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Protein

Insulin

Gene

INS

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • hormone activity Source: AgBase
  • identical protein binding Source: IntAct
  • insulin-like growth factor receptor binding Source: AgBase
  • insulin receptor binding Source: Ensembl
  • protease binding Source: Ensembl

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHormone
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SSC-264876 Insulin processing
R-SSC-422085 Synthesis, secretion, and deacylation of Ghrelin
R-SSC-6807878 COPI-mediated anterograde transport
R-SSC-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-SSC-74713 IRS activation
R-SSC-74749 Signal attenuation
R-SSC-74751 Insulin receptor signalling cascade
R-SSC-74752 Signaling by Insulin receptor
R-SSC-77387 Insulin receptor recycling

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Insulin
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INS
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSus scrofa (Pig)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9823 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008227 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Protein family/group databases

Allergome; a platform for allergen knowledge

More...
Allergomei
2122 Sus s Insulin

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 241 PublicationAdd BLAST24
<p>This subsection of the ‘PTM / Processing’ section describes the position and length of an active peptide in the mature protein.<p><a href='/help/peptide' target='_top'>More...</a></p>PeptideiPRO_000001587925 – 54Insulin B chainAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000001588057 – 85C peptideAdd BLAST29
PeptideiPRO_000001588188 – 108Insulin A chainAdd BLAST21

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi31 ↔ 94Interchain (between B and A chains)Combined sources3 Publications
Disulfide bondi43 ↔ 107Interchain (between B and A chains)Combined sources3 Publications
Disulfide bondi93 ↔ 98Combined sources3 Publications

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P01315

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-8437944,EBI-8437944

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P01315, 1 interactor

Molecular INTeraction database

More...
MINTi
P01315

STRING: functional protein association networks

More...
STRINGi
9823.ENSSSCP00000025428

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1108
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P01315

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P01315

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P01315

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the insulin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J0XC Eukaryota
ENOG4111VJB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015440

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG006137

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P01315

KEGG Orthology (KO)

More...
KOi
K04526

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00049 Insulin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00277 INSULIN
PR00276 INSULINFAMLY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00078 IlGF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56994 SSF56994, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00262 INSULIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P01315-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALWTRLLPL LALLALWAPA PAQAFVNQHL CGSHLVEALY LVCGERGFFY
60 70 80 90 100
TPKARREAEN PQAGAVELGG GLGGLQALAL EGPPQKRGIV EQCCTSICSL

YQLENYCN
Length:108
Mass (Da):11,672
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCB4491B429858EBE
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC77920 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF064555 mRNA Translation: AAC77920.1 Different initiation.
AY044828 Genomic DNA Translation: AAL69550.1
AY242098 Genomic DNA Translation: AAQ00952.1
AY242099 Genomic DNA Translation: AAQ00954.1
AY242100 Genomic DNA Translation: AAQ00957.1
AY242101 Genomic DNA Translation: AAQ00960.1
AY242102 Genomic DNA Translation: AAQ00963.1
AY242103 Genomic DNA Translation: AAQ00966.1
AY242104 Genomic DNA Translation: AAQ00969.1
AY242105 Genomic DNA Translation: AAQ00972.1
AY242106 Genomic DNA Translation: AAQ00975.1
AY242107 Genomic DNA Translation: AAQ00978.1
AY242108 Genomic DNA Translation: AAQ00981.1
AY242109 Genomic DNA Translation: AAQ00983.1
AY242110 Genomic DNA Translation: AAQ00985.1
AY242111 Genomic DNA Translation: AAQ00987.1
AY242112 Genomic DNA Translation: AAQ00990.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A01583 IPPG

NCBI Reference Sequences

More...
RefSeqi
NP_001103242.1, NM_001109772.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Ssc.583

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSSSCT00000064136; ENSSSCP00000044635; ENSSSCG00000033740

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
397415

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ssc:397415

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Protein Spotlight

Protein of the 20th century - Issue 9 of April 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064555 mRNA Translation: AAC77920.1 Different initiation.
AY044828 Genomic DNA Translation: AAL69550.1
AY242098 Genomic DNA Translation: AAQ00952.1
AY242099 Genomic DNA Translation: AAQ00954.1
AY242100 Genomic DNA Translation: AAQ00957.1
AY242101 Genomic DNA Translation: AAQ00960.1
AY242102 Genomic DNA Translation: AAQ00963.1
AY242103 Genomic DNA Translation: AAQ00966.1
AY242104 Genomic DNA Translation: AAQ00969.1
AY242105 Genomic DNA Translation: AAQ00972.1
AY242106 Genomic DNA Translation: AAQ00975.1
AY242107 Genomic DNA Translation: AAQ00978.1
AY242108 Genomic DNA Translation: AAQ00981.1
AY242109 Genomic DNA Translation: AAQ00983.1
AY242110 Genomic DNA Translation: AAQ00985.1
AY242111 Genomic DNA Translation: AAQ00987.1
AY242112 Genomic DNA Translation: AAQ00990.1
PIRiA01583 IPPG
RefSeqiNP_001103242.1, NM_001109772.1
UniGeneiSsc.583

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B17X-ray1.70A88-108[»]
B25-54[»]
1B18X-ray1.80A88-108[»]
B25-54[»]
1B19X-ray1.80A88-108[»]
B25-54[»]
1B2AX-ray1.70A88-108[»]
B25-54[»]
1B2BX-ray1.80A88-108[»]
B25-54[»]
1B2CX-ray1.80A88-108[»]
B25-54[»]
1B2DX-ray1.70A88-108[»]
B25-54[»]
1B2EX-ray1.90A88-108[»]
B25-54[»]
1B2FX-ray1.90A88-108[»]
B25-54[»]
1B2GX-ray1.80A88-108[»]
B25-54[»]
1DEIX-ray1.60A/C88-108[»]
B/D25-47[»]
1IZAX-ray2.50A/C88-108[»]
B/D25-53[»]
1IZBX-ray2.00A/C88-108[»]
B/D25-53[»]
1M5AX-ray1.20A/C88-108[»]
B/D25-54[»]
1MPJX-ray2.30A/C88-108[»]
B/D25-54[»]
1SDBX-ray1.65A88-108[»]
B27-49[»]
1WAVX-ray2.50A/C/E/G/I/K88-108[»]
B/D/F/H/J/L25-54[»]
1ZEIX-ray1.90A/B/C/D/E/F25-54[»]
A/B/C/D/E/F88-108[»]
1ZNIX-ray1.50A/C88-108[»]
B/D25-54[»]
2EFAneutron diffraction2.70A88-108[»]
B25-54[»]
2G4MX-ray1.80A88-108[»]
B25-54[»]
2TCIX-ray1.80A/C88-108[»]
B/D25-54[»]
2ZPPneutron diffraction2.50A88-108[»]
B25-54[»]
3FHPneutron diffraction2.00A/C88-108[»]
B/D25-54[»]
3GKYX-ray1.80A/C88-108[»]
B/D25-54[»]
3INSX-ray1.50A/C88-108[»]
B/D25-54[»]
3MTHX-ray1.90A/C88-108[»]
B/D25-54[»]
3RTOX-ray1.80A/C88-108[»]
B/D25-54[»]
3T2AX-ray2.10A88-108[»]
B25-54[»]
4A7EX-ray1.86A88-108[»]
B25-54[»]
4INSX-ray1.50A/C88-108[»]
B/D25-54[»]
5D52X-ray1.80A88-108[»]
B25-54[»]
5D53X-ray1.50A88-108[»]
B25-54[»]
5D54X-ray1.50A88-108[»]
B25-54[»]
5D5EX-ray2.41A88-108[»]
B25-54[»]
5FB6X-ray1.90A88-108[»]
B25-54[»]
5LISX-ray2.29A88-108[»]
B25-54[»]
6INSX-ray2.00E/F25-108[»]
7INSX-ray2.00A/C/E88-108[»]
B/D/F25-54[»]
9INSX-ray1.70A88-108[»]
B25-54[»]
ProteinModelPortaliP01315
SMRiP01315
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP01315, 1 interactor
MINTiP01315
STRINGi9823.ENSSSCP00000025428

Protein family/group databases

Allergomei2122 Sus s Insulin

Proteomic databases

PaxDbiP01315

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000064136; ENSSSCP00000044635; ENSSSCG00000033740
GeneIDi397415
KEGGissc:397415

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3630

Phylogenomic databases

eggNOGiENOG410J0XC Eukaryota
ENOG4111VJB LUCA
GeneTreeiENSGT00390000015440
HOVERGENiHBG006137
InParanoidiP01315
KOiK04526

Enzyme and pathway databases

ReactomeiR-SSC-264876 Insulin processing
R-SSC-422085 Synthesis, secretion, and deacylation of Ghrelin
R-SSC-6807878 COPI-mediated anterograde transport
R-SSC-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-SSC-74713 IRS activation
R-SSC-74749 Signal attenuation
R-SSC-74751 Insulin receptor signalling cascade
R-SSC-74752 Signaling by Insulin receptor
R-SSC-77387 Insulin receptor recycling

Miscellaneous databases

EvolutionaryTraceiP01315

Family and domain databases

InterProiView protein in InterPro
IPR004825 Insulin
IPR016179 Insulin-like
IPR036438 Insulin-like_sf
IPR022353 Insulin_CS
IPR022352 Insulin_family
PfamiView protein in Pfam
PF00049 Insulin, 1 hit
PRINTSiPR00277 INSULIN
PR00276 INSULINFAMLY
SMARTiView protein in SMART
SM00078 IlGF, 1 hit
SUPFAMiSSF56994 SSF56994, 1 hit
PROSITEiView protein in PROSITE
PS00262 INSULIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINS_PIG
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P01315
Secondary accession number(s): Q9TSJ5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: December 1, 2000
Last modified: November 7, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
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