Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Insulin-2

Gene

Ins2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

ReactomeiR-MMU-264876 Insulin processing
R-MMU-422085 Synthesis, secretion, and deacylation of Ghrelin
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-74713 IRS activation
R-MMU-74749 Signal attenuation
R-MMU-74751 Insulin receptor signalling cascade
R-MMU-74752 Signaling by Insulin receptor
R-MMU-77387 Insulin receptor recycling

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-2
Cleaved into the following 2 chains:
Gene namesi
Name:Ins2
Synonyms:Ins-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:96573 Ins2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
PeptideiPRO_000001584525 – 54Insulin-2 B chain1 PublicationAdd BLAST30
PropeptideiPRO_000001584657 – 87C peptideAdd BLAST31
PeptideiPRO_000001584790 – 110Insulin-2 A chain1 PublicationAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 96Interchain (between B and A chains)By similarity
Disulfide bondi43 ↔ 109Interchain (between B and A chains)By similarity
Disulfide bondi95 ↔ 100By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP01326
PRIDEiP01326

PTM databases

PhosphoSitePlusiP01326

Miscellaneous databases

PMAP-CutDBiP01326

Expressioni

Gene expression databases

BgeeiENSMUSG00000000215 Expressed in 67 organ(s), highest expression level in dorsal pancreas
CleanExiMM_INS2
ExpressionAtlasiP01326 baseline and differential
GenevisibleiP01326 MM

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000220

Structurei

3D structure databases

ProteinModelPortaliP01326
SMRiP01326
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0XC Eukaryota
ENOG4111VJB LUCA
GeneTreeiENSGT00390000015440
HOGENOMiHOG000261669
HOVERGENiHBG006137
InParanoidiP01326
KOiK04526
OrthoDBiEOG091G0H56
PhylomeDBiP01326
TreeFamiTF332820

Family and domain databases

InterProiView protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00277 INSULIN
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P01326-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALWMRFLPL LALLFLWESH PTQAFVKQHL CGSHLVEALY LVCGERGFFY
60 70 80 90 100
TPMSRREVED PQVAQLELGG GPGAGDLQTL ALEVAQQKRG IVDQCCTSIC
110
SLYQLENYCN
Length:110
Mass (Da):12,364
Last modified:August 13, 1987 - v1
Checksum:i3554C8803D24FDAD
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CXX7E0CXX7_MOUSE
Insulin
Ins2
98Annotation score:
D3Z596D3Z596_MOUSE
Insulin-2
Ins2
79Annotation score:
D3Z595D3Z595_MOUSE
Insulin-2
Ins2
106Annotation score:
D3YWU5D3YWU5_MOUSE
Insulin-2
Ins2
70Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04724 Genomic DNA Translation: CAA28433.1
CCDSiCCDS22034.1
PIRiA26342 INMS2
RefSeqiNP_001172012.1, NM_001185083.2
NP_001172013.1, NM_001185084.2
NP_032413.1, NM_008387.5
UniGeneiMm.4946

Genome annotation databases

EnsembliENSMUST00000000220; ENSMUSP00000000220; ENSMUSG00000000215
ENSMUST00000105932; ENSMUSP00000101552; ENSMUSG00000000215
ENSMUST00000105933; ENSMUSP00000101553; ENSMUSG00000000215
ENSMUST00000105934; ENSMUSP00000101554; ENSMUSG00000000215
ENSMUST00000210288; ENSMUSP00000147425; ENSMUSG00000000215
GeneIDi16334
KEGGimmu:16334
UCSCiuc009kof.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04724 Genomic DNA Translation: CAA28433.1
CCDSiCCDS22034.1
PIRiA26342 INMS2
RefSeqiNP_001172012.1, NM_001185083.2
NP_001172013.1, NM_001185084.2
NP_032413.1, NM_008387.5
UniGeneiMm.4946

3D structure databases

ProteinModelPortaliP01326
SMRiP01326
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000220

PTM databases

PhosphoSitePlusiP01326

Proteomic databases

PaxDbiP01326
PRIDEiP01326

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000220; ENSMUSP00000000220; ENSMUSG00000000215
ENSMUST00000105932; ENSMUSP00000101552; ENSMUSG00000000215
ENSMUST00000105933; ENSMUSP00000101553; ENSMUSG00000000215
ENSMUST00000105934; ENSMUSP00000101554; ENSMUSG00000000215
ENSMUST00000210288; ENSMUSP00000147425; ENSMUSG00000000215
GeneIDi16334
KEGGimmu:16334
UCSCiuc009kof.2 mouse

Organism-specific databases

CTDi16334
MGIiMGI:96573 Ins2

Phylogenomic databases

eggNOGiENOG410J0XC Eukaryota
ENOG4111VJB LUCA
GeneTreeiENSGT00390000015440
HOGENOMiHOG000261669
HOVERGENiHBG006137
InParanoidiP01326
KOiK04526
OrthoDBiEOG091G0H56
PhylomeDBiP01326
TreeFamiTF332820

Enzyme and pathway databases

ReactomeiR-MMU-264876 Insulin processing
R-MMU-422085 Synthesis, secretion, and deacylation of Ghrelin
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-74713 IRS activation
R-MMU-74749 Signal attenuation
R-MMU-74751 Insulin receptor signalling cascade
R-MMU-74752 Signaling by Insulin receptor
R-MMU-77387 Insulin receptor recycling

Miscellaneous databases

ChiTaRSiIns2 mouse
PMAP-CutDBiP01326
PROiPR:P01326
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000215 Expressed in 67 organ(s), highest expression level in dorsal pancreas
CleanExiMM_INS2
ExpressionAtlasiP01326 baseline and differential
GenevisibleiP01326 MM

Family and domain databases

InterProiView protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00277 INSULIN
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINS2_MOUSE
AccessioniPrimary (citable) accession number: P01326
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: November 7, 2018
This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again