000586.2, NM_000595.3
NP_001153212.1, NM_001159740.2
XP_011512917.1, XM_011514615.2
XP_011512918.1, XM_011514616.2
XP_011512919.1, XM_011514617.2
XP_011512920.1, XM_011514618.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.36

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000412851; ENSP00000412555; ENSG00000230279
ENST00000418386; ENSP00000413450; ENSG00000226979
ENST00000426845; ENSP00000402413; ENSG00000230279
ENST00000436519; ENSP00000395976; ENSG00000231408
ENST00000454550; ENSP00000416509; ENSG00000231408
ENST00000454783; ENSP00000403495; ENSG00000226979

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
4049

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:4049

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Lymphotoxin entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs
SeattleSNPs
SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01393 mRNA Translation: CAA25649.1
X02911 Genomic DNA Translation: CAA26670.1
D00102 mRNA Translation: BAA00064.1
M16441 Genomic DNA Translation: AAA61199.1
D12614 mRNA Translation: BAA02139.1
M55913 Genomic DNA Translation: AAB59455.1
Z15026 Genomic DNA Translation: CAA78746.1
Y14768 Genomic DNA Translation: CAA75071.1
AF129756 Genomic DNA Translation: AAD18092.1
BA000025 Genomic DNA Translation: BAB63397.1
AY070490 Genomic DNA Translation: AAL49956.1
AY216498 Genomic DNA Translation: AAO21135.1
BC034729 mRNA Translation: AAH34729.1
CCDSiCCDS4701.1
PIRiA92755 QWHUX
RefSeqiNP_000586.2, NM_000595.3
NP_001153212.1, NM_001159740.2
XP_011512917.1, XM_011514615.2
XP_011512918.1, XM_011514616.2
XP_011512919.1, XM_011514617.2
XP_011512920.1, XM_011514618.1
UniGeneiHs.36

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TNRX-ray2.85A62-205[»]
4MXVX-ray3.20A/B/D62-205[»]
4MXWX-ray3.60A/X62-205[»]
ProteinModelPortaliP01374
SMRiP01374
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110227, 8 interactors
CORUMiP01374
DIPiDIP-2910N
IntActiP01374, 8 interactors
MINTiP01374
STRINGi9606.ENSP00000403495

Chemistry databases

BindingDBiP01374
ChEMBLiCHEMBL2059
DrugBankiDB00005 Etanercept

PTM databases

GlyConnecti354
iPTMnetiP01374
UniCarbKBiP01374

Polymorphism and mutation databases

BioMutaiLTA
DMDMi135940

Proteomic databases

EPDiP01374
PaxDbiP01374
PeptideAtlasiP01374
PRIDEiP01374
ProteomicsDBi51378

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4049
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000412851; ENSP00000412555; ENSG00000230279
ENST00000418386; ENSP00000413450; ENSG00000226979
ENST00000426845; ENSP00000402413; ENSG00000230279
ENST00000436519; ENSP00000395976; ENSG00000231408
ENST00000454550; ENSP00000416509; ENSG00000231408
ENST00000454783; ENSP00000403495; ENSG00000226979
GeneIDi4049
KEGGihsa:4049

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4049
DisGeNETi4049
EuPathDBiHostDB:ENSG00000226979.8

GeneCards: human genes, protein and diseases

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GeneCardsi
LTA
HGNCiHGNC:6709 LTA
HPAiHPA007729
MalaCardsiLTA
MIMi153440 gene
607507 phenotype
610988 phenotype
neXtProtiNX_P01374
OpenTargetsiENSG00000226979
PharmGKBiPA30474

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IWT9 Eukaryota
ENOG410YQC4 LUCA
GeneTreeiENSGT00940000153265
HOGENOMiHOG000048729
HOVERGENiHBG012516
InParanoidiP01374
KOiK05468
OMAiFPKATPT
OrthoDBi1124938at2759
PhylomeDBiP01374
TreeFamiTF332169

Enzyme and pathway databases

ReactomeiR-HSA-5668541 TNFR2 non-canonical NF-kB pathway
R-HSA-5669034 TNFs bind their physiological receptors
R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
SIGNORiP01374

Miscellaneous databases

EvolutionaryTraceiP01374

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Lymphotoxin_alpha

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4049

Protein Ontology

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PROi
PR:P01374

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000226979 Expressed in 86 organ(s), highest expression level in dorsal plus ventral thalamus
CleanExiHS_LTA
ExpressionAtlasiP01374 baseline and differential
GenevisibleiP01374 HS

Family and domain databases

CDDicd00184 TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006053 TNF
IPR002960 TNF_beta
IPR021184 TNF_CS
IPR006052 TNF_dom
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PRINTSiPR01234 TNECROSISFCT
PR01236 TNFBETA
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251 TNF_1, 1 hit
PS50049 TNF_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNFB_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01374
Secondary accession number(s): Q8N4C3, Q9UKS8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: January 16, 2019
This is version 199 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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