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Protein

Gastrin

Gene

GAST

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • hormone activity Source: GO_Central

GO - Biological processi

  • G protein-coupled receptor signaling pathway Source: GO_Central
  • response to food Source: GO_Central
  • signal transduction Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-416476 G alpha (q) signalling events
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P01350

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Gastrin
Cleaved into the following 6 chains:
Alternative name(s):
Gastrin component I
Gastrin-52
Short name:
G52
Alternative name(s):
Gastrin component II
Gastrin-34
Short name:
G34
Alternative name(s):
Gastrin component III
Gastrin-17
Short name:
G17
Gastrin-14
Short name:
G14
Gastrin-6
Short name:
G6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GAST
Synonyms:GAS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000184502.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4164 GAST

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
137250 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P01350

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi86A → D: Small increase in ratio of gastrin-17 versus gastrin-34 production. No change in ratio of gastrin-17 versus gastrin-34 production; when associated with F-87. 1 Publication1
Mutagenesisi87Y → F: Small decrease in ratio of gastrin-17 versus gastrin-34 production. No change in ratio of gastrin-17 versus gastrin-34 production; when associated with D-86. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
2520

Open Targets

More...
OpenTargetsi
ENSG00000184502

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28577

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GAST

Domain mapping of disease mutations (DMDM)

More...
DMDMi
120952

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 211 PublicationAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000001063322 – 92Gastrin-71Add BLAST71
PeptideiPRO_000001063441 – 92Gastrin-52Add BLAST52
PeptideiPRO_000001063559 – 92Big gastrinAdd BLAST34
PeptideiPRO_000001063676 – 92GastrinAdd BLAST17
PeptideiPRO_000001063779 – 92Gastrin-14Add BLAST14
PeptideiPRO_000001063887 – 92Gastrin-66
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001063996 – 101Removed in mature form6

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei59Pyrrolidone carboxylic acid; in form big gastrin1 Publication1
Modified residuei76Pyrrolidone carboxylic acid; in form gastrin1 Publication1
Modified residuei87Sulfotyrosine; partial2 Publications1
Modified residuei92Phenylalanine amide1 Publication1
Modified residuei96Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71.
Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei40 – 41Cleavage2
Sitei58 – 59Cleavage2
Sitei75 – 76Cleavage2
Sitei95 – 96Cleavage2

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Phosphoprotein, Pyrrolidone carboxylic acid, Sulfation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01350

PeptideAtlas

More...
PeptideAtlasi
P01350

PRoteomics IDEntifications database

More...
PRIDEi
P01350

ProteomicsDB human proteome resource

More...
ProteomicsDBi
51377

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P01350

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P01350

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P01350

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184502 Expressed in 65 organ(s), highest expression level in stomach

CleanEx database of gene expression profiles

More...
CleanExi
HS_GAST

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P01350 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P01350 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB000038

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
TFP027875EBI-3436637,EBI-714319

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108796, 11 interactors

Database of interacting proteins

More...
DIPi
DIP-403N

Protein interaction database and analysis system

More...
IntActi
P01350, 17 interactors

Molecular INTeraction database

More...
MINTi
P01350

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000331358

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WRJX-ray2.31F/H/J/L81-92[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P01350

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P01350

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the gastrin/cholecystokinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J1ZA Eukaryota
ENOG4111D7Y LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000014792

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000073533

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG097593

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01350

KEGG Orthology (KO)

More...
KOi
K13768

Identification of Orthologs from Complete Genome Data

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OMAi
KKQGPWM

Database of Orthologous Groups

More...
OrthoDBi
1433918at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P01350

TreeFam database of animal gene trees

More...
TreeFami
TF336994

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039236 GAST
IPR001651 Gastrin/CCK
IPR013152 Gastrin/cholecystokinin_CS

The PANTHER Classification System

More...
PANTHERi
PTHR19309 PTHR19309, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00918 Gastrin, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00259 GASTRIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P01350-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRLCVYVLI FALALAAFSE ASWKPRSQQP DAPLGTGANR DLELPWLEQQ
60 70 80 90 100
GPASHHRRQL GPQGPPHLVA DPSKKQGPWL EEEEEAYGWM DFGRRSAEDE

N
Length:101
Mass (Da):11,394
Last modified:October 23, 1986 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA03C847FCFE7216C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0491273R → P. Corresponds to variant dbSNP:rs34309618Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X00183 Genomic DNA Translation: CAA25005.1
X00183 Genomic DNA Translation: CAA25006.1
X00183 Genomic DNA Translation: CAA25007.1
V00511 mRNA Translation: CAA23769.1
M15958 Genomic DNA Translation: AAA52520.1
K01254 Genomic DNA Translation: AAB59533.1
BC069724 mRNA Translation: AAH69724.1
BC069762 mRNA Translation: AAH69762.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11404.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A93997 GMHUB

NCBI Reference Sequences

More...
RefSeqi
NP_000796.1, NM_000805.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.2681

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000329402; ENSP00000331358; ENSG00000184502

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2520

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:2520

UCSC genome browser

More...
UCSCi
uc002hxl.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

Gastrin entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00183 Genomic DNA Translation: CAA25005.1
X00183 Genomic DNA Translation: CAA25006.1
X00183 Genomic DNA Translation: CAA25007.1
V00511 mRNA Translation: CAA23769.1
M15958 Genomic DNA Translation: AAA52520.1
K01254 Genomic DNA Translation: AAB59533.1
BC069724 mRNA Translation: AAH69724.1
BC069762 mRNA Translation: AAH69762.1
CCDSiCCDS11404.1
PIRiA93997 GMHUB
RefSeqiNP_000796.1, NM_000805.4
UniGeneiHs.2681

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WRJX-ray2.31F/H/J/L81-92[»]
ProteinModelPortaliP01350
SMRiP01350
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108796, 11 interactors
DIPiDIP-403N
IntActiP01350, 17 interactors
MINTiP01350
STRINGi9606.ENSP00000331358

PTM databases

iPTMnetiP01350
PhosphoSitePlusiP01350

Polymorphism and mutation databases

BioMutaiGAST
DMDMi120952

Proteomic databases

PaxDbiP01350
PeptideAtlasiP01350
PRIDEiP01350
ProteomicsDBi51377

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
2520
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329402; ENSP00000331358; ENSG00000184502
GeneIDi2520
KEGGihsa:2520
UCSCiuc002hxl.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2520
DisGeNETi2520
EuPathDBiHostDB:ENSG00000184502.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GAST
HGNCiHGNC:4164 GAST
HPAiCAB000038
MIMi137250 gene
neXtProtiNX_P01350
OpenTargetsiENSG00000184502
PharmGKBiPA28577

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J1ZA Eukaryota
ENOG4111D7Y LUCA
GeneTreeiENSGT00390000014792
HOGENOMiHOG000073533
HOVERGENiHBG097593
InParanoidiP01350
KOiK13768
OMAiKKQGPWM
OrthoDBi1433918at2759
PhylomeDBiP01350
TreeFamiTF336994

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK
SIGNORiP01350

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
GAST human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Gastrin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
2520
PMAP-CutDBiP01350

Protein Ontology

More...
PROi
PR:P01350

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184502 Expressed in 65 organ(s), highest expression level in stomach
CleanExiHS_GAST
ExpressionAtlasiP01350 baseline and differential
GenevisibleiP01350 HS

Family and domain databases

InterProiView protein in InterPro
IPR039236 GAST
IPR001651 Gastrin/CCK
IPR013152 Gastrin/cholecystokinin_CS
PANTHERiPTHR19309 PTHR19309, 1 hit
PfamiView protein in Pfam
PF00918 Gastrin, 1 hit
PROSITEiView protein in PROSITE
PS00259 GASTRIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGAST_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01350
Secondary accession number(s): P78463, P78464
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 23, 1986
Last modified: January 16, 2019
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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