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Protein

Insulin-1

Gene

Ins1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

ReactomeiR-MMU-264876 Insulin processing
R-MMU-422085 Synthesis, secretion, and deacylation of Ghrelin
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-74713 IRS activation
R-MMU-74749 Signal attenuation
R-MMU-74751 Insulin receptor signalling cascade
R-MMU-74752 Signaling by Insulin receptor
R-MMU-77387 Insulin receptor recycling

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-1
Cleaved into the following 2 chains:
Gene namesi
Name:Ins1
Synonyms:Ins-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:96572 Ins1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
PeptideiPRO_000001584225 – 54Insulin-1 B chainAdd BLAST30
PropeptideiPRO_000001584357 – 85C peptideAdd BLAST29
PeptideiPRO_000001584488 – 108Insulin-1 A chainAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi31 ↔ 94Interchain (between B and A chains)By similarity
Disulfide bondi43 ↔ 107Interchain (between B and A chains)By similarity
Disulfide bondi93 ↔ 98By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP01325
PRIDEiP01325

Expressioni

Gene expression databases

BgeeiENSMUSG00000035804 Expressed in 81 organ(s), highest expression level in islet of Langerhans
CleanExiMM_INS1
GenevisibleiP01325 MM

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.By similarity

GO - Molecular functioni

Protein-protein interaction databases

MINTiP01325
STRINGi10090.ENSMUSP00000049095

Structurei

3D structure databases

ProteinModelPortaliP01325
SMRiP01325
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J0XC Eukaryota
ENOG4111VJB LUCA
GeneTreeiENSGT00390000015440
HOGENOMiHOG000261669
HOVERGENiHBG006137
InParanoidiP01325
KOiK04526
OMAiELEDPQV
OrthoDBiEOG091G0H56
PhylomeDBiP01325
TreeFamiTF332820

Family and domain databases

InterProiView protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00277 INSULIN
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P01325-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLVHFLPL LALLALWEPK PTQAFVKQHL CGPHLVEALY LVCGERGFFY
60 70 80 90 100
TPKSRREVED PQVEQLELGG SPGDLQTLAL EVARQKRGIV DQCCTSICSL

YQLENYCN
Length:108
Mass (Da):12,160
Last modified:August 13, 1987 - v1
Checksum:iF63D9B7B896E0F88
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti37E → K in BAB25058 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04725 Genomic DNA Translation: CAA28434.1
DQ479923 Genomic DNA Translation: ABF48502.1
AK007345 mRNA Translation: BAB24974.1
AK007482 mRNA Translation: BAB25058.1
AK008358 mRNA Translation: BAB25628.1
AK148541 mRNA Translation: BAE28611.1
AC163452 Genomic DNA No translation available.
CH466585 Genomic DNA Translation: EDL01682.1
CH466585 Genomic DNA Translation: EDL01683.1
BC098468 mRNA Translation: AAH98468.1
BC145868 mRNA Translation: AAI45869.1
BC145870 mRNA Translation: AAI45871.1
CCDSiCCDS29898.1
PIRiB26342 INMS1
RefSeqiNP_032412.3, NM_008386.4
UniGeneiMm.46269

Genome annotation databases

EnsembliENSMUST00000039652; ENSMUSP00000049095; ENSMUSG00000035804
GeneIDi16333
KEGGimmu:16333
UCSCiuc008hwd.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X04725 Genomic DNA Translation: CAA28434.1
DQ479923 Genomic DNA Translation: ABF48502.1
AK007345 mRNA Translation: BAB24974.1
AK007482 mRNA Translation: BAB25058.1
AK008358 mRNA Translation: BAB25628.1
AK148541 mRNA Translation: BAE28611.1
AC163452 Genomic DNA No translation available.
CH466585 Genomic DNA Translation: EDL01682.1
CH466585 Genomic DNA Translation: EDL01683.1
BC098468 mRNA Translation: AAH98468.1
BC145868 mRNA Translation: AAI45869.1
BC145870 mRNA Translation: AAI45871.1
CCDSiCCDS29898.1
PIRiB26342 INMS1
RefSeqiNP_032412.3, NM_008386.4
UniGeneiMm.46269

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1L6Qmodel-C39-47[»]
3WS3X-ray2.34E/F101-107[»]
ProteinModelPortaliP01325
SMRiP01325
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiP01325
STRINGi10090.ENSMUSP00000049095

Proteomic databases

PaxDbiP01325
PRIDEiP01325

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039652; ENSMUSP00000049095; ENSMUSG00000035804
GeneIDi16333
KEGGimmu:16333
UCSCiuc008hwd.1 mouse

Organism-specific databases

CTDi16333
MGIiMGI:96572 Ins1

Phylogenomic databases

eggNOGiENOG410J0XC Eukaryota
ENOG4111VJB LUCA
GeneTreeiENSGT00390000015440
HOGENOMiHOG000261669
HOVERGENiHBG006137
InParanoidiP01325
KOiK04526
OMAiELEDPQV
OrthoDBiEOG091G0H56
PhylomeDBiP01325
TreeFamiTF332820

Enzyme and pathway databases

ReactomeiR-MMU-264876 Insulin processing
R-MMU-422085 Synthesis, secretion, and deacylation of Ghrelin
R-MMU-6807878 COPI-mediated anterograde transport
R-MMU-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-MMU-74713 IRS activation
R-MMU-74749 Signal attenuation
R-MMU-74751 Insulin receptor signalling cascade
R-MMU-74752 Signaling by Insulin receptor
R-MMU-77387 Insulin receptor recycling

Miscellaneous databases

PROiPR:P01325
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035804 Expressed in 81 organ(s), highest expression level in islet of Langerhans
CleanExiMM_INS1
GenevisibleiP01325 MM

Family and domain databases

InterProiView protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00277 INSULIN
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiINS1_MOUSE
AccessioniPrimary (citable) accession number: P01325
Secondary accession number(s): Q545I7, Q9D907
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 13, 1987
Last modified: November 7, 2018
This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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